Nature and Science of Sleep最新文献

{"title":"Impact of 30-minute and 90-minute Naps on Aerobic and Anaerobic Intermittent Performance in Collegiate Soccer Players.","authors":"Anran Xu, Ning Wang, Yang Gao, Xiaotian Li","doi":"10.2147/NSS.S498173","DOIUrl":"https://doi.org/10.2147/NSS.S498173","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to investigate the effects of 30-minute and 90-minute naps on collegiate soccer players' aerobic and anaerobic performance following a normal night of sleep, and to compare the performance differences between the two nap durations.</p><p><strong>Patients and methods: </strong>A total of 25 male collegiate soccer players (age: 20 ± 1 years, height: 180.4 ± 5.6 cm, weight: 72.1 ± 4.2 kg, BMI: 22.1 ± 2.2 kg·m⁻²) participated in the RAST and 30-15. Intermittent fitness test (IFT) under three conditions: no nap (N0), 30-minute nap (N30), and 90-minute nap (N90).</p><p><strong>Results: </strong>Post-nap assessments showed significant improvements in peak power per weight (p = 0.007, η² = 0.13), minimum power per weight (p < 0.001, η² = 0.25), and average power per weight (p < 0.001, η² = 0.28) in the RAST test, with no notable differences between the N30 and N90 groups. Additionally, the fatigue index (FI) in the N90 group significantly decreased compared to N0 (p = 0.005, d = 0.86). Both N30 and N90 groups exhibited higher VIFT values than the N0 group (p < 0.001, η² = 0.23). However, no significant changes were noted in average heart rate (p = 0.198) or perceived exertion (RPE) (p = 0.376) during the 30-15 IFT after napping.</p><p><strong>Conclusion: </strong>Napping effectively enhances the aerobic and anaerobic performance of collegiate soccer players following a normal night of sleep. Implementing strategic napping may be beneficial for athletes seeking to optimize their performance before training or competition.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"621-630"},"PeriodicalIF":3.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mediating Role of Negative Mood Affect in the Relationship Between Perceived Stress and Vulnerability to Insomnia Among Student Pharmacist Shift Workers.","authors":"Mohammed F Salahuddin, Blesson I Samuel, Richard Bugingo, Delilah Spencer, Md Dilshad Manzar, Ahmed S BaHammam","doi":"10.2147/NSS.S515923","DOIUrl":"https://doi.org/10.2147/NSS.S515923","url":null,"abstract":"<p><strong>Background: </strong>Perceived stress and vulnerability to develop insomnia are closely linked, with negative mood affect playing a key role. Shift workers, particularly student pharmacists juggling academic demands and irregular work schedules, are at heightened risk for stress-related sleep disturbances. While previous studies have explored their direct relationships, limited evidence exists on the dual role of negative mood affect as both a mediator and a non-mediator in these pathways. This study investigates the mediating role of negative mood affect in the relationship between perceived stress and vulnerability to develop insomnia and assesses whether negative mood affect mediates the reverse relationship.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 86 student pharmacist shift workers at Notre Dame of Maryland University. Participants completed validated self-report measures, including the Perceived Stress Scale (PSS), the Ford Insomnia Response to Stress Test (FIRST), and the Positive and Negative Affect Schedule (PANAS). Mediation analysis using Hayes' PROCESS macro (Model 4) examined the mediating role of negative mood affect in both pathways. Bias-corrected bootstrapping with 5000 iterations calculated confidence intervals for indirect effects, with significance set at p < 0.05.</p><p><strong>Results: </strong>Negative mood affect partially mediated the relationship between perceived stress and vulnerability to develop insomnia. Higher stress levels were associated with increased negative mood affect (b = 0.49, SE = 0.05, p < 0.01), which, in turn, was linked to greater insomnia vulnerability (b = 0.39, SE = 0.04, p < 0.01). The indirect effect was significant (b = 0.19, 95% CI [0.06, 0.33]). In contrast, negative mood affect did not mediate the reverse pathway (p = 0.15).</p><p><strong>Conclusion: </strong>Negative mood affect significantly mediates the relationship between perceived stress and insomnia vulnerability but not the reverse pathway. Interventions targeting emotional regulation may help reduce stress-related sleep disturbances. Longitudinal studies are needed to confirm these findings and refine interventions.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"649-662"},"PeriodicalIF":3.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening OSA in Chinese Smart Device Consumers: A Real-World Arrhythmia-Related Study.","authors":"Yibing Chen, Hui Zhang, Jing Li, Peida Xu, Yutao Guo, Lixin Xie","doi":"10.2147/NSS.S509097","DOIUrl":"https://doi.org/10.2147/NSS.S509097","url":null,"abstract":"<p><strong>Introduction: </strong>Early detection of obstructive sleep apnea (OSA) is critical due to its link to cardiovascular diseases. Our previous study validated an algorithm-based photoplethysmography (PPG) smartwatch for OSA risk detection.</p><p><strong>Objective: </strong>This study aimed to characterize OSA features and assess its association with arrhythmia risk among smart wearable device (SWD) consumers in China in a real-world setting.</p><p><strong>Methods: </strong>Between December 15, 2019, and January 31, 2022, SWD consumers across China were screened for OSA risk using HUAWEI devices. OSA diagnosis was confirmed via telecare follow-ups, including clinical evaluations and sleep test records. Disease characteristics and arrhythmia risks were analyzed.</p><p><strong>Results: </strong>In a large cohort of 1,056,494 participants, smart wearable devices (SWDs) effectively identified 19,563 individuals at high risk for OSA, with 1054 confirmed cases. OSA patients demonstrated high prevalence of obesity (46.8%), hypertension (19.8%), and arrhythmia (17.17%). SWDs detected abnormal heart rhythms or suspected arrhythmia in 95.9% of confirmed OSA cases. Age emerged as an independent predictor of arrhythmia risk, while hypertensive OSA patients were older, more obese, and experienced prolonged nocturnal hypoxia (Time length of SpO₂<90%, P=0.020). These findings underscore the utility of SWDs in OSA screening and highlight the significant cardiovascular risks associated with OSA.</p><p><strong>Conclusion: </strong>PPG-based SWD effectively screened for OSA and identified elevated arrhythmia risks. These findings support their utility for large-scale OSA screening and highlight cardiovascular risks management.</p><p><strong>Clinical trial registry name: </strong>Mobile Health (mHealth) technology for improved screening, patient involvement and optimizing integrated care in atrial fibrillation.</p><p><strong>Registration number: </strong>ChiCTR-OOC-17014138.</p><p><strong>Date of registration: </strong>2017-12-26.</p><p><strong>Date of last refreshed on: </strong>2018-11-18.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"663-676"},"PeriodicalIF":3.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gait Characteristics and Neuroanatomical Alterations in Obstructive Sleep Apnea-Hypopnea Syndrome.","authors":"Jialiu Jiang, Yuting Mo, Zulalai Abuduwaili, Chenglu Mao, Shuang Fang, Zhihong Ke, Zheqi Hu, Lili Huang, Shuai Xu, Dan Yang, Ruozhu Xiong, Pei Xie, Xiaolei Zhu, Yun Xu","doi":"10.2147/NSS.S502204","DOIUrl":"https://doi.org/10.2147/NSS.S502204","url":null,"abstract":"<p><strong>Background: </strong>Obstructive sleep apnea-hypopnea syndrome (OSAHS) affects over 936 million adults globally. Recently, it has been found to contribute to gait disorders, but there is limited information regarding how various indicators of OSAHS affect gait patterns.</p><p><strong>Methods: </strong>A total of 136 subjects recruited from Nanjing Drum Tower Hospital were categorized based on apnea hypopnea index (AHI) and oxygen saturation (SpO₂), respectively. All subjects underwent data collection regarding demographics, gait testing, sleep monitoring, multimodal magnetic resonance imaging (MRI), and a battery of clinical evaluations.</p><p><strong>Results: </strong>Subjects with elevated AHI exhibited increased step width and decreased stride length in comparison to those with lower AHI. The nm (no or mild)-hypoxemia group demonstrated faster stride frequency than the ms (moderate to severe)-hypoxemia group. High-frequency obstructive sleep apnea-hypopnea resulted in cortical atrophy of the orbital part of right inferior frontal gyrus and upregulation of functional connectivity between the basal ganglia and left inferior temporal gyrus, basal ganglia and left insula, while the severity of hypoxemia led to functional alternations between right angular gyrus and left gyrus rectus, which manifested as respective alternations in gait. The area under the curve (AUC) for gait tests evaluating moderate-to-severe OSAHS was 0.842, using logistic regression models.</p><p><strong>Conclusion: </strong>The frequency of respiratory events and the severity of hypoxemia caused different gait dysfunction and corresponding underlying mechanisms in patients with OSAHS. Gait testing might be a potential tool for rapidly screening OSAHS in the population.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"631-647"},"PeriodicalIF":3.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Metabolic Score for Insulin Resistance (METS-IR) and Risk of Obstructive Sleep Apnea: Analysis of NHANES Database and a Chinese Cohort.","authors":"Beini Zhou, Yan Yao, Yuhan Wang, Wuriliga Yue, Jingyi Zhang, Yang He, Qingfeng Zhang, Yixuan Wang, Ke Hu","doi":"10.2147/NSS.S400125","DOIUrl":"https://doi.org/10.2147/NSS.S400125","url":null,"abstract":"<p><strong>Purpose: </strong>Insulin resistance (IR) plays a significant role in the development of obstructive sleep apnea (OSA). The metabolic score for insulin resistance (METS-IR) is a novel method for assessing IR. This study aims to explore the relationship between METS-IR and the risk of OSA.</p><p><strong>Patients and methods: </strong>This cross-sectional study included a total of 8297 subjects from NHANES (National Health and Nutrition Examination Survey) database, as well as 581 patients who underwent sleep monitoring in Renmin Hospital of Wuhan University. Logistic regression, subgroup analysis, and receiver operating characteristic (ROC) curve analysis were employed for evaluation.</p><p><strong>Results: </strong>In the American population, a significant positive association was found between METS-IR and increased risk of OSA. For each unit increase in METS-IR, the risk of OSA increased by 4.4% (OR= 1.044; 95% CI: 1.037-1.059; P <0.001). A similar relationship was observed in the Chinese population. Multivariate Logistic regression model showed that for each unit increase in METS-IR, the prevalence of OSA increased by 6.7% (OR= 1.067; 95% CI: 1.035-1.103; P <0.001), and apnea-hypopnea index (AHI) increased by 0.732 (β= 0.732; 95% CI: 0.573-0.732; P <0.001). Gender subgroup analysis further showed that the association between METS-IR and OSA was particularly significant in male participants (OR= 1.111; 95% CI: 1.065-1.163; P <0.001). In the ROC analysis, the area under the curve (AUC) value of METS-IR for predicting OSA was 0.777, but it is not statistically significantly different from triglyceride glucose (TyG) (AUC = 0.749; P = 0.054), body mass index (BMI) (AUC = 0.769; P = 0.269), and triglyceride glucose-body mass index (TyG-BMI) (AUC = 0.777; P = 0.996).</p><p><strong>Conclusion: </strong>METS-IR is significantly associated with the risk of OSA and may serve as an effective predictive marker for identifying OSA.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"607-620"},"PeriodicalIF":3.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Quality and Insomnia Prevalence Among a Saudi Population: A Descriptive Study.","authors":"Mohammed Senitan, Nasser F BinDhim, Nora A Althumiri","doi":"10.2147/NSS.S503297","DOIUrl":"https://doi.org/10.2147/NSS.S503297","url":null,"abstract":"<p><strong>Background: </strong>Sleep quality is a critical factor for maintaining physical and mental well-being, with insomnia being one of the most common sleep disorders affecting global populations.</p><p><strong>Aim: </strong>To assess sleep quality and estimate the prevalence of insomnia among the general population across all regions of Saudi Arabia.</p><p><strong>Methods: </strong>A cross-sectional study was conducted using data from the Sharik Diet and Health Survey (SDHS), covering all 13 administrative regions of Saudi Arabia. The sample comprised 6051 participants aged between 18 and 90 years. Sleep quality and insomnia levels were evaluated using structured phone interviews conducted from July to August 2023.</p><p><strong>Results: </strong>The majority of participants did not report suffering from insomnia, with only a small fraction indicating its presence. The prevalence of insomnia, based on participant-reported dissatisfaction with sleep patterns, was relatively low, with 21.5% of respondents reporting dissatisfaction (16.1% \"Not Satisfied\" and 5.4% \"Very Unsatisfied\"). Additionally, 42.4% of participants reported being \"Not Concerned\" about their sleep, while 33.9% experienced no interference with daily life due to sleep issues.</p><p><strong>Conclusion: </strong>This study provides valuable insights into sleep quality and insomnia prevalence among the general population in Saudi Arabia. Although the overall prevalence of insomnia is lower compared to previous studies, a notable subset of the population experiences dissatisfaction and concerns regarding sleep. These findings underscore the need for targeted interventions addressing socio-economic disparities and mental health factors to improve sleep quality. Future research should focus on longitudinal assessments to better understand the factors influencing insomnia and the effectiveness of intervention strategies.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"597-606"},"PeriodicalIF":3.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Sleep Patterns and Influencing Factors of Chronic Heart Failure Patients in China: A Latent Profile Analysis.","authors":"Yan Li, Jiamin Li, Jingwen Qin, Sixin Zhou, Kaizheng Gong","doi":"10.2147/NSS.S509059","DOIUrl":"https://doi.org/10.2147/NSS.S509059","url":null,"abstract":"<p><strong>Purpose: </strong>Sleep problems such as reduced sleep efficiency, difficulty initiating sleep, and increased sleep disturbances significantly affect the quality of life and health status of patients with chronic heart failure (CHF). However, the sleep patterns of CHF patients and their influencing factors need to be further studied. Therefore, this study aimed to explore the latent sleep patterns in patients with CHF and to analyze the factors influencing different sleep patterns.</p><p><strong>Patients and methods: </strong>A convenience sampling method was adopted to select 290 patients with CHF who were hospitalized in the Department of Cardiology of a tertiary hospital in Yangzhou City, Jiangsu Province, China, from January to August 2024. The investigation utilized a general information questionnaire, the Pittsburgh Sleep Quality Index (PSQI), and the Fear of Progression Questionnaire-Short Form (FoP-Q-SF). Utilizing Mplus version 8.3 for potential profile analysis, the influences on potential categorization were examined through univariate and multivariate logistic regression analyses.</p><p><strong>Results: </strong>The sleep quality score of 290 patients with CHF was (12.00±3.95). The findings from latent profile analysis indicated that the sleep quality patterns of patients with CHF were categorized into three distinct profiles: relatively good sleep group (n=87, 30.3%), low sleep efficiency-low medication use group (n=160, 54.9%), and sleep disorder-substance dependence group (n=43, 14.8%). Multiple logistic regression analysis showed that age, monthly income, number of hospitalizations for heart failure in a year, number of comorbidities, and fear of progression were influential factors (P < 0.05).</p><p><strong>Conclusion: </strong>Sleep quality among patients with CHF exhibits distinct distributional profiles. Healthcare providers should implement tailored sleep management strategies and psychological interventions, aligning with the sleep patterns and influencing factors specific to patients with CHF. However, it is necessary to note that this study employed a cross-sectional design, and future research could benefit from a longitudinal design.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"571-581"},"PeriodicalIF":3.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Wings to Wellness: A Research Agenda Inspired by Migratory Bird Adaptations for Sleep and Circadian Medicine.","authors":"Ahmed Salem BaHammam","doi":"10.2147/NSS.S519493","DOIUrl":"https://doi.org/10.2147/NSS.S519493","url":null,"abstract":"<p><p>Migratory birds demonstrate remarkable temporal plasticity, adapting their circadian rhythms and sleep patterns to meet the demands of long-distance migration. This perspective explores how insights from avian temporal adaptations could inform novel research directions in human sleep and circadian medicine. Birds' ability to maintain precise temporal organization through multiple coordinated oscillators, particularly during migratory periods, provides a valuable framework for understanding circadian flexibility. Drawing from recent advances in avian chronobiology, we propose several research priorities for human applications, including biomarker-guided chronotherapy, circuit-specific interventions, and optimization of environmental cue timing. We explore how birds' sophisticated control of sleep architecture and metabolic regulation during migration might inspire new approaches to managing circadian disruptions in humans. Neuroimaging studies of human temporal adaptability, guided by avian insights, could reveal network-level mechanisms underlying circadian plasticity. Of particular interest is the parallel between avian unihemispheric sleep and human hemispheric asymmetry during sleep, suggesting the evolutionary conservation of adaptive sleep mechanisms. While acknowledging the fundamental differences between avian and human circadian systems, we outline specific research directions that could translate avian temporal adaptability principles into therapeutic strategies for circadian disorders. While these avian-inspired hypotheses require rigorous validation, and some may not prove viable, embracing creative exploration remains essential for advancing our understanding of human circadian biology and guiding the development of novel therapeutic approaches.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"583-595"},"PeriodicalIF":3.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediation Effect of Relaxin in Cerebrospinal Fluid on the Association Between Smoking and Sleep.","authors":"Zeping Xu, Mingwei Ma, Yanlong Liu, Jiayi Tang, Xingguang Luo, Yu-Hsin Chen, Kexin Wang, Xiyi Chen, Yimin Kang, Ke Zheng, Weiming Hu, Li Chen, Fan Wang, Yuyu Wu","doi":"10.2147/NSS.S479171","DOIUrl":"https://doi.org/10.2147/NSS.S479171","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the influence of CSF relaxin (RLN) on the association between smoking and sleep quality, considering previous findings linking smoking and RLN with psychiatric conditions.</p><p><strong>Methods: </strong>In a case-control study of 168 Chinese adult males (70 smokers, 98 non-smokers), levels of relaxin in cerebrospinal fluid (CSF) were measured. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), comprising seven scales. Logistic regression and mediation models analyzed the relationships between nicotine dependence, PSQI scores, and CSF relaxin. Logistic regression examined the interaction of nicotine dependence and relaxin gene on PSQI subdimension scores.</p><p><strong>Results: </strong>Smokers exhibited more severe sleep problems in PSQI total score and four PSQI subdimension scores (p < 0.05). CSF relaxin levels were significantly higher in smokers (20.7 ± 7.0 vs 16.3 ± 6.5, p < 0.001) and correlated closely with PSQI total score (r = 0.275, p < 0.001). Logistic regression found that CSF relaxin associated with PSQI subdimension scores, particularly in sleep disturbance (OR = 3.07 (1.61-5.99), adjusted p < 0.01). Mediation analysis indicated relationship between nicotine dependence and PSQI total score, with CSF relaxin as a mediator, and the indirect effect accounted for 25% of the total effect (Indirect effect = 0.124 (0.021-0.223), Total effect = 0.494 (0.193-0.807)). Additionally, polymorphisms in gene of relaxin and its receptors were closely tied to smoking behaviors and sleep quality (p < 0.05).</p><p><strong>Conclusion: </strong>CSF relaxin levels were significantly elevated in smokers and closely associated with PSQI subdimension scores, particularly with the sleep disturbance subdimension score. Moreover, CSF relaxin mediated the relationship between nicotine dependence and sleep quality. Polymorphisms (RLN3 rs12327666, rs1982632, and rs7249702, RLN3R1 rs35399, and RLN3R2 rs11264422) also played a role in smoking behaviors or sleep quality.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"545-556"},"PeriodicalIF":3.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception of Lemborexant Effectiveness as Assessed by the Patient Global Impression-Insomnia Questionnaire.","authors":"Christopher L Drake, Jane Yardley, Kate Pinner, Margaret Moline, Manoj Malhotra","doi":"10.2147/NSS.S499090","DOIUrl":"https://doi.org/10.2147/NSS.S499090","url":null,"abstract":"<p><strong>Objective: </strong>Using data from a clinical study of lemborexant, evaluate responses to the Patient Global Impression-Insomnia (PGI-I) questionnaire, a simple 4-item questionnaire that assesses patients' perceptions of the effects of medication on sleep, which may help evaluate clinically meaningful changes from the patient's perspective.</p><p><strong>Methods: </strong>Study E2006-G001-303, a 12-month, placebo (PBO)-controlled (first 6 months) Phase 3 study in adults with insomnia disorder, randomized subjects (1:1:1) to lemborexant 5 mg (LEM5; n=316), 10 mg (LEM10; n=315), or PBO (n=318). The second 6 months are not presented here. PGI-I results were analyzed post hoc in relation to patient-reported (subjective) sleep-onset latency (sSOL) and total-sleep-time (sTST).</p><p><strong>Results: </strong>At 6 months: 67.3% (LEM5) and 68.8% (LEM10) of subjects reported positive effects of medication helping them sleep versus 45.0% (both <i>p</i><0.0001) with PBO. Positive effects on \"time to fall asleep\" were reported by 72.8% (LEM5) and 73.1% (LEM10) versus 46.1% with PBO (<i>p</i><0.0001), and 58.0% (LEM5) and 62.0% (LEM10) reported positive effects on sleep duration versus 39.9% with PBO (<i>p</i><0.0001). Subjects reporting positive effects on \"time to fall asleep\" had greater change from baseline (CFB; improvement) at 6 months in median sSOL (in minutes; LEM5= -26.8; LEM10= -32.1; PBO= -17.5; <i>p</i><0.01) versus those reporting negative effects (LEM5= -9.1; LEM10= -10.4; PBO= -8.6; LEM5 vs PBO, <i>p</i>=0.52; LEM10 vs PBO, <i>p</i>=0.69). For sTST (in minutes) at 6 months, mean CFB tended to be greater for subjects reporting positive (LEM5=81.2, LEM10=93.2, PBO=74.8; LEM5 vs PBO, <i>p</i>=0.28; LEM10 vs PBO, <i>p</i>=0.18) versus negative (LEM5=46.4, LEM10=35.0, PBO=38.6; LEM5 vs PBO, <i>p</i>=0.44; LEM10 vs PBO, <i>p</i>=0.52) effects, although this was not statistically significant.</p><p><strong>Conclusion: </strong>Patient impressions of the effects of lemborexant were positive based on the PGI-I and reflected improvements in subjective sleep outcome measures, indicating that the brief PGI-I tool may be useful in clinical practice.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"557-570"},"PeriodicalIF":3.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}