水解酶的PET和SPECT分子成像。

IF 2.2 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

Molecular Imaging Pub Date : 2017-01-01 DOI:10.1177/1536012117717852

Brian P Rempel, Eric W Price, Christopher P Phenix

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引用次数: 19

摘要

水解酶是一大类生物催化剂，在维持人体健康所需的大量关键生化过程中起着至关重要的作用。然而，这些重要酶的表达和/或活性可以在许多不同的疾病中发生变化，因此代表了开发正电子发射断层扫描(PET)和单光子发射计算机断层扫描(SPECT)放射性示踪剂的令人兴奋的目标。本文综述了近年来报道的用于水解酶成像的PET和SPECT示踪剂的放射性标记底物、可逆抑制剂和不可逆抑制剂。通过学习最成功的水解酶示踪剂开发的例子，似乎早期关注仔细的酶动力学和基于细胞的研究是确定潜在有用的新分子显像剂的关键因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Molecular Imaging of Hydrolytic Enzymes Using PET and SPECT.

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Molecular Imaging of Hydrolytic Enzymes Using PET and SPECT.

Hydrolytic enzymes are a large class of biological catalysts that play a vital role in a plethora of critical biochemical processes required to maintain human health. However, the expression and/or activity of these important enzymes can change in many different diseases and therefore represent exciting targets for the development of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) radiotracers. This review focuses on recently reported radiolabeled substrates, reversible inhibitors, and irreversible inhibitors investigated as PET and SPECT tracers for imaging hydrolytic enzymes. By learning from the most successful examples of tracer development for hydrolytic enzymes, it appears that an early focus on careful enzyme kinetics and cell-based studies are key factors for identifying potentially useful new molecular imaging agents.

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来源期刊

Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology

自引率

3.60%

发文量

期刊介绍： Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.