Moderate ethanol exposure disrupts energy homesotasis between central and peripheral system in APP/PS1 mice.

IF 3.3 3区医学 Q2 NEUROSCIENCES

Molecular Brain Pub Date : 2025-03-17 DOI:10.1186/s13041-025-01192-z

Shinwoo Kang, Jeyeon Lee, Paul H Min, Doo-Sup Choi

引用次数: 0

Abstract

To investigate the effects of moderate ethanol exposure on glucose metabolism in APP/PS1 mice, an early-onset Alzheimer's disease (AD) mouse model, we employed an fluoro-deoxy-glucose (FDG)-micro-positron emission tomography (PET). We also utilized the comprehensive lab animal monitoring system (CLAMS) to measure whole-body energy expenditure and respiratory exchange ratio (RER). We found that ethanol exposure increased glucose metabolism in the brain as measured by FDG-PET. Also, CLAMS data indicated a decrease in RER, suggesting a shift toward fat utilization as the primary energy source. Following ethanol exposure in APP/PS1 mice, these findings reveal a distinct metabolic difference between brain and peripheral tissues.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Molecular Brain NEUROSCIENCES-

CiteScore

7.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Molecular Brain is an open access, peer-reviewed journal that considers manuscripts on all aspects of studies on the nervous system at the molecular, cellular, and systems level providing a forum for scientists to communicate their findings. Molecular brain research is a rapidly expanding research field in which integrative approaches at the genetic, molecular, cellular and synaptic levels yield key information about the physiological and pathological brain. These studies involve the use of a wide range of modern techniques in molecular biology, genomics, proteomics, imaging and electrophysiology.