“设计用于增强MRI的交联透明质酸纳米颗粒(cHANPs)的微流控平台”评论。

IF 2.2 4区 医学 Q3 BIOCHEMICAL RESEARCH METHODS
Maria Russo, Paolo Bevilacqua, Paolo Antonio Netti, Enza Torino
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引用次数: 10

摘要

最近,磁共振成像(MRI)用钆(Gd)基造影剂(CAs)的弛豫特性增强策略在诊断领域产生了强烈的影响,而不需要对其进行化学修饰。我们利用二乙基三胺五乙酸钆(Gd-DTPA)和透明质酸的水凝胶结构之间的相互作用,设计了35纳米的交联透明质酸纳米颗粒,用于MRI应用。所提出的生物制剂能够控制CAs的弛豫特性,从而提高T1的弛豫速率。我们的研究结果使我们确定这种方法是一种可调节的方案,可以设计血管内注射的水凝胶纳米颗粒包裹Gd-DTPA。这种方法克服了临床批准的ca松弛性差和毒性作用的一般缺点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Commentary on "A Microfluidic Platform to Design Crosslinked Hyaluronic Acid Nanoparticles (cHANPs) for Enhanced MRI".

Commentary on "A Microfluidic Platform to Design Crosslinked Hyaluronic Acid Nanoparticles (cHANPs) for Enhanced MRI".

Strategies to enhance the relaxometric properties of gadolinium (Gd)-based contrast agents (CAs) for magnetic resonance imaging (MRI), without the chemical modification of chelates, have recently had a strong impact on the diagnostic field. We have taken advantage of the interaction between Gadolinium diethylenetriamine penta-acetic acid (Gd-DTPA) and the hydrogel structure of hyaluronic acid to design cross-linked hyaluronic acid nanoparticles down to 35 nm for use in MRI applications. The proposed bioformulations enable the control of the relaxometric properties of CAs, thus boosting the relaxation rate of T1. Our results led us to identify this approach as an adjustable scenario to design intravascularly injectable hydrogel nanoparticles entrapping Gd-DTPA. This approach overcomes the general drawbacks of clinically approved CAs having poor relaxivity and toxic effects.

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来源期刊
Molecular Imaging
Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology
自引率
3.60%
发文量
21
期刊介绍: Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.
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