评估动脉自旋标记在诊断和监测髓鞘少突胶质细胞糖蛋白相关脑皮质脑炎中的应用。

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Multiple Sclerosis Journal Pub Date : 2024-10-29 DOI:10.1177/13524585241291444

Tomoya Shibahara, Kei Yamanaka, Mikiaki Matsuoka, Masaki Tachibana, Junya Kuroda, Hiroshi Nakane

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引用次数: 0

摘要

髓鞘少突胶质细胞糖蛋白（MOG）相关疾病是中枢神经系统的炎症性脱髓鞘疾病。脑皮质脑炎（CCE）的特点是皮质液减弱反转恢复高密度，伴有癫痫发作和头痛。我们报告了两例 MOG 抗体相关的 CCE（MOG-CCE）病例，在治疗前和治疗后使用序列 MRI 序列（包括动脉自旋标记（ASL））进行了评估。在这两名患者中，ASL 均显示出与疾病活动相关的高灌注，在类固醇治疗后灌注恢复正常。我们的病例凸显了 ASL 在早期检测、监测和评估 MOG-CCE 治疗反应方面的作用。

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Evaluation of arterial spin labeling in the diagnosis and monitoring of myelin oligodendrocyte glycoprotein-associated cerebral cortical encephalitis.

Myelin oligodendrocyte glycoprotein (MOG)-associated disorders are inflammatory demyelinating diseases of the CNS. Cerebral cortical encephalitis (CCE) is characterized by cortical fluid-attenuated inversion recovery hyperintensity with seizures and headaches. We report two cases of MOG antibody-associated CCE (MOG-CCE) evaluated using serial MRI sequences, including arterial spin labeling (ASL), pre- and posttreatment. In both patients, ASL demonstrated hyperperfusion correlating with disease activity, which normalized following steroid therapy. Our cases highlight the usefulness of ASL in early detection, monitoring, and assessment of treatment response in MOG-CCE.

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来源期刊

Multiple Sclerosis Journal 医学-临床神经学

CiteScore

10.90

自引率

6.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585