Nanotoxicology最新文献_第3页

The oxidative potential of nanomaterials: an optimized high-throughput protocol and interlaboratory comparison for the ferric reducing ability of serum (FRAS) assay. 纳米材料的氧化潜能：血清铁还原能力（FRAS）测定的优化高通量方案和实验室间比较。

IF 3.6 3区医学

Nanotoxicology Pub Date : 2024-12-01 Epub Date: 2024-12-14 DOI: 10.1080/17435390.2024.2438116

Nienke Ruijter, Matthew Boyles, Hedwig Braakhuis, Rafael Ayerbe Algaba, Morgan Lofty, Veronica di Battista, Wendel Wohlleben, Flemming R Cassee, Ana Candalija

{"title":"The oxidative potential of nanomaterials: an optimized high-throughput protocol and interlaboratory comparison for the ferric reducing ability of serum (FRAS) assay.","authors":"Nienke Ruijter, Matthew Boyles, Hedwig Braakhuis, Rafael Ayerbe Algaba, Morgan Lofty, Veronica di Battista, Wendel Wohlleben, Flemming R Cassee, Ana Candalija","doi":"10.1080/17435390.2024.2438116","DOIUrl":"10.1080/17435390.2024.2438116","url":null,"abstract":"Successful implementation of Safe and Sustainable by Design (SSbD) and grouping approaches requires simple, reliable, and cost-effective assays to facilitate hazard screening at early stages of product development. Especially for nanomaterials (NMs), which exist in many different forms, efficient hazard screening is of utmost importance. Oxidative potential (OP), which is the ability of a substance to induce reactive oxygen species (ROS), is an important indicator of the potential to induce oxidative damage and oxidative stress. A frequently used assay to measure OP of NMs is the ferric reducing ability of serum (FRAS) assay. Although the widely used cuvette-based FRAS protocol is considered a robust assay, its low throughput makes the screening of multiple materials challenging. Here, we adapt the original cuvette-based FRAS assay protocol, into a 96-well format and thereby improve its user-friendliness, simplicity, and screening capacity. The adapted protocol allows for the screening of multiple NMs per plate, and multiple plates per day, where the original protocol allows for the screening of one NM dose-range per day. When comparing the two protocols, the adapted protocol showed slightly decreased assay precision as compared to the original protocol. The results obtained with the adapted protocol were compared using eight reference NMs in an interlaboratory study and showed acceptably low intra- and interlaboratory variation. We conclude that the adapted FRAS assay protocol is suitable to be used for hazard screening to facilitate SSbD and grouping approaches.","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":" ","pages":"724-738"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbon quantum dots in breast cancer modulate cellular migration via cytoskeletal and nuclear structure. 乳腺癌中的碳量子点通过细胞骨架和核结构调节细胞迁移。

IF 3.6 3区医学

Nanotoxicology Pub Date : 2024-11-01 DOI: 10.1080/17435390.2024.2419418

Nikita Dinger, Carmela Russo, Sabato Fusco, Paolo A Netti, Mariano Sirignano, Valeria Panzetta

{"title":"Carbon quantum dots in breast cancer modulate cellular migration via cytoskeletal and nuclear structure.","authors":"Nikita Dinger, Carmela Russo, Sabato Fusco, Paolo A Netti, Mariano Sirignano, Valeria Panzetta","doi":"10.1080/17435390.2024.2419418","DOIUrl":"10.1080/17435390.2024.2419418","url":null,"abstract":"Carbon nanomaterials have been widely applied for cutting edge therapeutic applications as they offer tunable physio-chemical properties with economic scale-up options. Nuclear delivery of cancer drugs has been of prime focus since it controls important cellular signaling functions leading to greater anti-cancer drug efficacies. Better cellular drug uptake per unit drug injection drastically reduces severe side-effects of cancer therapies. Similarly, carbon dots (CDs) uptaken by the nucleus can also be used to set-up cutting edge nano delivery systems. In an earlier paper, we showed the cellular uptake and plasma membrane impact of combustion generated yellow luminescing CDs produced by our group from fuel rich combustion reactors in a one-step tunable production. In this paper, we aim to specifically study the nucleus by establishing the uptake kinetics of these combustion-generated yellow luminescing CDs. At sub-lethal doses, after crossing the plasma membrane, they impact the actin and microtubule mesh, affecting cell adhesion and migration; enter nucleus by diffusion processes; modify the overall appearance of the nucleus in terms of morphology; and alter chromatin condensation. We thus establish how this one-step produced, cost and bulk production friendly carbon dots from fuel rich combustion flames can be innovatively repurposed as potential nano delivery agents in cancer cells.","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":" ","pages":"618-644"},"PeriodicalIF":3.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraperitoneal hepatorenal toxicity of zinc oxide and nickel oxide nanoparticles in rats: a systematic review. 氧化锌和氧化镍纳米颗粒对大鼠腹腔肝肾的毒性：系统综述。

IF 3.6 3区医学

Nanotoxicology Pub Date : 2024-11-01 Epub Date: 2024-09-25 DOI: 10.1080/17435390.2024.2407352

Nour Kahil, Noura S Abouzeinab, Mohamed A A Hussein, Mahmoud I Khalil

{"title":"Intraperitoneal hepatorenal toxicity of zinc oxide and nickel oxide nanoparticles in rats: a systematic review.","authors":"Nour Kahil, Noura S Abouzeinab, Mohamed A A Hussein, Mahmoud I Khalil","doi":"10.1080/17435390.2024.2407352","DOIUrl":"10.1080/17435390.2024.2407352","url":null,"abstract":"Zinc oxide (ZnO) and nickel oxide (NiO) nanoparticles (NPs) are widely used in various industries due to their distinctive physico-chemical and biological properties. However, concerns have been raised about their potential toxicity in humans. While many studies have reviewed their effects on visceral organs upon ingestion, inhalation, or skin contact, limited reviews are available regarding their adverse consequences on the liver and kidneys resulting from intraperitoneal administration in rats. Hence, this systematic review is the first to uniquely address this issue. A systematic search was performed on PubMed and Google scholar to identify articles that explored the toxic effects of ZnO-NPs and NiO-NPs in rats following intraperitoneal injection. The quality of the articles was assessed using SYCLE's risk of bias tool, leading to the selection of 16 articles; 14 for ZnO-NPs, 1 for NiO-NPs and 1 for both NPs. This review revealed that ZnO-NPs induces an acute toxicity in liver and kidney that is dose dependent. The impairments were marked by changes in organs functional markers, lipid and glucose levels and antioxidant deficiencies and lipid peroxidation. NiO-NPs also showed considerable toxicity, despite the limited studies. Further, variability of physico-chemical properties among studies complicated the toxicity assessment. To conclude, this study provides a novel contribution by summarizing the literature findings that suggest potential adverse intraperitoneal hepatorenal toxic outcomes associated with ZnO-NPs and NiO-NPs. Future research should focus on long-term effects and standardizing protocols to ensure the safe use of ZnO-NPs and NiO-NPs in industrial and clinical practices.","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":" ","pages":"583-598"},"PeriodicalIF":3.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of physicochemical properties in silica nanoparticle-mediated immunostimulation. 理化特性在二氧化硅纳米粒子介导的免疫刺激中的作用

IF 3.6 3区医学

Nanotoxicology Pub Date : 2024-11-01 Epub Date: 2024-10-26 DOI: 10.1080/17435390.2024.2418088

Jason William Grunberger, Hannah S Newton, Duncan Donohue, Marina A Dobrovolskaia, Hamidreza Ghandehari

{"title":"Role of physicochemical properties in silica nanoparticle-mediated immunostimulation.","authors":"Jason William Grunberger, Hannah S Newton, Duncan Donohue, Marina A Dobrovolskaia, Hamidreza Ghandehari","doi":"10.1080/17435390.2024.2418088","DOIUrl":"10.1080/17435390.2024.2418088","url":null,"abstract":"Immunostimulation caused by nanoparticles may be beneficial or adverse depending on their intended application. Activation of immune cells is beneficial for indications targeting the immune system for therapeutic purposes, such as tumor microenvironment reprogramming, immunotherapy, and vaccines. When it is unwanted, however, immunostimulation may lead to excessive inflammation, cytokine storm, and hypersensitivity reactions. The increasing use of silica nanoparticles (SiNPs) for the delivery of drugs, imaging agents, and antigens warrants preclinical studies aimed at understanding carrier-mediated effects on the number, activation status, and function of immune cell subsets. Herein, we present an in vitro study utilizing primary human peripheral blood mononuclear cells (PBMC) to investigate the proinflammatory properties of four types of SiNPs varying in size and porosity. Cytokine analysis was performed in resting and LPS-primed PBMC cultures to understand the ability of silica nanoparticles to induce de novo and exaggerate preexisting inflammation, respectively. Changes in the number and activation status of lymphoid and myeloid cells were studied by flow cytometry to gain further insight into SiNP-mediated immunostimulation. Nonporous SiNPs were found to be more proinflammatory than mesoporous SiNPs, and larger-sized particles induced greater cytokine response. LPS-primed PBMC resulted in increased susceptibility to SiNPs. Immunophenotyping analysis of SiNP-treated PBMC resulted in T and B lymphocyte, natural killer cell, and dendritic cell activation. Additionally, a loss of regulatory T cells and an increase in γδ TCR T cell population were observed with all particles. These findings have implications for the utility of SiNPs for the delivery of drugs and imaging agents.","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":" ","pages":"599-617"},"PeriodicalIF":3.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HMGB1 derived from lung epithelial cells after cobalt nanoparticle exposure promotes the activation of lung fibroblasts. 钴纳米粒子暴露后，肺上皮细胞产生的 HMGB1 可促进肺成纤维细胞的活化。

IF 5 3区医学

Nanotoxicology Pub Date : 2024-09-19 DOI: 10.1080/17435390.2024.2404074

Jiali Yuan,Yiqun Mo,Yue Zhang,Yuanbao Zhang,Qunwei Zhang

{"title":"HMGB1 derived from lung epithelial cells after cobalt nanoparticle exposure promotes the activation of lung fibroblasts.","authors":"Jiali Yuan,Yiqun Mo,Yue Zhang,Yuanbao Zhang,Qunwei Zhang","doi":"10.1080/17435390.2024.2404074","DOIUrl":"https://doi.org/10.1080/17435390.2024.2404074","url":null,"abstract":"We have previously demonstrated that exposure to cobalt nanoparticles (Nano-Co) caused extensive interstitial fibrosis and inflammatory cell infiltration in mouse lungs. However, the underlying mechanisms of Nano-Co-induced pulmonary fibrosis remain unclear. In this study, we investigated the role of high-mobility group box 1 (HMGB1) in the epithelial cell-fibroblast crosstalk in Nano-Co-induced pulmonary fibrosis. Our results showed that Nano-Co exposure caused remarkable production and release of HMGB1, as well as nuclear accumulation of HIF-1α in human bronchial epithelial cells (BEAS-2B) in a dose- and a time-dependent manner. Pretreatment with CAY10585, an inhibitor against HIF-1α, significantly blocked the overexpression of HMGB1 in cell lysate and the release of HMGB1 in the supernatant of BEAS-2B cells induced by Nano-Co exposure, indicating that Nano-Co exposure induces HIF-1α-dependent HMGB1 overexpression and release. In addition, treatment of lung fibroblasts (MRC-5) with conditioned media from Nano-Co-exposed BEAS-2B cells caused increased RAGE expression, MAPK signaling activation, and enhanced expression of fibrosis-associated proteins, such as fibronectin, collagen 1, and α-SMA. However, conditioned media from Nano-Co-exposed BEAS-2B cells with HMGB1 knockdown had no effects on the activation of MRC-5 fibroblasts. Finally, inhibition of ERK1/2, p38, and JNK all abolished MRC-5 activation induced by conditioned media from Nano-Co-exposed BEAS-2B cells, suggesting that MAPK signaling might be a key downstream signal of HMGB1/RAGE to promote MRC-5 fibroblast activation. These findings have important implications for understanding the pro-fibrotic potential of Nano-Co.","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":"26 1","pages":"1-17"},"PeriodicalIF":5.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 5 3区医学

Nanotoxicology Pub Date : 2024-09-14 DOI: 10.1080/17435390.2024.2399039

Aurora Moen,Helge Johnsen,Danail Hristozov,Alex Zabeo,Lisa Pizzol,Oihane Ibarrola,Gary Hannon,Sarah Holmes,Fikirte Debebe Zegeye,Ulla Vogel,Adriele Prina Mello,Shan Zienolddiny-Narui,Håkan Wallin

{"title":"Inflammation related to inhalation of nano and micron sized iron oxides: a systematic review.","authors":"Aurora Moen,Helge Johnsen,Danail Hristozov,Alex Zabeo,Lisa Pizzol,Oihane Ibarrola,Gary Hannon,Sarah Holmes,Fikirte Debebe Zegeye,Ulla Vogel,Adriele Prina Mello,Shan Zienolddiny-Narui,Håkan Wallin","doi":"10.1080/17435390.2024.2399039","DOIUrl":"https://doi.org/10.1080/17435390.2024.2399039","url":null,"abstract":"Inhalation exposure to iron oxide occurs in many workplaces and respirable aerosols occur during thermal processes (e.g. welding, casting) or during abrasion of iron and steel products (e.g. cutting, grinding, machining, polishing, sanding) or during handling of iron oxide pigments. There is limited evidence of adverse effects in humans specifically linked to inhalation of iron oxides. This contrasts to oxides of other metals used to alloy or for coating of steel and iron of which several have been classified as being hazardous by international and national agencies. Such metal oxides are often present in the air at workplaces. In general, iron oxides might therefore be regarded as low-toxicity, low-solubility (LTLS) particles, and are often considered to be nontoxic even if very high and prolonged inhalation exposures might result in diseases. In animal studies, such exposures lead to cancer, fibrosis and other diseases. Our hypothesis was that pulmonary-workplace exposure during manufacture and handling of SPION preparations might be harmful. We therefore conducted a systematic review of the relevant literature to understand how iron oxides deposited in the lung are related to acute and subchronic pulmonary inflammation. We included one human and several in vivo animal studies published up to February 2023. We found 25 relevant studies that were useful for deriving occupational exposure limits (OEL) for iron oxides based on an inflammatory reaction. Our review of the scientific literature indicates that lowering of health-based occupational exposure limits might be considered.","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":"33 1","pages":"1-16"},"PeriodicalIF":5.0,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunological properties of silica nanoparticles: a structure-activity relationship study. 纳米二氧化硅的免疫学特性：结构-活性关系研究。

IF 3.6 3区医学

Nanotoxicology Pub Date : 2024-09-01 Epub Date: 2024-09-16 DOI: 10.1080/17435390.2024.2401448

Jason William Grunberger, Marina A Dobrovolskaia, Hamidreza Ghandehari

{"title":"Immunological properties of silica nanoparticles: a structure-activity relationship study.","authors":"Jason William Grunberger, Marina A Dobrovolskaia, Hamidreza Ghandehari","doi":"10.1080/17435390.2024.2401448","DOIUrl":"10.1080/17435390.2024.2401448","url":null,"abstract":"Silica nanoparticles are increasingly considered for drug delivery applications. These applications require an understanding of their biocompatibility, including their interactions with the immune system. However, systematic studies for silica nanoparticle immunological safety profiles are lacking. To fill this gap, we conducted an in vitro study investigating various aspects of silica nanoparticles' interactions with blood and immune cells. Four types of silica nanoparticles with variations in size and porosity were studied. These included nonporous Stöber silica nanoparticles with average diameters of approximately 50 and 100 nm (SNP50 and SNP100), mesoporous silica nanoparticles of approximately 100 nm (Meso100), and hollow mesoporous silica nanoparticles of approximately 100 nm (HMSNP100) in diameter, respectively. The hematological compatibility was assessed using hemolysis, complement activation, platelet aggregation, and plasma coagulation assays. The effects of nanoparticles on immune cell function were studied using in vitro phagocytosis, chemotaxis, natural killer cell cytotoxicity, leukocyte proliferation, human lymphocyte activation, colony-forming unit granulocyte-macrophage, and leukocyte procoagulant activity assays. The in vitro findings suggest that at high concentrations, corresponding to the in vivo human dose of 40 mg/kg, silica nanoparticles demonstrated an array of immunotoxic effects that depended on their physicochemical properties. However, all types of silica nanoparticles studied were not immunotoxic at concentrations corresponding to lower doses (≤ 8 mg/kg) comparable to that of nanocarriers in other nanomedicines currently used in the clinic. These findings are promising for using silica nanoparticles for the systemic delivery of bioactive and imaging agents.","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":" ","pages":"542-564"},"PeriodicalIF":3.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11581911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiologically based pharmacokinetic modeling of metal nanoparticles for risk assessment of inhalation exposures: a state-of-the-science expert panel review. 基于生理学的金属纳米粒子药代动力学建模，用于吸入暴露风险评估：科学现状专家小组综述。

IF 3.6 3区医学

Nanotoxicology Pub Date : 2024-09-01 Epub Date: 2024-09-23 DOI: 10.1080/17435390.2024.2401430

C R Kirman, B Kent, J Bigelow, R A Canady, Q Chen, W C Chou, D Li, Z Lin, V Kumar, A Paini, P Poulin, L M Sweeney, S M Hays

{"title":"Physiologically based pharmacokinetic modeling of metal nanoparticles for risk assessment of inhalation exposures: a state-of-the-science expert panel review.","authors":"C R Kirman, B Kent, J Bigelow, R A Canady, Q Chen, W C Chou, D Li, Z Lin, V Kumar, A Paini, P Poulin, L M Sweeney, S M Hays","doi":"10.1080/17435390.2024.2401430","DOIUrl":"10.1080/17435390.2024.2401430","url":null,"abstract":"A critical review of the current state-of-the-science for the physiologically based pharmacokinetic (PBPK) modeling of metal nanoparticles and their application to human health risk assessment for inhalation exposures was conducted. A systematic literature search was used to identify four model groups (defined as a primary publication along with multiple supplementary publications) subject to review. Using a recent guideline document from the Organization for Economic Cooperation and Development (OECD) for PBPK model evaluation, these model groups were critically peer-reviewed by an independent panel of experts to identify those to be considered for modeling and simulation application. Based upon the expert panel input, model confidence scores for the four model groups ranged from 30 to 41 (out of a maximum score of 50). The three highest-scoring model groups were then applied to compare predictions to a different metal nanoparticle (i.e. not specifically used to parameterize the original models) using a recently published data set for tissue burdens in rats, as well as predicting human tissue burdens expected for corresponding occupational exposures. Overall, the rat models performed reasonably well in predicting the lung but tended to overestimate systemic tissue burdens. Data needs for improving the state-of-the-science, including quantitative particle characterization in tissues, nanoparticle-corona data, long-term exposure data, interspecies extrapolation methods, and human biomonitoring/toxicokinetic data are discussed.","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":" ","pages":"527-541"},"PeriodicalIF":3.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic review of mechanistic evidence for TiO₂ nanoparticle-induced lung carcinogenicity. 对二氧化钛纳米粒子诱发肺癌的机理证据进行系统回顾。

IF 3.6 3区医学

Nanotoxicology Pub Date : 2024-08-01 Epub Date: 2024-08-05 DOI: 10.1080/17435390.2024.2384408

Susann Wolf, Krishnan Sriram, Laura M A Camassa, Dhruba Pathak, Helene L Bing, Benedicte Mohr, Shan Zienolddiny-Narui, Johanna Samulin Erdem

{"title":"Systematic review of mechanistic evidence for TiO2 nanoparticle-induced lung carcinogenicity.","authors":"Susann Wolf, Krishnan Sriram, Laura M A Camassa, Dhruba Pathak, Helene L Bing, Benedicte Mohr, Shan Zienolddiny-Narui, Johanna Samulin Erdem","doi":"10.1080/17435390.2024.2384408","DOIUrl":"10.1080/17435390.2024.2384408","url":null,"abstract":"Nano-sized titanium dioxide particles (TiO2 NPs) are a high-production volume nanomaterial widely used in the paints, cosmetics, food and photovoltaics industry. However, the potential carcinogenic effects of TiO2 NPs in the lung are still unclear despite the vast number of in vitro and in vivo studies investigating TiO2 NPs. Here, we systematically reviewed the existing in vitro and in vivo mechanistic evidence of TiO2 NP lung carcinogenicity using the ten key characteristics of carcinogens for identifying and classifying carcinogens. A total of 346 studies qualified for the quality and reliability assessment, of which 206 were considered good quality. Using a weight-of-evidence approach, these studies provided mainly moderate to high confidence for the biological endpoints regarding genotoxicity, oxidative stress and chronic inflammation. A limited number of studies investigated other endpoints important to carcinogenesis, relating to proliferation and transformation, epigenetic alterations and receptor-mediated effects. In summary, TiO2 NPs might possess the ability to induce chronic inflammation and oxidative stress, but it was challenging to compare the findings in the studies due to the wide variety of TiO2 NPs differing in their physicochemical characteristics, formulation, exposure scenarios/test systems, and experimental protocols. Given the limited number of high-quality and high-reliability studies identified within this review, there is a lack of good enough mechanistic evidence for TiO2 NP lung carcinogenicity. Future toxicology/carcinogenicity research must consider including positive controls, endotoxin testing (where necessary), statistical power analysis, and relevant biological endpoints, to improve the study quality and provide reliable data for evaluating TiO2 NP-induced lung carcinogenicity.","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":" ","pages":"437-463"},"PeriodicalIF":3.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic evaluation of pure and doped iron oxide nanoparticles on cancer cells: a magnetic fluid hyperthermia perspective. 纯氧化铁纳米粒子和掺杂氧化铁纳米粒子对癌细胞的细胞毒性评估：磁流体热疗的视角。

IF 3.6 3区医学

Nanotoxicology Pub Date : 2024-08-01 Epub Date: 2024-08-02 DOI: 10.1080/17435390.2024.2386019

Dharti Bhadla, Kinnari Parekh, Neeraj Jain

引用次数: 0