Independent Association of Sleep Apnea-Specific Hypoxic Burden and Sleep Breathing Impairment Index with Thyroid Function in Obstructive Sleep Apnea: A Retrospective Study.

IF 3.4 2区医学 Q2 CLINICAL NEUROLOGY

Nature and Science of Sleep Pub Date : 2025-07-05 eCollection Date: 2025-01-01 DOI:10.2147/NSS.S525750

Yanuo Zhou, Yewen Shi, Simin Zhu, Zine Cao, Yushan Xie, Chendi Lu, Xiaoxin Niu, Lina Ma, Zitong Wang, Yonglong Su, Zihan Xia, Yuqi Yuan, Jiayi Yang, Rui Lu, Yani Feng, Xiaoyong Ren, Wei Hou

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Abstract

Purpose: This study aimed to explore thyroid function changes in patients with obstructive sleep apnea (OSA) and analyze the relationships among the sleep apnea-specific hypoxic burden (SASHB), the sleep breathing impairment index (SBII), and the function during different sleep stages.

Methods: This retrospective study included 452 patients with OSA who visited the Second Affiliated Hospital of Xi'an Jiaotong University between August 2017 and March 2024. The severity of OSA was evaluated, grouping patients by their apnea-hypopnea index (AHI), SASHB, SBII, and both SASHB and SBII during non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. Multiple linear regression analyzed the independent relationships between the AHI, SASHB, SBII, and thyroid function indicators while adjusting for potential confounders.

Results: Significant intergroup differences were observed in thyroid function indicators under various grouping methods, with different trends. After adjusting for confounding factors, SASHB, SASHB during NREM sleep (NREM-SASHB), SASHB during REM sleep (REM-SASHB), SBII, SBII during NREM sleep (NREM-SBII), and SBII during REM sleep (REM-SBII) were independently associated with elevated serum free triiodothyronine (FT3) levels (p < 0.05). Similar results were noted in the male patients, whereas no significant associations were observed in the female patients.

Conclusion: There is an association between OSA and thyroid function, with SASHB and SBII independently linked to elevated FT3 levels across different sleep stages and sex subgroups. Future research should further explore these mechanisms to optimize clinical management and treatment strategies for patients with OSA.

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阻塞性睡眠呼吸暂停患者睡眠呼吸暂停特异性缺氧负担和睡眠呼吸障碍指数与甲状腺功能的独立关联：一项回顾性研究。

目的：探讨阻塞性睡眠呼吸暂停（OSA）患者甲状腺功能的变化，分析睡眠呼吸暂停特异性缺氧负担（SASHB）、睡眠呼吸障碍指数（SBII）与不同睡眠阶段甲状腺功能的关系。方法：回顾性研究2017年8月至2024年3月在西安交通大学第二附属医院就诊的452例OSA患者。评估OSA的严重程度，根据患者在非快速眼动（NREM）和快速眼动（REM）睡眠期间的呼吸暂停低通气指数（AHI）、SASHB、SBII以及SASHB和SBII进行分组。多元线性回归分析AHI、SASHB、SBII和甲状腺功能指标之间的独立关系，同时调整潜在的混杂因素。结果：不同分组方法下甲状腺功能指标组间差异显著，且趋势不同。校正混杂因素后，SASHB、非快速眼动睡眠期间SASHB （NREM-SASHB）、快速眼动睡眠期间SASHB （REM-SASHB）、SBII、非快速眼动睡眠期间SBII （NREM-SBII）、快速眼动睡眠期间SBII （REM-SBII）与血清游离三碘甲状腺原氨酸（FT3）水平升高独立相关（p < 0.05）。在男性患者中也观察到类似的结果，而在女性患者中没有观察到显著的关联。结论：OSA与甲状腺功能之间存在关联，SASHB和SBII与不同睡眠阶段和性别亚组中FT3水平升高独立相关。未来的研究应进一步探索这些机制，以优化OSA患者的临床管理和治疗策略。

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.