Nature Cell Biology最新文献

A three-dimensional spatial transcriptome atlas reconstructs early organogenesis in primate Carnegie stages 9 and 10 embryos. 三维空间转录组图谱重建了灵长类卡内基9期和10期胚胎的早期器官发生。

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-05-07 DOI: 10.1038/s41556-026-01956-2

Jia Ping Tan, Yifang Liu, Yuting Fu, Langchao Liang, Yan Wu, Tiantian Guo, Shikai Jia, Yujia Jiang, Tingli Yuan, Jie Li, Yixin Li, Zhi Huang, Shenglong Li, Jie Li, Xixi Yan, Zizhuo Liao, Xiaojing Liu, Bowen Hu, Shujie Fu, Shijie Hao, Luyi Tian, Zhen Liu, Leqian Yu, Longqi Liu, Xiaodong Liu

{"title":"A three-dimensional spatial transcriptome atlas reconstructs early organogenesis in primate Carnegie stages 9 and 10 embryos.","authors":"Jia Ping Tan, Yifang Liu, Yuting Fu, Langchao Liang, Yan Wu, Tiantian Guo, Shikai Jia, Yujia Jiang, Tingli Yuan, Jie Li, Yixin Li, Zhi Huang, Shenglong Li, Jie Li, Xixi Yan, Zizhuo Liao, Xiaojing Liu, Bowen Hu, Shujie Fu, Shijie Hao, Luyi Tian, Zhen Liu, Leqian Yu, Longqi Liu, Xiaodong Liu","doi":"10.1038/s41556-026-01956-2","DOIUrl":"https://doi.org/10.1038/s41556-026-01956-2","url":null,"abstract":"The early organogenesis stage is a critical phase of embryogenesis that lays the foundation for organ development, and is characterized by dynamic and spatially organized transcriptional programs. However, limited spatial transcriptomic information has constrained our understanding of early primate organogenesis. Here we present a comprehensive three-dimensional (3D) spatial transcriptomic atlas of cynomolgus monkey embryos at Carnegie stages (CS) 9 and 10, capturing key morphogenetic events including cardiogenesis, gut tube regionalization, neurulation, axial mesendoderm patterning and early somitogenesis. Using high-resolution spatial transcriptomics and 3D reconstruction, we identify spatially defined lineage domains across germ layers and resolve regionally restricted gene expression, transcription factor activity, and signalling landscapes along major embryonic axes, exemplified by the emergence of dorsoventrally patterned spinal cord subpopulations during neurulation. Cross-species comparisons with human and mouse datasets reveal conserved and species-biased transcriptional programs. Together, this atlas provides a foundational reference for studying early primate development.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":" ","pages":""},"PeriodicalIF":19.1,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

lncRNA in EGFR‑driven glioblastoma. EGFR成胶质母细胞瘤。

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-05-06 DOI: 10.1038/s41556-026-01947-3

Andrew Dhawan, Justin D Lathia

引用次数: 0

NAT10 maintains stem cell homeostasis by mitigating mRNA decay through an ac⁴C-independent mechanism. NAT10通过不依赖于ac4c的机制减轻mRNA衰变，从而维持干细胞稳态。

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-05-04 DOI: 10.1038/s41556-026-01949-1

Weiqian Li, Yue Huo, Zhaoru Zhang, Yiyang Liu, Xinyue Qian, Jia Ouyang, Rao Gu, Chenxi Han, Shuo Li, Rui Su, Jia Yu, Pengxu Qian, Fang Wang

{"title":"NAT10 maintains stem cell homeostasis by mitigating mRNA decay through an ac4C-independent mechanism.","authors":"Weiqian Li, Yue Huo, Zhaoru Zhang, Yiyang Liu, Xinyue Qian, Jia Ouyang, Rao Gu, Chenxi Han, Shuo Li, Rui Su, Jia Yu, Pengxu Qian, Fang Wang","doi":"10.1038/s41556-026-01949-1","DOIUrl":"https://doi.org/10.1038/s41556-026-01949-1","url":null,"abstract":"Haematopoietic stem cells (HSCs) represent a well-established system for studying stem cell maintenance. While RNA regulators have been reported in HSCs, a systematic characterization and how they define transcript fate remains outstanding. Here we profile RNA characteristics of HSC-essential genes and uncover a notable feature in both human and mouse: they have extended 3' untranslated regions specifically enriched with AU-rich elements (AREs). These AREs are crucial for the expression of HSC genes, primarily through NAT10, which stabilizes their mRNAs. Notably, Nat10 deficiency markedly disrupts HSCs self-renewal and long-term reconstitution capacity. Mechanistically, NAT10 recruits ribosomes to the 3' untranslated region AREs of HSC-essential mRNAs, sheltering them from degradation-an effect independent of NAT10's ac4C catalytic activity. Moreover, NAT10 dysregulations were associated with multiple human haematological malignancies. Collectively, our findings uncover a specific mechanism of RNA turnover control mediated by specific RNA ARE motifs and identify a non-catalytic role of NAT10 in maintaining HSC homeostasis.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":" ","pages":""},"PeriodicalIF":19.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping specific lipid-protein interactions in living cells. 绘制活细胞中特定的脂质-蛋白相互作用。

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-05-01 DOI: 10.1038/s41556-026-01952-6

引用次数: 0

SLC33A1-mediated glutathione transport regulates ER redox balance and function. slc33a1介导的谷胱甘肽转运调节内质网氧化还原平衡和功能。

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-05-01 DOI: 10.1038/s41556-026-01929-5

引用次数: 0

Characterizing the metabolomes of microglia, astrocytes and neurons in ageing and Alzheimer's brains. 表征衰老和阿尔茨海默氏症大脑中小胶质细胞、星形胶质细胞和神经元的代谢组。

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-04-30 DOI: 10.1038/s41556-026-01910-2

Jie Yu, Fengzhi Li, Xing-Jun Chen, Chenye Mou, Di Yao, Zhanying Bi, Xiaoli Chen, Lulu Du, Ziyan Feng, Xinshuang Zhang, Xiaoqian Yu, Lauren G Zacharias, Ralph J DeBerardinis, Li Zhang, Zhen Li, Benyan Luo, Xiao-Ling Hu, Woo-Ping Ge

{"title":"Characterizing the metabolomes of microglia, astrocytes and neurons in ageing and Alzheimer's brains.","authors":"Jie Yu, Fengzhi Li, Xing-Jun Chen, Chenye Mou, Di Yao, Zhanying Bi, Xiaoli Chen, Lulu Du, Ziyan Feng, Xinshuang Zhang, Xiaoqian Yu, Lauren G Zacharias, Ralph J DeBerardinis, Li Zhang, Zhen Li, Benyan Luo, Xiao-Ling Hu, Woo-Ping Ge","doi":"10.1038/s41556-026-01910-2","DOIUrl":"https://doi.org/10.1038/s41556-026-01910-2","url":null,"abstract":"Neurons and glia are distinct in their morphology, development and function, possessing unique transcriptomes and proteomes, but little is known about their metabolomes. The challenge of brain cell metabolic profiling is to obtain a large number of cells for reliable analysis. Here we purified microglia, astrocytes and neurons from mouse brains, identifying >70 metabolites through targeted metabolomics and 9,854 metabolite features via untargeted metabolomics. We systematically characterized cell type-enriched metabolites and metabolic pathways, revealing an enrichment of glutathione (GSH) and polyamine metabolism in microglia. This enrichment was validated in vivo and showed significant decreases with ageing and in an Alzheimer's disease model. Notably, GSH and polyamine metabolism correlated strongly with chemokine-related gene expression. Disrupting the GSH pathway in microglia resulted in downregulation of chemokine-related genes, aberrant morphogenesis and β-amyloid deposition. Our results provide a valuable resource ( https://metabolismocean.org/braincell ) for metabolic studies related to ageing, Alzheimer's disease and other neurological diseases.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":" ","pages":""},"PeriodicalIF":19.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress. 非典型E3连接酶HOIL-1在细胞应激时保护核糖体。

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-04-30 DOI: 10.1038/s41556-026-01936-6

Todd Douglas, Pengju Nie, Jiasheng Zhang, Kyrillos S Abdallah, Zhiping Wu, Meghan McReynolds, Kazuhiro Iwai, Junmin Peng, Wendy V Gilbert, Lawrence H Young, Craig M Crews

{"title":"The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress.","authors":"Todd Douglas, Pengju Nie, Jiasheng Zhang, Kyrillos S Abdallah, Zhiping Wu, Meghan McReynolds, Kazuhiro Iwai, Junmin Peng, Wendy V Gilbert, Lawrence H Young, Craig M Crews","doi":"10.1038/s41556-026-01936-6","DOIUrl":"10.1038/s41556-026-01936-6","url":null,"abstract":"The ribosome has emerged as a signalling hub that can sense metabolic perturbations and coordinate responses that either restore homeostasis or initiate cell death. The range of insults that signal via the ribosome and the mechanisms governing such cell fate decisions remain uncharacterized. Here we identify the atypical E3 ligase HOIL-1 as an unexpected node in the ribosome signalling network that resolves cellular stress. We find that truncating HOIL-1 mutations associated with dilated cardiomyopathy exacerbate cardiac dysfunction in mice and broadly sensitize cells to nutrient and translational stress. These diverse signals converge on the MAP3K ZAKα, a sentinel of ribotoxic stress. Mechanistically, HOIL-1 promotes ribosome ubiquitination and facilitates cytoprotective ribosome-associated quality control. HOIL-1 loss of function causes glucose starvation to become ribotoxic, leading to ZAKα-dependent ATF4 activation and disulfidptosis driven by the cystine-glutamate antiporter xCT. These data reveal a molecular circuit controlling cell fate during nutrient stress and establish the ribosome as a signalosome that responds to cellular glucose levels.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":" ","pages":""},"PeriodicalIF":19.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ATM lifts the cGAS handbrake on DNA replication. ATM解除了cGAS对DNA复制的控制。

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-04-29 DOI: 10.1038/s41556-026-01944-6

Yea-Lih Lin, Philippe Pasero

引用次数: 0

ATM counteracts chromatin-bound cGAS during DNA replication. ATM在DNA复制过程中抵消染色质结合的cGAS。

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-04-29 DOI: 10.1038/s41556-026-01931-x

Yunhao Song, Xiaojuan Ran, Yu Xu, Kartik Subramanian, Chao Dai, Mavrakis Konstantinos, Li Lan, Vipin Yadav, Lee Zou

{"title":"ATM counteracts chromatin-bound cGAS during DNA replication.","authors":"Yunhao Song, Xiaojuan Ran, Yu Xu, Kartik Subramanian, Chao Dai, Mavrakis Konstantinos, Li Lan, Vipin Yadav, Lee Zou","doi":"10.1038/s41556-026-01931-x","DOIUrl":"10.1038/s41556-026-01931-x","url":null,"abstract":"Cyclic GMP-AMP synthase (cGAS), a DNA sensor that activates type-I interferon responses, is restrained in the nucleus through chromatin binding, but its impact on DNA metabolism remains unknown. Here we show that chromatin-bound cGAS impedes DNA replication forks unless countered by ATM. Upon ATM loss, chromatin-bound cGAS slows replication forks, increases nascent DNA fragmentation and activates cytosolic cGAS. Remarkably, all these effects are alleviated upon the loss of cGAS chromatin binding, suggesting that ATM enables tolerance to chromatin-bound cGAS. Mechanistically, ATM, backed by ATR, releases cGAS from chromatin by phosphorylating MRE11. ATR inhibition in ATM-deficient cells exacerbates replication stress, causing synthetic lethality and stimulated interferon response. In ATM-deficient cancer cells, cGAS dictates replication stress and ATR inhibitor sensitivity, highlighting its potential as a biomarker for ATR-targeted therapy. Together, our findings uncover a regulatory circuit in which ATM and chromatin-bound cGAS jointly maintain the homeostasis of replication and cGAS signalling in cycling cells.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":" ","pages":""},"PeriodicalIF":19.1,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: A complex secretory program orchestrated by the inflammasome controls paracrine senescence. 作者更正：一个复杂的分泌程序由炎性体控制旁分泌衰老。

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-04-28 DOI: 10.1038/s41556-026-01959-z

Juan Carlos Acosta, Ana Banito, Torsten Wuestefeld, Athena Georgilis, Peggy Janich, Jennifer P Morton, Dimitris Athineos, Tae-Won Kang, Felix Lasitschka, Mindaugas Andrulis, Gloria Pascual, Kelly J Morris, Sadaf Khan, Hong Jin, Gopuraja Dharmalingam, Ambrosius P Snijders, Thomas Carroll, David Capper, Catrin Pritchard, Gareth J Inman, Thomas Longerich, Owen J Sansom, Salvador Aznar Benitah, Lars Zender, Jesús Gil

引用次数: 0