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Bridging art and science
IF 21.3 1区 生物学
Nature Cell Biology Pub Date : 2024-12-20 DOI: 10.1038/s41556-024-01587-5
Sabrya Carim
{"title":"Bridging art and science","authors":"Sabrya Carim","doi":"10.1038/s41556-024-01587-5","DOIUrl":"https://doi.org/10.1038/s41556-024-01587-5","url":null,"abstract":"Ahna Skop is a geneticist and artist at the University of Wisconsin–Madison, USA. Ahna’s lab studies the assembly and function of mammalian midbody and midbody remnant, which are assembled at the end of mitosis. Ahna also leans into her passion for scientific art to engage the public. We were fascinated to hear Ahna’s thoughts on open questions and challenges in the field and to learn about her passion of marrying science and art.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"91 1","pages":""},"PeriodicalIF":21.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Misshapen chromosomes in check by mechanics 机械控制畸形染色体
IF 21.3 1区 生物学
Nature Cell Biology Pub Date : 2024-12-18 DOI: 10.1038/s41556-024-01573-x
Joana C. Macedo, Maria M. da Silva, Elsa Logarinho
{"title":"Misshapen chromosomes in check by mechanics","authors":"Joana C. Macedo, Maria M. da Silva, Elsa Logarinho","doi":"10.1038/s41556-024-01573-x","DOIUrl":"https://doi.org/10.1038/s41556-024-01573-x","url":null,"abstract":"Errors in chromosome segregation during cell division lead to changes in nuclear features. A study now shows that a mechanosensitive nuclear checkpoint activates the tumour suppressor p53 to halt the proliferation of aneuploid cells. These findings provide mechanistic insights to explore in both ageing and cancer pathologies.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"50 1","pages":""},"PeriodicalIF":21.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Worrying through the ECM
IF 17.3 1区 生物学
Nature Cell Biology Pub Date : 2024-12-10 DOI: 10.1038/s41556-024-01579-5
Daryl J. V. David
{"title":"Worrying through the ECM","authors":"Daryl J. V. David","doi":"10.1038/s41556-024-01579-5","DOIUrl":"10.1038/s41556-024-01579-5","url":null,"abstract":"","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"26 12","pages":"2013-2013"},"PeriodicalIF":17.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cu in cancer metabolism
IF 17.3 1区 生物学
Nature Cell Biology Pub Date : 2024-12-10 DOI: 10.1038/s41556-024-01578-6
Zhe Wang
{"title":"Cu in cancer metabolism","authors":"Zhe Wang","doi":"10.1038/s41556-024-01578-6","DOIUrl":"10.1038/s41556-024-01578-6","url":null,"abstract":"","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"26 12","pages":"2013-2013"},"PeriodicalIF":17.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulating chromatin assembly
IF 17.3 1区 生物学
Nature Cell Biology Pub Date : 2024-12-10 DOI: 10.1038/s41556-024-01581-x
Sabrya Carim
{"title":"Regulating chromatin assembly","authors":"Sabrya Carim","doi":"10.1038/s41556-024-01581-x","DOIUrl":"10.1038/s41556-024-01581-x","url":null,"abstract":"","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"26 12","pages":"2013-2013"},"PeriodicalIF":17.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Making stronger T cells
IF 17.3 1区 生物学
Nature Cell Biology Pub Date : 2024-12-10 DOI: 10.1038/s41556-024-01577-7
Stylianos Lefkopoulos
{"title":"Making stronger T cells","authors":"Stylianos Lefkopoulos","doi":"10.1038/s41556-024-01577-7","DOIUrl":"10.1038/s41556-024-01577-7","url":null,"abstract":"","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"26 12","pages":"2013-2013"},"PeriodicalIF":17.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Women in Autophagy: an initiative to promote gender parity in science
IF 17.3 1区 生物学
Nature Cell Biology Pub Date : 2024-12-02 DOI: 10.1038/s41556-024-01566-w
Mericka McCabe, Patricia Boya, Ruey-Hwa Chen, Charleen T. Chu, Maria Isabel Colombo, Laura Delgui, Eeva-Liisa Eskelinen, Maho Hamasaki, Malene Hansen, Congcong He, Marja Jäättelä, Adi Kimchi, Claudine Kraft, Mondira Kundu, Alicia Melendez, Sophie Pattingre, Tassula Proikas-Cezanne, Salwa Sebti, Anna Katharina Simon, Anne Simonsen, Sharon A. Tooze, Maria Ines Vaccaro, Xiaochen Wang, Eileen White, Yan Zhao, Ana Maria Cuervo
{"title":"Women in Autophagy: an initiative to promote gender parity in science","authors":"Mericka McCabe, Patricia Boya, Ruey-Hwa Chen, Charleen T. Chu, Maria Isabel Colombo, Laura Delgui, Eeva-Liisa Eskelinen, Maho Hamasaki, Malene Hansen, Congcong He, Marja Jäättelä, Adi Kimchi, Claudine Kraft, Mondira Kundu, Alicia Melendez, Sophie Pattingre, Tassula Proikas-Cezanne, Salwa Sebti, Anna Katharina Simon, Anne Simonsen, Sharon A. Tooze, Maria Ines Vaccaro, Xiaochen Wang, Eileen White, Yan Zhao, Ana Maria Cuervo","doi":"10.1038/s41556-024-01566-w","DOIUrl":"10.1038/s41556-024-01566-w","url":null,"abstract":"Scientific questions are universal but the scientific workforce remains skewed, with women and gender minorities still underrepresented. Initiatives such as the Women in Autophagy network promote the careers of these underrepresented groups with a range of free, year-round scientific, mentoring and networking activities for all scientists.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"26 12","pages":"2009-2012"},"PeriodicalIF":17.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Plasma membrane curvature regulates the formation of contacts with the endoplasmic reticulum
IF 21.3 1区 生物学
Nature Cell Biology Pub Date : 2024-12-02 DOI: 10.1038/s41556-024-01585-7
Yang Yang, Luis A. Valencia, Chih-Hao Lu, Melissa L. Nakamoto, Ching-Ting Tsai, Chun Liu, Huaxiao Yang, Wei Zhang, Zeinab Jahed, Wan-Ru Lee, Francesca Santoro, Jen Liou, Joseph C. Wu, Bianxiao Cui
{"title":"Author Correction: Plasma membrane curvature regulates the formation of contacts with the endoplasmic reticulum","authors":"Yang Yang, Luis A. Valencia, Chih-Hao Lu, Melissa L. Nakamoto, Ching-Ting Tsai, Chun Liu, Huaxiao Yang, Wei Zhang, Zeinab Jahed, Wan-Ru Lee, Francesca Santoro, Jen Liou, Joseph C. Wu, Bianxiao Cui","doi":"10.1038/s41556-024-01585-7","DOIUrl":"https://doi.org/10.1038/s41556-024-01585-7","url":null,"abstract":"<p>Correction to: <i>Nature Cell Biology</i> https://doi.org/10.1038/s41556-024-01511-x, published online 17 September 2024.</p>","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"12 1","pages":""},"PeriodicalIF":21.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The enhancer module of Integrator controls cell identity and early neural fate commitment Integrator的增强子模块控制细胞特性和早期神经命运承诺
IF 21.3 1区 生物学
Nature Cell Biology Pub Date : 2024-11-26 DOI: 10.1038/s41556-024-01556-y
Yingjie Zhang, Connor M. Hill, Kelsey A. Leach, Luca Grillini, Sandra Deliard, Sarah R. Offley, Martina Gatto, Francis Picone, Avery Zucco, Alessandro Gardini
{"title":"The enhancer module of Integrator controls cell identity and early neural fate commitment","authors":"Yingjie Zhang, Connor M. Hill, Kelsey A. Leach, Luca Grillini, Sandra Deliard, Sarah R. Offley, Martina Gatto, Francis Picone, Avery Zucco, Alessandro Gardini","doi":"10.1038/s41556-024-01556-y","DOIUrl":"https://doi.org/10.1038/s41556-024-01556-y","url":null,"abstract":"<p>Lineage-specific transcription factors operate as master orchestrators of developmental processes by activating select <i>cis</i>-regulatory enhancers and proximal promoters. Direct DNA binding of transcription factors ultimately drives context-specific recruitment of the basal transcriptional machinery that comprises RNA polymerase II (RNAPII) and a host of polymerase-associated multiprotein complexes, including the metazoan-specific Integrator complex. Integrator is primarily known to modulate RNAPII processivity and to surveil RNA integrity across coding genes. Here we describe an enhancer module of Integrator that directs cell fate specification by promoting epigenetic changes and transcription factor binding at neural enhancers. Depletion of Integrator’s INTS10 subunit upends neural traits and derails cells towards mesenchymal identity. Commissioning of neural enhancers relies on Integrator’s enhancer module, which stabilizes SOX2 binding at chromatin upon exit from pluripotency. We propose that Integrator is a functional bridge between enhancers and promoters and a main driver of early development, providing new insight into a growing family of neurodevelopmental syndromes.</p>","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"80 1","pages":""},"PeriodicalIF":21.3,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142713099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FMRP gains mitochondrial fission control FMRP 获得线粒体裂变控制权
IF 17.3 1区 生物学
Nature Cell Biology Pub Date : 2024-11-15 DOI: 10.1038/s41556-024-01567-9
Carissa L. Sirois, Soraya O. Sandoval, Xinyu Zhao
{"title":"FMRP gains mitochondrial fission control","authors":"Carissa L. Sirois,&nbsp;Soraya O. Sandoval,&nbsp;Xinyu Zhao","doi":"10.1038/s41556-024-01567-9","DOIUrl":"10.1038/s41556-024-01567-9","url":null,"abstract":"Mitochondrial fission and fusion are crucial for neurons. The RNA-binding protein FMRP regulates mitochondrial dynamics, including fusion and trafficking in neurons. A study now identifies a mechanism by which FMRP regulates mitochondrial fission.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"26 12","pages":"2014-2015"},"PeriodicalIF":17.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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