Nature and Science of Sleep最新文献

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The Effect of Mattress Firmness on Sleep Architecture and PSG Characteristics. 床垫硬度对睡眠结构和PSG特征的影响。
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2025-05-09 eCollection Date: 2025-01-01 DOI: 10.2147/NSS.S503222
Xiaohong Hu, Yuhong Gao, Yixuan Song, Xiaoqin Yang, Keyang Liu, Bin Luo, Yan Sun, Li Li
{"title":"The Effect of Mattress Firmness on Sleep Architecture and PSG Characteristics.","authors":"Xiaohong Hu, Yuhong Gao, Yixuan Song, Xiaoqin Yang, Keyang Liu, Bin Luo, Yan Sun, Li Li","doi":"10.2147/NSS.S503222","DOIUrl":"10.2147/NSS.S503222","url":null,"abstract":"<p><strong>Background: </strong>The influence of sleep environments on sleep quality is well-established; however, the specific role of mattress design remains underexplored. Existing studies focus primarily on ergonomic aspects, such as pressure relief and spinal support, yet lack conclusive evidence linking these features to improved sleep quality.</p><p><strong>Objective and methods: </strong>This study aimed to evaluate the effects of mattress firmness on sleep quality. Twelve participants with a moderate body mass index (BMI) were tested across three levels of mattress firmness: soft (32.6 HA), medium (64.6 HA), and firm (83.8 HA). Sleep architecture and neurophysiological activity were assessed using polysomnography (PSG), with EEG-derived features, including power spectral characteristics, sleep spindle activity, and slow-wave parameters, further analyzed.</p><p><strong>Results: </strong>Our findings indicate that a medium-firm mattress provides better sleep quality, reflected in a narrower range (Range=xmax-xmin) of sleep duration, efficiency, and sleep latency, as well as increased sleep spindle activity. A repeated-measures ANOVA revealed a significant effect of mattress type on sleep latency (p < 0.05, partial η²=0.26), with sleep latency being longer on the soft mattress (12.42 ± 1.94 min) than the medium mattress (7.71 ± 1.31 min, p < 0.05). Another repeated-measures ANOVA showed significant differences in stage transitions (p < 0.05, partial η²=0.32), with more transitions on the soft mattress (29.17 ± 2.35) compared to the firm mattress (21.75 ± 2.13, p < 0.05). The firm mattress yielded mixed results, suggesting suitability for some individuals but not universally. Post-sleep vigilance differences were not statistically significant.</p><p><strong>Conclusion: </strong>This study provides evidence that mattress firmness significantly influences sleep quality, with medium firmness offering optimal outcomes for individuals with a moderate BMI. The findings contribute to the development of scientifically informed mattress designs, including smart mattresses aimed at improving sleep quality.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"865-878"},"PeriodicalIF":3.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12071755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dreams and Nightmares in Early Pregnancy: A Comparative Study with a Control Group. 怀孕早期的梦和噩梦:与对照组的比较研究。
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2025-05-09 eCollection Date: 2025-01-01 DOI: 10.2147/NSS.S520737
Serena Scarpelli, Marta Spinoni, Maurizio Gorgoni, Stefano Lasaponara, Paola Ciolli, Francesco Rech, Marco Di Muzio, Carlotta Med, Ilaria Di Pasquale Benedetti, Caterina Grano, Luigi De Gennaro
{"title":"Dreams and Nightmares in Early Pregnancy: A Comparative Study with a Control Group.","authors":"Serena Scarpelli, Marta Spinoni, Maurizio Gorgoni, Stefano Lasaponara, Paola Ciolli, Francesco Rech, Marco Di Muzio, Carlotta Med, Ilaria Di Pasquale Benedetti, Caterina Grano, Luigi De Gennaro","doi":"10.2147/NSS.S520737","DOIUrl":"https://doi.org/10.2147/NSS.S520737","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated dream characteristics in women during the first trimester of pregnancy compared to a group of non-pregnant women, aiming to identify variables associated with the observed differences.</p><p><strong>Participants and method: </strong>A sample of 100 pregnant women in their first trimester was compared to a control group of 100 age-matched non-pregnant women. Participants completed online questionnaires to assess dream activity, sleep quality, depressive symptoms, and sociodemographic variables.</p><p><strong>Results: </strong>Controlling for socio-demographic variables, statistical comparisons revealed that pregnant women reported fewer nightmares and showed less interest in their dream activity compared to non-pregnant women. Ordinal logistic regression revealed that being in the control group, greater attention to dreams, the presence of depressive symptoms, and a higher frequency of lucid dreaming were significant predictors of more frequent nightmares. Moderation analysis showed no significant interaction between pregnancy status and dream attitude.</p><p><strong>Conclusion: </strong>Contrary to expectations, first-trimester pregnant women had fewer nightmares than non-pregnant women. However, the results are coherent with the finding that parasomnia-like events decrease during pregnancy. The rapid hormonal changes and specific sleep and emotional features of this stage of gestation may explain the lower presence of nightmares as compared to our control group. Moreover, we confirmed a crucial role of dream attitude in recalling nightmares, suggesting that some stable, trait-like features may contribute to nightmare experiences independently of pregnancy status. Our results also confirmed, according to the Continuity hypothesis, that depressive symptoms are associated with nightmares. Also, the presence of lucid dreaming in association with nightmares may be interpreted as an attempt to cope with unpleasant emotions. Longitudinal studies are needed to examine how dream activity evolves across pregnancy stages.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"851-864"},"PeriodicalIF":3.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Short Naps on EEG Microstates: Improving Sleep Deprivation-Induced Cognitive Impairment. 小睡对脑电图微状态的影响:改善睡眠剥夺引起的认知障碍。
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2025-05-09 eCollection Date: 2025-01-01 DOI: 10.2147/NSS.S502469
Chaozong Ma, Jiaxi Peng, Yan Li, Anping Ouyang, Yangsen Huang, Wei He, Yuanqiang Zhu, Peng Fang
{"title":"Effects of Short Naps on EEG Microstates: Improving Sleep Deprivation-Induced Cognitive Impairment.","authors":"Chaozong Ma, Jiaxi Peng, Yan Li, Anping Ouyang, Yangsen Huang, Wei He, Yuanqiang Zhu, Peng Fang","doi":"10.2147/NSS.S502469","DOIUrl":"https://doi.org/10.2147/NSS.S502469","url":null,"abstract":"<p><strong>Purpose: </strong>Sleep can repair the brain damage caused by sleep deprivation (SD), however in many cases, it may not be feasible to get sufficient sleep. Napping is a simple strategy to mitigate the detrimental impacts of SD. However, the underlying mechanism behind how napping contributes to brain repair remains unclear. Electroencephalogram (EEG) microstate analysis is sensitive in detecting bottom-up and top-down attention control and rapid transitions between quasi-stable brain states due to its temporal resolution. This study aims to explore the effects of napping on cognitive impairments cause by SD and the potential mechanisms of cognitive recovery.</p><p><strong>Patients and methods: </strong>We recruited forty-two healthy volunteers and recorded their EEG signals and psychomotor vigilance task (PVT) data at three time points: rested wakefulness, post-SD, and post-nap. EEG microstates analysis was used to explore changes of brain dynamic network. In addition, we investigate the alterations in microstate parameters and their correlation with behavior.</p><p><strong>Results: </strong>We observed a significant decrease in participants' alertness levels following SD, which subsequently improved after napping. Four microstate classes (A, B, C, D) were identified by using EEG microstate analysis. The B-D transition increased significantly after SD and returned to baseline after napping, while A-D transition revealed opposite patterns. Notably, changes of time coverage and occurrence in microstate D were significantly correlated with changes of PVT performance after both SD and nap conditions.</p><p><strong>Conclusion: </strong>Our results provide empirical evidence that short naps can effectively reverse negative effects of SD on vigilant attention, primarily through restoring the functionality of key brain networks involved in attention regulation.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"905-916"},"PeriodicalIF":3.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatiotemporal Trends in the Prevalence of Obstructive Sleep Apnoea Across China: A Multilevel Meta-Analysis Incorporating Geographic and Demographic Stratification (2000-2024). 中国阻塞性睡眠呼吸暂停患病率的时空趋势:一个包含地理和人口分层的多水平荟萃分析(2000-2024)。
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2025-05-09 eCollection Date: 2025-01-01 DOI: 10.2147/NSS.S525547
Yuqi Niu, Shanwen Sun, Yali Wang, Linlin Chen, Yefan Shao, Xiaochun Zhang
{"title":"Spatiotemporal Trends in the Prevalence of Obstructive Sleep Apnoea Across China: A Multilevel Meta-Analysis Incorporating Geographic and Demographic Stratification (2000-2024).","authors":"Yuqi Niu, Shanwen Sun, Yali Wang, Linlin Chen, Yefan Shao, Xiaochun Zhang","doi":"10.2147/NSS.S525547","DOIUrl":"https://doi.org/10.2147/NSS.S525547","url":null,"abstract":"<p><strong>Purpose: </strong>China bears the highest global burden of obstructive sleep apnea (OSA), yet its spatiotemporal and occupational patterns remain unclear. We quantified OSA prevalence across Chinese subpopulations, focusing on geographic disparities, temporal trends, and occupational risks.</p><p><strong>Methods: </strong>Following PRISMA guidelines, we systematically searched six databases (2000-2024) for population-based OSA studies using polysomnography or validated portable monitoring. Two researchers independently screened studies with third-party adjudication of discrepancies. Risk of bias was assessed using Joanna Briggs Institute criteria. Random-effects models pooled prevalence estimates; meta-regression identified heterogeneity contributors. OSA diagnosis followed 2012 AASM criteria (AHI ≥5; pediatric studies: OAHI ≥1.5).</p><p><strong>Results: </strong>From 62 studies (N=178,049), pooled OSA prevalence was 11.8% (95% CI:10.1-13.4%), rising from 8.1% (2000-2005) to 26.9% (2021-2024). Prevalence was higher in males vs females (11.1% vs 6.0%, P<0.001), with marked geographic disparities: Northwest China had the highest prevalence (17.8%, 16.3-19.3%) versus Southwest (6.9%, 3.7-10.9%). Drivers exhibited the highest occupational risk (15.3%). Low-quality studies overestimated prevalence (15.0% vs 7.6-10.2% in higher-quality studies), and two-step sampling yielded higher estimates than single-risk-group designs (13.6% vs 7.4%, P<0.001). Meta-regression identified survey period (β=0.036, P=0.025), male sex (β=-0.062, P=0.047), geographic area (β=0.268, P=0.035), occupation (β=0.254, P=0.047), and sampling strategy (β=-0.029, P=0.012) as key predictors of heterogeneity.</p><p><strong>Conclusion: </strong>OSA prevalence in China has accelerated significantly. Standardized screening is urgently needed for aging populations, high-risk occupations (particularly drivers), and underserved regions. Policy priorities should address rural diagnostic inequities and integrate OSA surveillance into public health programs. Methodological harmonization is critical for tracking OSA's evolving burden.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"879-903"},"PeriodicalIF":3.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autonomic Nervous Regulation was Associated with Sleep Quality Among Peritoneal Dialysis Patients. 腹膜透析患者的自主神经调节与睡眠质量相关。
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2025-05-09 eCollection Date: 2025-01-01 DOI: 10.2147/NSS.S501926
Baodi Huang, Yujun Qian, Ying Gao, Zhenye Chen, Li Zhang, Huijuan Mao, Changying Xing, Haibin Ren, Jing Wang
{"title":"Autonomic Nervous Regulation was Associated with Sleep Quality Among Peritoneal Dialysis Patients.","authors":"Baodi Huang, Yujun Qian, Ying Gao, Zhenye Chen, Li Zhang, Huijuan Mao, Changying Xing, Haibin Ren, Jing Wang","doi":"10.2147/NSS.S501926","DOIUrl":"https://doi.org/10.2147/NSS.S501926","url":null,"abstract":"<p><strong>Background: </strong>The issue of compromised sleep quality among patients with end-stage kidney disease (ESKD), particularly those undergoing peritoneal dialysis (PD), is notably pronounced. Dialysis patients exhibit significant alterations in cardiac autonomic nerve activity. However, the relationship between autonomic nervous system activity and sleep remains inadequately elucidated.</p><p><strong>Methods: </strong>This cross-sectional study enrolled adult maintenance PD patients in our center. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality. Heart rate variability (HRV) and Skin sympathetic nerve activity (SKNA) parameters were recorded to reflect autonerve activity responses or regulation capacity.</p><p><strong>Results: </strong>A total of 73 PD patients participated in this study, with a prevalence of poor sleep quality at 38.4%. Serum creatinine (1157.0±294.3 vs 969.6±353.4 mmHg, p = 0.022) and phosphorus levels (2.1±0.5 vs 1.7±0.5 mmHg, p = 0.002) were higher in the poor sleep quality group compared to the good group. Linear regression analyses indicated that PSQI scores were associated with SKNA (β, -2.54; 95% CI, -4.90 to -0.19; P=0.035), standard deviation of all sinus RR intervals (SDNN) (β, -0.05; 95% CI, -0.09 to -0.01; P=0.015), and SD2 (β, -0.04; 95% CI, -0.07 to -0.01; P=0.018).</p><p><strong>Conclusion: </strong>Poor sleep quality in PD patients may be associated with longer dialysis vintage, higher BMI, higher diastolic blood pressure, and higher level of serum uremic toxin, and affected by cardiac autonomic nerve function disorder.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"839-849"},"PeriodicalIF":3.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Craniofacial Skeletal Patterns on Sleep Quality and Oral Health-Related Quality of Life Among Adults. 颅面骨骼模式对成人睡眠质量和口腔健康相关生活质量的影响
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2025-05-05 eCollection Date: 2025-01-01 DOI: 10.2147/NSS.S512617
Deniz Yenidunya, Berza Yilmaz
{"title":"The Impact of Craniofacial Skeletal Patterns on Sleep Quality and Oral Health-Related Quality of Life Among Adults.","authors":"Deniz Yenidunya, Berza Yilmaz","doi":"10.2147/NSS.S512617","DOIUrl":"https://doi.org/10.2147/NSS.S512617","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess the possible impact of sagittal and vertical skeletal patterns on sleep quality and oral health-related quality of life (OHRQoL).</p><p><strong>Patients and methods: </strong>Following the acquisition of their written informed consent, 330 patients who applied for orthodontic treatment and who met the inclusion requirements were invited to take part in the study by completing the following questionnaires: Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI), and Oral Health Impact Profile (OHIP-14). According to criteria like incomplete questionnaires, BDI score above 17 and body mass index higher than 30, 50 patients' data were excluded. Two hundred and eighty participants were classified according to their sagittal and vertical patterns and the hyoid bone distance to the mandibular plane (GoGn) and anterior cranial base (SN). Oral health-related quality of life and its components, sleep quality and its components were compared between groups.</p><p><strong>Results: </strong>The PSQI scores for the sagittal and vertical groups did not significantly differ from each other, except for the normodivergent and hyperdivergent groups' total scores. It was observed that when the Hyoid-SN line distance decreased; the sleep quality decreased with an increase in the \"sleep disturbance\" and \"daytime dysfunction\". Neither the Hyoid-GoGn distance nor vertical or sagittal patterns were found to be related to OHRQoL. There was a significant correlation between OHIP-14 and PSQI.</p><p><strong>Conclusion: </strong>Our findings showed that various vertical and sagittal craniofacial features would not affect the OHRQoL scores. PSQI scores appear to be unaffected by the sagittal pattern, but a significant difference was noted in the total score between groups formed considering the vertical pattern.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"801-812"},"PeriodicalIF":3.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What Links Sleep and Neuropathic Pain?: A Literature Review on the Neural Circuits for Sleep and Pain Control. 睡眠和神经性疼痛有什么联系?关于睡眠和疼痛控制的神经回路的文献综述。
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2025-05-05 eCollection Date: 2025-01-01 DOI: 10.2147/NSS.S509013
Anh Ho, Victor J Drew, Tae Kim
{"title":"What Links Sleep and Neuropathic Pain?: A Literature Review on the Neural Circuits for Sleep and Pain Control.","authors":"Anh Ho, Victor J Drew, Tae Kim","doi":"10.2147/NSS.S509013","DOIUrl":"https://doi.org/10.2147/NSS.S509013","url":null,"abstract":"<p><p>Neuropathic pain (NP), arising from lesions or diseases of the sensory nervous system, significantly disrupts sleep, creating a feedback loop where pain and sleep disturbances exacerbate each other. Research suggests that sleep disruption may contribute to progressing from acute to chronic NP. The neural circuits involved in sleep-wake regulation and pain processing are intricately interconnected, making it difficult to pinpoint the specific regions responsible for each function. This review seeks to disentangle these complex relationships by providing a detailed overview of the anatomical pathways involved in NP, extending from the peripheral to the central nervous system. Additionally, it examines the neurocircuits that govern sleep-wake cycles and their interaction with pain pathways. By illuminating these connections, this review aims to deepen our understanding of how sleep influences NP, ultimately guiding the development of more effective strategies for managing NP and its associated sleep disturbances to improve the quality of life for those affected.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"813-838"},"PeriodicalIF":3.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing the Robustness of MR Analysis on OSA and Migraine: Addressing Key Limitations [Response to Letter]. 增强OSA和偏头痛的MR分析的稳健性:解决关键限制[回复信件]。
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2025-05-02 eCollection Date: 2025-01-01 DOI: 10.2147/NSS.S529221
Yu-Pei Wang, Hui-Xia Wei, Yuan-Yuan Hu, Chao Zhang, Yu-Ming Niu
{"title":"Enhancing the Robustness of MR Analysis on OSA and Migraine: Addressing Key Limitations [Response to Letter].","authors":"Yu-Pei Wang, Hui-Xia Wei, Yuan-Yuan Hu, Chao Zhang, Yu-Ming Niu","doi":"10.2147/NSS.S529221","DOIUrl":"https://doi.org/10.2147/NSS.S529221","url":null,"abstract":"","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"747-748"},"PeriodicalIF":3.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TEX10: A Novel Drug Target and Potential Therapeutic Direction for Sleep Apnea Syndrome. TEX10:睡眠呼吸暂停综合征的新药物靶点及潜在治疗方向
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2025-05-01 eCollection Date: 2025-01-01 DOI: 10.2147/NSS.S499895
Zhitao Fan, Hui Su, Tong Qiao, Sunan Shi, Pengfei Shi, Anqi Zhang
{"title":"TEX10: A Novel Drug Target and Potential Therapeutic Direction for Sleep Apnea Syndrome.","authors":"Zhitao Fan, Hui Su, Tong Qiao, Sunan Shi, Pengfei Shi, Anqi Zhang","doi":"10.2147/NSS.S499895","DOIUrl":"https://doi.org/10.2147/NSS.S499895","url":null,"abstract":"<p><strong>Background: </strong>Sleep apnea syndrome (SAS) is a prevalent sleep disorder strongly associated with obesity, metabolic dysregulation, and cardiovascular diseases. While its underlying pathophysiological mechanisms remain incompletely understood, genetic factors likely play a pivotal role in SAS pathogenesis. This study investigates the causal relationships between potential drug target genes and SAS using multiple statistical approaches, aiming to provide novel insights for targeted therapeutic development.</p><p><strong>Methods: </strong>We conducted a comprehensive genetic analysis integrating multiple methodologies to investigate gene-SAS relationships. Using publicly available GWAS and eQTL databases, we performed Mendelian Randomization (MR) analysis with the inverse variance weighted (IVW) method, validated by weighted median and MR-Egger approaches. Summary-data-based MR (SMR) analysis, coupled with HEIDI testing, assessed direct gene expression-SAS associations while controlling for linkage disequilibrium (LD). Colocalization analysis evaluated the probability of shared causal variants between SNPs, gene expression, and SAS. Statistical significance was determined using Benjamini-Hochberg multiple testing correction (FDR < 0.05). Additionally, mediation analysis explored TEX10's influence on SAS through metabolic intermediates including BMI, waist circumference, and HDL cholesterol.</p><p><strong>Results: </strong>We identified 18 candidate drug target genes significantly associated with SAS, with MAPKAPK3, TNXB, MPHOSPH8, and TEX10 showing consistent associations across multiple analyses. TEX10, in particular, exhibited significant associations with SAS risk in blood, cerebral cortex, hippocampus, and basal ganglia (PP.H4 > 0.9). Mediation analysis suggested that TEX10 might influence SAS risk indirectly through BMI, waist circumference, and HDL cholesterol levels.</p><p><strong>Conclusion: </strong>Our study identified multiple potential therapeutic targets causally linked to SAS, with TEX10 emerging as a key candidate gene. These findings advance our understanding of SAS pathogenesis and offer promising directions for personalized diagnostics and targeted therapies.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"731-746"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient Sleep, Enhanced Attention: Exploring the Interplay With RBC-Inflammation Mechanisms in Hypoxic High-Altitude Areas. 高效睡眠,增强注意力:探索低氧高海拔地区红细胞炎症机制的相互作用。
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2025-05-01 eCollection Date: 2025-01-01 DOI: 10.2147/NSS.S498996
Chun-Yan Shi, Xiao-Juan Xue, Ze-Feng Li, Xiao-Yan Huang, Rui Su, Nian-Nian Wang, Jin-Guo Zhu, Hao Li, Hai-Lin Ma, Ming Liu, De-Long Zhang
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