Evaluation of the relationship between brainstem lesions and apnea hypopnea index in patients with multiple sclerosis.

IF 5 2区医学 Q1 CLINICAL NEUROLOGY

Multiple Sclerosis Journal Pub Date : 2025-06-01 Epub Date: 2025-03-29 DOI:10.1177/13524585251327875

Elle Levit, Inessa Cohen, Amit Mahajan, Adam Ulano, Erin E Longbrake, Andrew J Solomon

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引用次数: 0

Abstract

Background: Obstructive sleep apnea (OSA) may be more prevalent in people with multiple sclerosis (MS) and previous work suggests possible association with demyelinating brainstem lesions.

Objectives: The objectives of this study were to assess the relationship between demyelinating brainstem lesions in patients with MS referred for polysomnography (PSG) and the severity of the apnea-hypopnea index (AHI).

Methods: A total of 122 people with MS or clinically isolated syndrome (CIS) who underwent PSG due to concern for OSA or hypersomnia at two institutions between 2010 and 2022 were included. AHI was associated with the number of and presence of brainstem demyelinating lesions on magnetic resonance imaging (MRI) obtained within 1 year of PSG after controlling for body mass index (BMI), age, sleep study type, study center, and study year.

Results: Having one brainstem lesion was significantly associated with mildly elevated AHI (5 ⩽ AHI < 15; odds ratio (OR) = 2.71, 95% confidence interval (CI) = 1.29-5.67) and two or more lesions was associated with higher odds of mildly elevated AHI (OR = 3.27, 95% CI = 1.83-5.85) and moderately/severely elevated AHI (AHI > 15; OR = 3.23, 95% CI = 1.91-5.47). The presence of brainstem demyelinating lesion(s) conferred a higher odds of mildly elevated AHI (OR = 3.00, 95% CI = 1.75-5.16) and moderately/severely elevated AHI (OR = 1.65, 95% CI = 1.08-2.52).

Conclusions: These data suggest that brainstem lesions may be associated with elevated AHI in people with MS.

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多发性硬化症患者脑干病变与呼吸暂停低通气指数关系的评价。

背景：阻塞性睡眠呼吸暂停（OSA）可能在多发性硬化症（MS）患者中更为普遍，先前的研究表明其可能与脱髓鞘性脑干病变有关。目的：本研究的目的是评估多发性硬化症患者多导睡眠图（PSG）脱髓鞘性脑干病变与呼吸暂停低通气指数（AHI）严重程度之间的关系。方法：2010年至2022年间，共有122名MS或临床孤立综合征（CIS）患者在两家机构因担心OSA或嗜睡症而接受PSG。在控制体重指数（BMI）、年龄、睡眠、研究类型、研究中心和研究年份后，AHI与PSG 1年内磁共振成像（MRI）上脑干脱髓鞘病变的数量和存在程度相关。结果：单侧脑干病变与AHI轻度升高(5≥AHI 15；Or = 3.23, 95% ci = 1.91-5.47)。脑干脱髓鞘病变的存在使轻度AHI升高（OR = 3.00, 95% CI = 1.75-5.16）和中度/重度AHI升高（OR = 1.65, 95% CI = 1.08-2.52）的几率更高。结论：这些数据表明脑干病变可能与MS患者AHI升高有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Multiple Sclerosis Journal 医学-临床神经学

CiteScore

10.90

自引率

6.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585