Nature and Science of Sleep最新文献

筛选
英文 中文
Increased Risk of Sudden Sensorineural Hearing Loss in Patients Receiving Sedative-Hypnotics: A Propensity Score Weighting Cohort Study. 接受镇静催眠的患者突发性感音神经性听力损失的风险增加:倾向评分加权队列研究。
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2024-12-25 eCollection Date: 2024-01-01 DOI: 10.2147/NSS.S491544
Hui-Wen Yang, Yu-Chieh Huang, Kuan-Wei Chiang, Yuan-Liang Wen, Sheng-Yin To, Senyeong Kao, Li-Ting Kao
{"title":"Increased Risk of Sudden Sensorineural Hearing Loss in Patients Receiving Sedative-Hypnotics: A Propensity Score Weighting Cohort Study.","authors":"Hui-Wen Yang, Yu-Chieh Huang, Kuan-Wei Chiang, Yuan-Liang Wen, Sheng-Yin To, Senyeong Kao, Li-Ting Kao","doi":"10.2147/NSS.S491544","DOIUrl":"10.2147/NSS.S491544","url":null,"abstract":"<p><strong>Purpose: </strong>Benzodiazepine receptor agonists (BZRAs), including benzodiazepines (BZDs) and Z drugs, are widely prescribed for anxiety and sleep. Therefore, issues of tolerance, dependence and adverse effects are of concern. Recent studies suggested a potential link between BZRAs and hearing problems. However, the actual relationship was still unclear. Accordingly, this study aims to investigate the actual association between BZRA use and risk of sudden sensorineural hearing loss (SSNHL) using population data.</p><p><strong>Patients and methods: </strong>This study used the Taiwan Longitudinal Health Insurance Database. 137,277 BZRA users and 1,328,554 nonusers were identified for relevant analyses. We used cohort design with inverse-probability treatment weighting (IPTW) strategy to balance the baseline differences of demographics and comorbidities between two groups. The 5-year incidence of SSNHL was followed. Cox proportional-hazard regression analyses were used to estimate the hazard ratios (HRs).</p><p><strong>Results: </strong>BZRA users showed an increased 5-year SSNHL risk (adjusted HR: 1.244) after weighting. Subgroup and sensitivity analyses produced consistent results. Notably, SSNHL risk was higher among young BZRA users (adjusted HR: 1.397). BZRA users had the highest SSNHL risk in the first year (adjusted HR: 2.037) after IPTW.</p><p><strong>Conclusion: </strong>BZRA use elevated the risk of SSNHL, particularly in young adults and in the first year. This emphasises the importance for physicians and policymakers should be aware of the potential hearing difficulties among BZRA users and take necessary examinations.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"2231-2241"},"PeriodicalIF":3.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11682672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Cross-Sectional Association Between Multimorbidity and Sleep Quality and Duration Among the Elderly Community Dwellers in Northwest China. 西北地区老年社区居民多病与睡眠质量和持续时间的横断面关系
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2024-12-25 eCollection Date: 2024-01-01 DOI: 10.2147/NSS.S497036
Qiaolifanayi Nuermaimaiti, Mulalibieke Heizhati, Qin Luo, Nanfang Li, Lin Gan, Ling Yao, Wenbo Yang, Mei Li, Xiufang Li, Xiayire Aierken, Jing Hong, Hui Wang, Miaomiao Liu, Adalaiti Maitituersun, Aketilieke Nusufujiang, Li Cai
{"title":"The Cross-Sectional Association Between Multimorbidity and Sleep Quality and Duration Among the Elderly Community Dwellers in Northwest China.","authors":"Qiaolifanayi Nuermaimaiti, Mulalibieke Heizhati, Qin Luo, Nanfang Li, Lin Gan, Ling Yao, Wenbo Yang, Mei Li, Xiufang Li, Xiayire Aierken, Jing Hong, Hui Wang, Miaomiao Liu, Adalaiti Maitituersun, Aketilieke Nusufujiang, Li Cai","doi":"10.2147/NSS.S497036","DOIUrl":"10.2147/NSS.S497036","url":null,"abstract":"<p><strong>Background: </strong>Multimorbidity, defined as the coexistence of two or more chronic diseases, is highly prevalent among the elderly population and is associated with adverse outcomes. However, little is known about its relationship with sleep issues, particularly in this demographic. Therefore, this study aimed to investigate its association with sleep quality and duration among the elderly.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in Emin County, Xinjiang, China, which included a population aged 60 years and above. We employed the Pittsburgh Sleep Quality Index (PSQI) score to assess sleep quality and duration. Multimorbidity was determined through self-reports, physical examination, blood tests, and imaging. Logistic regression analyses were used to explore the association between multimorbidity and sleep patterns, adjusting for confounders.</p><p><strong>Results: </strong>A total of 8205 elderly participants were included, of whom 66.8% suffered from multimorbidity. Participants with multimorbidity exhibited higher total PSQI scores [6 (3,9)], and a higher percentage of poor sleep quality (50.6%), compared to those without multimorbidity. Multimorbidity was significantly associated with the presence of poor sleep quality (OR = 1.27, 95% CI: 1.14-1.41, P < 0.001) before and after adjusting for confounders. The risk of having poor sleep quality significantly increased as the number of multimorbidities increased. The OR (95% CI) values were 1.16 (1.02,1.32) for two diseases, 1.54 (1.26,1.90) for ≥5 diseases. In the adjusted model for total participants, having four diseases (OR = 1.26, 95% CI: 1.05-1.51, p = 0.013) and five or more diseases (OR = 1.29, 95% CI: 1.03-1.61, p = 0.029) were associated with shorter sleep duration. Furthermore, those with five or more diseases associated with longer sleep duration (OR = 1.40, 95% CI: 1.00-1.95, p = 0.057).</p><p><strong>Conclusion: </strong>There is a significant association between multimorbidity and poor sleep quality in older community dwellers, which may provide clues for disease prevention.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"2217-2230"},"PeriodicalIF":3.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11682665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diffusion Tensor Imaging Analysis Along the Perivascular Space (DTI-ALPS) Demonstrates That Sleep Disorders Exacerbate Glymphatic Circulatory Impairment and Cognitive Impairment in Patients with Alzheimer's Disease. 沿血管周围间隙弥散张量成像分析(DTI-ALPS)表明睡眠障碍加重阿尔茨海默病患者的淋巴循环功能障碍和认知功能障碍
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2024-12-23 eCollection Date: 2024-01-01 DOI: 10.2147/NSS.S496607
Yi Shang, Lefan Yu, Hanqi Xing, Yue Chang, Ke Dong, Yao Xiao, Yuanqing Liu, Mengmeng Feng, Yiren Qin, Hui Dai
{"title":"Diffusion Tensor Imaging Analysis Along the Perivascular Space (DTI-ALPS) Demonstrates That Sleep Disorders Exacerbate Glymphatic Circulatory Impairment and Cognitive Impairment in Patients with Alzheimer's Disease.","authors":"Yi Shang, Lefan Yu, Hanqi Xing, Yue Chang, Ke Dong, Yao Xiao, Yuanqing Liu, Mengmeng Feng, Yiren Qin, Hui Dai","doi":"10.2147/NSS.S496607","DOIUrl":"10.2147/NSS.S496607","url":null,"abstract":"<p><strong>Objective: </strong>Sleep disorders are common in Alzheimer's disease (AD) patients and can impair the glymphatic system, leading to cognitive decline. This study aimed to investigate whether AD patients with sleep disorders exhibit worse glymphatic function and more severe cognitive impairment compared to those without sleep disorders and to explore the underlying molecular imaging mechanisms.</p><p><strong>Methods: </strong>This study included 40 AD patients with sleep disorders (ADSD), 39 cognitively matched AD patients without sleep disorders (ADNSD), and 25 healthy middle-aged and elderly controls (NC). Participants underwent functional magnetic resonance imaging (fMRI), and cognitive and sleep assessments. The ALPS (Along the Perivascular Space) index was calculated, followed by intergroup comparisons, correlation analyses, and mediation analyses. The diagnostic utility of the ALPS index was assessed using a receiver operating characteristic (ROC) curve.</p><p><strong>Results: </strong>The ALPS index was lower in the ADNSD and ADSD groups compared to the NC group. In the ADSD group, PSQI scores were negatively correlated with MMSE scores. The ALPS index was positively correlated with MMSE scores and negatively with PSQI scores. Mediation analyses indicated that the ALPS index partially mediated the effect of sleep disturbances on cognitive impairment (indirect effect = -0.134; mediation effect = 30.505%). The area under the ROC curve (AUROC) for distinguishing ADSD from ADNSD was 0.86, with a cutoff ALPS index value 1.309.</p><p><strong>Conclusion: </strong>Sleep disorders worsen glymphatic function and cognitive impairment in AD patients. The ALPS index partially mediates the impact of sleep disorders on cognitive function and shows moderate accuracy in distinguishing between patients with ADSD and ADNSD.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"2205-2215"},"PeriodicalIF":3.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11675307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Total Sleep Deprivation on the Cognitive and In-Game Performance of Rocket League Esport Players. 完全睡眠剥夺对《火箭联盟》电子竞技选手认知和游戏表现的影响。
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2024-12-21 eCollection Date: 2024-01-01 DOI: 10.2147/NSS.S470105
Tim D Smithies, Adam J Toth, Mark J Campbell
{"title":"The Effect of Total Sleep Deprivation on the Cognitive and In-Game Performance of Rocket League Esport Players.","authors":"Tim D Smithies, Adam J Toth, Mark J Campbell","doi":"10.2147/NSS.S470105","DOIUrl":"10.2147/NSS.S470105","url":null,"abstract":"<p><strong>Purpose: </strong>It is presumed by many that acute sleep loss results in degraded in-game esports (competitive, organized video game play) performance. However, this has not been experimentally investigated to date. The objective of the current experiment was to elucidate whether ~29hrs of total sleep deprivation impacts in-game performance for the popular esport <i>Rocket League.</i></p><p><strong>Patients and methods: </strong>Twenty skill-matched pairs (N = 40 total) were recruited. Within each pair, one participant was assigned to an intervention <i>group</i> (TSD), while the other was assigned to a control <i>group</i> (CON). Two test <i>sessions</i> occurred; one while both participants were rested (baseline), and the other while the CON participant was rested but the TSD participant was sleep deprived (experimental).</p><p><strong>Results: </strong>Following total sleep deprivation, TSD participants reported higher Karolinska Sleepiness Scale-measured subjective sleepiness and lower subjective alertness and motivation, as well as worsened PVT response speed and ~5 times greater PVT lapse incidence, and worsened response speed on a two-choice categorization task. However, overall in-game <i>Rocket League</i> performance did not worsen due to total sleep deprivation. Exploratory analyses of performance indicators suggest a potential shift toward a simpler and safer strategy following sleep deprivation.</p><p><strong>Conclusion: </strong>Following a bout of ~29hrs total sleep deprivation, overall in-game Rocket League performance remained unaffected. This presents as a promising finding given the high potential for acute pre-competition sleep disturbance in esports, though habitual sleep remains a concern for esport athletes.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"2183-2204"},"PeriodicalIF":3.0,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Causal Associations Between Sleep Traits and Delirium: A Bidirectional Two-Sample Mendelian Randomization Study. 睡眠特征与谵妄之间的因果关系:一项双向双样本孟德尔随机研究。
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2024-12-21 eCollection Date: 2024-01-01 DOI: 10.2147/NSS.S491216
Hao Liu, Zhengze Zhang, Yuewen He, Longfei Ding, Tong Wu, Yong Wang, Wuhua Ma
{"title":"Causal Associations Between Sleep Traits and Delirium: A Bidirectional Two-Sample Mendelian Randomization Study.","authors":"Hao Liu, Zhengze Zhang, Yuewen He, Longfei Ding, Tong Wu, Yong Wang, Wuhua Ma","doi":"10.2147/NSS.S491216","DOIUrl":"10.2147/NSS.S491216","url":null,"abstract":"<p><strong>Purpose: </strong>Numerous studies have identified a correlation between sleep and delirium; however, the causal relationship remains ambiguous. This bidirectional two-sample Mendelian randomization (MR) study was conducted to examine the possible causal relationships between sleep traits and delirium.</p><p><strong>Patients and methods: </strong>Utilizing genome-wide association studies (GWAS), we identified ten sleep traits: chronotype, sleep duration, short sleep duration, long sleep duration, daytime napping, daytime sleepiness, insomnia, number of sleep episodes (NSE), sleep efficiency, and rapid eye movement sleep behavior disorder (RBD). In this MR study, genetic variants independently associated with exposures were selected as instrumental variables (IVs). To establish causal inferences, three regression models were employed-inverse variance weighted (IVW), MR Egger, and weighted median (WM) -and conducted sensitivity analyses to assess the robustness of our findings.</p><p><strong>Results: </strong>Our results suggest no significant causal association between the ten sleep traits and the risk of delirium. The reverse MR analysis revealed that delirium is associated with an increased propensity for morning chronotype [OR<sub>IVW</sub>, 1.025; 95% CI, 1.012-1.036; p = 1.50E-05; adjusted p values (p<sub>adjusted</sub>)= 1.35E-04] and a decreased risk of long sleep duration [OR<sub>IVW</sub>, 0.996; 95% CI, 0.993-0.999; p = 0.013; p<sub>adjusted</sub>= 0.059]. However, no robust evidence currently exists to substantiate a causal relationship between delirium and other sleep traits.</p><p><strong>Conclusion: </strong>Our bidirectional, two-sample MR analysis study did not provide definitive evidence that sleep traits may augment the susceptibility to delirium. However, the reverse MR results indicate that delirium may predispose patients to an earlier sleep-wake cycle. Additional large-scale investigations are necessary to examine the bidirectional causality between delirium and sleep traits.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"2171-2181"},"PeriodicalIF":3.0,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Craniofacial Development Characteristics in Children with Obstructive Sleep Apnea for Establishment and External Validation of the Prediction Model. 阻塞性睡眠呼吸暂停患儿颅面发育特征预测模型的建立及外部验证。
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2024-12-21 eCollection Date: 2024-01-01 DOI: 10.2147/NSS.S492714
Yonglong Su, Zitong Wang, Huanhuan Chang, Simin Zhu, Yanuo Zhou, Zine Cao, Lina Ma, Yuqi Yuan, Yushan Xie, Xiaoxin Niu, Chendi Lu, Yitong Zhang, Haiqin Liu, Na Shao, Libo Yin, Chao Si, Xiaoyong Ren, Yewen Shi
{"title":"Craniofacial Development Characteristics in Children with Obstructive Sleep Apnea for Establishment and External Validation of the Prediction Model.","authors":"Yonglong Su, Zitong Wang, Huanhuan Chang, Simin Zhu, Yanuo Zhou, Zine Cao, Lina Ma, Yuqi Yuan, Yushan Xie, Xiaoxin Niu, Chendi Lu, Yitong Zhang, Haiqin Liu, Na Shao, Libo Yin, Chao Si, Xiaoyong Ren, Yewen Shi","doi":"10.2147/NSS.S492714","DOIUrl":"10.2147/NSS.S492714","url":null,"abstract":"<p><strong>Purpose: </strong>Aimed to analyze the developmental characteristics of craniofacial structures and soft tissues in children with obstructive sleep apnea (OSA) and to establish and evaluate prediction model.</p><p><strong>Methods: </strong>It's a retrospective study comprising 747 children aged 2-12 years (337 patients and 410 controls) visited the Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Xi'an Jiaotong University (July 2017 to March 2024). Lateral head radiographs were obtained to compare the cephalometric measurements. The clinical prediction model was constructed using LASSO regression analysis. We analyzed 300 children from the Xi'an Children's Hospital for external validation.</p><p><strong>Results: </strong>Children with OSA had a higher body mass, a higher tonsil grade, larger AN ratio (ratio of the adenoids to the skeletal upper airway width), larger radius of the tonsils, a smaller angle between the skull base and maxilla (SNA) and smaller angle between the skull base and mandible (SNB), a larger distance from the hyoid to the mandibular plane (H-MP) and smaller distance between the third cervical vertebra and hyoid (H-C), a larger thickness of the soft palate (SPT) and smaller inclination angle of the soft palate than those of the controls (all <i>p</i> < 0.05). A prediction model was constructed for 2-12 years group (AUC of 0.812 [95% CI: 0.781-0.842]). Age-specific prediction models were developed for preschool children (AUC of 0.769 [95% CI: 0.725-0.814]), for school-aged children (AUC of 0.854 [95% CI: 0.812-0.895]).</p><p><strong>Conclusion: </strong>Our study findings support the important role of craniofacial structures such as the hyoid, maxilla, mandible, and soft palate in pediatric OSA. Age-stratified predictive models for pediatric OSA indicated varying parameters across different age groups which underscore the necessity for stratifying by age in future research. The prediction model designed will greatly assist health care practitioners with rapidly identifying.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"2151-2170"},"PeriodicalIF":3.0,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Sleep Fragmentation and Arousal on Nonalcoholic Fatty Liver Disease in Patients with Obstructive Sleep Apnea: A Cross-Sectional Study. 睡眠破碎和觉醒对阻塞性睡眠呼吸暂停患者非酒精性脂肪性肝病的影响:一项横断面研究
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI: 10.2147/NSS.S480186
Yue Zhong, Biying Wang, Jiefeng Huang, Meixin Nian, Jianming Zhao, Gongping Chen
{"title":"Impact of Sleep Fragmentation and Arousal on Nonalcoholic Fatty Liver Disease in Patients with Obstructive Sleep Apnea: A Cross-Sectional Study.","authors":"Yue Zhong, Biying Wang, Jiefeng Huang, Meixin Nian, Jianming Zhao, Gongping Chen","doi":"10.2147/NSS.S480186","DOIUrl":"10.2147/NSS.S480186","url":null,"abstract":"<p><strong>Purpose: </strong>Obstructive sleep apnea (OSA) is a contributing factor to nonalcoholic fatty liver disease (NAFLD). This study aimed to investigate the clinical and polysomnographic characteristics of OSA patients with and without NAFLD, focusing on the relationships between sleep fragmentation, arousal and NAFLD.</p><p><strong>Materials and methods: </strong>We consecutively enrolled patients who underwent polysomnography, anthropometry, blood sampling, and abdominal ultrasonography. Patients were categorized into NAFLD and non-NAFLD groups. A comparative analysis of clinical and polysomnographic profiles was conducted, followed by multivariate binary logistic regression to explore the relationship between sleep disturbance indices and NAFLD.</p><p><strong>Results: </strong>A total of 403 subjects were included, including 92 patients with NAFLD and 311 with non-NAFLD. NAFLD patients exhibited a greater apnea-hypopnea index (AHI) (51.19/h vs 33.60/h, p = 0.002) and oxygen desaturation index (ODI) (37.90/h vs 21.40/h, p=0.034) compared to non-NAFLD patients. Specifically, NAFLD patients had a higher rapid eye movement (REM)-AHI (53.70/h vs 43.60/h, p=0.001) and greater arousal index (AI) (32 vs 25, p = 0.009). Additionally, sleep latency (SL) was significantly lower in the NAFLD group (p < 0.05). Multivariate logistic regression analysis confirmed that REM-AHI (OR=1.023, p = 0.024), AI (OR=1.140, p = 0.01), and SL (OR=0.956, p = 0.035) were significantly associated with NAFLD in OSA patients.</p><p><strong>Conclusion: </strong>This study revealed that sleep disturbance indices, especially AI, REM-AHI and SL, were closely related to NAFLD. When evaluating whether OSA patients are complicated with NAFLD, more attention should be given to sleep fragmentation and arousal.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"2143-2150"},"PeriodicalIF":3.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TRPC5 Promotes Intermittent Hypoxia-Induced Cardiomyocyte Injury Through Oxidative Stress. TRPC5通过氧化应激促进间歇性缺氧诱导的心肌细胞损伤。
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2024-12-19 eCollection Date: 2024-01-01 DOI: 10.2147/NSS.S494748
Xuan Qiu, Yanli Yao, Yulan Chen, Yu Li, Xiaojing Sun, Xiaoli Zhu
{"title":"TRPC5 Promotes Intermittent Hypoxia-Induced Cardiomyocyte Injury Through Oxidative Stress.","authors":"Xuan Qiu, Yanli Yao, Yulan Chen, Yu Li, Xiaojing Sun, Xiaoli Zhu","doi":"10.2147/NSS.S494748","DOIUrl":"10.2147/NSS.S494748","url":null,"abstract":"<p><strong>Purpose: </strong>Intermittent hypoxia (IH), a defining feature of obstructive sleep apnea (OSA), is associated with heart damage and linked to transient receptor potential canonical channel 5 (TRPC5). Nonetheless, the function of TRPC5 in OSA-induced cardiac injury remains uncertain. For this research, we aimed to explore the role and potential mechanism of TRPC5 in cardiomyocyte injury induced by intermittent hypoxia.</p><p><strong>Methods: </strong>30 patients with newly diagnosed OSA and 30 patients with primary snoring(PS) were included in this study. Participants were subjected to polysomnography (PSG) for OSA diagnosis. Echocardiography was used to evaluate the structure and function of the heart, while peripheral blood samples were obtained. Additionally, RT-qPCR was utilized to quantify the relative expression level of TRPC5 mRNA in peripheral blood. H9c2 cells experienced IH or normoxia. TRPC5 levels in H9c2 cells were determined via RT-qPCR and Western blotting (WB) methods. H9c2 cells overexpressing TRPC5 were subjected to either normoxic or intermittent hypoxia conditions. Cell viability was determined by CCK8, the apoptosis rate, reactive oxygen species(ROS) levels, and Ca<sup>2+</sup> concentration were assessed by flow cytometry, and the protein levels of TRPC5, Bcl-2, Bax, and Caspase-3 were analyzed by WB. Mitochondrial membrane potential(MMP), mitochondrial membrane permeability transition pore(mPTP), and transmission electron microscopy(TEM) were employed to observe mitochondrial function and structure. After inhibiting ROS with N-acetylcysteine (NAC), apoptosis, mitochondrial function and structure, and the concentration of Ca<sup>2+</sup> were further detected.</p><p><strong>Results: </strong>TRPC5 and left atrial diameter (LAD) were higher in OSA individuals, while the E/A ratio was lower(all <i>P</i><0.05). IH impaired cell viability, triggered cell apoptosis, and enhanced TRPC5 expression in H9c2 cells(all <i>P</i><0.05). The effects of IH on apoptosis, cell viability, mitochondrial function and structure damage, and oxidative stress (OxS) in H9c2 cells were accelerated by the overexpression of TRPC5(all <i>P</i><0.05). Furthermore, cell apoptosis and mitochondrial structural and functional damage caused by overexpression of TRPC5 were attenuated by ROS inhibition.</p><p><strong>Conclusion: </strong>TRPC5 is associated with structural and functional cardiac damage in patients with OSA, and TRPC5 promotes IH-induced apoptosis and mitochondrial damage in cardiomyocytes through OxS. TRPC5 may be a novel target for the diagnosis and treatment of OSA-induced myocardial injury.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"2125-2141"},"PeriodicalIF":3.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-Reported Symptoms of Obstructive Sleep Apnea are Associated with Increased Risk of Kidney Stones: A Cross-Sectional Study from NHANES 2015-2020. 自我报告的阻塞性睡眠呼吸暂停症状与肾结石风险增加相关:NHANES 2015-2020的一项横断面研究
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2024-12-18 eCollection Date: 2024-01-01 DOI: 10.2147/NSS.S491657
Dongru Du, Jianjun Luo, Weiling Cai, Jiangyue Qin, Yao Yang, Xueru Hu, Xiaohua Li, Fengming Luo, Yongchun Shen
{"title":"Self-Reported Symptoms of Obstructive Sleep Apnea are Associated with Increased Risk of Kidney Stones: A Cross-Sectional Study from NHANES 2015-2020.","authors":"Dongru Du, Jianjun Luo, Weiling Cai, Jiangyue Qin, Yao Yang, Xueru Hu, Xiaohua Li, Fengming Luo, Yongchun Shen","doi":"10.2147/NSS.S491657","DOIUrl":"10.2147/NSS.S491657","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether self-reported symptoms of obstructive sleep apnea (OSA), including snoring, snorting/stopping breathing, and sleepiness, are associated with increased risk of kidney stones.</p><p><strong>Methods: </strong>This cross-sectional study was conducted based on the 2015-2020 National Health and Nutrition Examination Survey (NHANES). Self-reported symptoms of OSA and history of kidney stones were diagnosed via questionnaires. Multivariable logistic regression was used to determine the associations between self-reported symptoms of OSA and kidney stones. Subgroup analyses and interaction tests were performed to address this issue further.</p><p><strong>Results: </strong>A total of 9,973 participants were enrolled, and the prevalence of kidney stones was 10.76%. Although no significant association was observed between frequent snoring and kidney stones after covariate adjustments (OR 1.033, 95% CI 0.726, 1.469 p = 0.850), frequent snorting/stopping breathing was associated with a greater risk of kidney stones after covariate adjustments (OR 1.655, 95% CI 1.262, 2.172, p = 0.002). Participants who often or almost always felt sleepy also had a greater risk of kidney stones after covariate adjustment (OR 1.651, 95% CI 1.222, 2.229; p = 0.004). The interaction tests suggested that marital status (p = 0.015) and smoking status (p < 0.001) significantly interacted with the association between snorting/stopping breathing and kidney stones.</p><p><strong>Conclusion: </strong>Self-reported frequent snorting/stopping breathing and sleepiness may be associated with increased risk of kidney stones. Although these findings may emphasize prevention of kidney stones in these people, further research was still needed to verify our results.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"2099-2110"},"PeriodicalIF":3.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Continuous Positive Airway Pressure Treatment on Sawtooth Waves During Rapid Eye Movement Sleep in Obstructive Sleep Apnea Patients. 持续气道正压治疗对阻塞性睡眠呼吸暂停患者快速眼动睡眠时锯齿波的影响。
IF 3 2区 医学
Nature and Science of Sleep Pub Date : 2024-12-17 eCollection Date: 2024-01-01 DOI: 10.2147/NSS.S489288
Yuhao Mao, Qi Li, Xueliang Zou, Zhijun Zhong, Qian Ouyang, Chunmei Gan, Fang Yi, Yaxing Luo, Zilin Cheng, Dongyuan Yao
{"title":"Effects of Continuous Positive Airway Pressure Treatment on Sawtooth Waves During Rapid Eye Movement Sleep in Obstructive Sleep Apnea Patients.","authors":"Yuhao Mao, Qi Li, Xueliang Zou, Zhijun Zhong, Qian Ouyang, Chunmei Gan, Fang Yi, Yaxing Luo, Zilin Cheng, Dongyuan Yao","doi":"10.2147/NSS.S489288","DOIUrl":"10.2147/NSS.S489288","url":null,"abstract":"<p><strong>Background: </strong>Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder characterized by recurrent upper airway collapse and obstruction, leading to reduced or absent breathing during sleep, especially rapid eye movement (REM) sleep, and continuous positive airway pressure treatment (CPAP) is often used for treatment of OSA. Sawtooth waves (STWs) are a characteristic of REM sleep.</p><p><strong>Objective: </strong>To examine effects of CPAP treatment on STWs during REM sleep in the OSA patients.</p><p><strong>Methods: </strong>Polysomnographic recordings were performed on 20 moderate-to-severe OSA patients and 16 normal controls, and comparisons of STWs during REM sleep in the OSA patients with and without CPAP treatment (paired <i>t</i>-test or Wilcoxon signed-rank test wherever appropriate), and between OSA patients and normal controls (Student's <i>t</i>-test or Wilcoxon rank-sum test) were carried out. In addition, linear correlation analyses were used to estimate the relationship of STWs and REM sleep with duration of non-REM (NREM) sleep stage 3 (N3).</p><p><strong>Results: </strong>The STWs were classified to be apnea/hypopnea associated and not associated (isolated), and the amplitude of the isolated STWs was significantly higher than that of the apnea/hypopnea associated. With CPAP treatment, the percentage of REM sleep with STWs and the amplitude of STWs were significantly increased to the levels, which were not significantly different from those in the normal controls, while the frequency of STWs was not significantly changed. In addition, the total duration of REM sleep and the duration of REM sleep with STWs were both positively correlated with the duration of N3 sleep in the normal controls and the OSA patients with CPAP treatment. Furthermore, CPAP treatment also caused a significant increase in the duration of rapid eye movements in REM sleep.</p><p><strong>Conclusion: </strong>These findings suggest that there are some interconnections between NREM and REM sleep, and STWs not only represent the quality of REM sleep but also are correlated with N3 sleep.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"16 ","pages":"2111-2124"},"PeriodicalIF":3.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信