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NMDA receptor antagonist coupled to GLP1 analogue in highly effective experimental weight loss drug NMDA 受体拮抗剂与 GLP1 类似物联用的高效减肥实验药物。
IF 31 1区 医学
Nature Reviews Endocrinology Pub Date : 2024-06-04 DOI: 10.1038/s41574-024-01007-6
Olivia Tysoe
{"title":"NMDA receptor antagonist coupled to GLP1 analogue in highly effective experimental weight loss drug","authors":"Olivia Tysoe","doi":"10.1038/s41574-024-01007-6","DOIUrl":"10.1038/s41574-024-01007-6","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":31.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediabetes remission for type 2 diabetes mellitus prevention 预防 2 型糖尿病的糖尿病前期缓解。
IF 31 1区 医学
Nature Reviews Endocrinology Pub Date : 2024-05-28 DOI: 10.1038/s41574-024-00996-8
Andreas L. Birkenfeld, Viswanathan Mohan
{"title":"Prediabetes remission for type 2 diabetes mellitus prevention","authors":"Andreas L. Birkenfeld, Viswanathan Mohan","doi":"10.1038/s41574-024-00996-8","DOIUrl":"10.1038/s41574-024-00996-8","url":null,"abstract":"Current guidelines for the delay and prevention of type 2 diabetes mellitus recommend for people with prediabetes to lose at least 7% of their body weight. Here, we advocate to use glycaemic remission as a goal of prevention in people with prediabetes and those who are at high risk for type 2 diabetes mellitus.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":31.0,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sertoli cell lysosomal dysfunction drives age-related testicular degeneration 溶质细胞溶酶体功能障碍导致与年龄有关的睾丸退化
IF 40.5 1区 医学
Nature Reviews Endocrinology Pub Date : 2024-05-22 DOI: 10.1038/s41574-024-01001-y
Olivia Tysoe
{"title":"Sertoli cell lysosomal dysfunction drives age-related testicular degeneration","authors":"Olivia Tysoe","doi":"10.1038/s41574-024-01001-y","DOIUrl":"10.1038/s41574-024-01001-y","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":40.5,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141079278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obesity dysregulates a pituitary–liver axis through disruption of the unfolded protein response 肥胖症通过破坏未折叠蛋白反应使垂体-肝脏轴失调。
IF 40.5 1区 医学
Nature Reviews Endocrinology Pub Date : 2024-05-21 DOI: 10.1038/s41574-024-01002-x
Shimona Starling
{"title":"Obesity dysregulates a pituitary–liver axis through disruption of the unfolded protein response","authors":"Shimona Starling","doi":"10.1038/s41574-024-01002-x","DOIUrl":"10.1038/s41574-024-01002-x","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":40.5,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141076263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcriptional control of metabolism by interferon regulatory factors 干扰素调节因子对新陈代谢的转录控制
IF 31 1区 医学
Nature Reviews Endocrinology Pub Date : 2024-05-20 DOI: 10.1038/s41574-024-00990-0
Zunair Ahmad, Wahab Kahloan, Evan D. Rosen
{"title":"Transcriptional control of metabolism by interferon regulatory factors","authors":"Zunair Ahmad, Wahab Kahloan, Evan D. Rosen","doi":"10.1038/s41574-024-00990-0","DOIUrl":"10.1038/s41574-024-00990-0","url":null,"abstract":"Interferon regulatory factors (IRFs) comprise a family of nine transcription factors in mammals. IRFs exert broad effects on almost all aspects of immunity but are best known for their role in the antiviral response. Over the past two decades, IRFs have been implicated in metabolic physiology and pathophysiology, partly as a result of their known functions in immune cells, but also because of direct actions in adipocytes, hepatocytes, myocytes and neurons. This Review focuses predominantly on IRF3 and IRF4, which have been the subject of the most intense investigation in this area. IRF3 is located in the cytosol and undergoes activation and nuclear translocation in response to various signals, including stimulation of Toll-like receptors, RIG-I-like receptors and the cGAS–STING pathways. IRF3 promotes weight gain, primarily by inhibiting adipose thermogenesis, and also induces inflammation and insulin resistance using both weight-dependent and weight-independent mechanisms. IRF4, meanwhile, is generally pro-thermogenic and anti-inflammatory and has profound effects on lipogenesis and lipolysis. Finally, new data are emerging on the role of other IRF family members in metabolic homeostasis. Taken together, data indicate that IRFs serve as critical yet underappreciated integrators of metabolic and inflammatory stress. Interferon regulatory factors (IRFs) are well known as mediators of the antiviral response but there is growing appreciation of their role in metabolism. This Review discusses the current understanding of IRFs as metabolic regulators, with a particular focus on IRF3 and IRF4.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":31.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141069487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AMPK as a mediator of tissue preservation: time for a shift in dogma? 作为组织保存介质的 AMPK：转变教条的时候到了吗？
IF 31 1区 医学
Nature Reviews Endocrinology Pub Date : 2024-05-17 DOI: 10.1038/s41574-024-00992-y
Henning Tim Langer, Maria Rohm, Marcus DaSilva Goncalves, Lykke Sylow
{"title":"AMPK as a mediator of tissue preservation: time for a shift in dogma?","authors":"Henning Tim Langer, Maria Rohm, Marcus DaSilva Goncalves, Lykke Sylow","doi":"10.1038/s41574-024-00992-y","DOIUrl":"10.1038/s41574-024-00992-y","url":null,"abstract":"Ground-breaking discoveries have established 5′-AMP-activated protein kinase (AMPK) as a central sensor of metabolic stress in cells and tissues. AMPK is activated through cellular starvation, exercise and drugs by either directly or indirectly affecting the intracellular AMP (or ADP) to ATP ratio. In turn, AMPK regulates multiple processes of cell metabolism, such as the maintenance of cellular ATP levels, via the regulation of fatty acid oxidation, glucose uptake, glycolysis, autophagy, mitochondrial biogenesis and degradation, and insulin sensitivity. Moreover, AMPK inhibits anabolic processes, such as lipogenesis and protein synthesis. These findings support the notion that AMPK is a crucial regulator of cell catabolism. However, studies have revealed that AMPK’s role in cell homeostasis might not be as unidirectional as originally thought. This Review explores emerging evidence for AMPK as a promoter of cell survival and an enhancer of anabolic capacity in skeletal muscle and adipose tissue during catabolic crises. We discuss AMPK-activating interventions for tissue preservation during tissue wasting in cancer-associated cachexia and explore the clinical potential of AMPK activation in wasting conditions. Overall, we provide arguments that call for a shift in the current dogma of AMPK as a mere regulator of cell catabolism, concluding that AMPK has an unexpected role in tissue preservation. This Review discusses the role of AMPK in cancer cachexia and metabolic dysfunction, including discussion of how targeting AMPK might be an option to preserve muscle and adipose tissue mass.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":31.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140953923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of brown adipose tissue in metabolic health 棕色脂肪组织在代谢健康中的作用
IF 40.5 1区 医学
Nature Reviews Endocrinology Pub Date : 2024-05-14 DOI: 10.1038/s41574-024-00999-5
Claire Greenhill
{"title":"The role of brown adipose tissue in metabolic health","authors":"Claire Greenhill","doi":"10.1038/s41574-024-00999-5","DOIUrl":"10.1038/s41574-024-00999-5","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":40.5,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140919696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the management of achondroplasia 软骨发育不全的治疗进展
IF 31 1区 医学
Nature Reviews Endocrinology Pub Date : 2024-05-13 DOI: 10.1038/s41574-024-00994-w
Ravi Savarirayan
{"title":"Advances in the management of achondroplasia","authors":"Ravi Savarirayan","doi":"10.1038/s41574-024-00994-w","DOIUrl":"10.1038/s41574-024-00994-w","url":null,"abstract":"The first precision therapy for children with achondroplasia, vosoritide, is now approved in many regions, including Australia, the USA, the European Union and Japan. This article discusses the recent trial results for this therapy regarding growth and the co-morbidities associated with achondroplasia and considers the rationale for its clinical use.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":31.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140915110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hearing abnormalities in patients treated with teprotumumab 接受替普鲁单抗治疗的患者听力异常
IF 40.5 1区 医学
Nature Reviews Endocrinology Pub Date : 2024-05-13 DOI: 10.1038/s41574-024-00995-9
Jason A. Brant, Don O. Kikkawa, Terry J. Smith
{"title":"Hearing abnormalities in patients treated with teprotumumab","authors":"Jason A. Brant, Don O. Kikkawa, Terry J. Smith","doi":"10.1038/s41574-024-00995-9","DOIUrl":"10.1038/s41574-024-00995-9","url":null,"abstract":"The introduction of teprotumumab for the treatment of thyroid eye disease has dramatically improved management of this life-changing condition; however, clinical trials and experience in the clinic have revealed associated hearing abnormalities.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":40.5,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140914906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publisher Correction: Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency 出版商更正：精氨酸加压素缺乏症：诊断、管理和催产素缺乏症的相关性。
IF 31 1区 医学
Nature Reviews Endocrinology Pub Date : 2024-05-08 DOI: 10.1038/s41574-024-00998-6
Cihan Atila, Julie Refardt, Mirjam Christ-Crain
{"title":"Publisher Correction: Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency","authors":"Cihan Atila, Julie Refardt, Mirjam Christ-Crain","doi":"10.1038/s41574-024-00998-6","DOIUrl":"10.1038/s41574-024-00998-6","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":31.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41574-024-00998-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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