Nature Cell Biology最新文献_第7页

Real-time mirroring of therapy 治疗的实时镜像

IF 17.3 1区生物学

Nature Cell Biology Pub Date : 2025-01-16 DOI: 10.1038/s41556-024-01600-x

Stylianos Lefkopoulos

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Adapting to improve the author experience 适应提高作者体验

IF 17.3 1区生物学

Nature Cell Biology Pub Date : 2025-01-16 DOI: 10.1038/s41556-024-01596-4

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Chaperoning RNA into granules 陪伴RNA进入颗粒

IF 17.3 1区生物学

Nature Cell Biology Pub Date : 2025-01-16 DOI: 10.1038/s41556-024-01602-9

Daryl J. V. David

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Retraction Note: Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma 注：通过rna - rna结合蛋白复合物的肿瘤微环境编程，在idh野生型胶质母细胞瘤中产生了可药物的脆弱性

IF 17.3 1区生物学

Nature Cell Biology Pub Date : 2025-01-16 DOI: 10.1038/s41556-025-01613-0

Lele Wu, Zheng Zhao, Yong Jae Shin, Yiyun Yin, Anandhkumar Raju, Thamil Selvan Vaiyapuri, Khaireen Idzham, Miseol Son, Yeri Lee, Jason K. Sa, Joelle Yi Heng Chua, Bilal Unal, You Zhai, Wenhua Fan, Lijie Huang, Huimin Hu, Jayantha Gunaratne, Do-Hyun Nam, Tao Jiang, Vinay Tergaonkar

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Mitotic lethality prevents inflammation 有丝分裂致死能防止炎症

IF 17.3 1区生物学

Nature Cell Biology Pub Date : 2025-01-14 DOI: 10.1038/s41556-024-01529-1

Christian Zierhut, Andreas Villunger

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Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage 同源重组促进DNA损伤后非免疫原性有丝分裂细胞死亡

IF 17.3 1区生物学

Nature Cell Biology Pub Date : 2025-01-13 DOI: 10.1038/s41556-024-01557-x

Radoslaw Szmyd, Sienna Casolin, Lucy French, Anna G. Manjón, Melanie Walter, Léa Cavalli, Christopher B. Nelson, Scott G. Page, Andrew Dhawan, Eric Hau, Hilda A. Pickett, Harriet E. Gee, Anthony J. Cesare

{"title":"Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage","authors":"Radoslaw Szmyd, Sienna Casolin, Lucy French, Anna G. Manjón, Melanie Walter, Léa Cavalli, Christopher B. Nelson, Scott G. Page, Andrew Dhawan, Eric Hau, Hilda A. Pickett, Harriet E. Gee, Anthony J. Cesare","doi":"10.1038/s41556-024-01557-x","DOIUrl":"10.1038/s41556-024-01557-x","url":null,"abstract":"Double-strand breaks (DSBs) can initiate mitotic catastrophe, a complex oncosuppressive phenomenon characterized by cell death during or after cell division. Here we unveil how cell cycle-regulated DSB repair guides disparate cell death outcomes through single-cell analysis of extended live imaging. Following DSB induction in S or G2, passage of unresolved homologous recombination intermediates into mitosis promotes non-immunogenic intrinsic apoptosis in the immediate attempt at cell division. Conversely, non-homologous end joining, microhomology-mediated end joining and single-strand annealing cooperate to enable damaged G1 cells to complete the first cell cycle with an aberrant cell division at the cost of delayed extrinsic lethality and interferon production. Targeting non-homologous end joining, microhomology-mediated end joining or single-strand annealing promotes mitotic death, while suppressing mitotic death enhances interferon production. Together the data indicate that a temporal repair hierarchy, coupled with cumulative DSB load, serves as a reliable predictor of mitotic catastrophe outcomes following genome damage. In this pathway, homologous recombination suppresses interferon production by promoting mitotic lethality. Szmyd et al. show that DNA repair pathways impact whether cells with DNA lesions arrest in mitosis. The formation of homologous recombination-driven double Holliday junctions elicits mitotic cell death and suppresses inflammatory signalling.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"27 1","pages":"59-72"},"PeriodicalIF":17.3,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41556-024-01557-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial transcriptomic characterization of a Carnegie stage 7 human embryo 卡内基7期人类胚胎的空间转录组学特征

IF 17.3 1区生物学

Nature Cell Biology Pub Date : 2025-01-10 DOI: 10.1038/s41556-024-01597-3

Lina Cui, Sirui Lin, Xiaolong Yang, Xinwei Xie, Xiaoyan Wang, Nannan He, Jingyu Yang, Xin Zhang, Xiaojian Lu, Xiaodi Yan, Yifei Guo, Bailing Zhang, Ran Li, Hefan Miao, Mei Ji, Runzhao Zhang, Leqian Yu, Zhenyu Xiao, Yulei Wei, Jingtao Guo

{"title":"Spatial transcriptomic characterization of a Carnegie stage 7 human embryo","authors":"Lina Cui, Sirui Lin, Xiaolong Yang, Xinwei Xie, Xiaoyan Wang, Nannan He, Jingyu Yang, Xin Zhang, Xiaojian Lu, Xiaodi Yan, Yifei Guo, Bailing Zhang, Ran Li, Hefan Miao, Mei Ji, Runzhao Zhang, Leqian Yu, Zhenyu Xiao, Yulei Wei, Jingtao Guo","doi":"10.1038/s41556-024-01597-3","DOIUrl":"10.1038/s41556-024-01597-3","url":null,"abstract":"Gastrulation marks a pivotal stage in mammalian embryonic development, establishing the three germ layers and body axis through lineage diversification and morphogenetic movements. However, studying human gastrulating embryos is challenging due to limited access to early tissues. Here we show the use of spatial transcriptomics to analyse a fully intact Carnegie stage 7 human embryo at single-cell resolution, along with immunofluorescence validations in a second embryo. Employing 82 serial cryosections and Stereo-seq technology, we reconstructed a three-dimensional model of the embryo. Our findings reveal early specification of distinct mesoderm subtypes and the presence of the anterior visceral endoderm. Notably, primordial germ cells were located in the connecting stalk, and haematopoietic stem cell-independent haematopoiesis was observed in the yolk sac. This study advances our understanding of human gastrulation and provides a valuable dataset for future research in early human development. Guo and colleagues characterize an intact Carnegie stage 7 human embryo at single-cell resolution in a spatially resolved manner.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"27 2","pages":"360-369"},"PeriodicalIF":17.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Boosting cargo turnover with receptor mobility 利用受体流动性促进货物周转率

IF 17.3 1区生物学

Nature Cell Biology Pub Date : 2025-01-09 DOI: 10.1038/s41556-024-01576-8

Yi Lu, Chunmei Chang

引用次数: 0

The nuclear matrix stabilizes primed-specific genes in human pluripotent stem cells 核基质稳定了人类多能干细胞中的引物特异性基因

IF 17.3 1区生物学

Nature Cell Biology Pub Date : 2025-01-09 DOI: 10.1038/s41556-024-01595-5

Gang Ma, Xiuling Fu, Lulu Zhou, Isaac A. Babarinde, Liyang Shi, Wenting Yang, Jiao Chen, Zhen Xiao, Yu Qiao, Lisha Ma, Yuhao Ou, Yuhao Li, Chen Chang, Boping Deng, Ran Zhang, Li Sun, Guoqing Tong, Dongwei Li, Yiming Li, Andrew P. Hutchins

{"title":"The nuclear matrix stabilizes primed-specific genes in human pluripotent stem cells","authors":"Gang Ma, Xiuling Fu, Lulu Zhou, Isaac A. Babarinde, Liyang Shi, Wenting Yang, Jiao Chen, Zhen Xiao, Yu Qiao, Lisha Ma, Yuhao Ou, Yuhao Li, Chen Chang, Boping Deng, Ran Zhang, Li Sun, Guoqing Tong, Dongwei Li, Yiming Li, Andrew P. Hutchins","doi":"10.1038/s41556-024-01595-5","DOIUrl":"10.1038/s41556-024-01595-5","url":null,"abstract":"The nuclear matrix, a proteinaceous gel composed of proteins and RNA, is an important nuclear structure that supports chromatin architecture, but its role in human pluripotent stem cells (hPSCs) has not been described. Here we show that by disrupting heterogeneous nuclear ribonucleoprotein U (HNRNPU) or the nuclear matrix protein, Matrin-3, primed hPSCs adopted features of the naive pluripotent state, including morphology and upregulation of naive-specific marker genes. We demonstrate that HNRNPU depletion leads to increased chromatin accessibility, reduced DNA contacts and increased nuclear size. Mechanistically, HNRNPU acts as a transcriptional co-factor that anchors promoters of primed-specific genes to the nuclear matrix with POLII to promote their expression and their RNA stability. Overall, HNRNPU promotes cell-type stability and when reduced promotes conversion to earlier embryonic states. Ma et al. show that heterogeneous nuclear ribonucleoprotein U promotes the primed state in human pluripotent stem cells by interacting with nuclear matrix protein, Matrin-3, and regulating primed-specific genes.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"27 2","pages":"232-245"},"PeriodicalIF":17.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MDM2 functions as a timer reporting the length of mitosis MDM2作为一个计时器，报告有丝分裂的长度

IF 17.3 1区生物学

Nature Cell Biology Pub Date : 2025-01-09 DOI: 10.1038/s41556-024-01592-8

Luke J. Fulcher, Tomoaki Sobajima, Caleb Batley, Ian Gibbs-Seymour, Francis A. Barr

{"title":"MDM2 functions as a timer reporting the length of mitosis","authors":"Luke J. Fulcher, Tomoaki Sobajima, Caleb Batley, Ian Gibbs-Seymour, Francis A. Barr","doi":"10.1038/s41556-024-01592-8","DOIUrl":"10.1038/s41556-024-01592-8","url":null,"abstract":"Delays in mitosis trigger p53-dependent arrest in G1 of the next cell cycle, thus preventing repeated cycles of chromosome instability and aneuploidy. Here we show that MDM2, the p53 ubiquitin ligase, is a key component of the timer mechanism triggering G1 arrest in response to prolonged mitosis. This timer function arises due to the attenuation of protein synthesis in mitosis. Because MDM2 has a short half-life and ongoing protein synthesis is therefore necessary to maintain its steady-state concentration, the amount of MDM2 gradually falls during mitosis but normally remains above a critical threshold for p53 regulation at the onset of G1. When mitosis is extended by prolonged spindle assembly checkpoint activation, the amount of MDM2 drops below this threshold, stabilizing p53. Subsequent p53-dependent p21 accumulation then channels G1 cells into a sustained cell-cycle arrest, whereas abrogation of the response in p53-deficient cells allows them to bypass this crucial defence mechanism. Fulcher et al. show that MDM2 times mitosis through self-catalysed ubiquitination and proteasomal destruction, triggering G1 arrest following delays in mitosis associated with chromosome instability and aneuploidy.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"27 2","pages":"262-272"},"PeriodicalIF":17.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41556-024-01592-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0