Molecular Brain最新文献_第3页

Correction: The properties of TREM1 and its emerging role in pain-related diseases. 更正：TREM1的特性及其在疼痛相关疾病中的新作用。

IF 3.3 3区医学

Molecular Brain Pub Date : 2025-03-20 DOI: 10.1186/s13041-025-01193-y

Zhenzhen Fan, Longde Wang, Songtang Sun, Zhaoming Ge

引用次数: 0

The terpenes alpha-bisabolol and camphene modulate pruritus via an action on Cav3.2 T-type calcium channels. 萜烯-双abolol和camphene通过作用于Cav3.2 t型钙通道来调节瘙痒。

IF 3.3 3区医学

Molecular Brain Pub Date : 2025-03-18 DOI: 10.1186/s13041-025-01196-9

Flavia T T Antunes, Vinicius M Gadotti, Gerald W Zamponi

{"title":"The terpenes alpha-bisabolol and camphene modulate pruritus via an action on Cav3.2 T-type calcium channels.","authors":"Flavia T T Antunes, Vinicius M Gadotti, Gerald W Zamponi","doi":"10.1186/s13041-025-01196-9","DOIUrl":"10.1186/s13041-025-01196-9","url":null,"abstract":"Alpha-bisabolol and camphene have demonstrated analgesic effects in inflammatory pain models by blocking Cav3.2 calcium channels. As the pain pathway overlaps with mechanisms for itch, and because Cav3.2 channels have been associated with itch in our previous work, we aimed to investigate the potential anti-itch effects of these two terpenes. Although both terpenes failed to show anti-pruritogenic properties when dissolved in aqueous PBS, when diluted in Hydroxypropyl-beta-cyclodextrin their bioactivity significantly increased. Both compounds significantly reduced scratching in the histaminergic itch model, whether administered subcutaneously or intraperitoneally. Camphene reduced itching in the non-histaminergic model regardless of the route of administration, whereas alpha-bisabolol did not alleviate chloroquine-induced itching. When tested in Cav3.2-/- mice, neither camphene nor alpha-bisabolol significantly reduced histamine-induced scratching behavior. This suggests that the anti-pruritic actions of these terpenes may involve Cav3.2 block to mitigate itch.","PeriodicalId":18851,"journal":{"name":"Molecular Brain","volume":"18 1","pages":"22"},"PeriodicalIF":3.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The psychedelic psilocybin and light exposure have similar and synergistic effects on gene expression patterns in the visual cortex. 迷幻药裸盖菇素和光照对视觉皮层的基因表达模式有相似的协同作用。

IF 3.3 3区医学

Molecular Brain Pub Date : 2025-03-18 DOI: 10.1186/s13041-025-01191-0

Ram Harari, Dmitriy Getselter, Evan Elliott

{"title":"The psychedelic psilocybin and light exposure have similar and synergistic effects on gene expression patterns in the visual cortex.","authors":"Ram Harari, Dmitriy Getselter, Evan Elliott","doi":"10.1186/s13041-025-01191-0","DOIUrl":"10.1186/s13041-025-01191-0","url":null,"abstract":"Psilocybin, a psychedelic compound found in specific hallucinogenic mushrooms, is known to induce changes in visual perception and experience in humans. However, there is little knowledge of the molecular mechanisms through which psilocybin affects vision-associated regions in the brain, such as the visual cortex. The current study determined both psilocybin-induced and experience-dependent changes (exposure to light) in visual cortex gene expression in mice. Of great interest, psilocybin induced robust gene expression changes in the visual cortex that closely mirror light-induced gene expression changes, even when the mice are kept in the dark. These gene expression changes correspond to specific molecular pathways, including synaptic functioning, and represent genes expressed in specific subtypes of neurons. In addition, exposure to both psilocybin and light induced synergetic changes in genes involved in epigenetic programming. Overall, the study determined that psilocybin induces robust changes in gene expression in the visual cortex that may have functional consequences in visual perception both in the absence and in synergy with visual experience.","PeriodicalId":18851,"journal":{"name":"Molecular Brain","volume":"18 1","pages":"23"},"PeriodicalIF":3.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moderate ethanol exposure disrupts energy homesotasis between central and peripheral system in APP/PS1 mice. 中度乙醇暴露破坏APP/PS1小鼠中枢和外周系统之间的能量稳态。

IF 3.3 3区医学

Molecular Brain Pub Date : 2025-03-17 DOI: 10.1186/s13041-025-01192-z

Shinwoo Kang, Jeyeon Lee, Paul H Min, Doo-Sup Choi

引用次数: 0

Analysis of neurexin-neuroligin complexes supports an isoform-specific role for beta-neurexin-1 dysfunction in a mouse model of autism. 神经素-神经素复合物的分析支持自闭症小鼠模型中β -神经素-1功能障碍的异构体特异性作用。

IF 3.3 3区医学

Molecular Brain Pub Date : 2025-03-14 DOI: 10.1186/s13041-025-01183-0

Francisco Arias-Aragón, Estefanía Robles-Lanuza, Ángela Sánchez-Gómez, Amalia Martinez-Mir, Francisco G Scholl

{"title":"Analysis of neurexin-neuroligin complexes supports an isoform-specific role for beta-neurexin-1 dysfunction in a mouse model of autism.","authors":"Francisco Arias-Aragón, Estefanía Robles-Lanuza, Ángela Sánchez-Gómez, Amalia Martinez-Mir, Francisco G Scholl","doi":"10.1186/s13041-025-01183-0","DOIUrl":"10.1186/s13041-025-01183-0","url":null,"abstract":"Neurexins are presynaptic plasma membrane proteins that regulate key aspects of synapse physiology through the formation of transcellular complexes with postsynaptic ligands, including neuroligins (Nlgns). Each neurexin gene (NRXN1-3) generates two main alternative-spliced transcripts that generate alpha and beta-Nrxn isoforms differing in their extracellular domains. Mutations in NRXN1 are associated with autism and other neurodevelopmental disorders. However, whether dysfunction of NRXN1 occurs through common or isoform-specific postsynaptic partners for alpha- and beta-Nrxn1 is not completely known. The association of Nrxn1 proteins with postsynaptic partners has been mostly analysed in experiments that test binding, but Nrxn proteins must interact with Nlgns in opposing cells, which requires transcellular oligomerization. Here, we studied the interactions of Nrxn1/Nlgn pairs across the synapse and identified the type of association affected in a mouse model of autism. We found that beta-Nrxn1 can be recruited at synaptic contacts by glutamatergic Nlgn1 and GABAergic Nlgn2, whereas alpha-Nrxn1 is a presynaptic partner of Nlgn2. Insertion of alternative spliced segment 4 (AS4) negatively modulates the presynaptic recruitment of Nrxn1 by Nlgns. These data obtained in transcellular assays help clarify previous knowledge based on the ability of Nrxn1 to bind to Nlgns. Interestingly, we found that a mutant beta-Nrxn1 shows ligand restriction for glutamatergic Nlgn1 in the brain of a mouse model of autism. These findings suggest that autism-associated mutations affecting beta-Nrxn1 can act through specific synaptic partners that may be different from those of its alpha-Nrxn1 counterparts.","PeriodicalId":18851,"journal":{"name":"Molecular Brain","volume":"18 1","pages":"20"},"PeriodicalIF":3.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virally mediated expression of a biologically active peptide to restrain the nuclear functions of ERK1/2 attenuates learning extinction but not acquisition. 通过病毒介导表达具有生物活性的多肽来抑制ERK1/2的核功能，可减轻学习的消退，但不会影响习得。

IF 3.3 3区医学

Molecular Brain Pub Date : 2025-03-14 DOI: 10.1186/s13041-025-01190-1

Bar Izkovich, Adonis Yiannakas, Sapir Ne'eman, Sailendrakumar Kolatt Chandran, Kobi Rosenblum, Efrat Edry

{"title":"Virally mediated expression of a biologically active peptide to restrain the nuclear functions of ERK1/2 attenuates learning extinction but not acquisition.","authors":"Bar Izkovich, Adonis Yiannakas, Sapir Ne'eman, Sailendrakumar Kolatt Chandran, Kobi Rosenblum, Efrat Edry","doi":"10.1186/s13041-025-01190-1","DOIUrl":"10.1186/s13041-025-01190-1","url":null,"abstract":"Peptide drug technologies offer powerful approaches to develop potent and selective lead molecules for therapeutic and research applications. However, new and optimized delivery approaches are necessary to overcome current pitfalls including fast degradation in cells and tissue. Extracellular signal-regulated kinases 1/2 (ERK1/2) exemplifies proteins that play crucial and varied roles within distinct cellular compartments. Here, we established an innovative method, based on viral vectors, which utilizes the endogenous biogenesis of neurotrophins to deliver and express a biologically active peptide to attenuate specifically ERK1/2 nuclear functions in specific brain area of the adult forebrain. In contrast to our hypothesis, nuclear functions of ERK1/2 in the forebrain are fundamental for the extinction of associative-aversive memories, but not for acquisition, nor for retrieval of these memories. Our research demonstrates the feasibility and applicability of viral vectors to deliver a peptide of interest to manipulate specific molecular processes and/or protein interactions in specific tissue.","PeriodicalId":18851,"journal":{"name":"Molecular Brain","volume":"18 1","pages":"19"},"PeriodicalIF":3.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct neural responses of ventromedial prefrontal cortex-projecting nucleus reuniens neurons during aversive memory extinction. 腹内侧前额叶皮层突出的团聚核神经元在厌恶记忆消退过程中的不同神经反应。

IF 3.3 3区医学

Molecular Brain Pub Date : 2025-03-05 DOI: 10.1186/s13041-025-01185-y

Yuki Mochizuki, Asuka Joji-Nishino, Kazuo Emoto, Akira Uematsu

{"title":"Distinct neural responses of ventromedial prefrontal cortex-projecting nucleus reuniens neurons during aversive memory extinction.","authors":"Yuki Mochizuki, Asuka Joji-Nishino, Kazuo Emoto, Akira Uematsu","doi":"10.1186/s13041-025-01185-y","DOIUrl":"10.1186/s13041-025-01185-y","url":null,"abstract":"Animals adaptively regulate aversive memories in safe environments through extinction, a process central to exposure therapy for anxiety disorders. The limbic thalamus controls cognitive function in concert with interconnected cortical and limbic structures. Though medial prefrontal (mPFC) afferents to the limbic thalamus regulate aversive memory, the functional role of limbic thalamus efferents to mPFC is unclear. Here, we investigated the roles of thalamic nuclei, the reuniens (RE) and mediodorsal (MD) thalamus, projecting to the medial prefrontal cortex (mPFC) in aversive memory conditioning and extinction in male mice. Using retrograde tracing, we demonstrated that ventromedial PFC (vmPFC)- and dorsomedial PFC (dmPFC)-projecting neurons are topologically segregated within the RE and MD. Fiber photometry revealed that both RE→vmPFC and MD→vmPFC neurons respond to aversive stimuli. Notably, RE→vmPFC neurons develop shock-associated cue (CS+) response during aversive conditioning. During extinction, RE→vmPFC neurons exhibited a biphasic response to CS+, while MD→vmPFC neurons showed no cue-evoked activity. Neither optogenetic activation nor inactivation of these populations altered freezing behavior during extinction compared to controls. Collectively, these findings indicate that RE→vmPFC neurons encode aversive cue information during extinction but are dispensable for behavioral modulation. This study highlights the distinct contributions of limbic thalamus-PFC circuits to aversive memory processing.","PeriodicalId":18851,"journal":{"name":"Molecular Brain","volume":"18 1","pages":"18"},"PeriodicalIF":3.3,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quercetin carbon quantum dots: dual-target therapy for intracerebral hemorrhage in mice. 槲皮素碳量子点：治疗小鼠脑内出血的双靶点疗法。

IF 3.3 3区医学

Molecular Brain Pub Date : 2025-03-03 DOI: 10.1186/s13041-024-01159-6

Guangyu Jia, Xinyu Yang, Yamei Yu, Yuanyuan Li, Zhe Zhang, Xiaolong Tang, Qi Wang, Heqing Zheng, Yao Xiao, Shiyong Li, Ye Wang

引用次数: 0

Extinction of contextual fear memory is facilitated in TRPM2 knockout mice. TRPM2基因敲除小鼠促进了情境恐惧记忆的消失。

IF 3.3 3区医学

Molecular Brain Pub Date : 2025-02-27 DOI: 10.1186/s13041-025-01181-2

Seung Yeon Ko, Do Gyeong Kim, Huiju Lee, Sung Jun Jung, Hyeon Son

{"title":"Extinction of contextual fear memory is facilitated in TRPM2 knockout mice.","authors":"Seung Yeon Ko, Do Gyeong Kim, Huiju Lee, Sung Jun Jung, Hyeon Son","doi":"10.1186/s13041-025-01181-2","DOIUrl":"10.1186/s13041-025-01181-2","url":null,"abstract":"Transient receptor potential melastatin type 2 (TRPM2) is a nonselective cation channel involved in synaptic plasticity. We investigated its role in contextual fear conditioning and extinction of conditioned fear using Trpm2-deficient (Trpm2-/-) mice. Trpm2-/- mice exhibited reduced acquisition of contextual fear memory during conditioning but had an intact freezing response to conditioning context 24 h after conditioning. They also showed a reduced freezing response to extinction training, indicating facilitated extinction. Consistent with this, infusion of flufenamic acid (FFA), a TRPM2 antagonist, into the dentate gyrus (DG) of the hippocampus in fear-conditioned mice facilitated extinction of contextual fear. The enhanced extinction in Trpm2-/- and FFA-treated mice was associated with down-regulation of immediate-early genes (IEGs) including Npas4, c-Fos, Arc and Egr1 in the hippocampus after extinction training. Our results indicate that TRPM2 plays a positive role in retention of contextual fear memory by modulating neuronal activity in the hippocampus, and suggest that TRPM2 activity could potentially be targeted to strengthen extinction-based exposure therapies for post-traumatic stress disorder (PTSD).","PeriodicalId":18851,"journal":{"name":"Molecular Brain","volume":"18 1","pages":"16"},"PeriodicalIF":3.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The properties of TREM1 and its emerging role in pain-related diseases. TREM1的特性及其在疼痛相关疾病中的新作用

IF 3.3 3区医学

Molecular Brain Pub Date : 2025-02-26 DOI: 10.1186/s13041-025-01187-w

Zhenzhen Fan, Longde Wang, Songtang Sun, Zhaoming Ge

引用次数: 0