Nature and Science of Sleep最新文献

{"title":"Hypoxic Burden and T90% as Predictive Indicators of Cardiovascular Risk and Myocardial Ischemia in Patients with Obstructive Sleep Apnea.","authors":"Wenmei Zeng, Sulong Wu, Zhuofan Liu, Long Yuan, Bilin Chen, Yan Rong","doi":"10.2147/NSS.S533596","DOIUrl":"10.2147/NSS.S533596","url":null,"abstract":"<p><strong>Purpose: </strong>This study analyzed the role of hypoxic burden and the percentage of time with blood oxygen saturation below 90% (T90%) in assessing the myocardial ischemia and cardiovascular risk in obstructive sleep apnea (OSA) patients using portable sleep monitors.</p><p><strong>Patients and methods: </strong>We conducted a prospective observational study of hospitalized OSA patients diagnosed by portable sleep monitors at a single tertiary center in Southern China from January 2022 to March 2024. Cardiovascular risk was assessed with the China-PAR model including anthropometric measurements and risk factors. Myocardial ischemia was evaluated via electrocardiogram. Factors including hypoxic burden severity categories, apnea-hypopnea index severity categories, respiratory event durations (apnea%, hypopnea%, and combined%), and oxygen desaturation metrics (T90%/T85%/T80%) were analyzed with binary logistic regression for 10-year atherosclerotic cardiovascular disease (ASCVD) risk and myocardial ischemia evaluation in OSA patients. The diagnostic value was analyzed with the receiver operating characteristic curve.</p><p><strong>Results: </strong>A total of 311 OSA patients were included, with a median age of 53 years, 75.6% of whom were male. Among them, 51.4% demonstrated electrocardiogram changes indicative of myocardial ischemia, and 55.3% had moderate-to-high 10-year ASCVD risk. Patients with moderate-to-high ASCVD risk had higher hypoxic burdens and T90%. Both the hypoxic burden and T90% showed significant predictive value for cardiovascular risk stratification. Clinically meaningful thresholds were established: 125.8%min/h for hypoxic burden and 3.05% for T90% in ASCVD risk prediction (area under the curve 0.747-0.754), and 112.6%min/h and 4.20% for myocardial ischemia detection (area under the curve 0.741-0.769).</p><p><strong>Conclusion: </strong>The hypoxic burden and T90% obtained from portable sleep monitors can be valuable indicators for assessing cardiovascular risk in OSA patients. Cardiovascular risk stratification increases patient and physician vigilance toward the detrimental effects of OSA and provides practical decision points for clinicians for further evaluation and treatment.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1557-1570"},"PeriodicalIF":3.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent Association of Sleep Apnea-Specific Hypoxic Burden and Sleep Breathing Impairment Index with Thyroid Function in Obstructive Sleep Apnea: A Retrospective Study.","authors":"Yanuo Zhou, Yewen Shi, Simin Zhu, Zine Cao, Yushan Xie, Chendi Lu, Xiaoxin Niu, Lina Ma, Zitong Wang, Yonglong Su, Zihan Xia, Yuqi Yuan, Jiayi Yang, Rui Lu, Yani Feng, Xiaoyong Ren, Wei Hou","doi":"10.2147/NSS.S525750","DOIUrl":"10.2147/NSS.S525750","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to explore thyroid function changes in patients with obstructive sleep apnea (OSA) and analyze the relationships among the sleep apnea-specific hypoxic burden (SASHB), the sleep breathing impairment index (SBII), and the function during different sleep stages.</p><p><strong>Methods: </strong>This retrospective study included 452 patients with OSA who visited the Second Affiliated Hospital of Xi'an Jiaotong University between August 2017 and March 2024. The severity of OSA was evaluated, grouping patients by their apnea-hypopnea index (AHI), SASHB, SBII, and both SASHB and SBII during non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. Multiple linear regression analyzed the independent relationships between the AHI, SASHB, SBII, and thyroid function indicators while adjusting for potential confounders.</p><p><strong>Results: </strong>Significant intergroup differences were observed in thyroid function indicators under various grouping methods, with different trends. After adjusting for confounding factors, SASHB, SASHB during NREM sleep (NREM-SASHB), SASHB during REM sleep (REM-SASHB), SBII, SBII during NREM sleep (NREM-SBII), and SBII during REM sleep (REM-SBII) were independently associated with elevated serum free triiodothyronine (FT3) levels (<i>p</i> < 0.05). Similar results were noted in the male patients, whereas no significant associations were observed in the female patients.</p><p><strong>Conclusion: </strong>There is an association between OSA and thyroid function, with SASHB and SBII independently linked to elevated FT3 levels across different sleep stages and sex subgroups. Future research should further explore these mechanisms to optimize clinical management and treatment strategies for patients with OSA.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1543-1556"},"PeriodicalIF":3.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Acupuncture Clinically Ready for Post-Stroke Sleep Disorders? A Critical Commentary on a Recent Network Meta-Analysis [Letter].","authors":"Fei-Yi Zhao, Qiang-Qiang Fu, Yuen-Shan Ho","doi":"10.2147/NSS.S547791","DOIUrl":"10.2147/NSS.S547791","url":null,"abstract":"","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1539-1541"},"PeriodicalIF":3.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Disturbance in Parkinson's Disease: Consequences for the Brain and Disease Progression - A Narrative Review.","authors":"Kirstie N Anderson, Michael J Keogh, Luca Gosse","doi":"10.2147/NSS.S478860","DOIUrl":"10.2147/NSS.S478860","url":null,"abstract":"<p><p>Sleep disturbance in Parkinson's disease (PD) is recognized to be one of the most common non-motor complications. It occurs before disease onset as a prodromal symptom, during and then throughout the disease course. Causes are multifactorial and can be multiple in the same patient. Specific sleep disorders that are known to occur in those with Parkinson's disease include REM sleep behavior disorder, sleep disordered breathing including obstructive sleep apnea, restless legs and periodic limb movements, nightmare disorder, insomnia alongside direct side-effects of the medication used for therapy. One key question is whether these sleep disorders impact upon the motor and non-motor symptoms of Parkinson's disease. There has been significant interest in recent years in using certain sleep disorders, in particular, REM sleep behavior disorder, as a biomarker both for those at risk of Parkinson's disease but also influencing the subsequent severity and speed of progression. However, other sleep disorders in the general population may also increase the risk of developing Parkinson's disease. It is important to understand whether the treatment of sleep disturbance and specific sleep disorders modifies the long-term risk of developing Parkinson's disease or its progression.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1521-1537"},"PeriodicalIF":3.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persisting Short or Long Sleep Duration Predicts Post-Stroke Depression One year After Stroke and Transient Ischemic Attack.","authors":"Yang Hu, Lijun Zuo, Yuesong Pan, Hongyi Yan, Yongjun Wang, Xingquan Zhao","doi":"10.2147/NSS.S492838","DOIUrl":"10.2147/NSS.S492838","url":null,"abstract":"<p><strong>Objective: </strong>Disrupted sleep duration is associated with the risk of stroke, and abnormal sleep duration predicts depression. However, the association of changes in sleep duration with functional outcome and depression after acute ischemic stroke (AIS) or transient ischemic attack (TIA) is still unclear.</p><p><strong>Methods: </strong>All patients diagnosed with AIS or TIA in the impairment of cognition and sleep (ICONS) from the China National Stroke Registry III were included. Post-stroke depression (PSD) was defined as a value on the Patient Health Questionnaire-9 (PHQ-9) ≥5. Sleep duration was classified as normal (7-8 hours), short (<7 hours), or long (≥9 hours). According to the sleep duration, patients were divided into four groups: group A (persisting normal), group B (changed from long or short to normal), group C (changed from normal to long or short), and group D (persisting long or short). Logistic regression was performed to evaluate the effects of sleep duration changes on PSD, quality of life, and functional outcome at 1-year follow-ups.</p><p><strong>Results: </strong>A total of 1450 AIS or TIA patients at baseline with a mean age of 60.73±10.82 years were followed for 1-year. The group with persisting long or short sleep duration exhibited a significantly higher risk of PSD [OR 1.58(95% CI (1.06~2.33)] and poor quality of life [OR 1.42(95% CI 1.04~1.94)] than those in the persisting normal group at 1-year after AIS and TIA when adjusted for covariates. Patients with a decreased sleep duration of > 1 hour had more risk of moderate to severe PSD [OR 2.26(95% CI 1.13~4.53)] than the persisting normal group. Patients with newly developed abnormal sleep duration (changed from normal to long or short) had a higher risk of poor functional outcome [OR 2.82(95% CI 1.33~5.96)] than the persisting normal group.</p><p><strong>Conclusion: </strong>The alterations in sleep duration were independently associated with PSD, poor quality of life, and adverse outcomes at 1-year, suggesting that inadequate sleep quantity plays an important role in 1-year depression, quality of life, and adverse outcomes after AIS or TIA.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1507-1519"},"PeriodicalIF":3.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of the Alice NightOne Single-Belt Monitor for Obstructive Sleep Apnea and Reliability of Wireless Data Transfer.","authors":"MaoHuan Peng, YuanYuan Zhang, Rui Zhao, Jing Li, XueLi Zhang, LiHua Deng, Long Zhao, Bing Zhou, XinRu Wang, XiaoSong Dong, Fang Han","doi":"10.2147/NSS.S527805","DOIUrl":"10.2147/NSS.S527805","url":null,"abstract":"<p><strong>Objective: </strong>To validate the performance of a single-belt type 3 portable monitor Alice NightOne for diagnosis of obstructive sleep apnea and its reliability in remote data transmission.</p><p><strong>Methods: </strong>Our study included two parts: in-laboratory Alice NightOne (ANO) monitoring (ANO_lab) and home sleep apnea testing (HSAT) using ANO (ANO_home). For ANO_lab, the participants underwent polysomnography (PSG) with ANO_lab simultaneously. For ANO_home, the participants completed unattended overnight ANO_home out of sleep center and PSG was performed in another night. The ANO recordings were transmitted to cloud database wirelessly in addition to traditional wire transmission. Message digest-5 (MD5) algorithm was utilized to verify the integrity of the cloud data.</p><p><strong>Results: </strong>Ninety-one ANO_lab and 170 ANO_home recordings were analyzed. Both the respiratory event index (REI) on ANO_lab and that on ANO_home were lower than the corresponding apnea-hypopnea index (AHI) on PSG (24.9 ± 20.5 events/h vs 31.6 ± 25.0 events/h, and 26.7 ± 17.0 events/h vs 35.3 ± 21.2 events/h respectively, P < 0.001). Bland-Altman analysis of REI on ANO_lab versus AHI on PSG showed a mean difference (95% confidence interval) of -6.7 (-8.4, -4.9) events/h. For REI on ANO_home versus AHI on PSG, the difference is -8.0 (-9.9, -6.0) events/h. With threshold of REI ≥ 5 events/h for OSA diagnosis, ANO_home had 98.8% sensitivity, 90.0% specificity, 99.4% positive predictive value. The MD5 algorithm verified the identity between uploaded cloud data and original data.</p><p><strong>Conclusion: </strong>With single thoracoabdominal belt, Alice NightOne can help diagnosis of obstructive sleep apnea with good sensitivity and specificity, though it may underestimate AHI. Furthermore, it provides reliable support based on solid data teletransmission and scoring synchronization, which may increase the ability of diagnosis and management of OSA through telemedicine.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1493-1505"},"PeriodicalIF":3.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Association Between the Weight-Adjusted Waist Index and OSA Risk: Insights from the NHANES 2017-2020 and Mendelian Randomization Analyses [Corrigendum].","authors":"","doi":"10.2147/NSS.S548011","DOIUrl":"https://doi.org/10.2147/NSS.S548011","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2147/NSS.S489433.].</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1491-1492"},"PeriodicalIF":3.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Narcolepsy Advocacy: Bridging Patient Narratives and Systemic Change.","authors":"Ahmed Salem BaHammam, Lindsay Jesteadt, Hamza Dhafar, Amir Sharafkhaneh","doi":"10.2147/NSS.S537298","DOIUrl":"10.2147/NSS.S537298","url":null,"abstract":"<p><p>We introduce the Stigma-to-Structure Advocacy Framework, a novel, evidence-based model designed to transform narcolepsy advocacy by systematically bridging patient narratives with structural change. Narcolepsy remains a profoundly underdiagnosed and misunderstood neurological disorder, with persistent diagnostic delays and pervasive cultural stigma undermining patient well-being and access to care. Despite recent progress in awareness and support, advocacy efforts remain fragmented and insufficiently integrated with health policy, particularly in low- and middle-income countries. This perspective advances a strategic evolution of narcolepsy advocacy through the Stigma-to-Structure Advocacy Framework, which is anchored in three pillars: narrative-driven awareness, clinical system integration, and policy activation. Drawing on recent evidence, patient testimonies, and global case studies, we identify critical gaps in current advocacy models, such as limited representation of youth and marginalized populations, insufficient adaptation to cultural contexts, and the absence of standardized impact metrics. For example, ongoing diagnostic delays and entrenched cultural stigma continue to impede timely care and social inclusion for many individuals. We outline five priority actions for the next decade: developing outcome metrics, building culturally responsive advocacy hubs, integrating narcolepsy into rare disease registries, expanding peer mentoring networks, and reforming policy frameworks. By centering equity, digital inclusion, and cross-sector collaboration, this framework aims to dismantle entrenched barriers and promote timely diagnosis, effective care, and social inclusion for all individuals with narcolepsy. We conclude by calling for a globally coordinated, patient-powered movement that redefines advocacy as a driver of structural transformation in sleep medicine.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1431-1446"},"PeriodicalIF":3.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Sleep and Vertigo Severity in Benign Paroxysmal Positional Vertigo: Mediating Role of Psychological Factors.","authors":"Juanli Xing, Xinyu Xu, Hongying Shan, Jiaqian Wu, Peiyu Liu, Wenyan Shi, Peihua Ren, JinLing Liu, Yuge Huang, Baibing Mi","doi":"10.2147/NSS.S529355","DOIUrl":"10.2147/NSS.S529355","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between sleep quality and vertigo severity among patients with benign paroxysmal positional vertigo (BPPV) and to elucidate the mediating effects of anxiety and depression on this association.</p><p><strong>Methods: </strong>We analyzed baseline data from an ongoing cohort study of 1056 BPPV patients in Northwest China. Vertigo severity was assessed using the Dizziness Handicap Inventory (DHI), sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI), and psychological states were evaluated using the Hospital Anxiety and Depression Scale (HADS), Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS). Multiple regression and mediation analysis were conducted to explore the relationships between sleep quality, psychological factors, and vertigo severity.</p><p><strong>Results: </strong>Robust correlations were demonstrated between total PSQI scores and all DHI subscales (p < 0.001). Multivariate ordered logistic regression revealed that patients exhibiting sleep disorders manifested a substantially elevated risk of severe vertigo compared to those without (OR: 2.024; 95% CI: 1.571-2.608). Psychological factors emerged as significant mediators in this relationship, with anxiety accounting for 28.5% of the mediation effect, depression contributing 38%, and HADS mediating 37.7% of the association. A pronounced dose-response relationship was noted, with increased risk of vertigo severity as PSQI scores exceeded 7.</p><p><strong>Conclusion: </strong>This study shows a strong correlation between poor sleep quality and increased vertigo severity in BPPV patients, with anxiety and depression as significant mediators. These findings emphasize the need to address sleep-related factors and psychological symptoms in BPPV management, suggesting integrated sleep therapy and psychological interventions.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1477-1490"},"PeriodicalIF":3.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor Sleep Quality and Mood Disorders: Risk Factors of Increasing Chronic Pain in Patients with Insomnia.","authors":"Liu Liu, Xianchao Zhao, Xinyan Zhang, Jiafeng Ren, Si Zeng, Yuee Dai, Wensheng Zhang, Junying Zhou","doi":"10.2147/NSS.S518518","DOIUrl":"10.2147/NSS.S518518","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to examine the prevalence of chronic pain and its risk factors in patients with insomnia.</p><p><strong>Methods: </strong>We consecutively enrolled patients with chronic insomnia from Sleep Medicine Center in West China Hospital between May 2019 and February 2021. All patients were divided into two groups according to comorbid chronic pain or not. We used subjective questionnaires to assess sleep, daytime sleepiness, mood symptoms, and the characteristics and intensity of pain. Objective sleep quality was measured by polysomnography. The logistic regression analyses were used to identify the risk factors of chronic pain.</p><p><strong>Results: </strong>Among 358 patients with chronic insomnia, 48.9% had chronic pain. These patients had significantly higher scores in Hamilton Rating Scale for Anxiety (HAMA), Hamilton Rating Scale for Depression (HAMD), Visual Analog Scale (VAS) and Short-Form McGill Pain Questionnaire (SF-MPQ) (all <i>PS</i> < 0.001) compared to those without chronic pain. After controlling for the confounding factors, higher HAMA scores adjusted odds ratio = 1.083, 95% CI 1.033-1.135, <i>P</i> = 0.001), higher HAMD scores (adjusted odds ratio = 1.109, 95% CI 1.058-1.163, <i>P</i> < 0.001) and shorter N3 sleep duration (adjusted odds ratio = 0.969, 95% CI 0.940-0.999, <i>P</i> = 0.041) were significantly associated with an increased risk of chronic pain. Multiple linear regression analyses showed that higher scores in Pittsburgh Sleep Quality Index (PSQI) (β = 0.108, 95% CI 0.026-0.191, <i>P</i> = 0.010), HAMA (β = 0.085, 95% CI 0.043-0.127, <i>P</i> < 0.001) and HAMD (β = 0.141, 95% CI 0.093-0.188, <i>P</i> < 0.001) were positively related to pain intensity.</p><p><strong>Conclusion: </strong>Nearly half of patients with insomnia are comorbid with chronic pain. Poor subjective and objective sleep quality, as well as the anxious and depressive symptoms, are risk factors of chronic pain.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1447-1457"},"PeriodicalIF":3.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}