Multiple Sclerosis Journal最新文献

Migraines, the multiple sclerosis prodrome, and multiple sclerosis susceptibility.

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-02-19 DOI: 10.1177/13524585251318293

Vinicius A Schoeps, Jessica B Smith, Annette Langer-Gould

{"title":"Migraines, the multiple sclerosis prodrome, and multiple sclerosis susceptibility.","authors":"Vinicius A Schoeps, Jessica B Smith, Annette Langer-Gould","doi":"10.1177/13524585251318293","DOIUrl":"https://doi.org/10.1177/13524585251318293","url":null,"abstract":"Background: Multiple studies identified an association between migraines and multiple sclerosis (MS).Objective: To investigate whether migraines increase MS risk or are part of the MS prodrome.Methods: Incident MS cases and matched controls completed structured interviews that included a detailed headache and MS history. Participants were classified as having migraines if they fulfilled the third edition of the International Classification of Headache Disorders criteria. The association between migraine onset concurrent with or before the first MS symptom/index date was estimated using multivariable logistic regression.Results: Among the 591 MS cases (70.6% females, 42.0% White), 21.2% developed migraines concurrent with or before the onset of MS compared to 18.7% of the 651 controls (70.4% females, 42.1% White, adjusted odds ratio (aOR) = 1.15, 95% confidence interval (CI) = 0.87-1.53). Migraine onset was more likely to occur either concurrently or 1 year before MS symptom onset/index date among MS cases (n = 18, 14.4%) than controls (n = 8, 6.6%; aOR = 2.52, 95% CI = 1.08-5.86, p = 0.032). However, not when restricted to only those with migraine onset before MS onset.Conclusion: Migraine was associated with an increased odds of MS only when co-occurrence was considered. These findings imply that migraines are part of the constellation of MS onset symptoms rather than a risk factor for or prodromal symptom of MS.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"13524585251318293"},"PeriodicalIF":4.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of life is decreased in persons with relapsing-remitting multiple sclerosis experiencing progression independent of relapse activity.

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-02-18 DOI: 10.1177/13524585251318516

Sarah Lindberg, Sofia Sandgren, Markus Axelsson, Igal Rosenstein, Jan Lycke, Lenka Novakova

{"title":"Quality of life is decreased in persons with relapsing-remitting multiple sclerosis experiencing progression independent of relapse activity.","authors":"Sarah Lindberg, Sofia Sandgren, Markus Axelsson, Igal Rosenstein, Jan Lycke, Lenka Novakova","doi":"10.1177/13524585251318516","DOIUrl":"https://doi.org/10.1177/13524585251318516","url":null,"abstract":"Introduction: Reduced quality of life (QoL) is an early feature of multiple sclerosis (MS). The effect of progression independent of relapse activity (PIRA) on QoL is poorly investigated.Objective: To assess the impact of PIRA on QoL using patient-reported outcome measures (PROMs).Methods: In a prospective observational study, 125 newly diagnosed persons with relapsing-remitting MS (PwRRMS) were assessed over 5 years with: EuroQoL-5-Dimension-3-level (EQ-5D-3L), EQ-visual-analogous-scale (EQ-VAS) and 29-item-MS-Impact-Scale (MSIS-29). PwRRMS were dichotomized: PIRA (worsening of expanded disability status scale (EDSS), timed-25-foot-walk or 9-hole-peg-test, independent of relapses) versus non-PIRA. PwRRMS were compared at baseline, year 5 (y5) and delta values (baseline scores subtracted from y5 scores) and annually using linear-mixed-effects-models.Results: At y5, 19.2% had PIRA. PIRA versus non-PIRA PwRRMS were older (p < 0.001). At y5 PIRA PwRRMS had lower EQ-5D-3L (p = 0.001), higher MSIS-29-PHYS (p < 0.001), delta values showed lower EQ-5D-3L (p < 0.001) and EQ-VAS (p = 0.010), higher MSIS-29-PHYS (p = 0.004) and MSIS-29-PSYCH (p = 0.036). Linear-mixed-effects-models showed that, compared to PIRA, non-PIRA PwRRMS had an improvement in QoL: EQ-5D-3L: β = 0.039, p < 0.001; EQ-VAS: β = 2.401, p < 0.001; MSIS-29-PHYS: β = -0.107, p < 0.001; MSIS-29-PSYCH, β = -0.115, p < 0.001, during the 5-year study period.Conclusion: Deteriorating QoL in the early course of relapsing-remitting multiple sclerosis (RRMS) is strongly associated with PIRA. Our results suggest that QoL PROMs should be monitored and recognized as an important aspect of progression.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"13524585251318516"},"PeriodicalIF":4.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of optic neuritis among Afro-descendant, a cohort study.

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-02-18 DOI: 10.1177/13524585251317339

Benoit Bobelna, Quentin Lobjois, Stefana Croitoru, Edmond Jalkh, Eric Ventura, Harold Merle

{"title":"Incidence of optic neuritis among Afro-descendant, a cohort study.","authors":"Benoit Bobelna, Quentin Lobjois, Stefana Croitoru, Edmond Jalkh, Eric Ventura, Harold Merle","doi":"10.1177/13524585251317339","DOIUrl":"https://doi.org/10.1177/13524585251317339","url":null,"abstract":"Background: Optic neuritis (ON) is a multifactorial condition with a strong association with ethnicity.Objectives: We conducted a retrospective cohort study in a Caribbean Island, Martinique, French West Indies to assess the incidence and characteristics of ON among an Afro-descendant (AD) population.Methods: We reviewed medical records of all patients presenting ON at the Fort de France University Hospital, Martinique between 2018 and 2022. We analysed clinical, paraclinical, and biological examinations at onset and during follow-up (6 months, 1, 2 and 3 years). ON was confirmed after a neuro-ophthalmological evaluation according to the latest criteria defined in the Lancet, 2022.Results: Overall, 44 patients with a condition suggestive of ON were evaluated, out of which 29 fulfilled the criteria for ON. The overall incidence was 1.61 (95% CI: 1.12-2.08) per 100,000 person-years. The final diagnosis was distributed as follows: neuromyelitis optica spectrum disorder (NMOSD) (10%), myelin oligodendrocyte glycoprotein (MOG) ON (20%), multiple sclerosis (35%), single isolated ON (24%), relapsing isolated ON (7%) and (4%) unclassified diagnosis.Conclusion: This is the first cohort study assessing the incidence of ON and its characteristics among AD. We found a high proportion of severe disease, such as NMOSD and MOG-associated disease.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"13524585251317339"},"PeriodicalIF":4.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing gait in people with multiple sclerosis using digital data from smartphone sensors: A proposed framework.

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-02-18 DOI: 10.1177/13524585251316242

Angelos Karatsidis, Lorenza Angelini, Matthew Scaramozza, Emmanuel Bartholome, Susanne P Clinch, Changyu Shen, Michael Lindemann, Claudia Mazzà, Alf Scotland, Johan van Beek, Shibeshih Belachew, Licinio Craveiro

{"title":"Characterizing gait in people with multiple sclerosis using digital data from smartphone sensors: A proposed framework.","authors":"Angelos Karatsidis, Lorenza Angelini, Matthew Scaramozza, Emmanuel Bartholome, Susanne P Clinch, Changyu Shen, Michael Lindemann, Claudia Mazzà, Alf Scotland, Johan van Beek, Shibeshih Belachew, Licinio Craveiro","doi":"10.1177/13524585251316242","DOIUrl":"https://doi.org/10.1177/13524585251316242","url":null,"abstract":"Background: Mobility assessment is essential for monitoring disease progression in people with multiple sclerosis (PwMS). Technologies such as wearable sensors show potential for this purpose, but consensus is needed to optimize collection and interpretation of digital measures in PwMS.Objective: To propose a framework for measuring and interpreting key aspects of impaired gait in PwMS using a smartphone worn at the waist level.Methods: The framework was developed on the basis of clinical understanding and knowledge of sensor signal processing, supported by a systematic literature review (SLR). The SLR targeted articles published after 2011 that measured gait characteristics in PwMS. Findings were used to propose standardized definitions for complementary gait domains and define digital measures that should be captured for each domain.Results: The resulting framework for PwMS recommends definitions for pace, rhythm, stability, symmetry, variability, smoothness, complexity and fatigability gait domains. For each domain, a set of digital measures is described with respect to their interpretability and associated caveats.Conclusion: This framework provides recommendations for measuring complex gait patterns in PwMS using widely available technology. This work promotes the use of standardized gait domain definitions and harmonized descriptions of associated digital measures, paving the way for future validation efforts.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"13524585251316242"},"PeriodicalIF":4.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient-reported outcomes of quality of life before and after autologous hematopoietic stem cell transplantation for multiple sclerosis.

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-02-17 DOI: 10.1177/13524585251315363

Ann-Christine Mitrache Desaga, Yassine Noui, Thomas Silfverberg, Kristina Carlson, Joachim Burman

{"title":"Patient-reported outcomes of quality of life before and after autologous hematopoietic stem cell transplantation for multiple sclerosis.","authors":"Ann-Christine Mitrache Desaga, Yassine Noui, Thomas Silfverberg, Kristina Carlson, Joachim Burman","doi":"10.1177/13524585251315363","DOIUrl":"https://doi.org/10.1177/13524585251315363","url":null,"abstract":"Background: Autologous hematopoietic stem cell transplantation (AHSCT) is a therapeutic intervention for multiple sclerosis (MS) that has gained increased attention in the last decade. The impact of this intervention on the quality of life (QoL) of patients with MS remains unclear.Objective: The aim of this study was to investigate the impact of AHSCT on QoL in patients with MS using Multiple Sclerosis Impact Scale (MSIS-29) scores.Methods: In this observational retrospective cohort study, patients with relapsing-remitting MS treated with AHSCT in Sweden from 2004, when the first transplant was performed, until 31 December 2019, were considered for participation. Anonymized outcome data were extracted from the Swedish MS registry in May 2022.Results: Out of 213 patients assessed for eligibility in the study, 96 were included in the final analysis. After a median follow-up of 5.2 (IQR 3.2-6.8) years, 58% improved, 14% remained unchanged and 28% worsened in the physical domain of the MSIS-29. In the psychological domain, 63% improved, 18% remained unchanged and 19% worsened. Improvements in both domains occurred early, within the first year following intervention.Conclusions: Treatment intervention with AHSCT is associated with a clinically meaningful improvement in QoL.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"13524585251315363"},"PeriodicalIF":4.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced childbirth rates in multiple sclerosis from the prodromal phase: Evidence from a population-based cohort study.

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-02-17 DOI: 10.1177/13524585251315077

Cecilia Smith Simonsen, Heidi Øyen Flemmen, Line Broch, Kamilla Brekke, Harald Myklebust, Pål Berg-Hansen, Cathrine Brunborg, Elisabeth Gulowsen Celius

{"title":"Reduced childbirth rates in multiple sclerosis from the prodromal phase: Evidence from a population-based cohort study.","authors":"Cecilia Smith Simonsen, Heidi Øyen Flemmen, Line Broch, Kamilla Brekke, Harald Myklebust, Pål Berg-Hansen, Cathrine Brunborg, Elisabeth Gulowsen Celius","doi":"10.1177/13524585251315077","DOIUrl":"https://doi.org/10.1177/13524585251315077","url":null,"abstract":"Background: The age of multiple sclerosis (MS) onset coincides with fertile age, and both improved prognosis and treatment may influence birth rates in people with MS (pwMS).Objectives: To investigate birth rates over time in pwMS compared with controls.Methods: This cohort study included pwMS from three hospitals in the southeast of Norway. Clinical data were collected prospectively. Statistics Norway provided year of live births and marital status in pwMS and controls matched for age, sex, and place of residence at age 16.Results: We included 1599 pwMS (1118 women with MS (wMS) and 481 men with MS (mMS)) and 23,855 controls. The mean number of live births was 1.5 (standard deviation (SD) 1.2) for pwMS versus 1.8 (SD 1.2) for controls (p < 0.001). Birth rates in wMS declined significantly starting 3 years before onset, with 4.5% giving birth versus 8.4% of controls 2 years before onset (p = 0.046). Birth rates were also lower 1 year after onset (p = 0.002). mMS showed a dip 2 years before onset (p = 0.002), but otherwise had rates similar to controls. There were no differences in marital status.Conclusion: wMS have reduced rates of childbirth compared with controls. This is significant already in the prodromal phase.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"13524585251315077"},"PeriodicalIF":4.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presence of slowly expanding lesions in multiple sclerosis predicts progressive demyelination within lesions and normal-appearing tissue over time.

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-02-14 DOI: 10.1177/13524585251316519

Irene Vavasour, Colm Elliott, Douglas L Arnold, Laura Gaetano, David Clayton, Stefano Magon, Ulrike Bonati, Carrado Bernasconi, Anthony Traboulsee, Shannon Kolind

{"title":"Presence of slowly expanding lesions in multiple sclerosis predicts progressive demyelination within lesions and normal-appearing tissue over time.","authors":"Irene Vavasour, Colm Elliott, Douglas L Arnold, Laura Gaetano, David Clayton, Stefano Magon, Ulrike Bonati, Carrado Bernasconi, Anthony Traboulsee, Shannon Kolind","doi":"10.1177/13524585251316519","DOIUrl":"https://doi.org/10.1177/13524585251316519","url":null,"abstract":"Background: Multiple sclerosis (MS) slowly expanding lesions (SELs) are defined on magnetic resonance imaging (MRI) as contiguous regions of pre-existing focal non-contrast-enhancing T2 lesions with constant and concentric local expansion on conventional T1-weighted and T2-weighted images. SELs are associated with an increased risk of disability progression.Methods: Myelin-related changes detected using myelin water fraction (MWF) and magnetisation transfer ratio (MTR) in SELs and T2 lesions were measured over 192 weeks in participants with relapsing MS.Results: In participants with SELs (SEL+), SELs (MWF: 0.12 ± 0.03, MTR: 33.1 ± 3.6 pu) showed reduced myelin measures at baseline compared to T2 lesions (MWF: 0.13 ± 0.02, MTR: 35.1 ± 2.4 pu). In participants without SELs (SEL-), T2 lesions had higher myelin measures (MWF: 0.15 ± 0.02, MTR: 36.2 ± 2.0 pu) compared to T2 lesions in SEL+. Over 4 years, only SELs showed decreases in MWF (-11.4%). The percentage of abnormal voxels within normal-appearing white matter was higher in SEL+ and increased over time (SEL+ MWF Week 0: 0.56%, Week 192: 0.98%; SEL- MWF Week 0: 0.13%, Week 192: 0.25%).Conclusion: Our results indicate progressive focal and global demyelination in SEL+ participants and that the presence of SELs might be a biomarker for participants with ongoing diffuse or smouldering inflammation within the whole brain.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"13524585251316519"},"PeriodicalIF":4.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aerobic capacity moderates the association between cervical cord atrophy and clinical disability in mildly disabled multiple sclerosis patients.

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-02-14 DOI: 10.1177/13524585251318647

Matteo Albergoni, Paolo Preziosa, Alessandro Meani, Chiara Dallari, Paola Valsasina, Maria A Rocca, Massimo Filippi

{"title":"Aerobic capacity moderates the association between cervical cord atrophy and clinical disability in mildly disabled multiple sclerosis patients.","authors":"Matteo Albergoni, Paolo Preziosa, Alessandro Meani, Chiara Dallari, Paola Valsasina, Maria A Rocca, Massimo Filippi","doi":"10.1177/13524585251318647","DOIUrl":"https://doi.org/10.1177/13524585251318647","url":null,"abstract":"Background: Spinal cord volume loss is associated with clinical disability in multiple sclerosis (MS). Aerobic capacity may mitigate the impact of central nervous system (CNS) damage accumulation, exerting beneficial effects on MS-related disability.Objectives: We investigated whether aerobic capacity could moderate the association between spinal cord atrophy and clinical disability in MS.Methods: In this cross-sectional analysis, expanded disability status scale (EDSS), peak of oxygen consumption (VO2peak), brain volumetric measures, and the normalized mean upper cervical cord area (nMUCCA) were collected from 51 MS patients and 33 healthy controls (HCs). Low aerobic capacity was defined as having a VO2peak z-score less than -1.64 standard deviations. In MS patients, we explored whether the association between nMUCCA and EDSS is moderated by the level of aerobic capacity.Results: The relationship between nMUCCA and EDSS was moderated by aerobic capacity, with a significant nMUCCA × aerobic capacity interaction (β = -0.099, 95% bootstrapped confidence interval [CI] = [-0.172; -0.014], p = 0.012). Lower nMUCCA was significantly associated with higher EDSS score in MS patients with low aerobic capacity (β = -0.073, p < 0.001), but not in those with high aerobic capacity (β = 0.026, p = 0.417).Conclusions: In MS patients with mild disability, higher aerobic capacity can potentially mitigate the negative impact of spinal cord damage on clinical disability.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"13524585251318647"},"PeriodicalIF":4.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurofilament light biomarkers in MS: Effects of extended natalizumab dosing. 多发性硬化症的神经丝光生物标志物：延长纳他珠单抗用药时间的影响。

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-02-11 DOI: 10.1177/13524585251315342

Gloria Dalla Costa, Aiden Haghikia, Ralf Gold, Roberto Furlan, Giancarlo Comi

引用次数: 0

We need to engage representative patients' community rather than "expert patients" to increase impact of research in the era of personalized medicine: NO.

IF 4.8 2区医学

Multiple Sclerosis Journal Pub Date : 2025-02-11 DOI: 10.1177/13524585251315354

Alberto Gajofatto, Michela Rimondini

引用次数: 0