Molecular Imaging最新文献

{"title":"Use of Innovative SPECT Techniques in the Presurgical Evaluation of Patients with Nonlesional Extratemporal Drug-Resistant Epilepsy.","authors":"Ahmed Yassin,&nbsp;Khalid El-Salem,&nbsp;Abdel-Hameed Al-Mistarehi,&nbsp;Aiman Momani,&nbsp;Anas M Zein Alaabdin,&nbsp;Palak Shah,&nbsp;James Michael Mountz,&nbsp;Anto I Bagić","doi":"10.1155/2021/6614356","DOIUrl":"https://doi.org/10.1155/2021/6614356","url":null,"abstract":"<p><p>Up to 30% of patients with epilepsy may not respond to antiepileptic drugs. Patients with drug-resistant epilepsy (DRE) should undergo evaluation for seizure onset zone (SOZ) localization to consider surgical treatment. Cases of drug-resistant nonlesional extratemporal lobe epilepsy (ETLE) pose the biggest challenge in localizing the SOZ and require multiple noninvasive diagnostic investigations before planning the intracranial monitoring (ICM) or direct resection. Ictal Single Photon Emission Computed Tomography (i-SPECT) is a unique functional diagnostic tool that assesses the SOZ using the localized hyperperfusion that occurs early in the seizure. Subtraction ictal SPECT coregistered to MRI (SISCOM), statistical ictal SPECT coregistered to MRI (STATISCOM), and PET interictal subtracted ictal SPECT coregistered with MRI (PISCOM) are innovative SPECT methods for the determination of the SOZ. This article comprehensively reviews SPECT and sheds light on its vital role in the presurgical evaluation of the nonlesional extratemporal DRE.</p>","PeriodicalId":18855,"journal":{"name":"Molecular Imaging","volume":" ","pages":"6614356"},"PeriodicalIF":2.8,"publicationDate":"2021-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25500988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Experimental Study on [¹²⁵I]I-pHLIP (Var7) for SPECT/CT Imaging of an MDA-MB-231 Triple-Negative Breast Cancer Mouse Model by Targeting the Tumor Microenvironment.","authors":"Mingming Yu,&nbsp;Yanqin Sun,&nbsp;Guangjie Yang,&nbsp;Zhenguang Wang","doi":"10.1155/2021/5565932","DOIUrl":"https://doi.org/10.1155/2021/5565932","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the diagnostic efficacy of MDA-MB-231 triple-negative breast cancer with ¹²⁵I-labeled pHLIP (Var7) by single-photon emission computed tomography/computed tomography (SPECT/CT) imaging.</p><p><strong>Methods: </strong>The binding fraction of [¹²⁵I]I-pHLIP (Var7) and MDA-MB-231 cells was measured at pH 7.4 and pH 6.0, and tumor-bearing mice were subjected to small-animal SPECT/CT imaging studies.</p><p><strong>Results: </strong>At pH = 6.0, the binding fractions of [¹²⁵I]I-pHLIP (Var7) and MDA-MB-231 cells at 10 min, 40 min, 1 h, and 2 h were 1.9 ± 0.1%, 3.5 ± 0.1%, 6.3 ± 0.8%, and 6.6 ± 0.3%, respectively. At pH = 7.4, there was no measured binding between [¹²⁵I]I-pHLIP (Var7) and MDA-MB-231 cells. Small-animal SPECT/CT imaging showed clearly visible tumors at 1 and 2 h after injection.</p><p><strong>Conclusions: </strong>[¹²⁵I]I-pHLIP (Var7) could bind to MDA-MB-231 cells in an acidic environment, and small-animal SPECT/CT imaging showed clear tumors at 1 and 2 h after probe injection.</p>","PeriodicalId":18855,"journal":{"name":"Molecular Imaging","volume":" ","pages":"5565932"},"PeriodicalIF":2.8,"publicationDate":"2021-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25500987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of HER2-Targeted Antibodies for Fluorescence-Guided Surgery in Breast Cancer.","authors":"Solmaz AghaAmiri,&nbsp;Jo Simien,&nbsp;Alastair M Thompson,&nbsp;Julie Voss,&nbsp;Sukhen C Ghosh,&nbsp;Servando Hernandez Vargas,&nbsp;Sarah Kim,&nbsp;Ali Azhdarinia,&nbsp;Hop S Tran Cao","doi":"10.1155/2021/5540569","DOIUrl":"https://doi.org/10.1155/2021/5540569","url":null,"abstract":"<p><strong>Background: </strong>Although therapeutic advances have led to enhanced survival in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer, detection of residual disease remains challenging. Here, we examine two approved anti-HER2 monoclonal antibodies (mAbs), trastuzumab and pertuzumab, as potential candidates for the development of immunoconjugates for fluorescence-guided surgery (FGS).</p><p><strong>Methods: </strong>mAbs were conjugated to the near-infrared fluorescent (NIRF) dye, IRDye800, and for quantitative <i>in vitro</i> assessment, to the radiometal chelator, desferrioxamine, to enable dual labeling with ⁸⁹Zr. <i>In vitro</i> binding was evaluated in HER2-overexpressing (BT474, SKBR3) and HER2-negative (MCF7) cell lines. BT474 and MCF7 xenografts were used for <i>in vivo</i> and <i>ex vivo</i> fluorescence imaging.</p><p><strong>Results: </strong><i>In vitro</i> findings demonstrated HER2-mediated binding for both fluorescent immunoconjugates and were in agreement with radioligand assays using dual-labeled immunoconjugates. <i>In vivo</i> and <i>ex vivo</i> studies showed preferential accumulation of the fluorescently-labeled mAbs in tumors and similar tumor-to-background ratios. <i>In vivo</i> HER2 specificity was confirmed by immunohistochemical staining of resected tumors and normal tissues.</p><p><strong>Conclusions: </strong>We showed for the first time that fluorescent trastuzumab and pertuzumab immunoconjugates have similar NIRF imaging performance and demonstrated the possibility of performing HER2-targeted FGS with agents that possess distinct epitope specificity.</p>","PeriodicalId":18855,"journal":{"name":"Molecular Imaging","volume":" ","pages":"5540569"},"PeriodicalIF":2.8,"publicationDate":"2021-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39126801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Amino Acid PET to Advanced and Emerging MRI Techniques for Neurooncology Imaging: A Systematic Review of the Recent Studies.","authors":"Brittany M Stopa, Csaba Juhász, Sandeep Mittal","doi":"10.1155/2021/8874078","DOIUrl":"10.1155/2021/8874078","url":null,"abstract":"<p><strong>Introduction: </strong>Standard neuroimaging protocols for brain tumors have well-known limitations. The clinical use of additional modalities including amino acid PET (aaPET) and advanced MRI (aMRI) techniques (including DWI, PWI, and MRS) is emerging in response to the need for more accurate detection of brain tumors. In this systematic review of the past 2 years of the literature, we discuss the most recent studies that directly compare or combine aaPET and aMRI for brain tumor imaging.</p><p><strong>Methods: </strong>A PubMed search was conducted for human studies incorporating both aaPET and aMRI and published between July 2018 and August 2020.</p><p><strong>Results: </strong>A total of 22 studies were found in the study period. Recent studies of aaPET with DWI showed a superiority of MET, FET, FDOPA, and AMT PET for detecting tumor, predicting recurrence, diagnosing progression, and predicting survival. Combining modalities further improved performance. Comparisons of aaPET with PWI showed mixed results about spatial correlation. However, both modalities were able to detect high-grade tumors, identify tumor recurrence, differentiate recurrence from treatment effects, and predict survival. aaPET performed better on these measures than PWI, but when combined, they had the strongest results. Studies of aaPET with MRS demonstrated that both modalities have diagnostic potential but MET PET and FDOPA PET performed better than MRS. MRS suffered from some data quality issues that limited analysis in two studies, and, in one study that combined modalities, overall performance actually decreased. Four recent studies compared aaPET with emerging MRI approaches (such as CEST imaging, MR fingerprinting, and SISTINA), but the initial results remain inconclusive.</p><p><strong>Conclusions: </strong>aaPET outperformed the aMRI imaging techniques in most recent studies. DWI and PWI added meaningful complementary data, and the combination of aaPET with aMRI yielded the best results in most studies.</p>","PeriodicalId":18855,"journal":{"name":"Molecular Imaging","volume":" ","pages":"8874078"},"PeriodicalIF":2.2,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39126804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Quantitative Analysis of ¹⁸F-Sodium Fluoride Coronary Imaging.","authors":"Jacek Kwiecinski,&nbsp;Martin Lyngby Lassen,&nbsp;Piotr J Slomka","doi":"10.1155/2021/8849429","DOIUrl":"https://doi.org/10.1155/2021/8849429","url":null,"abstract":"<p><p>¹⁸F-sodium fluoride (¹⁸F-NaF) positron emission tomography (PET) has emerged as a promising noninvasive imaging tool for the assessment of active calcification processes in coronary artery disease. ¹⁸F-NaF uptake colocalizes to high-risk and ruptured atherosclerotic plaques. Most recently, ¹⁸F-NaF coronary uptake was shown to be a robust and independent predictor of myocardial infarction in patients with advanced coronary artery disease. In this review, we provide an overview of the advances in coronary ¹⁸F-NaF imaging. In particular, we discuss the recently developed and validated motion correction techniques which address heart contractions, tidal breathing, and patient repositioning during the prolonged PET acquisitions. Additionally, we discuss a novel quantification approach-the coronary microcalcification activity (which has been inspired by the widely employed method in oncology total active tumor volume measurement). This new method provides a single number encompassing ¹⁸F-NaF activity within the entire coronary vasculature rather than just information regarding a single area of most intense tracer uptake.</p>","PeriodicalId":18855,"journal":{"name":"Molecular Imaging","volume":" ","pages":"8849429"},"PeriodicalIF":2.8,"publicationDate":"2021-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25500990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular MR-Imaging for Noninvasive Quantification of the Anti-Inflammatory Effect of Targeting Interleukin-1β in a Mouse Model of Aortic Aneurysm.","authors":"Julia Brangsch, Carolin Reimann, Jan Ole Kaufmann, Lisa Christine Adams, David Onthank, Christa Thöne-Reineke, Simon Robinson, Marco Wilke, Michael Weller, Rebecca Buchholz, Uwe Karst, Rene Botnar, Bernd Hamm, Marcus Richard Makowski","doi":"10.1177/1536012120961875","DOIUrl":"10.1177/1536012120961875","url":null,"abstract":"<p><strong>Background: </strong>Molecular-MRI is a promising imaging modality for the assessment of abdominal aortic aneurysms (AAAs). Interleukin-1β (IL-1β) represents a new therapeutic tool for AAA-treatment, since pro-inflammatory cytokines are key-mediators of inflammation. This study investigates the potential of molecular-MRI to evaluate therapeutic effects of an anti-IL-1β-therapy on AAA-formation in a mouse-model.</p><p><strong>Methods: </strong>Osmotic-minipumps were implanted in apolipoprotein-deficient-mice (N = 27). One group (Ang-II+01BSUR group, n = 9) was infused with angiotensin-II (Ang-II) for 4 weeks and received an anti-murine IL-1β-antibody (01BSUR) 3 times. One group (Ang-II-group, n = 9) was infused with Ang-II for 4 weeks but received no treatment. Control-group (n = 9) was infused with saline and received no treatment. MR-imaging was performed using an elastin-specific gadolinium-based-probe (0.2 mmol/kg).</p><p><strong>Results: </strong>Mice of the Ang-II+01BSUR-group showed a lower aortic-diameter compared to mice of the Ang-II-group and control mice (p < 0.05). Using the elastin-specific-probe, a significant decrease in elastin-destruction was observed in mice of the Ang-II+01BSUR-group. In vivo MR-measurements correlated well with histopathology (y = 0.34x-13.81, R² = 0.84, p < 0.05), ICP-MS (y = 0.02x+2.39; R² = 0.81, p < 0.05) and LA-ICP-MS. Immunofluorescence and western-blotting confirmed a reduced IL-1β-expression.</p><p><strong>Conclusions: </strong>Molecular-MRI enables the early visualization and quantification of the anti-inflammatory-effects of an IL-1β-inhibitor in a mouse-model of AAAs. Responders and non-responders could be identified early after the initiation of the therapy using molecular-MRI.</p>","PeriodicalId":18855,"journal":{"name":"Molecular Imaging","volume":"19 ","pages":"1536012120961875"},"PeriodicalIF":2.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38624854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[¹¹C]Methionine and [¹¹C]PBR28 as PET Imaging Tracers to Differentiate Metastatic Tumor Recurrence or Radiation Necrosis.","authors":"Thuy T Tran,&nbsp;Jean-Dominique Gallezot,&nbsp;Lucia B Jilaveanu,&nbsp;Christopher Zito,&nbsp;Gabriela Turcu,&nbsp;Keunpoong Lim,&nbsp;Nabeel Nabulsi,&nbsp;Henry Huang,&nbsp;Anita Huttner,&nbsp;Harriet M Kluger,&nbsp;Veronica L Chiang,&nbsp;Richard Carson","doi":"10.1177/1536012120968669","DOIUrl":"https://doi.org/10.1177/1536012120968669","url":null,"abstract":"<p><strong>Purpose: </strong>As stereotactic radiosurgery (SRS) and immunotherapy are increasingly used to treat brain metastases, incidence of radiation necrosis (RN) is consequently rising. Differentiating tumor regrowth (TR) from RN is vital in management but difficult to assess using MRI. We hypothesized that tumor methionine levels would be elevated given increased metabolism and high amino acid uptake, whereas RN would increase inflammation marked by upregulated translocator protein (PBR-TSPO), which can be quantified with specific PET tracers.</p><p><strong>Procedures: </strong>We performed a feasibility study to prospectively evaluate [¹¹C]methionine and [¹¹C]PBR28 using PET in 5 patients with 7 previously SRS-treated brain metastases demonstrating regrowth to differentiate TR from RN.</p><p><strong>Results: </strong>Sequential imaging with dual tracers was well-tolerated. [¹¹C]methionine was accurate for detecting pathologically confirmed TR in 7/7 lesions, whereas [¹¹C]PBR28 was only accurate in 3/7 lesions. Tumor PBR-TSPO expression was elevated in both melanoma and lung cancer cells, contributing to lack of specificity of [¹¹C]PBR28-PET.</p><p><strong>Conclusion: </strong>Sequential use of PET tracers is safe and effective. [¹¹C]Methionine was a reliable TR marker, but [¹¹C]PBR28 was not a reliable marker of RN. Studies are needed to determine the causes of post-radiation inflammation and identify specific markers of RN to improve diagnostic imaging.</p>","PeriodicalId":18855,"journal":{"name":"Molecular Imaging","volume":"19 ","pages":"1536012120968669"},"PeriodicalIF":2.8,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1536012120968669","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38660675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Decade's Progress in the Development of Molecular Imaging Agents Targeting the Growth Hormone Secretagogue Receptor.","authors":"Marina D Childs,&nbsp;Leonard G Luyt","doi":"10.1177/1536012120952623","DOIUrl":"https://doi.org/10.1177/1536012120952623","url":null,"abstract":"<p><p>The growth hormone secretagogue receptor 1a (GHSR), also called the ghrelin receptor, is a G protein-coupled receptor known to play an important metabolic role in the regulation of various physiological processes, including energy expenditure, growth hormone secretion, and cell proliferation. This receptor has been implicated in numerous health issues including obesity, gastrointestinal disorders, type II diabetes, and regulation of body weight in patients with Prader-Willi syndrome, and there has been growing interest in studying its mechanism of behavior to unlock further applications of GHSR-targeted therapeutics. In addition, the GHSR is expressed in various types of cancer including prostate, breast, and testicular cancers, while aberrant expression has been reported in cardiac disease. Targeted molecular imaging of the GHSR could provide insights into its role in biological processes related to these disease states. Over the past decade, imaging probes targeting this receptor have been discovered for the imaging modalities PET, SPECT, and optical imaging. High-affinity analogues of ghrelin, the endogenous ligand for the GHSR, as well as small molecule inhibitors have been developed and evaluated both <i>in vitro</i> and in pre-clinical models. This review provides a comprehensive overview of the molecular imaging agents targeting the GHSR reported to the end of 2019.</p>","PeriodicalId":18855,"journal":{"name":"Molecular Imaging","volume":"19 ","pages":"1536012120952623"},"PeriodicalIF":2.8,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1536012120952623","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38528878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the Outside in: An Overview of Positron Imaging of Plant and Soil Processes.","authors":"Michael P Schmidt,&nbsp;Steven D Mamet,&nbsp;Richard A Ferrieri,&nbsp;Derek Peak,&nbsp;Steven D Siciliano","doi":"10.1177/1536012120966405","DOIUrl":"https://doi.org/10.1177/1536012120966405","url":null,"abstract":"<p><p>Positron-emitting nuclides have long been used as imaging agents in medical science to spatially trace processes non-invasively, allowing for real-time molecular imaging using low tracer concentrations. This ability to non-destructively visualize processes in real time also makes positron imaging uniquely suitable for probing various processes in plants and porous environmental media, such as soils and sediments. Here, we provide an overview of historical and current applications of positron imaging in environmental research. We highlight plant physiological research, where positron imaging has been used extensively to image dynamics of macronutrients, signalling molecules, trace elements, and contaminant metals under various conditions and perturbations. We describe how positron imaging is used in porous soils and sediments to visualize transport, flow, and microbial metabolic processes. We also address the interface between positron imaging and other imaging approaches, and present accompanying chemical analysis of labelled compounds for reviewed topics, highlighting the bridge between positron imaging and complementary techniques across scales. Finally, we discuss possible future applications of positron imaging and its potential as a nexus of interdisciplinary biogeochemical research.</p>","PeriodicalId":18855,"journal":{"name":"Molecular Imaging","volume":"19 ","pages":"1536012120966405"},"PeriodicalIF":2.8,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1536012120966405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38548086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Imaging Windows for Tau PET Imaging Using ¹⁸F-PI2620 in Cognitively Normal Individuals, Mild Cognitive Impairment, and Alzheimer's Disease Patients.","authors":"Chanisa Chotipanich,&nbsp;Monchaya Nivorn,&nbsp;Anchisa Kunawudhi,&nbsp;Chetsadaporn Promteangtrong,&nbsp;Natphimol Boonkawin,&nbsp;Attapon Jantarato","doi":"10.1177/1536012120947582","DOIUrl":"10.1177/1536012120947582","url":null,"abstract":"<p><strong>Background: </strong>The study aimed to evaluate the appropriate uptake-timing in cognitively normal individuals, mild cognitive impairment (MCI), and Alzheimer's disease (AD) patients, using ¹⁸F-PI 2620 dynamic PET acquisition.</p><p><strong>Methods: </strong>Thirty-four MCI patients, 6 AD patients, and 24 cognitively normal individuals were enrolled in this study. A dynamic ¹⁸F-PI 2620 PET study was conducted at 30-75 minutes post-injection in these groups. Co-registration was applied between the dynamic acquisition PET and T1-weighted MRI to delineate various cortical regions. The standardized uptake value ratio (SUVR) was used for quantitative analysis. P-mod software with the Automated Anatomical Labeling (AAL)-merged atlas was employed to generate automatic volumes of interest for 11 brain regions.</p><p><strong>Results: </strong>The curves in most brain regions presented an average SUVR stability at 30-40 minutes post-injection in each group. The appropriate uptake-timing interval of ¹⁸F-PI 2620 was 30-75 minutes post injection for AD group and 30-40 minutes post injection for both cognitively normal individuals and MCI groups.</p><p><strong>Conclusion: </strong>Short uptake time around 30-40 minutes post-injection would be more comfortable and convenient for all patients, especially in those with dementia who were unable to stay motionless for long periods of scanning time in the scanner.</p>","PeriodicalId":18855,"journal":{"name":"Molecular Imaging","volume":"19 ","pages":"1536012120947582"},"PeriodicalIF":2.8,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1536012120947582","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38325157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}