Nature and Science of Sleep最新文献

{"title":"Design and Validation of Sleep Apnea Risk Assessment (SARA): A Screening Tool for Moderate-to-Severe Obstructive Sleep Apnea.","authors":"Sarka Solecka, Hana Tomaskova, Milos Chudy, Tomas Kostlivy, Jana Slonkova","doi":"10.2147/NSS.S518391","DOIUrl":"10.2147/NSS.S518391","url":null,"abstract":"<p><strong>Purpose: </strong>We designed and validated a concise, efficient screening tool, the Sleep Apnea Risk Assessment (SARA), to identify patients at high risk of moderate to-severe obstructive sleep apnea.</p><p><strong>Patients and methods: </strong>We conducted a two-phase, multicenter study from September 1, 2018, to October 31, 2023. We created Cohort A (n=221, mean age 50.5±13.0 years, 69.2% male) to design SARA and compared the results with the Epworth Sleepiness Scale, Berlin Questionnaire, Pittsburgh Sleep Quality Index, STOP-Bang, and STOP questionnaires. Cohort B (n=253, mean age 48.0±13.4 years, 75.5% male) served for validation.</p><p><strong>Results: </strong>SARA comprises six variables with the highest accuracy: sleep apnea observed by the bedroom partner (8 points), snoring (5 points), male sex (3 points), age≥50 years (3 points), daytime fatigue (3 points), and body mass index≥30 kg/m² (2 points). SARA yielded an area under the receiver operating characteristic curve (AUC) of 0.77 (95% CI: 0.71-0.83) and sensitivity of 87.2% (95% CI: 80.8-92.1) in cohort A at a cut-off score of ≥11 points. Validation in cohort B showed an AUC of 0.79 (95% CI: 0.74-0.84) and a sensitivity of 98% (95% CI: 89.2-95.4). SARA performance significantly outperformed the other questionnaires tested.</p><p><strong>Conclusion: </strong>The SARA is a promising new screening tool for moderate-to-severe obstructive sleep apnea, demonstrating high sensitivity and a strong ROC curve. Further large-scale validation is recommended.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1163-1174"},"PeriodicalIF":3.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping Connection and Direction Among Symptoms of Sleep Disturbance and Perceived Stress in Firefighters: Embracing the Network Analysis Perspective.","authors":"Bin Liu, Mingxuan Zou, Lin Liu, Zhongying Wu, Yinchuan Jin, Yuting Feng, Qiannan Jia, Mengze Li, Lei Ren, Qun Yang","doi":"10.2147/NSS.S517178","DOIUrl":"10.2147/NSS.S517178","url":null,"abstract":"<p><strong>Purpose: </strong>There is an intricate relationship between sleep disturbances and perceived stress in firefighters. Network analysis offers novel perspectives for examining the interactions between diseases. Hence, this study aimed to elucidate the relationship between sleep disturbances and perceived stress in firefighters through network analysis approaches.</p><p><strong>Methods: </strong>A total of 786 Chinese firefighters were included in this study. Two methodologies, the regularized partial correlation network (RPCN) and the directed acyclic graph (DAG), were employed to perform network analysis.</p><p><strong>Results: </strong>Within the RPCN, P2 \"Unable to control important things\" and P7 \"Unable to control irritations in life\" were identified as central symptoms that simultaneously maintained sleep disturbances and perceived stress among firefighters. S7 \"Daytime dysfunction\" and P3 \"Felt nervous and stressed\" were classified as bridge symptoms, connecting sleep disturbances with perceived stress and perpetuating their comorbid nature. From a probabilistic priority perspective, the DAG demonstrated that the bidirectional spiral between sleep disturbances and perceived stress might be attributed to the fact that the upstream symptom S7 \"Daytime dysfunction\" influenced the perceived self-efficacy dimension of perceived stress, which in turn influenced other sleep disturbance symptoms.</p><p><strong>Conclusion: </strong>Our findings not only provided innovative insights into further understanding the relationship between sleep disturbances and perceived stress among firefighters, but also identified potential targets for ameliorating these symptoms, such as the central, bridge, and upstream symptoms. Future intervention programs should prioritize these potential targets. Through the implementation of interventions like mindfulness-based stress reduction, cognitive behavioral therapy, and group psychotherapy, tailored to address these targeted symptoms, it is feasible to effectively mitigate both sleep disturbances and perceived stress in firefighters, and ultimately improve the mental health of this particular occupational group.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1143-1162"},"PeriodicalIF":3.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SCUBE-1 Levels and Their Relationship with Endothelial Dysfunction in Obstructive Sleep Apnea Syndrome Patients.","authors":"Nevin Fazlıoğlu, Cihan Aydın, Aykut Demirkıran, Demet Özkaramanlı Gür, Ahsen Yılmaz, Aliye Çelikkol","doi":"10.2147/NSS.S509757","DOIUrl":"10.2147/NSS.S509757","url":null,"abstract":"<p><strong>Objective: </strong>Obstructive sleep apnea syndrome (OSAS) increases the risk of vascular dysfunction by causing hypoxemia due to recurrent obstructions in the upper airway. This can put pressure on the vasculature and impair endothelial function. SCUBE-1 gains importance in OSAS as a biomarker that may reflect this dysfunction. We focused in this study on the association between levels of SCUBE-1 and endothelial dysfunction in patients suffering from OSAS.</p><p><strong>Methods: </strong>A study population of 75 individuals participated in the study. Participants were categorized as normal (n=18), mild OSAS (n=22), moderate OSAS (n=19) and severe OSAS (n=16) according to polysomnography findings. Evaluation parameters included SCUBE-1 levels, polysomnography measurements, flow-mediated dilatation (FMD), carotid intima-media thickness (CIMT), and comprehensive laboratory analyses.</p><p><strong>Results: </strong>SCUBE-1 levels were significantly higher in the severe OSAS group (15.8 ± 4.2 ng/mL, p<0.001). SCUBE-1 showed a moderate negative correlation with FMD (r = -0.248, p < 0.001) and a significant negative correlation with CIMT (r = -0.512, p < 0.001). ROC analysis demonstrated good diagnostic accuracy (AUC: 0.871, 95% CI: 0.797-0.945) for SCUBE-1 in identifying severe OSAS.</p><p><strong>Conclusion: </strong>OSAS severity correlates with the rise in SCUBE-1 levels, and this biomarker may serve as an important attribute in profiling endothelial dysfunction. SCUBE-1 can indeed be an effective biomarker to identify subtle changes in the vascular biology of OSAS patients and aid early interventions.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1175-1190"},"PeriodicalIF":3.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between Serum Neurotransmitters and Cognitive Impairment in Adults with Obstructive Sleep Apnea.","authors":"Fangli Yang, Simin Zhu, Xinru Lv, Yanuo Zhou, Zitong Wang, Chendi Lu, Zihan Xia, Haiqin Liu, Jin Hou, Jing Yan, Jingguo Chen, Hui Lv, Yewen Shi, Xiaoyong Ren","doi":"10.2147/NSS.S522352","DOIUrl":"10.2147/NSS.S522352","url":null,"abstract":"<p><strong>Introduction: </strong>The primary aim of this study was to investigate the serum levels of acetylcholine (Ach), norepinephrine (NE), dopamine (DA), and 5-hydroxytryptamine (5-HT) in two groups: those with obstructive sleep apnea (OSA) and cognitive impairment (CI) and those with OSA but no cognitive impairment (NCI).</p><p><strong>Methods: </strong>A total of 30 adults (CI) and 75 adults (NCI) who completed polysomnography examinations between December 2023 and September 2024 were enrolled in the study. Enzyme-linked immunosorbent assays were used to measure serum levels of Ach, NE, DA, and 5-HT. Correlation and pooled analyses were conducted to assess the relationship between cognitive scores and four serological indicators. Logistic regression was performed to identify risk factors for cognitive impairment.</p><p><strong>Results: </strong>Serum DA levels were higher in the CI group (275.10, 216.73-426.91, pg/mL) than in the NCI group (219.69, 138.46-261.97, pg/mL) (<i>P</i> < 0.001). No significant differences were found in serum NE, 5-HT, and Ach levels between the two groups (<i>P</i> = 0.582, <i>P</i> = 0.287, and <i>P</i> = 0.715, respectively). Moreover, the correlation analysis showed a correlation between DA and body mass index, Montreal Cognitive Assessment, average saturated oxygen (SaO₂), minimum SaO₂, the percentage of oxygen saturation less than 90% (all <i>P</i> < 0.05). The area under the receiver operating characteristic curve of DA was 0.732 (95% confidence interval: 0.628-0.836) (<i>P</i> < 0.001). Logistic regression analysis revealed a correlation between tonsil size, hypertension, DA, stuffy nose, and cognitive impairment.</p><p><strong>Conclusion: </strong>Serum DA levels were associated with the severity of cognitive impairment in adults diagnosed with OSA and might serve as a potential, objective biomarker for identifying cognitive dysfunction in this population.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1127-1141"},"PeriodicalIF":3.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Hourly Apnea-Hypopnea Duration Better Correlates with OSA-Related Nocturnal Hypoxemia and Excessive Daytime Sleepiness Rather Than AHI.","authors":"Yuhan Wang, Wuriliga Yue, Beini Zhou, Jingyi Zhang, Yang He, Mengcan Wang, Ke Hu","doi":"10.2147/NSS.S505702","DOIUrl":"10.2147/NSS.S505702","url":null,"abstract":"<p><strong>Background: </strong>The apnea-hypopnea index (AHI) has limitations in assessing nocturnal hypoxemia and excessive daytime sleepiness (EDS) in obstructive sleep apnea (OSA) patients. This study evaluated whether hourly apnea-hypopnea duration (HAD) and mean apnea-hypopnea duration (MAD) could complement or outperform AHI.</p><p><strong>Methods: </strong>This study included 1069 OSA patients, of whom 754 completed the Epworth Sleepiness Scale (ESS). Multivariable regression models evaluated the associations between AHI, MAD, HAD, and nocturnal hypoxemia, and standardized <i>Z</i> scores were used for comparison. The predictive ability of AHI, MAD, and HAD models for EDS was evaluated using goodness-of-fit indices, and receiver operating characteristic (ROC) curve analysis was performed using bootstrapping techniques.</p><p><strong>Results: </strong>Nocturnal hypoxemia was observed in 317 participants (29.65%). Patients with nocturnal hypoxemia had significantly higher AHI (43.19 ± 18.41 vs 21.78 ± 14.73 events/hour, P < 0.001) and longer HAD (16.71 ± 7.48 vs 8.24 ± 5.40 minutes, P < 0.001). After adjusting for age, sex, and BMI, AHI and HAD were still significantly associated with nocturnal hypoxemia (P < 0.05). Standardized <i>Z</i> scores analysis revealed that HAD had the strongest association with nocturnal hypoxemia (HAD: OR = 3.69, 95% CI: 3.06-4.46, P < 0.0001; AHI: OR = 3.48, 95% CI: 2.90-4.18, P < 0.0001; MAD: OR = 1.01, 95% CI: 0.88-1.15, P = 0.9314) and mean SpO₂ (HAD: β = -0.91, 95% CI: -1.02--0.79, P < 0.0001; AHI: β = -0.85, 95% CI: -0.97--0.74, P < 0.0001; MAD: β = 0.00, 95% CI: -0.12-0.12, P = 0.9595), outperforming AHI and MAD. The HAD model showed the best fit for predicting EDS, with an area under the curve of 0.61 at a threshold of 5.63.</p><p><strong>Conclusion: </strong>The HAD better correlates with OSA-related nocturnal hypoxemia and EDS rather than AHI. The duration of respiratory events warrants more investigation in clinical assessment.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1101-1112"},"PeriodicalIF":3.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bed Partners' Perspectives and Sleep Quality After Hypoglossal Nerve Stimulation Therapy for Obstructive Sleep Apnea.","authors":"Christopher Seifen, Katharina Ludwig, Christian Ruckes, Christoph Matthias, Haralampos Gouveris","doi":"10.2147/NSS.S518889","DOIUrl":"10.2147/NSS.S518889","url":null,"abstract":"<p><strong>Introduction: </strong>Hypoglossal nerve stimulation (HGNS) is a treatment option for patients with moderate-to-severe obstructive sleep apnea (OSA) and intolerance or non-acceptance of positive airway pressure (PAP) therapy. Improvements in respiratory outcomes, sleepiness and quality of life have been demonstrated in treated patients. We aimed at evaluating the bed partner's perspective on HGNS therapy.</p><p><strong>Methods: </strong>In a cross-sectional exploratory prospective study (Clinical Trial Registration: DRKS00030554), 33 consecutive bed partners of patients treated with a unilateral, respiratory-coupled HGNS device in a tertiary medical center completed a 23-item custom-made questionnaire with questions that addressed the bed partner's perceptions and their satisfaction with HGNS therapy.</p><p><strong>Results: </strong>Bed partners reported that the patients were more comfortable with HGNS therapy (97.0%) compared to PAP therapy, their own sleep quality was better (90.9%) and their sexual partnership was equivalent in 69.0% and better in 27.3%. Their partners' snoring was reported as reduced in 87.9%. This trend was especially reported by bed partners of therapy responders. Bed partners did not need to motivate the patients to use HGNS therapy (81.8%), were satisfied with their partners' HGNS therapy (78.9%) and would recommend HGNS therapy to others (81.8%). Response to HGNS treatment or sex did not influence the reported outcomes.</p><p><strong>Conclusion: </strong>Bed partners of HGNS-implanted OSA patients perceive the HGNS therapy mostly positive and are very often satisfied with this therapy. Nonetheless, single aspects of HGNS therapy for OSA may be experienced differently by the patients' bed partners.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1113-1126"},"PeriodicalIF":3.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing Sleep Science: A Narrative Review of the Historical Origins and Current Applications of Sleep Neuroimaging.","authors":"Daniel B Kay, Kara McRae Duraccio, Lars Michels, Francesca Siclari, Helmet T Karim, Elijah B Davis, Isaac J Wilkins","doi":"10.2147/NSS.S492585","DOIUrl":"10.2147/NSS.S492585","url":null,"abstract":"<p><p>Sleep neuroimaging is a subfield of sleep science that goes beyond polysomnography by combining neuroimaging techniques with validated sleep research methods to characterize sleep-wake states and investigate sleep-related processes across the 24-hour day. In this article, we review the historical advancements and applications that grew out of somnography leading to current sleep neuroimaging methods. We highlight the power of somnoimages to help visualize sleep research results and communicate complex information about sleep processes. We also suggest several ways in which applying neuroimaging during sleep has opened new avenues to more fully capture the nature of sleep, uncovered mechanisms of sleep-wake regulation, and increased understanding of sleep-related processes. Current applications and future directions of sleep neuroimaging are also discussed.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1079-1099"},"PeriodicalIF":3.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-Induced Sleep Endoscopy and Its Recent Clinical Applications in Combination with Other Procedures in Children: A Narrative Review.","authors":"Zhixian Xiao, Xing Li, Li Zhou, Xiaocui Long, Li Tian, Weiqi Li","doi":"10.2147/NSS.S498360","DOIUrl":"10.2147/NSS.S498360","url":null,"abstract":"<p><p>Drug-induced sleep endoscopy (DISE) is a dynamic diagnostic tool that is increasingly used to evaluate upper airway obstruction, especially in pediatric obstructive sleep apnea. Although initially established in adult populations, its pediatric application is expanding. Since 1990, more than 80 studies have explored various aspects of DISE, with a growing subset focusing specifically on its use in children, supported by advancements in sedation protocols. This narrative review summarizes the clinical indications for pediatric DISE, preparation protocols, and validated scoring systems, including the VOTE and Chan classifications. We also highlight the integration of DISE with adjunctive tools such as positive airway pressure titration, long-range optical coherence tomography, and dynamic magnetic resonance imaging for improved diagnostic accuracy and individualized treatment planning. These developments suggest that DISE, when standardized, holds strong potential to refine the management of complex pediatric airway disorders.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1067-1077"},"PeriodicalIF":3.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation and Effects of an Online Intervention Designed to Promote Sleep During Early Infancy: A Randomized Trial.","authors":"Stephanie Anzman-Frasca, Juliana Goldsmith, Amanda B Hassinger, Jennifer S Savage, Vaishali Gupta","doi":"10.2147/NSS.S501807","DOIUrl":"10.2147/NSS.S501807","url":null,"abstract":"<p><strong>Objective: </strong>Examine the implementation and effects of an interactive online intervention designed to support new parents with their young infants' sleep.</p><p><strong>Design: </strong>First-time parents were enrolled when infants were ~6 weeks old and randomized to a sleep intervention or general baby care control group, with intervention content provided weekly between infant ages 2 to 4 months, primarily as brief videos and infographics in private online groups.</p><p><strong>Methods: </strong>Parents (n=74) completed online surveys at baseline (infant age ~6 weeks), midpoint (3 months), post-intervention (4 months), and follow-up (7 months), reporting on infant sleep duration and night wakings (via Brief Infant Sleep Questionnaire), as well as their own sleep duration (via Pittsburgh Sleep Quality Index), and parenting satisfaction and self-efficacy (via Perceived Sense of Competence Scale). Marginal models examined sleep intervention effects on infants' total and nightly sleep duration and night wakings, parent sleep duration, and parenting satisfaction and self-efficacy over time.</p><p><strong>Results: </strong>Eighty-one percent of parents joined the online groups. There was a group-by-time interaction predicting total infant sleep duration, with total sleep increasing in the intervention group relative to controls. Tests of least squares means showed that intervention group infants slept 1.4 hours longer than controls at age 4 months (p=0.004). There were no significant effects on infants' nighttime sleep, but daytime napping increased in the intervention group relative to controls (p=0.04). Group differences in parent sleep were not statistically significant but were in a consistent direction when compared with intervention impacts on infant sleep. Parenting satisfaction increased significantly in both groups.</p><p><strong>Conclusion: </strong>Findings demonstrate the potential of an interactive online sleep intervention to support first-time parents with early infant sleep. Parent perspectives support acceptability of the approach and highlight the potential for further development of this scalable online intervention and examination of its impacts on additional aspects of well-being.</p><p><strong>Clinical trial registration: </strong>The study was registered prior to participant enrollment at clinicaltrials.gov (NCT05322174). URL: https://clinicaltrials.gov/study/NCT05322174.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1037-1048"},"PeriodicalIF":3.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and Validation of a Nomogram Model for Predicting Pulmonary Hypertension in Patients with Obstructive Sleep Apnea.","authors":"Rou Zhang, Zhijuan Liu, Ran Li, Li Ai, Yongxia Li","doi":"10.2147/NSS.S520758","DOIUrl":"10.2147/NSS.S520758","url":null,"abstract":"<p><strong>Purpose: </strong>Pulmonary hypertension (PH) is a common cardiovascular complication of obstructive sleep apnea (OSA), posing a significant threat to the health and life of patients with OSA. However, no clinical prediction model is currently available to evaluate the risk of PH in OSA patients. This study aimed to develop and validate a nomogram for predicting PH risk in OSA patients.</p><p><strong>Patients and methods: </strong>We collected medical records of OSA patients diagnosed by polysomnography (PSG) from January 2016 to June 2024. Transthoracic echocardiography (TTE) was performed to evaluate PH. A total of 511 OSA patients were randomly divided into training and validation sets for model development and validation. Potential predictive factors were initially screened using univariate logistic regression and Lasso regression. Independent predictive factors for PH risk were identified via multivariate logistic regression, and a nomogram model was constructed. Model performance was assessed in terms of discrimination, calibration, and clinical applicability.</p><p><strong>Results: </strong>Eight independent predictive factors were identified: age, recent pulmonary infection, coronary atherosclerotic heart disease (CHD), apnea-hypopnea index (AHI), mean arterial oxygen saturation (MSaO₂), lowest arterial oxygen saturation (LSaO₂), alpha-hydroxybutyrate dehydrogenase (α-HBDH), and fibrinogen (FIB). The nomogram model demonstrated good discriminative ability (AUC = 0.867 in the training set, AUC = 0.849 in the validation set). Calibration curves and decision curve analysis (DCA) also indicated good performance. Based on this model, a web-based nomogram tool was developed.</p><p><strong>Conclusion: </strong>We developed and validated a stable and practical web-based nomogram for predicting the probability of PH in OSA patients, aiding clinicians in identifying high-risk patients for early diagnosis and treatment.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1049-1066"},"PeriodicalIF":3.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}