TREM1的特性及其在疼痛相关疾病中的新作用

IF 3.3 3区医学 Q2 NEUROSCIENCES

Molecular Brain Pub Date : 2025-02-26 DOI:10.1186/s13041-025-01187-w

Zhenzhen Fan, Longde Wang, Songtang Sun, Zhaoming Ge

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引用次数: 0

摘要

TREM1受体是trem家族的一员，由骨髓细胞表达，是炎症反应的启动者或增强者，在炎症调节中起关键作用。近年来，研究发现trem1介导的炎症反应参与疼痛相关疾病的调控。本文就TREM1在疼痛疾病中的结构特征和分布模式、配体、信号通路、抑制剂和病理生理作用等方面进行综述，旨在进一步阐明其生物学功能，并为针对疼痛相关疾病的临床干预提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The properties of TREM1 and its emerging role in pain-related diseases.

The TREM1 receptor, a member of the TREMs family, is expressed by myeloid cells and functions as an initiator or enhancer of the inflammatory response, playing a pivotal role in the regulation of inflammation. In recent years, it has been found that TREM1-mediated inflammatory response is involved in the regulation of pain-related diseases. This article provides an extensive review on the structural characteristics and distribution patterns, ligand, signaling pathways, inhibitors, and pathophysiological roles of TREM1 in pain disorders aiming to further elucidate its biological function and offer novel insights for clinical interventions targeting pain-related diseases.

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来源期刊

Molecular Brain NEUROSCIENCES-

CiteScore

7.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Molecular Brain is an open access, peer-reviewed journal that considers manuscripts on all aspects of studies on the nervous system at the molecular, cellular, and systems level providing a forum for scientists to communicate their findings. Molecular brain research is a rapidly expanding research field in which integrative approaches at the genetic, molecular, cellular and synaptic levels yield key information about the physiological and pathological brain. These studies involve the use of a wide range of modern techniques in molecular biology, genomics, proteomics, imaging and electrophysiology.