利用受体流动性促进货物周转率

IF 17.3 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2025-01-09 DOI:10.1038/s41556-024-01576-8

Yi Lu, Chunmei Chang

引用次数: 0

摘要

通过选择性自噬清除生物大分子对细胞稳态至关重要。一项研究现在确定受体迁移率是影响货物可降解性的关键因素。一个动态的货物-受体表面使必要的自噬起始蛋白相分离，这驱动吞噬体的形成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Boosting cargo turnover with receptor mobility

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Boosting cargo turnover with receptor mobility

The clearance of biomacromolecules through selective autophagy is crucial for cellular homeostasis. A study now identifies receptor mobility as a key factor influencing cargo degradability. A dynamic cargo–receptor surface enables phase separation of essential autophagy initiation proteins, which drives phagophore formation.

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology