Multiple Sclerosis Journal最新文献_第3页

JC virus or extended interval dosing? More data are needed. JC病毒还是延长间隔用药？需要更多数据。

IF 5.4 2区医学

Multiple Sclerosis Journal Pub Date : 2024-11-01 Epub Date: 2024-09-06 DOI: 10.1177/13524585241272975

Ahmed Z Obeidat

引用次数: 0

Multiple sclerosis subgroups: Data-driven clusters based on patient-reported outcomes and a large clinical sample. 多发性硬化症亚群：基于患者报告结果和大量临床样本的数据驱动分组。

IF 5.4 2区医学

Multiple Sclerosis Journal Pub Date : 2024-11-01 Epub Date: 2024-10-17 DOI: 10.1177/13524585241282763

Alessandro S De Nadai, Ryan J Zamora, Alyse Finch, Deborah M Miller, Daniel Ontaneda, Douglas D Gunzler, Farren S Briggs

{"title":"Multiple sclerosis subgroups: Data-driven clusters based on patient-reported outcomes and a large clinical sample.","authors":"Alessandro S De Nadai, Ryan J Zamora, Alyse Finch, Deborah M Miller, Daniel Ontaneda, Douglas D Gunzler, Farren S Briggs","doi":"10.1177/13524585241282763","DOIUrl":"10.1177/13524585241282763","url":null,"abstract":"Background: While standard clinical assessments provide great value for people with multiple sclerosis (PwMS), they are limited in their ability to characterize patient perspectives and individual-level symptom heterogeneity.Objectives: To identify PwMS subgroups based on patient-reported outcomes (PROs) of physical, cognitive, and emotional symptoms. We also sought to connect PRO-based subgroups with demographic variables, functional impairment, hypertension and smoking status, traditional qualitative multiple sclerosis (MS) symptom groupings, and neuroperformance measurements.Methods: Using a cross-sectional design, we applied latent profile analysis (LPA) to a large database of PROs; analytic sample N = 6619).Results: We identified nine distinct MS subtypes based on PRO patterns. The subtypes were primarily categorized into low, moderate, and high mobility impairment clusters. Approximately 70% of participants were classified in a low mobility impairment group, 10% in a moderate mobility impairment group, and 20% in a high mobility impairment group. Within these subgroups, several unexpected patterns were observed, such as high mobility impairment clusters reporting low non-mobility impairment.Conclusions: The present study highlights an opportunity to advance precision medicine approaches in MS. Combining PROs with data-driven methodology allows for a cost-effective and personalized characterization of symptom presentations. that can inform clinical practice and future research designs.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1642-1652"},"PeriodicalIF":5.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trajectories and management of vascular risk following the diagnosis of multiple sclerosis: A population-based matched cohort study between 1987 and 2018 in England. 多发性硬化症确诊后的血管风险轨迹和管理：1987年至2018年间英国一项基于人群的匹配队列研究。

IF 5.4 2区医学

Multiple Sclerosis Journal Pub Date : 2024-11-01 Epub Date: 2024-10-17 DOI: 10.1177/13524585241287388

Raffaele Palladino, Jeremy Chataway, Mekha Mathew, Azeem Majeed, Ruth Ann Marrie

{"title":"Trajectories and management of vascular risk following the diagnosis of multiple sclerosis: A population-based matched cohort study between 1987 and 2018 in England.","authors":"Raffaele Palladino, Jeremy Chataway, Mekha Mathew, Azeem Majeed, Ruth Ann Marrie","doi":"10.1177/13524585241287388","DOIUrl":"10.1177/13524585241287388","url":null,"abstract":"Background: People with multiple sclerosis (PwMS) have an increased cardiovascular and cerebrovascular disease burden, but this could be mitigated by vascular risk factor management.Objectives: We compared the trajectories of vascular risk factors, vascular comorbidities and clinical management in PwMS against the general population post-MS diagnosis while controlling for frailty.Methods: Retrospective longitudinal analysis using English data from the Clinical Practice Research Datalink between 1987 and 2018 comprising PwMS matched with up to six controls without MS by age, sex and general practice.Results: We compared 12,251 PwMS with 72,572 matched controls; 3.8% of PwMS had mild-moderate frailty, 1.2% more than matched controls. Compared to controls, PwMS had an elevated incidence of Type 2 diabetes (HR 1.18, 95% CI (1.04, 1.34)), and starting antihypertensive medications (HR 1.40, 95% CI (1.33, 1.47)). Among those with hypertension at baseline, blood pressure trajectories did not differ between PwMS and controls. PwMS had increased rates of meeting targets for hypertension management (HR 1.25, 95% CI (1.12, 1.41)).Conclusion: The observation that PwMS with hypertension are more likely to meet treatment targets than matched controls is encouraging, but the elevated rates of vascular comorbidities suggest that tighter vascular management may be needed in this population.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1653-1663"},"PeriodicalIF":5.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical and psychological aspects of multiple sclerosis: Revisiting the Multiple Sclerosis Impact Scale (MSIS-29). 多发性硬化症的生理和心理方面：重新审视多发性硬化症影响量表（MSIS-29）。

IF 5.4 2区医学

Multiple Sclerosis Journal Pub Date : 2024-11-01 Epub Date: 2024-10-30 DOI: 10.1177/13524585241288393

Carolyn A Young, David J Rog, Basil Sharrack, Radu Tanasescu, Seema Kalra, Suresh K Chhetri, Lisa Wilde, Roger J Mills, Alan Tennant

{"title":"Physical and psychological aspects of multiple sclerosis: Revisiting the Multiple Sclerosis Impact Scale (MSIS-29).","authors":"Carolyn A Young, David J Rog, Basil Sharrack, Radu Tanasescu, Seema Kalra, Suresh K Chhetri, Lisa Wilde, Roger J Mills, Alan Tennant","doi":"10.1177/13524585241288393","DOIUrl":"10.1177/13524585241288393","url":null,"abstract":"Background: The MSIS-29 measures the physical and psychological impact of MS.Objective: The associations between MSIS-29 domains and demographic/clinical aspects were examined and trajectories analysed over time.Methods: Data were collected in the Trajectories of Outcome in Neurological Conditions study for a diverse population of people with MS, with follow-up for up to 5 years. Following Rasch analysis, minimal important change (MIC) was computed for ensuing total, physical and psychological domains.Results: Fit to the Rasch model using data from 5921 participants validated physical, psychological and total domains, and the conversion table transforms raw scores to interval-level metric equivalents. These domains showed significant differences across demographic (age, gender, employment, education, and marital status) and clinical (subtype, treatment, and duration) factors with large effect sizes. The MIC scores were physical: 9.1, total: 14.1, which were both above measurement error, and psychological: 5.5 which was not, so 1.6% of participants reported psychological change which was clinically important but not statistically significant. Trajectory analysis showed three groups, one stable and two with significant slopes, improving and deteriorating.Conclusion: The MSIS-29 has shown adequate fit to the Rasch model after accommodating problems with local item dependency, through a bi-factor solution. The domains showed good discrimination across key factors.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1630-1641"},"PeriodicalIF":5.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To halt disease progression rehabilitation in MS should start early: Commentary. 多发性硬化症康复治疗应及早开始，以阻止疾病进展：评论。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-11-01 DOI: 10.1177/13524585241292900

Veronica Popescu

引用次数: 0

Impact of serum neurofilament light on clinical decisions in a tertiary multiple sclerosis clinic. 血清神经丝光对一家三级多发性硬化症诊所临床决策的影响。

IF 5.4 2区医学

Multiple Sclerosis Journal Pub Date : 2024-11-01 Epub Date: 2024-10-17 DOI: 10.1177/13524585241277044

Zoë Ygj van Lierop, Mark Hj Wessels, Womei Ml Lekranty, Bastiaan Moraal, Sam N Hof, Laura Hogenboom, Brigit A de Jong, Nandi Meijs, Liselore A Mensing, Bob W van Oosten, Nik Sol, Zoé LE van Kempen, Lisa Vermunt, Myrthe J Willems, Eva Mm Strijbis, Bernard Mj Uitdehaag, Joep Killestein, Charlotte E Teunissen

{"title":"Impact of serum neurofilament light on clinical decisions in a tertiary multiple sclerosis clinic.","authors":"Zoë Ygj van Lierop, Mark Hj Wessels, Womei Ml Lekranty, Bastiaan Moraal, Sam N Hof, Laura Hogenboom, Brigit A de Jong, Nandi Meijs, Liselore A Mensing, Bob W van Oosten, Nik Sol, Zoé LE van Kempen, Lisa Vermunt, Myrthe J Willems, Eva Mm Strijbis, Bernard Mj Uitdehaag, Joep Killestein, Charlotte E Teunissen","doi":"10.1177/13524585241277044","DOIUrl":"10.1177/13524585241277044","url":null,"abstract":"Background and objectives: Serum neurofilament light (sNfL) is a biomarker for neuro-axonal damage in multiple sclerosis (MS). Clinical implementation remains limited. We investigated the impact of implementation on clinical decisions using questionnaires at the MS Center Amsterdam, a tertiary outpatient clinic.Methods: sNfL assessments were added to routine clinical practice (August 2021-December 2022). Before and after the results, clinicians filled in questionnaires on context of testing, clinical decisions, certainty herein, expectation of magnetic resonance imaging (MRI) activity, urgency, and motivation to receive the sNfL result and perceived value of sNfL.Results: sNfL was assessed in 166 cases (age 41 ± 12 years, 68% female, 64% disease-modifying therapy (DMT) use) for the following contexts: \"DMT monitoring\" (55%), \"new symptoms\" (18%), \"differential diagnosis\" (17%), and \"DMT baseline\" (11%). Clinical decisions changed in 19.3% of cases post-disclosure, particularly in context \"new symptoms\" (38%) and with higher sNfL levels (β = 0.03, p = 0.04). Certainty increased (p = 0.004), while expectation of MRI activity decreased with disclosure of low sNfL levels (p = 0.01). Motivation was highest in context \"differential diagnosis\" (p < 0.001); perceived value and urgency were highest in context \"new symptoms\" (p = 0.02).Conclusion: In this study, sNfL implementation had considerable impact on clinical decision-making and certainty herein. Standard implementation may complement patient care but warrants caution and more exploration in diverse clinical settings.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1620-1629"},"PeriodicalIF":5.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intrathecal immune reactivity against Measles-, Rubella-, and Varicella Zoster viruses is associated with cerebrospinal fluid inflammation in multiple sclerosis. 针对麻疹、风疹和水痘带状疱疹病毒的鞘内免疫反应与多发性硬化症的脑脊液炎症有关。

IF 5.4 2区医学

Multiple Sclerosis Journal Pub Date : 2024-11-01 Epub Date: 2024-10-08 DOI: 10.1177/13524585241279645

Benjamin Vlad, Stephan Neidhart, Marc Hilty, Klara Asplund Högelin, Ina Reichen, Mario Ziegler, Mohsen Khademi, Andreas Lutterotti, Axel Regeniter, Roland Martin, Faiez Al Nimer, Ilijas Jelcic

{"title":"Intrathecal immune reactivity against Measles-, Rubella-, and Varicella Zoster viruses is associated with cerebrospinal fluid inflammation in multiple sclerosis.","authors":"Benjamin Vlad, Stephan Neidhart, Marc Hilty, Klara Asplund Högelin, Ina Reichen, Mario Ziegler, Mohsen Khademi, Andreas Lutterotti, Axel Regeniter, Roland Martin, Faiez Al Nimer, Ilijas Jelcic","doi":"10.1177/13524585241279645","DOIUrl":"10.1177/13524585241279645","url":null,"abstract":"Background/objectives: We aimed to determine in multiple sclerosis (MS) whether intrathecal immunoglobulin G (IgG) production against measles- (M), rubella- (R), and varicella zoster (Z) viruses, which is called MRZ reaction (MRZR) and considered the most specific soluble biomarker for MS, is associated with demographic and basic cerebrospinal fluid (CSF) parameters reflecting inflammation.Methods: We analyzed the presence of positive MRZR and associations with demographic and clinical routine CSF parameters in 513 patients with MS and 182 non-MS patients.Results: Comparing MS patients versus non-MS patients, positive MRZR (38.8% versus 2.2%; specificity 97.8%; positive likelihood ratio, PLR 17.7) had a better specificity and PLR for MS than CSF-specific OCB (89.5% versus 22.0%; specificity 78.0%; PLR 4.1). A positive MRZR in MS patients was associated with female sex (p = 0.0001), pleocytosis (p < 0.0001), higher frequency of presence of plasma cells in CSF (p = 0.0248), normal CSF/serum albumin ratio (p = 0.0005), and intrathecal production of total IgG or CSF-specific OCB (both p < 0.0001), but not with intrathecal production of total IgA or IgM.Conclusions: This study confirms the MRZR as a highly specific marker of MS and shows that MRZR-positive MS patients more frequently are female and show inflammatory changes of basic CSF parameters than MRZR-negative MS patients.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1598-1608"},"PeriodicalIF":5.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum neurofilament light and glial fibrillary acidic protein levels are not associated with wearing-off symptoms in natalizumab-treated multiple sclerosis patients. 纳他珠单抗治疗的多发性硬化症患者血清神经丝蛋白和胶质纤维酸性蛋白水平与消退症状无关。

IF 5.4 2区医学

Multiple Sclerosis Journal Pub Date : 2024-11-01 Epub Date: 2024-11-04 DOI: 10.1177/13524585241293940

Alyssa A Toorop, Mark Hj Wessels, Lynn Boonkamp, Liza My Gelissen, E Hoitsma, Esther Mpe Zeinstra, Luuk C van Rooij, Caspar Ep van Munster, Anke Vennegoor, Jop P Mostert, Beatrijs Ha Wokke, Nynke F Kalkers, Erwin Lj Hoogervorst, Jeroen Jj van Eijk, Christiaan M Roosendaal, Jolijn J Kragt, Marijke Eurelings, Jessie van Genugten, Jessica Nielsen, Lgf Sinnige, Mark E Kloosterziel, Edo Pj Arnoldus, Gert W van Dijk, Willem H Bouvy, Eva Mm Strijbis, Bob W van Oosten, Brigit A de Jong, Bernard Mj Uitdehaag, Theo Rispens, Joep Killestein, Zoé LE van Kempen, Charlotte E Teunissen

{"title":"Serum neurofilament light and glial fibrillary acidic protein levels are not associated with wearing-off symptoms in natalizumab-treated multiple sclerosis patients.","authors":"Alyssa A Toorop, Mark Hj Wessels, Lynn Boonkamp, Liza My Gelissen, E Hoitsma, Esther Mpe Zeinstra, Luuk C van Rooij, Caspar Ep van Munster, Anke Vennegoor, Jop P Mostert, Beatrijs Ha Wokke, Nynke F Kalkers, Erwin Lj Hoogervorst, Jeroen Jj van Eijk, Christiaan M Roosendaal, Jolijn J Kragt, Marijke Eurelings, Jessie van Genugten, Jessica Nielsen, Lgf Sinnige, Mark E Kloosterziel, Edo Pj Arnoldus, Gert W van Dijk, Willem H Bouvy, Eva Mm Strijbis, Bob W van Oosten, Brigit A de Jong, Bernard Mj Uitdehaag, Theo Rispens, Joep Killestein, Zoé LE van Kempen, Charlotte E Teunissen","doi":"10.1177/13524585241293940","DOIUrl":"10.1177/13524585241293940","url":null,"abstract":"Background: Biomarkers of neuronal and axonal damage (serum neurofilament light (sNfL) and serum glial fibrillary acidic protein (sGFAP)) may provide insight into the aetiology of natalizumab wearing-off symptoms (WoSs).Objectives: We investigated the longitudinal association between and predictive value of sNfL and sGFAP and the occurrence of WoS in MS patients treated with natalizumab.Methods: We performed longitudinal measurements of sNfL and sGFAP in NEXT-MS trial participants who completed a questionnaire about WoS.Results: A total of 364 participants were included. In total, 55.5% presented with WoS and 44.5% without WoS during natalizumab treatment. Longitudinal analyses showed no association between sNfL and sGFAP levels and WoS at any timepoint. Biomarker levels at baseline did not predict first-time WoS occurrence.Conclusion: Acute and chronic neuronal and axonal damage are most likely not the underlying cause of WoS.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1683-1688"},"PeriodicalIF":5.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of arterial spin labeling in the diagnosis and monitoring of myelin oligodendrocyte glycoprotein-associated cerebral cortical encephalitis. 评估动脉自旋标记在诊断和监测髓鞘少突胶质细胞糖蛋白相关脑皮质脑炎中的应用。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-10-29 DOI: 10.1177/13524585241291444

Tomoya Shibahara, Kei Yamanaka, Mikiaki Matsuoka, Masaki Tachibana, Junya Kuroda, Hiroshi Nakane

引用次数: 0

Phenotyping in vivo chronic inflammation in multiple sclerosis by combined ¹¹C-PBR28 MR-PET and 7T susceptibility-weighted imaging. 通过联合 11C-PBR28 MR-PET 和 7T 磁感加权成像对多发性硬化症体内慢性炎症进行表型分析。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2024-10-22 DOI: 10.1177/13524585241284157

Constantina A Treaba, Elena Herranz, Valeria T Barletta, Ambica Mehndiratta, Jacob A Sloane, Tobias Granberg, Alessandro Miscioscia, Roberto Bomprezzi, Marco L Loggia, Caterina Mainero

{"title":"Phenotyping in vivo chronic inflammation in multiple sclerosis by combined 11C-PBR28 MR-PET and 7T susceptibility-weighted imaging.","authors":"Constantina A Treaba, Elena Herranz, Valeria T Barletta, Ambica Mehndiratta, Jacob A Sloane, Tobias Granberg, Alessandro Miscioscia, Roberto Bomprezzi, Marco L Loggia, Caterina Mainero","doi":"10.1177/13524585241284157","DOIUrl":"https://doi.org/10.1177/13524585241284157","url":null,"abstract":"Background: 11C-PBR28 positron emission tomography (PET), targeting the translocator protein, and paramagnetic rim lesions (PRL) have emerged as promising imaging markers of MS chronic inflammation. No consensus on which is the optimal marker exists.Objectives: To investigate the ability of 11C-PBR28 PET and PRL assessment to identify chronic inflammation in white matter (WM) MS lesions and their relation to neurological impairment.Methods: Based on 11C-PBR28 uptake, brain WM lesions from 30 MS patients were classified as PET active or inactive. The PRL presence was assessed on 7T phase reconstructions, T1/T2 ratio was calculated to measure WM microstructural integrity.Results: Less than half (44%) of non-PRL WM lesions were active on 11C-PBR28 imaging either throughout the lesion (whole active) or at its periphery. PET peripherally active lesions and PRL did not differ in T1/T2 ratio and 11C-PBR28 uptake. A positive correlation was observed between PRL and active PET lesion count. Whole active PET lesion volume was the strongest predictor (β = 0.97, p < 0.001) of increased Expanded Disability Status Scale scores.Conclusion: 11C-PBR28 imaging reveals more active WM lesions than 7T PRL assessment. Although PRL and PET active lesion counts are related, neurological disability is better explained by PET whole active lesion volume.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"13524585241284157"},"PeriodicalIF":4.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0