Female-specific inflammatory signalling exacerbates central nervous system autoimmunity in obesity

IF 3.7 3区医学 Q2 CHEMISTRY, MEDICINAL

Chemical Research in Toxicology Pub Date : 2024-09-19 DOI:10.1038/s41574-024-01040-5

Olivia Tysoe

引用次数: 0

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女性特有的炎症信号加剧了肥胖症中枢神经系统的自身免疫性

多发性硬化症（MS）的目标是中枢神经系统（CNS）神经元的髓鞘。多发性硬化症是由自反应性 CD4+ T 细胞引发的，而肥胖与多发性硬化症风险的增加有关，尤其是对女性而言。为了进一步研究这些性别依赖性炎症特征，研究人员使用了饮食诱导肥胖（DIO）小鼠模型和实验性自身免疫性脑脊髓炎（EAE），后者是一种T细胞对髓鞘具有自身反应性的多发性硬化症小鼠模型。雌性小鼠与雄性小鼠相比，DIO（与正常体重的EAE对照组相比）在更大程度上加剧了EAE的进展和症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Research in Toxicology 医学-毒理学

CiteScore

7.90

自引率

7.30%

发文量

215

审稿时长

3.5 months

期刊介绍： Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.