Nature Cell Biology最新文献

Monocyte surface Y RNAs potentiate innate immunity 单核细胞表面Y rna增强先天免疫

IF 21.3 1区生物学

Nature Cell Biology Pub Date : 2026-10-19 DOI: 10.1038/s41556-026-02100-w

Xiao Jiang, Weizhi He, Chu Xu, Wanwei Zheng, Chenye Li, Danhua Xu, Qixin Shao, Yin Li, Zhuo Liu, Wenshuai Li, Shuang He, Zhiqiang Wang, Ronghua Liu, Yiwei Chu, Zhongguang Luo, Xinxin Huang, Jie Liu, Enzhuo Yang, Lulu Hu

{"title":"Monocyte surface Y RNAs potentiate innate immunity","authors":"Xiao Jiang, Weizhi He, Chu Xu, Wanwei Zheng, Chenye Li, Danhua Xu, Qixin Shao, Yin Li, Zhuo Liu, Wenshuai Li, Shuang He, Zhiqiang Wang, Ronghua Liu, Yiwei Chu, Zhongguang Luo, Xinxin Huang, Jie Liu, Enzhuo Yang, Lulu Hu","doi":"10.1038/s41556-026-02100-w","DOIUrl":"https://doi.org/10.1038/s41556-026-02100-w","url":null,"abstract":"RNAs can associate with the surface of diverse cell types, yet the functions of specific RNA species on primary immune cells remain unclear. Here, utilizing methods developed to profile, image and quantify surface RNAs in rare primary cell populations, we found that Y RNAs, a family of small noncoding RNAs, preferentially localize to human monocyte surface. In an exploratory pooled inflammatory bowel disease cohort, the proportion of cell-surface-Y-RNA-positive peripheral monocytes was markedly higher in patients with inflammatory bowel disease than in healthy donors or individuals with irritable bowel syndrome. In vivo depletion of cell-surface Y RNAs ameliorates disease activity in mice with colitis. Mechanistically, cell-surface Y RNAs co-cluster with Toll-like receptors TLR2 and TLR4, bind extracellular histones and promote receptor-mediated histone recognition, thereby activating NF-κB and AP-1 signalling and increasing IL6 expression and IL-6 secretion. These findings identify cell-surface Y RNAs as previously unrecognized amplifiers of inflammatory activation.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"285 1","pages":""},"PeriodicalIF":21.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: A kinetics-based model of haematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells. 作者更正：基于动力学的造血模型揭示了干细胞倾斜谱系输出的外在调节。

IF 22.7 1区生物学

Nature Cell Biology Pub Date : 2026-10-16 DOI: 10.1038/s41556-026-02103-7

Esther Rodríguez-Correa, Florian Grünschläger, Tamar Nizharadze, Natasha Anstee, Jude Al-Sabah, Vojtech Kumpost, Anastasia Sedlmeier, Congxin Li, Melanie Ball, Foteini Fotopoulou, Jeyan Jayarajan, Ian Ghezzi, Julia Knoch, Megan Druce, Kleo Aurich, Marleen Büchler-Schäff, Susanne Lux, Pablo Hernández-Malmierca, Julius Gräsel, Dominik Vonficht, Marta López-Osias, Elvira González-Saiz, Daniel Fernández-Pérez, Anna Mathioudaki, Judith Zaugg, Alejo Rodríguez-Fraticelli, Ralf Mikut, Andreas Trumpp, Thomas Höfer, Daniel Hübschmann, Simon Haas, Michael D Milsom

引用次数: 0

Author Correction: Remote control of AMPK via extracellular adenosine controls tissue growth. 作者更正：通过细胞外腺苷远程控制AMPK控制组织生长。

IF 22.7 1区生物学

Nature Cell Biology Pub Date : 2026-10-15 DOI: 10.1038/s41556-026-02104-6

Yao Zhang, Katrin Strassburger, Aurelio A Teleman

引用次数: 0

Author Correction: p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford progeria syndrome. 作者更正：p300核细胞质穿梭是Hutchinson-Gilford早衰综合征中mTORC1过度激活的基础。

IF 22.7 1区生物学

Nature Cell Biology Pub Date : 2026-10-12 DOI: 10.1038/s41556-026-02120-6

Sung Min Son, So Jung Park, Sophia Y Breusegem, Delphine Larrieu, David C Rubinsztein

引用次数: 0

Chromosome crowding shapes spindle geometry 染色体拥挤形成纺锤体几何形状。

IF 22.7 1区生物学

Nature Cell Biology Pub Date : 2026-10-09 DOI: 10.1038/s41556-026-02021-8

Jing Xie, Daniele Fachinetti

引用次数: 0

Goals and challenges for senescence research 衰老研究的目标与挑战。

IF 22.7 1区生物学

Nature Cell Biology Pub Date : 2026-10-09 DOI: 10.1038/s41556-026-02076-7

Cleo L. Bishop, Feyza Engin, Jing-Dong Jackie Han, Valery Krizhanovsky, Guang-Hui Liu, Ana O’Loghlen, João F. Passos, Zhongjun Zhou

引用次数: 0

RNA architecture regulates DNA replication RNA结构调节DNA复制。

IF 22.7 1区生物学

Nature Cell Biology Pub Date : 2026-10-09 DOI: 10.1038/s41556-026-02093-6

Sabrya Carim

引用次数: 0

In vivo DNA damage protection during cell migration across confining embryonic tissue environments 在体内DNA损伤保护在细胞迁移跨越限制胚胎组织环境。

IF 22.7 1区生物学

Nature Cell Biology Pub Date : 2026-10-09 DOI: 10.1038/s41556-026-02065-w

Hanna-Maria Häkkinen, Soraya Villaseca, Zain Alhashem, Atrin Hamidzadeh, Szymon Chomiczewski, Maxime Desevedavy, Solene Leleux, You-Hsuan Liu, Julia Monika Becker, Mint R. Htun, Filomena Gallo, Dina El-Zohiry, Victor Petre, Kasia Stefanowski, Kristian Franze, Jörg Renkawitz, Elena Scarpa

{"title":"In vivo DNA damage protection during cell migration across confining embryonic tissue environments","authors":"Hanna-Maria Häkkinen, Soraya Villaseca, Zain Alhashem, Atrin Hamidzadeh, Szymon Chomiczewski, Maxime Desevedavy, Solene Leleux, You-Hsuan Liu, Julia Monika Becker, Mint R. Htun, Filomena Gallo, Dina El-Zohiry, Victor Petre, Kasia Stefanowski, Kristian Franze, Jörg Renkawitz, Elena Scarpa","doi":"10.1038/s41556-026-02065-w","DOIUrl":"10.1038/s41556-026-02065-w","url":null,"abstract":"Cells migrating through confined spaces can experience nuclear deformation, nuclear envelope damage and DNA lesions, but the physiological consequences of confinement in vivo remain unclear. Using the zebrafish neural crest as a model of developmental migration, we show that tissue confinement increases along the antero–posterior axis and scales with the extent of nuclear deformation. Genetic and mechanical disruption of surrounding tissues relieves confinement and restores nuclear morphology in vivo. Surprisingly, even under extreme deformation, neural crest cells exhibit nucleo-cytoplasmic leakage without nuclear envelope rupture or increased DNA damage. Instead, confinement is associated with reduced LaminB2 at the nuclear envelope. Functional perturbation of LaminB2 reveals that its depletion accelerates recovery from deformation, whereas sustained expression causes persistent nuclear distortion, identifying LaminB2 as a regulator of nuclear deformability. RNA-seq of confined trunk neural crest cells reveals broad upregulation of DNA repair pathways, suggesting that these embryonic stem-like cells are intrinsically resistant to confinement-induced mechanical stress. Häkkinen et al. show that zebrafish neural crest cells encounter increased tissue-scale confinement along the body axis. Despite nuclear deformation, migrating neural crest cells experience neither nuclear envelope rupture nor increased DNA damage.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"28 10","pages":"2088-2105"},"PeriodicalIF":22.7,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41556-026-02065-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Power-law scaling of mitotic spindles with genome sizes across eukaryotes is driven by chromosome crowding 有丝分裂纺锤体的幂律缩放与基因组大小跨越真核生物是由染色体拥挤驱动的。

IF 22.7 1区生物学

Nature Cell Biology Pub Date : 2026-10-09 DOI: 10.1038/s41556-026-02005-8

Lovro Gudlin, Kruno Vukušić, Maja Novak, Monika Trupinić, Matko Ljulj, Iva Dundović, Ana Petelinec, Loren Petrušić, Anna Hertel, Thomas van Ravesteyn, Marianna Trakala, Geert J. P. L. Kops, Zuzana Storchová, Josip Tambača, Nenad Pavin, Iva M. Tolić

{"title":"Power-law scaling of mitotic spindles with genome sizes across eukaryotes is driven by chromosome crowding","authors":"Lovro Gudlin, Kruno Vukušić, Maja Novak, Monika Trupinić, Matko Ljulj, Iva Dundović, Ana Petelinec, Loren Petrušić, Anna Hertel, Thomas van Ravesteyn, Marianna Trakala, Geert J. P. L. Kops, Zuzana Storchová, Josip Tambača, Nenad Pavin, Iva M. Tolić","doi":"10.1038/s41556-026-02005-8","DOIUrl":"10.1038/s41556-026-02005-8","url":null,"abstract":"Genome size varies more than 10,000-fold across eukaryotes, yet how the mitotic spindle adapts to this range remains unknown. Here we show that metaphase plate width scales with genome size following a power law with an exponent of ~1/3 across eukaryotes. Comparative analysis and a physical model reveal that this scaling arises from the linear relationship between total chromosome volume and genome size, with chromosome number playing a secondary role. The same scaling holds across ploidy levels in cell lines, patient-derived cancer organoids and meiotic systems. Physical model and acute spindle compression demonstrate that chromosome crowding generates interchromosome pushing forces that set metaphase plate width. By contrast, spindle length is regulated by microtubule dynamics, cytoplasmic forces and cell size, indicating that spindle dimensions are independently controlled. The revealed scaling law provides a robust mechanism for accommodating large genomic variation and offers insight into the evolution of open mitosis and mitotic cell rounding, as well as polyploidy tolerance in tumours and during speciation. Gudlin, Vukušić, Novak and colleagues propose spindle scaling in response to chromosome crowding consistent across eukaryotes. They show that metaphase plate width scales with genome size following a power law with an exponent of ~1/3.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"28 10","pages":"1996-2007"},"PeriodicalIF":22.7,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41556-026-02005-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A signal to boost cholesterol 这是增加胆固醇的信号。

IF 22.7 1区生物学

Nature Cell Biology Pub Date : 2026-10-09 DOI: 10.1038/s41556-026-02084-7

Melina Casadio

引用次数: 0