{"title":"Sleep Disturbance in Parkinson's Disease: Consequences for the Brain and Disease Progression - A Narrative Review.","authors":"Kirstie N Anderson, Michael J Keogh, Luca Gosse","doi":"10.2147/NSS.S478860","DOIUrl":null,"url":null,"abstract":"<p><p>Sleep disturbance in Parkinson's disease (PD) is recognized to be one of the most common non-motor complications. It occurs before disease onset as a prodromal symptom, during and then throughout the disease course. Causes are multifactorial and can be multiple in the same patient. Specific sleep disorders that are known to occur in those with Parkinson's disease include REM sleep behavior disorder, sleep disordered breathing including obstructive sleep apnea, restless legs and periodic limb movements, nightmare disorder, insomnia alongside direct side-effects of the medication used for therapy. One key question is whether these sleep disorders impact upon the motor and non-motor symptoms of Parkinson's disease. There has been significant interest in recent years in using certain sleep disorders, in particular, REM sleep behavior disorder, as a biomarker both for those at risk of Parkinson's disease but also influencing the subsequent severity and speed of progression. However, other sleep disorders in the general population may also increase the risk of developing Parkinson's disease. It is important to understand whether the treatment of sleep disturbance and specific sleep disorders modifies the long-term risk of developing Parkinson's disease or its progression.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"1521-1537"},"PeriodicalIF":3.0000,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219153/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature and Science of Sleep","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/NSS.S478860","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Sleep disturbance in Parkinson's disease (PD) is recognized to be one of the most common non-motor complications. It occurs before disease onset as a prodromal symptom, during and then throughout the disease course. Causes are multifactorial and can be multiple in the same patient. Specific sleep disorders that are known to occur in those with Parkinson's disease include REM sleep behavior disorder, sleep disordered breathing including obstructive sleep apnea, restless legs and periodic limb movements, nightmare disorder, insomnia alongside direct side-effects of the medication used for therapy. One key question is whether these sleep disorders impact upon the motor and non-motor symptoms of Parkinson's disease. There has been significant interest in recent years in using certain sleep disorders, in particular, REM sleep behavior disorder, as a biomarker both for those at risk of Parkinson's disease but also influencing the subsequent severity and speed of progression. However, other sleep disorders in the general population may also increase the risk of developing Parkinson's disease. It is important to understand whether the treatment of sleep disturbance and specific sleep disorders modifies the long-term risk of developing Parkinson's disease or its progression.
期刊介绍:
Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep.
Specific topics covered in the journal include:
The functions of sleep in humans and other animals
Physiological and neurophysiological changes with sleep
The genetics of sleep and sleep differences
The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness
Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness
Sleep changes with development and with age
Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause)
The science and nature of dreams
Sleep disorders
Impact of sleep and sleep disorders on health, daytime function and quality of life
Sleep problems secondary to clinical disorders
Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health)
The microbiome and sleep
Chronotherapy
Impact of circadian rhythms on sleep, physiology, cognition and health
Mechanisms controlling circadian rhythms, centrally and peripherally
Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health
Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption
Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms
Epigenetic markers of sleep or circadian disruption.