陪伴RNA进入颗粒

IF 17.3 1区 生物学 Q1 CELL BIOLOGY
Daryl J. V. David
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引用次数: 0

摘要

生物分子凝聚的形成需要多价相互作用和快速周转。应激颗粒是在应激条件下rna -蛋白相互作用形成的凝结物,需要rna结合蛋白G3BP。Parker等人的研究表明,G3BP1是一种RNA凝结剂,可促进初始RNA - RNA相互作用,但对于稳定性是必不可少的;相反,稳定性需要RNA-RNA相互作用。作者对RNA颗粒的体外模型进行了测试,发现尽管蛋白酶消化了G3BP1,但颗粒只有在足够的老化或时间形成RNA - RNA相互作用后才会持续存在。RNA变性可溶解颗粒,而交联可稳定颗粒。作者还认为RNA-RNA相互作用是分子间的高阶组装。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chaperoning RNA into granules
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来源期刊
Nature Cell Biology
Nature Cell Biology 生物-细胞生物学
CiteScore
28.40
自引率
0.90%
发文量
219
审稿时长
3 months
期刊介绍: Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology
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