Multiple Sclerosis Journal最新文献_第2页

Copy number variation at the complement C4 locus is associated with risk for multiple sclerosis. 补体C4位点的拷贝数变异与多发性硬化症的风险相关。

IF 5 2区医学

Multiple Sclerosis Journal Pub Date : 2025-09-01 Epub Date: 2025-03-15 DOI: 10.1177/13524585251324850

Jacqueline Williams, Wesley M Marin, Kristen J Wade, Rayo Suseno, Kerry Kizer, Stacy Caillier, Danillo G Augusto, Paul J Norman, Jill A Hollenbach

引用次数: 0

A breathtaking case of NMOSD: About pulmonary involvement in patients with AQP4-antibodies. 一个令人震惊的NMOSD病例：关于aqp4抗体患者肺部累及。

IF 5 2区医学

Multiple Sclerosis Journal Pub Date : 2025-09-01 Epub Date: 2025-03-13 DOI: 10.1177/13524585251320923

Romain Marignier

引用次数: 0

Practical issues concerning the use of optical coherence tomography in multiple sclerosis in Latin America: Discussion from 19 centres on behalf of the Foro Latam EM study group. 关于在拉丁美洲多发性硬化症中使用光学相干断层扫描的实际问题：代表Foro Latam EM研究小组来自19个中心的讨论。

IF 5 2区医学

Multiple Sclerosis Journal Pub Date : 2025-09-01 Epub Date: 2025-03-29 DOI: 10.1177/13524585251329159

Ethel Ciampi, Lorena García, Claudia Carcamo, Bernardita Soler, Jefferson Becker, Adriana Carra, Edgar Correa-Díaz, Fernando Cortés, Juan Garcia Bonitto, Carolina Guerra, Miguel Angel Macias, Alejandra Martinez, Nelson Novarro, Linda Rivera-Sarabia, Valeria Rocha, Virginia Rodriguez, Douglas Sato, Judith Steinberg, Irene Treviño Frenk, Guido Vasquez, Luis Peña

{"title":"Practical issues concerning the use of optical coherence tomography in multiple sclerosis in Latin America: Discussion from 19 centres on behalf of the Foro Latam EM study group.","authors":"Ethel Ciampi, Lorena García, Claudia Carcamo, Bernardita Soler, Jefferson Becker, Adriana Carra, Edgar Correa-Díaz, Fernando Cortés, Juan Garcia Bonitto, Carolina Guerra, Miguel Angel Macias, Alejandra Martinez, Nelson Novarro, Linda Rivera-Sarabia, Valeria Rocha, Virginia Rodriguez, Douglas Sato, Judith Steinberg, Irene Treviño Frenk, Guido Vasquez, Luis Peña","doi":"10.1177/13524585251329159","DOIUrl":"10.1177/13524585251329159","url":null,"abstract":"The 2024 McDonald Criteria now include the optic nerve as the fifth topography for dissemination in space. Optical coherence tomography (OCT) is a valuable biomarker for the diagnosis, prognosis and monitoring of multiple sclerosis (MS). A panel of MS neurologists from 19 centres across 9 Latin American (LATAM) countries discussed OCT use, access, standardized protocols and research potential. They found inequities in OCT access between private (80%) and public healthcare (44%). Only 9 centres had standardized protocols, 50% of which followed the OSCAR-IB consensus criteria for retinal OCT quality assessment and 53% had a neuro-ophthalmologist. The panel concluded that OCT should be available in all MS centres and that standardized acquisition and reporting, as well as improved knowledge of OCT use, in clinical practice are necessary. OCT has significant research potential in LATAM that requires further development and implementation.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1141-1146"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Onset Multiple Sclerosis (POMS): Exploring phenotypic characterization and pubertal influences in modulating the disease activity from the Danish MS Registry (DMSR). 儿童发病多发性硬化症（POMS）：从丹麦多发性硬化症登记处（DMSR）探索表型特征和青春期对调节疾病活动的影响。

IF 5 2区医学

Multiple Sclerosis Journal Pub Date : 2025-08-01 Epub Date: 2025-04-28 DOI: 10.1177/13524585251335476

Silvy Pilotto, Luigi Pontieri, Helle Hvilsted Nielsen, Peter Vestergaard Rasmussen, Kristina Bacher Svendsen, Rikke Marie Jensen, Morten Blinkenberg, Anja Thormann, Eleonora Cocco, Maura Pugliatti, Melinda Magyari

{"title":"Pediatric Onset Multiple Sclerosis (POMS): Exploring phenotypic characterization and pubertal influences in modulating the disease activity from the Danish MS Registry (DMSR).","authors":"Silvy Pilotto, Luigi Pontieri, Helle Hvilsted Nielsen, Peter Vestergaard Rasmussen, Kristina Bacher Svendsen, Rikke Marie Jensen, Morten Blinkenberg, Anja Thormann, Eleonora Cocco, Maura Pugliatti, Melinda Magyari","doi":"10.1177/13524585251335476","DOIUrl":"10.1177/13524585251335476","url":null,"abstract":"Background: Pediatric-onset multiple sclerosis (POMS) constitutes ~5% of multiple sclerosis (MS) cases and presents distinct clinical and diagnostic challenges. Puberty, characterized by significant hormonal changes, may influence disease presentation, relapse rates, and long-term outcomes.Objectives: To investigate the impact of pubertal stages on clinical characteristics, relapse activity and disability progression in POMS using data from the Danish MS Registry (DMSR).Methods: A nationwide cohort of 185 POMS patients were included and categorized by pre- (<11 years), peri- (11-14 years), and post-pubertal (>14 years) onset. Demographics, presenting symptoms, magnetic resonance imaging (MRI) findings, relapse rates, and Expanded Disability Status Scale (EDSS) scores were compared. Patients transitioning across the three pubertal stages (n = 54) were analyzed longitudinally for relapse rate.Results: Pre-pubertal onset was associated with severe symptoms (cerebellar involvement, p = 0.042), greater lesion burden, higher 10-year disability (EDSS median = 3.75, p = 0.039), and lower relapse rates (annualized relapse rate (ARR) = 0.200). Male sex reduced relapse rates (p = 0.013). Female-to-male ratio increased from 1:1 pre-puberty to ~2:1 after puberty. Patients with pre-pubertal onset transitioning to peri- or post-puberty showed increasing relapse rates, peaking during peri-puberty (ARR = 0.302).Conclusions: Puberty significantly modulates disease course in POMS, emphasizing the need for early, sex-specific interventions, proactive monitoring, and further exploration of hormonal influences on disease progression and treatment response.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1061-1069"},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy outcomes in adolescent and young adult patients with multiple sclerosis: A case series. 青少年和年轻成人多发性硬化症患者的妊娠结局：一个病例系列。

IF 5 2区医学

Multiple Sclerosis Journal Pub Date : 2025-08-01 Epub Date: 2024-12-07 DOI: 10.1177/13524585241303490

Gina Chang, Sarah Stoney, Sona Narula

引用次数: 0

Outcomes of immunosuppressive therapy discontinuation in patients with myelin oligodendrocyte glycoprotein antibody-associated disease. 髓鞘少突胶质细胞糖蛋白抗体相关疾病患者停止免疫抑制治疗的结果

IF 5 2区医学

Multiple Sclerosis Journal Pub Date : 2025-08-01 Epub Date: 2025-04-28 DOI: 10.1177/13524585251320046

You-Ri Kang, Hyunjin Ju, Ki Hoon Kim, Seung Ho Choo, Woohee Ju, Sung-Min Kim, Sooyoung Kim, Eunhee Sohn, Tai-Seung Nam, Sun-Young Oh, Byeol-A Yoon, Jong Kuk Kim, Hyunjin Kim, Eun-Jae Lee, Young-Min Lim, Young Nam Kwon, Seung Woo Kim, Ha Young Shin, Jee-Eun Kim, In Soo Joo, Minsu Park, Hyung-Soo Lee, Byung-Jo Kim, Jin-Woo Park, Suk Yoon Lee, Woojun Kim, Jae-Won Hyun, Su-Hyun Kim, Ju-Hong Min, Ho Jin Kim

{"title":"Outcomes of immunosuppressive therapy discontinuation in patients with myelin oligodendrocyte glycoprotein antibody-associated disease.","authors":"You-Ri Kang, Hyunjin Ju, Ki Hoon Kim, Seung Ho Choo, Woohee Ju, Sung-Min Kim, Sooyoung Kim, Eunhee Sohn, Tai-Seung Nam, Sun-Young Oh, Byeol-A Yoon, Jong Kuk Kim, Hyunjin Kim, Eun-Jae Lee, Young-Min Lim, Young Nam Kwon, Seung Woo Kim, Ha Young Shin, Jee-Eun Kim, In Soo Joo, Minsu Park, Hyung-Soo Lee, Byung-Jo Kim, Jin-Woo Park, Suk Yoon Lee, Woojun Kim, Jae-Won Hyun, Su-Hyun Kim, Ju-Hong Min, Ho Jin Kim","doi":"10.1177/13524585251320046","DOIUrl":"10.1177/13524585251320046","url":null,"abstract":"Background: Research on the optimal duration of immunosuppressive therapy (IST) and the outcome upon its discontinuation in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) remains limited.Objective: To evaluate the outcomes following IST discontinuation in MOGAD.Methods: This multicenter retrospective study collected data from 333 MOGAD patients in Korea. Among 273 patients who received IST, 41 who discontinued IST were analyzed.Results: The median age at disease onset was 38.3 years (interquartile range (IQR), 27.6-53.1). Before IST withdrawal, 21 (51%) patients exhibited relapsing courses. Over a median follow-up of 23.5 months (IQR, 12.1-39.5) after discontinuation, 10 patients (24.4%) relapsed after a median of 8.2 months (IQR, 6.3-11.5). All relapses occurred in patients with a prior relapsing course (10/21, 47.6%); none with prior monophasic courses relapsed. Among 21 prior relapsing patients, relapse after discontinuation group had a shorter IST duration than non-relapse group (median, 9.4 vs 50.9 months, p = 0.036). None of the 41 patients had severe disability (Expanded Disability Status Scale (EDSS) score ⩾ 4.0 or Visual Functional System score ⩾ 5) at the last visit.Conclusion: IST discontinuation did not necessarily lead to relapse and could be considered with an individualized approach based on factors such as disease course and IST duration.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1102-1109"},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic accuracy of inter-eye difference of ganglion cell layer alone in identifying optic neuritis in multiple sclerosis. 单用神经节细胞层眼间差异诊断多发性硬化症视神经炎的准确性。

IF 5 2区医学

Multiple Sclerosis Journal Pub Date : 2025-08-01 Epub Date: 2025-04-22 DOI: 10.1177/13524585251332895

Nik Krajnc, Fabian Föttinger, Markus Ponleitner, Barbara Kornek, Fritz Leutmezer, Stefan Macher, Paulus Rommer, Christiane Schmied, Karin Zebenholzer, Gudrun Zulehner, Tobias Zrzavy, Thomas Berger, Berthold Pemp, Gabriel Bsteh

{"title":"Diagnostic accuracy of inter-eye difference of ganglion cell layer alone in identifying optic neuritis in multiple sclerosis.","authors":"Nik Krajnc, Fabian Föttinger, Markus Ponleitner, Barbara Kornek, Fritz Leutmezer, Stefan Macher, Paulus Rommer, Christiane Schmied, Karin Zebenholzer, Gudrun Zulehner, Tobias Zrzavy, Thomas Berger, Berthold Pemp, Gabriel Bsteh","doi":"10.1177/13524585251332895","DOIUrl":"10.1177/13524585251332895","url":null,"abstract":"Introduction: The 2024 McDonald criteria for diagnosing multiple sclerosis (MS) include optic nerve involvement as a fifth region for establishing dissemination in space. Optic neuritis (ON) can be detected through optical coherence tomography (OCT) using an inter-eye absolute or percentage difference (IEAD, IEPD) in ganglion cell-inner plexiform layer (GCIPL) thickness.Objective: To compare the diagnostic accuracy of GCIPL IEAD/IEPD with GCL and IPL IEAD/IEPD alone for identifying a history of ON.Methods: This cross-sectional retrospective study included people with MS (pwMS) who underwent an OCT scan. Diagnostic accuracy was assessed using ROC analysis.Results: A total of 241 pwMS (mean age 34.7 years [SD 9.7], 70.1% female) were included. Sixty-eight (28.2%) patients had a documented history of unilateral ON. GCL IEAD (AUC 0.79, cut-off ⩾ 0.06 mm3 or ⩾2µm, 58.9% sensitivity, 85.1% specificity) and IEPD (AUC 0.80, cut-off ⩾ 3%, 48.7% sensitivity, 89.8% specificity) demonstrated excellent diagnostic accuracy for unilateral ON, showing non-inferiority to the established GCIPL IEAD/IEPD.Conclusion: GCL IEAD and IEPD provide strong diagnostic accuracy for identifying unilateral ON and can be effectively used as an alternative to GCIPL IEAD/IEPD to facilitate implementation in clinical routine.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1051-1060"},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health care use preceding pediatric multiple sclerosis: A population-based study from Ontario, Canada. 儿童多发性硬化症前的医疗保健使用：一项来自加拿大安大略省的基于人群的研究。

IF 5 2区医学

Multiple Sclerosis Journal Pub Date : 2025-08-01 Epub Date: 2025-05-23 DOI: 10.1177/13524585251338745

Ruth Ann Marrie, Colleen J Maxwell, Karl Everett, Feng Zhu, Ping Li, Kyla A McKay, Yinshan Zhao, Helen Tremlett

{"title":"Health care use preceding pediatric multiple sclerosis: A population-based study from Ontario, Canada.","authors":"Ruth Ann Marrie, Colleen J Maxwell, Karl Everett, Feng Zhu, Ping Li, Kyla A McKay, Yinshan Zhao, Helen Tremlett","doi":"10.1177/13524585251338745","DOIUrl":"10.1177/13524585251338745","url":null,"abstract":"Background: Investigations of a prodrome in multiple sclerosis (MS) usually have included adults.Objective: To compare rates and reasons for health care use in youth with and without MS, considering time relative to the MS index date and to birth.Methods: This retrospective cohort study used population-based administrative data (1991-2020) from Ontario, Canada. We matched youth (<18 years) with MS up to 5:1 to youth without MS by sex, birth year, region, and duration of observation (full cohorts). Subcohorts had data from birth to MS index date (first demyelinating disease claim). We compared health services use, adjusting for age, sex, area-level income, region, and year.Results: We included 451 individuals with pediatric-onset MS and 1422 without MS. As of 6 years pre-index, the full MS cohort had higher physician services use (year 6: rate ratio (RR) = 1.45; 95% confidence interval (95% CI) = 1.25-1.67) and hospitalizations (RR = 2.79; 95% CI = 1.31-5.94). Findings were similar in subcohorts. The MS subcohort had elevated physician visit rates in early life that rose as the MS index date approached.Discussion: Youth with pediatric-onset MS exhibit increased health care use from birth. Early life may be a risk period for MS. A prodromal phase may emerge 6 years before the onset of typical MS symptoms.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1078-1087"},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment discontinuation in MOGAD: A reassuring step forward. 莫加德停止治疗：令人放心的一步。

IF 5 2区医学

Multiple Sclerosis Journal Pub Date : 2025-08-01 Epub Date: 2025-04-28 DOI: 10.1177/13524585251336891

Yael Hacohen, Romain Marignier

引用次数: 0

Physical activity demonstrates protective associations with structural visual metrics in children with multiple sclerosis through time. 随着时间的推移，体育活动证明与多发性硬化症儿童的结构性视觉指标有保护作用。

IF 5 2区医学

Multiple Sclerosis Journal Pub Date : 2025-08-01 Epub Date: 2025-04-28 DOI: 10.1177/13524585251335510

Samantha Stephens, Nahid Iseyas, E Ann Yeh

{"title":"Physical activity demonstrates protective associations with structural visual metrics in children with multiple sclerosis through time.","authors":"Samantha Stephens, Nahid Iseyas, E Ann Yeh","doi":"10.1177/13524585251335510","DOIUrl":"10.1177/13524585251335510","url":null,"abstract":"Background: Previous work has demonstrated that higher levels of physical activity (PA) are associated with better retinal fiber integrity in children with multiple sclerosis (MS).Objective: To determine whether high PA levels are associated with retinal fiber integrity through time in children with demyelinating disease.Methods: Children with MS or monophasic acquired demyelinating syndromes (mono-ADS) were included. PA level was assessed by questionnaire, and a spectral-domain optical coherence tomography (OCT) scanner determined retinal nerve and ganglion cell inner plexiform fiber layer thickness (RNFL and GCIPL, respectively). Linear mixed models were used to analyze longitudinal associations.Results: Children with MS (n = 28, 20F, mean age 14.6 (standard deviation (SD) ±2.4)) and mono-ADS (n = 24, 11F, mean age 9.5 (SD ±4.5)) took part. In children with MS, RNFL and GCIPL thickness was shown to decline by 1.0 mm (p < 0.05) over time. More active children with MS had thicker GCIPL through time compared to those who were inactive (2.5 mm, p < 0.01). Furthermore, taking part in any strenuous PA was associated with greater RNFL and GCIPL thickness (1.5-2.1 mm, p < 0.05). These differences were not found in children with mono-ADS.Conclusion: Moderate to vigorous PA is associated with better retinal integrity over time in pediatric MS. Future interventions should evaluate whether changes to PA level coincide with changes to retinal integrity in children with MS.","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1070-1077"},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0