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Multiple Sclerosis Journal最新文献

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Navigating the uncharted-Progressive multifocal leukoencephalopathy in a child with NMOSD treated with rituximab. 利妥昔单抗治疗NMOSD患儿的进展性多灶性脑白质病
IF 5 2区 医学
Multiple Sclerosis Journal Pub Date : 2025-11-01 Epub Date: 2025-04-18 DOI: 10.1177/13524585251331875
Kumaran Deiva
{"title":"Navigating the uncharted-Progressive multifocal leukoencephalopathy in a child with NMOSD treated with rituximab.","authors":"Kumaran Deiva","doi":"10.1177/13524585251331875","DOIUrl":"10.1177/13524585251331875","url":null,"abstract":"","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1608"},"PeriodicalIF":5.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Baló's concentric sclerosis successfully treated with alemtuzumab: Long-term follow-up. Baló的同心硬化成功治疗阿仑单抗：长期随访。
IF 5 2区 医学
Multiple Sclerosis Journal Pub Date : 2025-11-01 Epub Date: 2025-04-12 DOI: 10.1177/13524585251331536
Sandra Elias, Todd A Hardy, Aijaz Khan, Jessica Redgrave, Nigel Hoggard, Stuart Coley, Richard Dyde, Ronan O'Malley, Zeid Yasiry, David Paling
{"title":"Baló's concentric sclerosis successfully treated with alemtuzumab: Long-term follow-up.","authors":"Sandra Elias, Todd A Hardy, Aijaz Khan, Jessica Redgrave, Nigel Hoggard, Stuart Coley, Richard Dyde, Ronan O'Malley, Zeid Yasiry, David Paling","doi":"10.1177/13524585251331536","DOIUrl":"10.1177/13524585251331536","url":null,"abstract":"<p><p>Baló's concentric sclerosis (BCS) is regarded as a rare variant of multiple sclerosis (MS), characterised by multi-layered ring-like lesions in cerebral white matter. Despite pathological overlap with MS, the effect of treatment with MS disease-modifying therapies remains unclear. The only extant case report of alemtuzumab in BCS described a lack of clinical response in a patient who had previously not responded to corticosteroids, plasmapheresis and cyclophosphamide. The authors speculated that alemtuzumab may have been effective if started earlier in the disease process. We present the outcomes of a patient with BCS who responded clinically and radiologically to alemtuzumab over a 6-year follow-up.</p>","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1600-1602"},"PeriodicalIF":5.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treating Balo's concentric sclerosis in the monoclonal antibody era. 单克隆抗体时代治疗Balo同心圆硬化。
IF 5 2区 医学
Multiple Sclerosis Journal Pub Date : 2025-11-01 Epub Date: 2025-04-12 DOI: 10.1177/13524585251331551
Jun-Ichi Kira
{"title":"Treating Balo's concentric sclerosis in the monoclonal antibody era.","authors":"Jun-Ichi Kira","doi":"10.1177/13524585251331551","DOIUrl":"10.1177/13524585251331551","url":null,"abstract":"","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1603-1604"},"PeriodicalIF":5.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A first report of progressive multifocal leukoencephalopathy in childhood-onset NMOSD. 儿童期发病NMOSD中进行性多灶性脑白质病的首次报道。
IF 5 2区 医学
Multiple Sclerosis Journal Pub Date : 2025-11-01 Epub Date: 2025-04-18 DOI: 10.1177/13524585251331855
Pakeeran Siriratnam, Simon Gosling, Maneesh Bhojak, Michael Griffiths, Rachel Kneen, Evangeline Wassmer, Saif Huda
{"title":"A first report of progressive multifocal leukoencephalopathy in childhood-onset NMOSD.","authors":"Pakeeran Siriratnam, Simon Gosling, Maneesh Bhojak, Michael Griffiths, Rachel Kneen, Evangeline Wassmer, Saif Huda","doi":"10.1177/13524585251331855","DOIUrl":"10.1177/13524585251331855","url":null,"abstract":"<p><strong>Background: </strong>Progressive multifocal leukoencephalopathy (PML) has not been reported in pediatric neuromyelitis optica spectrum disorder (NMOSD) and rarely described in children.</p><p><strong>Objectives: </strong>To report a case of PML in childhood-onset NMOSD.</p><p><strong>Methods: </strong>A single retrospective case report.</p><p><strong>Results: </strong>Nine years after diagnosis of aquaporin-4 antibody positive NMOSD, a 17-year-old boy treated with rituximab presented with painless right visual loss over 6 weeks coinciding with CD19 repopulation. Acute relapse treatment was given but he continued to deteriorate, and JC virus was detected in cerebrospinal fluid confirming PML.</p><p><strong>Conclusion: </strong>PML can occur in childhood-onset NMOSD and protracted clinical presentations with unusual radiological features should prompt JCV testing. Balancing effective immunosuppression while mitigating the risks of associated complications in long-term relapsing conditions remains a challenge.</p>","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1604-1607"},"PeriodicalIF":5.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12589659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary on: Acute retinal necrosis associated with dimethyl fumarate. 评论：富马酸二甲酯引起的急性视网膜坏死。
IF 5 2区 医学
Multiple Sclerosis Journal Pub Date : 2025-10-01 Epub Date: 2025-05-04 DOI: 10.1177/13524585251326487
Angela Vidal-Jordana
{"title":"Commentary on: Acute retinal necrosis associated with dimethyl fumarate.","authors":"Angela Vidal-Jordana","doi":"10.1177/13524585251326487","DOIUrl":"10.1177/13524585251326487","url":null,"abstract":"","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1508-1509"},"PeriodicalIF":5.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute retinal necrosis associated with dimethyl fumarate. 富马酸二甲酯引起的急性视网膜坏死。
IF 5 2区 医学
Multiple Sclerosis Journal Pub Date : 2025-10-01 Epub Date: 2025-05-04 DOI: 10.1177/13524585251326475
Christopher Paisey, Karen Curtin, Simon J Epps, Claire M Rice
{"title":"Acute retinal necrosis associated with dimethyl fumarate.","authors":"Christopher Paisey, Karen Curtin, Simon J Epps, Claire M Rice","doi":"10.1177/13524585251326475","DOIUrl":"10.1177/13524585251326475","url":null,"abstract":"<p><strong>Background: </strong>The full range of side effects of disease-modifying treatment for multiple sclerosis (MS) remains to be determined. To date, four serious varicella zoster virus (VZV) infections have been reported in association with dimethyl fumarate (DMF).</p><p><strong>Report: </strong>A 44-year-old man on DMF for relapsing remitting MS presented with monocular pain and visual impairment. Ophthalmological examination revealed panuveitis with arteritis, retinitis and vitritis. Vitreous PCR was positive for VZV confirming the clinical impression of acute retinal necrosis (ARN).</p><p><strong>Discussion: </strong>ARN due to VZV may mimic optic neuritis in people on disease-modifying therapy for MS.</p>","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1506-1508"},"PeriodicalIF":5.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12547032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opportunistic enteroviral infections in MS patients treated with anti-CD20 therapies. 接受抗cd20治疗的MS患者的机会性肠病毒感染。
IF 5 2区 医学
Multiple Sclerosis Journal Pub Date : 2025-09-01 Epub Date: 2025-01-20 DOI: 10.1177/13524585241310395
James A Varley, Nicholas Ws Davies
{"title":"Opportunistic enteroviral infections in MS patients treated with anti-CD20 therapies.","authors":"James A Varley, Nicholas Ws Davies","doi":"10.1177/13524585241310395","DOIUrl":"10.1177/13524585241310395","url":null,"abstract":"","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1262-1263"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of neuromyelitis optica spectrum disorder complicated with aquaporin-4-antibody-associated organizing pneumonia. 视神经脊髓炎伴水通道蛋白-4抗体相关性组织性肺炎1例。
IF 5 2区 医学
Multiple Sclerosis Journal Pub Date : 2025-09-01 Epub Date: 2025-01-06 DOI: 10.1177/13524585241310397
Tomoya Shibahara, Kei Yamanaka, Mikiaki Matsuoka, Masaki Tachibana, Junya Kuroda, Hiroshi Nakane
{"title":"A case of neuromyelitis optica spectrum disorder complicated with aquaporin-4-antibody-associated organizing pneumonia.","authors":"Tomoya Shibahara, Kei Yamanaka, Mikiaki Matsuoka, Masaki Tachibana, Junya Kuroda, Hiroshi Nakane","doi":"10.1177/13524585241310397","DOIUrl":"10.1177/13524585241310397","url":null,"abstract":"<p><p>An 80-year-old man with aquaporin-4-antibody-positive neuromyelitis optica spectrum disorder presented with a 2-week history of cough and hiccups, followed by progressive bilateral lower limb weakness, a bandlike burning sensation in the upper body, and urinary retention. Magnetic resonance imaging showed area postrema and thoracic central medullary lesions. Thorax computed tomography showed bilateral upper lung lobe consolidations. Lung biopsy confirmed organizing pneumonia. Immunohistochemistry of these lesions demonstrated aquaporin-4 loss, immunoglobulin G-binding, and complement deposits, akin to central nervous system lesions found in neuromyelitis optica spectrum disorder. Thus, aquaporin-4-antibodies may be involved in extra-central nervous system manifestations of neuromyelitis optica spectrum disorder.</p>","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1254-1257"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe coxsackie virus B5 encephalitis mimics autoimmune limbic encephalitis in a young woman under long-term B-cell depletion with ocrelizumab: A case report. 严重柯萨奇病毒B5脑炎模拟自身免疫性边缘脑炎在长期使用奥克雷单抗b细胞消耗的年轻女性：一个病例报告。
IF 5 2区 医学
Multiple Sclerosis Journal Pub Date : 2025-09-01 Epub Date: 2025-02-27 DOI: 10.1177/13524585251322327
Jakob Stögbauer, Victoria Schegerer, Fabian K Berger, Walter Schulz-Schaeffer, Klaus Fassbender, Jasmin Naumann, Sigrun Smola, Janina Eisenbeis, Moritz Bewarder, Florian Rosar, Michael Kettner, Thomas Gilcher, Sabine Diedrich, Mathias Fousse
{"title":"Severe coxsackie virus B5 encephalitis mimics autoimmune limbic encephalitis in a young woman under long-term B-cell depletion with ocrelizumab: A case report.","authors":"Jakob Stögbauer, Victoria Schegerer, Fabian K Berger, Walter Schulz-Schaeffer, Klaus Fassbender, Jasmin Naumann, Sigrun Smola, Janina Eisenbeis, Moritz Bewarder, Florian Rosar, Michael Kettner, Thomas Gilcher, Sabine Diedrich, Mathias Fousse","doi":"10.1177/13524585251322327","DOIUrl":"10.1177/13524585251322327","url":null,"abstract":"<p><strong>Background: </strong>B-cell-depleting therapies are increasingly being used to treat autoimmune diseases. Although thousands of patients are and have been treated with these agents, the data are not yet strong enough to identify rare side effects with certainty.</p><p><strong>Methods: </strong>We report the case of a patient undergoing ocrelizumab therapy for relapsing multiple sclerosis who developed a severe limbic syndrome.</p><p><strong>Results: </strong>Autoimmune pathogenesis was initially suspected, with worsening on immunosuppressive therapy. Later, after diagnosis of an enterovirus infection, treatment with ribavirin and favipiravir in combination with intravenous immunoglobulins was initiated. After 4 weeks of therapy, the patient's clinical condition had stabilized with residual cognitive deficits.</p><p><strong>Conclusion: </strong>Diagnosis and treatment of enterovirus infections remain challenging, especially in patients receiving immunosuppressive therapy.</p>","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1258-1261"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurofilament light biomarkers in MS: Effects of extended natalizumab dosing. 多发性硬化症的神经丝光生物标志物：延长纳他珠单抗用药时间的影响。
IF 5 2区 医学
Multiple Sclerosis Journal Pub Date : 2025-09-01 Epub Date: 2025-02-11 DOI: 10.1177/13524585251315342
Gloria Dalla Costa, Aiden Haghikia, Ralf Gold, Roberto Furlan, Giancarlo Comi
{"title":"Neurofilament light biomarkers in MS: Effects of extended natalizumab dosing.","authors":"Gloria Dalla Costa, Aiden Haghikia, Ralf Gold, Roberto Furlan, Giancarlo Comi","doi":"10.1177/13524585251315342","DOIUrl":"10.1177/13524585251315342","url":null,"abstract":"","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1264-1265"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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