68ga -柠檬酸PET成像肝细胞癌:首次临床经验。

IF 2.2 4区 医学 Q3 BIOCHEMICAL RESEARCH METHODS
Carina Mari Aparici, Spencer C Behr, Youngho Seo, R Kate Kelley, Carlos Corvera, Kenneth T Gao, Rahul Aggarwal, Michael J Evans
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引用次数: 7

摘要

虽然计算机断层成像(CT)和磁共振成像是诊断肝细胞癌(HCC)的主要方法,但它们对这种分子异质性疾病提供的生物学见解很少。核成像工具可以检测肿瘤的分子亚群,可以极大地改善HCC的诊断和治疗。为此,我们进行了一项患者研究,以确定是否可以使用68ga -柠檬酸正电子发射断层扫描(PET)来解决HCC。1例复发性HCC患者注射300 MBq柠檬酸68ga,注射249分钟后PET/CT成像。14个肝脏病变中有4个(28%)对68ga -柠檬酸盐敏感。一肝外病变未见PET显像。病变的平均最大标准化摄取值(SUVmax)为7.2(范围:6.2-8.4),正常肝实质的SUVmax为4.7,血池的SUVmax为5.7。剧烈病变并不明显大于静止病变,并且先前的CT对比显示病变之间均匀增强,表明肿瘤信号是由于放射性示踪剂与转铁蛋白受体的特异性结合,而不是肿瘤微环境中的血管增强。需要在更大的患者队列中进行进一步的研究,以验证放射性示踪剂摄取的分子基础和该工具的临床应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Imaging Hepatocellular Carcinoma With <sup>68</sup>Ga-Citrate PET: First Clinical Experience.

Imaging Hepatocellular Carcinoma With <sup>68</sup>Ga-Citrate PET: First Clinical Experience.

Imaging Hepatocellular Carcinoma With <sup>68</sup>Ga-Citrate PET: First Clinical Experience.

Imaging Hepatocellular Carcinoma With 68Ga-Citrate PET: First Clinical Experience.

While cross-sectional imaging with computed tomography (CT) and magnetic resonance imaging is the primary method for diagnosing hepatocellular carcinoma (HCC), they provide little biological insight into this molecularly heterogeneous disease. Nuclear imaging tools that can detect molecular subsets of tumors could greatly improve diagnosis and management of HCC. To this end, we conducted a patient study to determine whether HCC can be resolved using 68Ga-citrate positron emission tomography (PET). One patient with recurrent HCC was injected with 300 MBq of 68Ga-citrate and imaged with PET/CT 249 minutes post injection. Four (28%) of 14 hepatic lesions were avid for 68Ga-citrate. One extrahepatic lesion was not PET avid. The average maximum standardized uptake value (SUVmax) for the lesions was 7.2 (range: 6.2-8.4), while the SUVmax of the normal liver parenchyma was 4.7 and blood pool was 5.7. The avid lesions were not significantly larger than the quiescent lesions, and a prior contrast CT showed uniform enhancement among the lesions, suggesting that tumor signals are due to specific binding of the radiotracer to the transferrin receptor, rather than enhanced vascularity in the tumor microenvironment. Further studies are required in a larger patient cohort to verify the molecular basis of radiotracer uptake and the clinical utility of this tool.

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来源期刊
Molecular Imaging
Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology
自引率
3.60%
发文量
21
期刊介绍: Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.
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