Nature and Science of Sleep最新文献

{"title":"Linking Gut Microbiota, Oral Microbiota, and Serum Metabolites in Insomnia Disorder: A Preliminary Study.","authors":"Weifeng Lin, Yifan Yang, Yurong Zhu, Rong Pan, Chaonan Liu, Jiyang Pan","doi":"10.2147/NSS.S472675","DOIUrl":"10.2147/NSS.S472675","url":null,"abstract":"<p><strong>Purpose: </strong>Despite recent findings suggesting an altered gut microbiota in those suffering from insomnia disorder (ID), research into the gut microbiota, oral microbiota, serum metabolites, and their interactions in patients with ID is sparse.</p><p><strong>Patients and methods: </strong>We collected a total of 114 fecal samples, 133 oral cavity samples and 20 serum samples to characterize the gut microbiota, oral microbiota and serum metabolites in a cohort of 76 ID patients (IDs) and 59 well-matched healthy controls (HCs). We assessed the microbiota as potentially biomarkers for ID for ID by 16S rDNA sequencing and elucidated the interactions involving gut microbiota, oral microbiota and serum metabolites in ID in conjunction with untargeted metabolomics.</p><p><strong>Results: </strong>Gut and oral microbiota of IDs were dysbiotic. Gut and oral microbial biomarkers could be used to differentiate IDs from HCs. Eleven significantly altered serum metabolites, including adenosine, phenol, and phenol sulfate, differed significantly between groups. In multi-omics analyses, adenosine showed a positive correlation with genus_<i>Lachnospira</i> (<i>p=</i>0.029) and total sleep time (<i>p</i>=0.016). Additionally, phenol and phenol sulphate had a negative correlation with genus<i>_Coprococcus</i> (<i>p</i>=0.0059; <i>p</i>=0.0059) and a positive correlation with Pittsburgh Sleep Quality Index (<i>p</i>=0.006; <i>p</i>=0.006) and Insomnia Severity Index (<i>p</i>=0.021; <i>p</i>=0.021).</p><p><strong>Conclusion: </strong>Microbiota and serum metabolite changes in IDs are strongly correlated with clinical parameters, implying mechanistic links between altered bacteria, serum metabolites and ID. This study offers novel perspective into the interaction among gut microbiota, oral microbiota, and serum metabolites for ID.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"1959-1972"},"PeriodicalIF":3.0,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Sleep Quality and Cirrhotic Cardiomyopathy: A Prospective Case-Control Study.","authors":"Fei Liu, Tianqing Cao, Yacong Liu, Dian Huang, Jingxin Zhang","doi":"10.2147/NSS.S482592","DOIUrl":"10.2147/NSS.S482592","url":null,"abstract":"<p><strong>Objective: </strong>The main purpose of this study is to evaluate the changes in sleep quality among patients with cirrhotic cardiomyopathy (CCM).</p><p><strong>Methods: </strong>The study included liver cirrhosis patients aged 18-75 from Northern Jiangsu People's Hospital Affiliated to Yangzhou University and collected their clinical examination results to assess the clinical characteristics and related risk factors of patients with CCM.</p><p><strong>Results: </strong>The study found that the onset of CCM was not related to the etiology of inducing cirrhosis. Pittsburgh Sleep Quality Index (PSQI) score (odds ratio (OR) = 13.476, 95% confidence interval (CI) = 1.514-119.923, P = 0.020), absolute GLS (OR = 0.328, 95% CI = 0.210-0.510, P < 0.001), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) (OR = 1.050, 95% CI = 1.025-1.076, P < 0.001) were identified as independent risk factors for inducing CCM.</p><p><strong>Conclusion: </strong>In patients with CCM, a decrease in sleep quality often occurs. When cirrhotic patients also have poor sleep quality, along with a decrease in absolute Global Left Ventricular Strain (GLS) levels and an increase in NT-proBNP levels, these factors may pose a higher risk for CCM development. However, further validation of these research findings is required in larger sample sizes.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"1949-1958"},"PeriodicalIF":3.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11630714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Obstructive Sleep Apnea and Continuous Positive Airway Pressure Treatment on Dry Eye Disease: A Systematic Review and Meta-Analysis.","authors":"Chung-Wei Lin, Yung-Chun Su, Jin-Dien Liu, Hsiao-Chun Su, Ting-Yi Chiang, Li-Wen Chiu, Hsin-Ching Lin, Chun-Tuan Chang, Pei-Wen Lin","doi":"10.2147/NSS.S495883","DOIUrl":"10.2147/NSS.S495883","url":null,"abstract":"<p><p>Obstructive sleep apnea (OSA) has been reported to influence the ocular surface and may lead to dry eye disease (DED). Continuous positive airway pressure (CPAP) is the first-line conservative treatment for OSA. However, CPAP might also have mask-related side effects that could deteriorate DED simultaneously. This study investigated the impact of OSA on DED (Aim 1), and CPAP on DED (Aim 2). Five databases were searched for articles published up to May, 2024. OSA severity, CPAP usage, and DED parameters, including tear breakup time (TBUT), Schirmer test, Ocular Surface Disease Index (OSDI), and Corneal Fluorescence Staining Score (CFS), were analyzed. For Aim 1, the random-effects model was used for meta-analysis, and the leave-one-out method was used for sensitivity analysis. For Aim 2, a narrative synthesis with critical appraisal of the literature was performed. Eleven studies with 1,526 patients for Aim 1 and three studies with 180 patients for Aim 2 were included. For Aim 1, OSA patients had poorer dry eye profiles of TBUT, Schirmer test, and OSDI when compared to non-OSA patients. For Aim 2, it seemed that those wearing CPAP for less than half a year did not have enough improvement in dry eye status. Instead, those wearing CPAP for at least a year reached greater therapeutic effects for OSA and DED. We concluded that OSA patients may suffer from poorer dry eye condition compared to non-OSA patients. Besides, wearing CPAP for long enough duration (at least 1 year) seemed to have better improvement in DED.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"1921-1935"},"PeriodicalIF":3.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Sleep Reactivity, Pre-Sleep Arousal State, and Neuroendocrine Hormones in Patients with Chronic Insomnia Disorder.","authors":"Ke Yu, Lan Xia, Hui-Hui Chen, Tian-Tian Zou, Yu Zhang, Ping Zhang, Ye Yang, Ru-Meng Wei, Zeng-Feng Su, Gui-Hai Chen","doi":"10.2147/NSS.S491040","DOIUrl":"10.2147/NSS.S491040","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to look into the relationship between pre-sleep arousal state, sleep reactivity, and serum levels of neuroendocrine hormones (cortisol, copeptin, and corticotropin-releasing hormone) in patients with chronic insomnia disorders (CID), and whether the effects of sleep reactivity and pre-sleep arousal on insomnia are related to the levels of these neuroendocrine hormones.</p><p><strong>Patients and methods: </strong>This study included 61 CID patients and 27 healthy controls (HC) whose base data were matched to those of the CID patients. The Pittsburgh Sleep Quality Index(PSQI), Pre-Sleep Arousal Scale (PSAS), and the Ford Insomnia Response to Stress Test (FIRST) were used to evaluate the participants' sleep, stress, and neuropsychological function. We measured the participants' serum concentration levels of cortisol, copeptin, and corticotropin-releasing hormone (CRH), using quantitative sandwich enzyme-linked immunosorbent assays.</p><p><strong>Results: </strong>The CID group had significantly greater serum levels of copeptin, CRH, and cortisol, as well as higher FIRST and PSAS scores than the HC group. The partial correlation analysis revealed a substantial and positive association among cortisol, CRH, copeptin PSQI, PSAS, and FIRST after adjusting for sex, age, depression, and cognition. Principal component analysis showed that PSQI, FIRST, and PSAS, as well as cortisol, CRH, and copeptin, were all loaded on factor 1.</p><p><strong>Conclusion: </strong>Patients with CID showed increased sleep reactivity and pre-sleep arousal, which correlated with serum levels of cortisol, copeptin, and CRH. Changes in neuroendocrine hormone levels may influence how pre-sleep arousal and sleep reactivity affect the development of insomnia.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"1907-1919"},"PeriodicalIF":3.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-State EEG Microstates Dynamics Associated with Interindividual Vulnerability to Sleep Deprivation.","authors":"Zehui Liu, Tian Xie, Ning Ma","doi":"10.2147/NSS.S485412","DOIUrl":"10.2147/NSS.S485412","url":null,"abstract":"<p><strong>Purpose: </strong>Sleep deprivation can induce severe deficits in vigilant maintenance and alternation in large-scale networks. However, differences in the dynamic brain networks after sleep deprivation across individuals have rarely been investigated. In the present study, we used EEG microstate analysis to investigate the effects of sleep deprivation and how it differentially affects resting-state brain activity in different individuals.</p><p><strong>Participants and methods: </strong>A total of 44 healthy adults participated in a within-participant design study involving baseline sleep and 24-hour sleep deprivation, with resting-state EEG recorded during wakefulness. The psychomotor vigilance task (PVT) was used to measure vigilant attention. Participants were median split as vulnerable or resilient according to their changes in the number of lapses between the baseline sleep and sleep deprivation conditions.</p><p><strong>Results: </strong>Sleep deprivation caused decreases in microstates A, B, and D, and increases in microstate C. We also found increased transition probabilities of microstates C and D between each other, lower transition probabilities from microstates C and D to microstate B, and higher transition probabilities from microstates A and B to microstate C. Sleep-deprived vulnerable individuals showed decreased occurrence of microstate B and transition probability from microstate C to B after sleep deprivation, but not in resilient individuals.</p><p><strong>Conclusion: </strong>The findings suggest that sleep deprivation critically affects dynamic brain-state properties and the differences in time parameters of microstates might be the underlying neural basis of interindividual vulnerability to sleep deprivation.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"1937-1948"},"PeriodicalIF":3.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the Rigor of Mendelian Randomization: Methodological Insights from the Study on Obstructive Sleep Apnea and Temporomandibular Disorders [Response to Letter].","authors":"Yu-Pei Wang, Hui-Xia Wei, Yuan-Yuan Hu, Yu-Ming Niu","doi":"10.2147/NSS.S502292","DOIUrl":"10.2147/NSS.S502292","url":null,"abstract":"","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"1905-1906"},"PeriodicalIF":3.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Waiting for in-Lab Polysomnography May Unnecessarily Prolong Treatment Start in Patients with Moderate or Severe OSA at Home Sleep Apnea Testing.","authors":"Johannes Pordzik, Christopher Seifen, Katharina Ludwig, Christian Ruckes, Tilman Huppertz, Christoph Matthias, Haralampos Gouveris","doi":"10.2147/NSS.S482614","DOIUrl":"10.2147/NSS.S482614","url":null,"abstract":"<p><strong>Purpose: </strong>The gold standard in obstructive sleep apnea (OSA) diagnostics is nocturnal full-night polysomnography (PSG). Due to high costs and high time effort portable respiratory polygraphy (PG or home sleep apnea testing-HSAT) has been developed. In contrast to PG the PSG gains relevant further information concerning sleep stages, arousals and leg movements. However, the role of PG in the diagnostic of OSA remains largely undefined. The aim of this study was to investigate the difference of PG- and PSG- related metrics in OSA, to understand if there is a difference in PG and PSG-based treatment decision and show up the time between performed PG and PSG.</p><p><strong>Patients and methods: </strong>99 consecutive patients with existing outpatient performed PG and followed PSG in our tertiary care otorhinolaryngology department between February 2020 and December 2023 were retrospectively assessed. All patients were treatment-naive at the time of consultation. The time between performed outpatient PG and PSG was calculated. Furthermore, clinical baseline parameter and PG as well as PSG data were evaluated. All data were then blinded presented with relevant comorbid diseases to two experts in sleep medicine in our tertiary care centre to decide whether PAP therapy was indicated or not.</p><p><strong>Results: </strong>Mean AHI was significantly higher in PSG (32.32 ± 22.78/h) compared to PG (22.60 ± 15.12/h) (p<0.001). Mean duration between performed PG and PSG was 194.99 ± 131.96 days (range between 37 and 842 days). Only in two patients PAP-therapy was indicated with PG results but not with PSG results. Only in one case PAP-therapy was not indicated with PG results but with PSG results.</p><p><strong>Conclusion: </strong>These data suggest initiating OSA therapy based on PG results for patients with at least moderate OSA on PG, followed by a confirming PSG and a control PSG under treatment to avoid unnecessary prolongation of treatment start.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"1881-1889"},"PeriodicalIF":3.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Density of Resting-State Long- and Short-Range Functional Connectivity in Patients with Moderate-to-Severe Obstructive Sleep Apnea.","authors":"Yumeng Liu, Huizhen Xin, Yongqiang Shu, Lifeng Li, Ting Long, Li Zeng, Ling Huang, Xiang Liu, Yingke Deng, Yu Zhu, Haijun Li, Dechang Peng","doi":"10.2147/NSS.S483030","DOIUrl":"10.2147/NSS.S483030","url":null,"abstract":"<p><strong>Purpose: </strong>This study is to evaluate the altered number of functional connection (s) in patients with obstructive sleep apnea (OSA) by functional connectivity density (FCD), to investigate its relationship with cognitive function, and to explore whether these features could be used to distinguish OSA from healthy controls (HCs).</p><p><strong>Methods: </strong>Seventy-six OSA patients and 72 HCs were included in the analysis. All participants underwent resting-state functional magnetic resonance imaging scan. Subsequently, intergroup differences between long-and short-range FCD groups were obtained in the Matlab platform by using the degree centrality option with a 75 mm cutoff. The partial correlation analysis were used to assess the relationship between the altered FCD value and clinical assessments in OSA patients. The FCD values of the different brain regions were used as classification features to distinguish the two groups by support vector machine (SVM).</p><p><strong>Results: </strong>Compared to HCs, OSA patients had decreased long-range FCD in the right superior frontal gyrus (SFG), right precuneus, and left middle frontal gyrus (MFG). Simultaneously, increased long-range FCD in the right cingulate gyrus (CG). Meanwhile, the short-range FCD were decreased in the right postcentral gyrus (PoCG), right SFG, left MFG, and right CG. The short-range FCD values of the right PoCG were correlated with the Montreal Cognitive Assessment scores in OSA patients. SVM analysis showed that FCD in differential brain regions could differentiate OSA patients from HCs.</p><p><strong>Conclusion: </strong>Long- and short-range FCD values in different brain regions of OSA patients may be related to cognitive decline, and also be effective in distinguishing OSA patients from HCs. These findings provide new perspectives on neurocognition in OSA patients.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"1891-1904"},"PeriodicalIF":3.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased Memory-Related Regional Cerebral Perfusion in Severe Obstructive Sleep Apnea with a Mild Cognitive Impairment During Wakefulness.","authors":"Xiangbo Yan, Wanqing Liu, Danyang Li, Qiang Huang, Jianlin Wu, Qing Zhang","doi":"10.2147/NSS.S481602","DOIUrl":"10.2147/NSS.S481602","url":null,"abstract":"<p><strong>Purpose: </strong>Previous studies have found that obstructive sleep apnea (OSA) can induce cognitive impairment (CI). However, the exact mechanisms of CI development in patients with OSA remains unclear. We investigated the neuropathological basis of CI development by examining changes in cerebral blood perfusion.</p><p><strong>Patients and methods: </strong>Thirty-five patients with untreated OSA (15 with CI and 20 without CI [NCI]) and 15 good sleepers (GS) diagnosed using polysomnography were recruited. All participants underwent resting state brain scans in a Siemens 3.0 Tesla magnetic resonance imaging scanner with a pulsed arterial spin labeling sequence and completed a battery of neuropsychological tests.</p><p><strong>Results: </strong>Compared to the regional cerebral blood flow (rCBF) values in the GS group, both the CI and NCI groups exhibited lower rCBF values in the bilateral inferior temporal, left lingual, and right medial and paracingulate gyri, as well as higher rCBF values in the bilateral middle frontal gyrus (<i>p</i> < 0.05 in all cases). Compared to the rCBF values in the NCI group, the CI group had lower rCBF values in the bilateral inferior temporal and left lingual gyri, and higher rCBF values in the right rectus and right middle orbital frontal gyri (<i>p</i> < 0.05 in all cases). In the CI group, rCBF values in the bilateral inferior temporal (right, <i>p</i> = 0.025; left, <i>p</i> = 0.005) and left lingual gyri (<i>p</i> = 0.018) were positively associated with the delayed memory scores, and rCBF values in the left inferior temporal gyrus positively correlated with the attention scores (<i>p</i> = 0.011).</p><p><strong>Conclusion: </strong>Regions with abnormal perfusion in the NCI and CI groups were mostly memory-related. Blood perfusion in the bilateral inferior temporal and left lingual gyri decreased in the following order: GS > OSA-NCI > OSA-CI. These findings provide blood perfusion-level insights into the neuropathological basis of OSA-CI development.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"1869-1880"},"PeriodicalIF":3.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Tobacco Use on the Macrostructure and Microstructure of Sleep in Patients with OSA.","authors":"Wei Ji, Liyong Shi, Zhiqiang Ji, Zhihuang Zhao, Lianshun Lin, Xiali Wang, Jing Cheng, Xiaoyang Chen","doi":"10.2147/NSS.S480116","DOIUrl":"10.2147/NSS.S480116","url":null,"abstract":"<p><strong>Objective: </strong>Both tobacco use and obstructive apnea-hypopnea syndrome (OSA) can affect sleep, and it is speculated that tobacco use may further affect the sleep of those with OSA. Our primary objective is to clarify the associations between tobacco use and the macrostructure and microstructure of sleep in patients with OSA.</p><p><strong>Methods: </strong>This retrospective study encompasses a cohort of 1017 patients who were hospitalized between January 2020 and January 2023 for the investigation of sleep disorders. Rigorous inclusion criteria were applied, and all patients underwent a comprehensive polysomnography (PSG) assessment and completed a Pittsburgh Sleep Quality Index (PSQI) questionnaire.</p><p><strong>Results: </strong>Patients with OSA who concurrently used tobacco exhibited markedly inferior sleep quality than those who did not. Notably, there was no association between the degree of tobacco dependence and sleep quality. Those with OSA who used tobacco demonstrated a significant prolongation of stage 1 light sleep and a reduction of deep sleep duration (N3). In this group, those who demonstrated poor sleep quality had more pronounced alterations in light sleep stages with prolonged N1 and shortened N2 stages.</p><p><strong>Conclusion: </strong>Our findings reveal a substantial reduction in sleep quality amongst OSA patients who also use tobacco, compared to those with OSA who do not use tobacco. The rate of poor sleep quality was not linearly associated with the level of tobacco dependence. Tobacco use was associated with alterations in both light and slow wave sleep in those with OSA. Importantly, the effects of tobacco dependence on sleep structure were more pronounced in those with more severe OSA.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"1849-1868"},"PeriodicalIF":3.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}