Speckle signatures dictate cancer prognosis

IF 17.3 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2025-01-03 DOI:10.1038/s41556-024-01569-7

Hiro Takakuwa, Tetsuro Hirose

引用次数: 0

Abstract

Nuclear speckles are dynamic structures enriched in RNA and RNA regulators, with varying compositions. A study now reports two distinct signatures of nuclear speckles that are linked to the prognosis of clear cell renal cell carcinoma. The signatures influence the expression of genes regulated by the transcription factor HIF2α.

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斑点特征指示癌症预后

核斑是富含RNA和RNA调节因子的动态结构，具有不同的组成。一项研究报告了与透明细胞肾细胞癌预后相关的核斑点的两个不同特征。这些特征影响转录因子HIF2α调控基因的表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology