Nature and Science of Sleep最新文献

{"title":"Gut Microbiome Composition Changes During Insomnia Treatment with Lemborexant.","authors":"Seiko Miyata, Kunihiro Iwamoto, Mikako Ito, Ippei Okada, Nao Matsuyama, Akihiro Fujimoto, Yuki Kogo, Hiroshi Nishiwaki, Jun Ueyama, Kinji Ohno, Norio Ozaki","doi":"10.2147/NSS.S526037","DOIUrl":"10.2147/NSS.S526037","url":null,"abstract":"<p><strong>Purpose: </strong>Insomnia is a common disorder worldwide. Growing evidence has revealed that the microbiota-gut-brain axis contributes to the regulation of sleep continuity and duration, both directly and indirectly. Although lemborexant is effective in treating insomnia, its effect on the gut microbiota remains unclear. Here, we investigated the relationship between the gut microbiota and hypnotic use in insomnia.</p><p><strong>Participants and methods: </strong>We enrolled 29 adults with insomnia and performed sleep electroencephalography and stool analyses at baseline and after 4 and 12 weeks of open-label lemborexant treatment. Changes in gut microbiota were analyzed using 16S rRNA sequencing and metabolite analysis was performed to assess short-chain fatty acids (SCFAs).</p><p><strong>Results: </strong>Beta diversity (Jaccard dissimilarity) and Firmicutes/Bacteroidetes ratio significantly increased after administration of lemborexant for 12 weeks (p < 0.05). Seven genera were significantly different (p < 0.05). Among these, <i>Tannerellaceae Parabacteroides</i> decreased significantly after 12 weeks of lemborexant treatment (p = 0.013), even after correcting for false discovery rates. <i>Akkermansia</i> was strongly negatively correlated with sleep efficiency (r = -0.754, p = 0.0003). <i>Allisonella</i> showed opposite correlations with latency to persistent sleep and sleep efficiency after 12 weeks of lemborexant treatment (r = 0.523, p = 0.018, r = -0.516, p = 0.020, respectively). There were no significant differences in SCFAs during the treatment period.</p><p><strong>Conclusion: </strong>Our findings suggest that prolonged lemborexant treatment in individuals with insomnia may induce notable shifts in gut microbiota composition, including a significant reduction in <i>Parabacteroides</i> underscoring the potential interaction between hypnotic use and gut microbial balance.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1709-1726"},"PeriodicalIF":3.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restless Legs Syndrome Patients with Early Onset Disease or a Relevant Family History Associated with Pramipexole Ineffectiveness but Not Pregabalin.","authors":"Miaofa Ying, Tiantian Wang, Ting Zhang, Ziyang Zhai, Lisan Zhang","doi":"10.2147/NSS.S532626","DOIUrl":"10.2147/NSS.S532626","url":null,"abstract":"<p><strong>Background: </strong>Restless legs syndrome (RLS) is a complex condition characterized by significant heterogeneity. Factors that affect medication efficacy remain unclear; different RLS subtypes may respond differently to various drugs.</p><p><strong>Objective: </strong>To identify factors associated with the ineffectiveness of pramipexole and pregabalin in patients with various subtypes of RLS.</p><p><strong>Methods: </strong>This retrospective nested case-control study enrolled 257 RLS patients prescribed pramipexole or pregabalin between March 2019 and April 2024 at the sleep center of Sir Run Run Shaw Hospital. All patients completed a semi-structured questionnaire, underwent polysomnography and laboratory evaluations, and participated in a telephone survey. To represent iron-storage status, one principal component score that included five indicators of peripheral iron metabolism was extracted by principal component analysis. Treatment effectiveness was assessed using the Clinical Global Impression-Improvement (CGI-I) scale, with scores of 1-3 indicating effective treatment and higher scores reflecting ineffective treatment. Multivariate logistic regression was employed to assess the risk factors (or RLS subtypes) of medication ineffectiveness.</p><p><strong>Results: </strong>Of patients treated with pramipexole, 42.7% (70/164) reported poor outcomes. Early onset RLS (OR = 5.076; 95% CI, 1.836-14.033) and relevant family history (OR = 4.537; 95% CI, 1.556-13.437) increased pramipexole ineffectiveness risk. Among pregabalin users, 34.4% (32/93) reported ineffectiveness, which was associated with hemoglobin levels (OR = 1.039; 95% CI, 1.001-1.079).</p><p><strong>Conclusion: </strong>These findings suggest that RLS patients with familial or early-onset characteristics may represent a distinct subtype that responds preferentially to α2δ ligands over dopamine agonists, supporting personalized treatment approaches based on clinical phenotyping.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1695-1708"},"PeriodicalIF":3.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Restriction and Weekend Sleep Compensation Relate to Eating Behavior in School-Aged Children.","authors":"Rodrigo Chamorro, Marcelo Garrido-González, Mariolly Gutierrez, José L Santos, Gerardo Weisstaub","doi":"10.2147/NSS.S509636","DOIUrl":"10.2147/NSS.S509636","url":null,"abstract":"<p><strong>Purpose: </strong>Several studies showed that shortened sleep duration and subsequent sleep debt are related to obesity risk in children. We evaluated the association between habitual sleep restriction and eating behavior in school-aged children with and without obesity.</p><p><strong>Patients and methods: </strong>In 131 school-aged children (mean [±SD] age 10.2 ± 2.0 years), we assessed eating behavior through the Child Eating Behavior Questionnaire (CEBQ). Actigraphic recordings measured sleep patterns for 4 consecutive days, including a weekend day. CEBQ scores were calculated in sleep-restricted children (having a nighttime sleep duration <8 hours) during week and weekend days and compared for those with (n = 67) and without obesity (n = 64). CEBQ scores were also compared between children with and without sleep compensation (a weekend catch-up in sleep duration ≥1 hour compared to weekdays' sleep duration).</p><p><strong>Results: </strong>The mean sleep duration was 8.0 ± 1.3 h, and about 70% of children slept less than the daily sleep recommendation. Children having sleep restriction had higher scores in the four CEBQ pro-ingestion dimensions (all <i>P</i><0.021) as well as lower \"satiety responsiveness\" but higher \"emotional undereating\" scores (both <i>P</i><0.049). No differences in CEBQ were found in the normal-weight group when comparing children with or without sleep restriction. In the group with obesity, however, those sleep-restricted showed lower ratings in \"slowness of eating\" (<i>P</i><0.015), \"satiety responsiveness\", and \"food fussiness\" (both <i>P</i><0.035) compared to non-restricted, particularly during weekend days. Finally, children showing no sleep compensation on weekend days had higher pro-ingestion (all <i>P</i><0.020) and lower anti-ingestion scores (all <i>P</i><0.041).</p><p><strong>Conclusion: </strong>Sleep duration was lower than the recommended sleep in this sample of school-aged children. Sleep restriction was associated with enhanced pro-ingestion eating behavior scores and reduced anti-ingestion scores. Sleep compensation appears to have a positive effect on eating behavior scores.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1671-1681"},"PeriodicalIF":3.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived Stress Mediates the Relationship Between Childhood Trauma and Onset of Bruxism Among Adolescents.","authors":"Lei-Lei Wang, Shuang-Jiang Zhou, Hong-Juan Li, Jiu-Ju Li, Meng Qi, Jing Zhao, Yun-Long Tan, Jing-Xu Chen","doi":"10.2147/NSS.S531172","DOIUrl":"10.2147/NSS.S531172","url":null,"abstract":"<p><strong>Purpose: </strong>Bruxism is relatively common among adolescents; however, the psychological factors affecting its occurrence remain unclear. This study explored the incidence of bruxism in adolescents, and the role of childhood trauma and perceived stress in the occurrence of bruxism.</p><p><strong>Patients and methods: </strong>This was an online cross-sectional survey of 7794 adolescents aged 12-18 years, with 6780 adolescents meeting the inclusion criteria. We used the Adverse Childhood Experiences Questionnaire (ACEQ) to assess childhood trauma experiences, the Perceived Stress Scale (PSS) to evaluate stress in adolescents, and three items to assess bruxism. The chi-square test was used for demographic data and <i>t</i>-test was used for continuous variables. A mediation analysis was used to explore the mechanism of childhood trauma as it relates to bruxism.</p><p><strong>Results: </strong>Our research shows that about 21.6% of sampled adolescents had bruxism. Being in adolescents, childhood trauma, and high levels of perceived stress were risk factors for bruxism, and good academic performance was a protective factor against bruxism. Adolescents with bruxism had higher levels of childhood trauma and perceived stress. Perceived stress levels played a mediating role in the relationship between childhood trauma and the development of bruxism.</p><p><strong>Conclusion: </strong>Bruxism is common in adolescents, and its occurrence is related to childhood trauma and perceived stress levels. Childhood trauma mediates bruxism through perceived stress levels. Attention should be paid to the childhood trauma experiences and perceived stress levels of adolescents with bruxism, and timely interventions should be provided that are conducive to reducing the occurrence of bruxism.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1683-1694"},"PeriodicalIF":3.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Circadian Rhythm and Sleep Architecture Changes on Prognosis in Patients with Acute Hemorrhagic Stroke.","authors":"Xiaodong Yuan, Yongshan Fu, Ya Ou, Jing Xue, Na Yang, Hongrui Liu, Tiantian Wang, Jing Wang, Cuiping Yan, Pingshu Zhang","doi":"10.2147/NSS.S533202","DOIUrl":"10.2147/NSS.S533202","url":null,"abstract":"<p><strong>Objective: </strong>Research is limited on whether circadian rhythm and sleep architecture alterations during acute intracerebral hemorrhage (ICH) influence patient outcomes. This study aims to characterize these changes and explore their association with clinical prognosis, offering new insights for diagnosis and treatment.</p><p><strong>Methods: </strong>We enrolled 100 acute hemorrhagic stroke patients who underwent continuous, contactless sleep monitoring via a smart mattress for 3-5 consecutive days. Prognosis was evaluated at discharge using the modified Rankin Scale (mRS), and patients were classified into favorable or unfavorable outcome groups. Circadian rhythm parameters (IS, IV, RA) and sleep metrics (eg, total sleep time, sleep latency, REM latency) during day and night were compared between groups. Multivariate logistic regression identified independent prognostic factors, and ROC analysis evaluated their predictive value.</p><p><strong>Results: </strong>Group comparisons revealed statistically significant differences in RA and nighttime sleep latency between the favorable and unfavorable prognosis groups (P < 0.05). Binary logistic regression analysis identified nighttime sleep latency as an independent predictor of functional outcome (95% CI: 1.066 ~ 1.128, P < 0.05), which remained significant after adjusting for potential confounders (95% CI: 1.016 ~ 1.148, P < 0.05). The mean nighttime sleep latency was 18.14 minutes in the favorable group and 12.30 minutes in the unfavorable group. The area under the ROC curve (AUC) for nighttime sleep latency was 0.642 (95% CI: 0.526-0.757, P = 0.028), with an optimal cutoff value of 10.95 minutes, yielding a sensitivity of 72.2% and specificity of 53.6%.</p><p><strong>Conclusion: </strong>Hemorrhagic stroke patients show disrupted circadian stability, with greater RA reductions in those with worse outcomes. Nighttime sleep latency independently predicts poor prognosis with moderate accuracy. Circadian rhythm stability may serve as a prognostic marker in hemorrhagic stroke to avoid implying causality.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1655-1668"},"PeriodicalIF":3.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"Exploring New Avenues for OSA Screening: Optimization and Future Perspectives of Nomogram for Hypertensive Patients\" [Response to Letter].","authors":"Weilong Ye, Jinhua Liang, Zhenzhen Zheng, Weifeng Liao, Yitian Yang, Mingdi Chen, Weimin Yao, Riken Chen","doi":"10.2147/NSS.S531471","DOIUrl":"10.2147/NSS.S531471","url":null,"abstract":"","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1669-1670"},"PeriodicalIF":3.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships Between Self-Reported Sleep Quality, Quantity and Timing on Workdays vs Work-Free Days and Lifestyle Factors in Healthy Adults.","authors":"Diana Aslamyar, Luísa K Pilz, Charlotte von Gall","doi":"10.2147/NSS.S537593","DOIUrl":"10.2147/NSS.S537593","url":null,"abstract":"<p><strong>Purpose: </strong>Sufficient quantity and quality of sleep are crucial for physical and mental health and performance. The ideal duration and time of sleep varies from person to person, with the latter depending on chronotype. However, rather than accommodating these needs, everyday life is often structured around rigid societal times that can result in sleep deficits and poor sleep quality. This survey study in healthy adults investigated the relationships between sleep duration, quality, and timing and how they relate to chronotype, lifestyle, perceived workload and anxiety/depression symptoms.</p><p><strong>Patients and methods: </strong>Participants (N =315) were recruited from a large German metropolitan region. Sleep quality and quantity were evaluated separately on workdays and work-free days using assessments of tiredness upon waking and the Pittsburgh Sleep Quality Index (PSQI). Sleep time, duration, chronotype, sleep loss, and social jetlag were assessed using the Munich ChronoType Questionnaire (MCTQ). Lifestyle variables assessed in this study included exercise and substance use. Self-reported sleep quality, timing and duration were compared between work and work-free days. The relationships between variables were explored using correlation and correlation-based network analyses.</p><p><strong>Results: </strong>Our data suggest that workday sleep duration is a significant determinant of self-reported sleep quality, which in turn is negatively correlated with daytime dysfunction, anxiety/depression, and perception of workload. Moreover, physical activity and not smoking were significantly associated with self-reported sleep quality as well as with depression and anxiety symptoms.</p><p><strong>Conclusion: </strong>In addition to a healthy lifestyle, strategies to advance bedtime and/or adapt working hours to chronotype may improve sleep quality and thus mental health.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1641-1654"},"PeriodicalIF":3.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Fractional Exhaled Nitric Oxide (FeNO) and Cognitive Function in Patients with Obstructive Sleep Apnea.","authors":"Qilin Zhu, Lili Huang, Licheng Zhu, Xiaobai Zhang, Honghua Ji, Donghua Niu, Wangfei Ji, Qingqing Ma, Rong Chen, Haiyan Shi, Yihua Wang, Lina Xu","doi":"10.2147/NSS.S524831","DOIUrl":"10.2147/NSS.S524831","url":null,"abstract":"<p><strong>Purpose: </strong>Obstructive sleep apnea (OSA) is characterised by intermittent hypoxia and sleep fragmentation, both of which can impair cognition. This study aimed to investigate the association between fractional exhaled nitric oxide (FeNO), a non-invasive marker of airway inflammation, and memory performance in patients with OSA.</p><p><strong>Methods: </strong>A total of 102 participants were enrolled: 62 with moderate or severe OSA (apnea-hypopnea index, AHI≥15) and 40 with snoring or mild OSA (AHI <15). Memory was assessed with the Rey-Osterrieth Complex Figure Test (RCFT), Digit Ordering Test (DOT), and Logical Memory Test (LMT). FeNO was measured at 50mL/s (FeNO₅₀) and 200mL/s (FeNO₂₀₀); alveolar NO (CaNO) was calculated. Group comparisions used <i>t</i>-tests and chi-square tests, cognitive scores employed mixed-design ANOVA, and associations were examined with Spearman correlation plus hierarchical regression.</p><p><strong>Results: </strong>Compared with the snoring or mild OSA group, participants with moderate or severe OSA had larger neck circumference, higher body-mass index, greater daytime sleepiness, and elevated FeNO₅₀ and FeNO₂₀₀ (<i>P</i> < 0.05). They also showed poorer immediate and delayed visual memory (both <i>P</i>< 0.05), which correlated negatively with AHI (<i>r</i> = -0.088/-0.103, <i>P</i> < 0.05) and FeNO₅₀ (<i>r</i> = -0.286/-0.302, <i>P</i> < 0.05). RCFT scores fell over time (<i>F</i> = 271.171, <i>P</i> < 0.05), with a significant group × time interaction (<i>F</i> = 3.065, <i>P</i> < 0.05). FeNO₅₀ independently predicted poorer immediate recall (<i>β</i> = -0.28, <i>P</i> = 0.018), whereas FeNO₂₀₀ was not significant.</p><p><strong>Conclusion: </strong>Moderate or severe OSA is associated with impaired immediate and delayed visual memory. Higher FeNO₅₀ correlates with memory decline, supporting a link between airway inflammation and cognitive dysfunction in OSA.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1603-1614"},"PeriodicalIF":3.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Model to Bedside: What Kind of OSA Risk Prediction Tools Do We Need More of? [Letter].","authors":"Hongyu Pan, Yuchang Fei","doi":"10.2147/NSS.S549821","DOIUrl":"10.2147/NSS.S549821","url":null,"abstract":"","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1601-1602"},"PeriodicalIF":3.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating ADHD Symptoms and Sleep Disturbances in Young Adults: A Cross-Sectional Study.","authors":"Arda Kazim Demirkan, Umit Basar Semiz","doi":"10.2147/NSS.S537569","DOIUrl":"10.2147/NSS.S537569","url":null,"abstract":"<p><strong>Purpose: </strong>Attention-deficit/hyperactivity disorder (ADHD), a prevalent condition affecting 2.5-5% of adults, impacting daily functioning. Sleep quality is essential for cognitive and socio-emotional well-being, and the association between ADHD symptoms and sleep disturbances necessitates identifying populations at risk. This study aimed to assess the associations between ADHD symptoms and sleep disorders by conducting a thorough assessment of sleep measures in a cross-sectional group of university students.</p><p><strong>Patients and methods: </strong>Recruiting participants from a Turkish university (n=503; mean age=21.3 ± 1.8 years), subgroups were formed based on ADHD scores from the Adult ADHD Self-report Scale. Sleep was assessed using the Van Dream Anxiety Scale, Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS). Beck Depression Inventory (BDI) was employed to evaluate depressive symptoms.</p><p><strong>Results: </strong>ADHD symptoms group exhibited higher dream-related anxiety, PSQI, ESS, and BDI scores. Nightmares were more prevalent in the ADHD symptoms group. Subjective sleep measures showed differences in various domains, emphasizing poorer sleep quality in the ADHD symptoms group. Correlation analyses revealed intricate relationships between socio-economic factors, psychiatric health, family history, ADHD symptoms, nightmares, and sleep aspects.</p><p><strong>Conclusion: </strong>University students with ADHD symptoms face increased susceptibility to insufficient sleep, impacting daytime functioning and academic performance. Findings underscore the need for increased attention to sleep health in this population.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1615-1627"},"PeriodicalIF":3.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}