中度乙醇暴露破坏APP/PS1小鼠中枢和外周系统之间的能量稳态。

IF 3.3 3区医学 Q2 NEUROSCIENCES

Molecular Brain Pub Date : 2025-03-17 DOI:10.1186/s13041-025-01192-z

Shinwoo Kang, Jeyeon Lee, Paul H Min, Doo-Sup Choi

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引用次数: 0

摘要

为了研究适度乙醇暴露对早发性阿尔茨海默病（AD）小鼠模型APP/PS1小鼠葡萄糖代谢的影响，我们采用了氟脱氧葡萄糖(FDG)-微正电子发射断层扫描（PET）。我们还利用综合实验动物监测系统（CLAMS）测量全身能量消耗和呼吸交换率（RER）。我们发现，通过FDG-PET测量，乙醇暴露增加了大脑中的葡萄糖代谢。此外，CLAMS数据显示RER下降，表明脂肪利用作为主要能量来源的转变。在APP/PS1小鼠中暴露乙醇后，这些发现揭示了脑和外周组织之间明显的代谢差异。

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Moderate ethanol exposure disrupts energy homesotasis between central and peripheral system in APP/PS1 mice.

To investigate the effects of moderate ethanol exposure on glucose metabolism in APP/PS1 mice, an early-onset Alzheimer's disease (AD) mouse model, we employed an fluoro-deoxy-glucose (FDG)-micro-positron emission tomography (PET). We also utilized the comprehensive lab animal monitoring system (CLAMS) to measure whole-body energy expenditure and respiratory exchange ratio (RER). We found that ethanol exposure increased glucose metabolism in the brain as measured by FDG-PET. Also, CLAMS data indicated a decrease in RER, suggesting a shift toward fat utilization as the primary energy source. Following ethanol exposure in APP/PS1 mice, these findings reveal a distinct metabolic difference between brain and peripheral tissues.

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来源期刊

Molecular Brain NEUROSCIENCES-

CiteScore

7.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Molecular Brain is an open access, peer-reviewed journal that considers manuscripts on all aspects of studies on the nervous system at the molecular, cellular, and systems level providing a forum for scientists to communicate their findings. Molecular brain research is a rapidly expanding research field in which integrative approaches at the genetic, molecular, cellular and synaptic levels yield key information about the physiological and pathological brain. These studies involve the use of a wide range of modern techniques in molecular biology, genomics, proteomics, imaging and electrophysiology.