Nature reviews. Chemistry最新文献_第8页

On the aqueous origins of the condensation polymers of life 生命缩合聚合物的水性起源。

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-09-27 DOI: 10.1038/s41570-024-00648-5

Daniel Whitaker, Matthew W. Powner

{"title":"On the aqueous origins of the condensation polymers of life","authors":"Daniel Whitaker, Matthew W. Powner","doi":"10.1038/s41570-024-00648-5","DOIUrl":"10.1038/s41570-024-00648-5","url":null,"abstract":"Water is essential for life as we know it, but it has paradoxically been considered inimical to the emergence of life. Proteins and nucleic acids have sustained evolution and life for billions of years, but both are condensation polymers, suggesting that their formation requires the elimination of water. This presents intrinsic challenges at the origins of life, including how condensation polymer synthesis can overcome the thermodynamic pressure of hydrolysis in water and how nucleophiles can kinetically outcompete water to yield condensation products. The answers to these questions lie in balancing thermodynamic activation and kinetic stability. For peptides, an effective strategy is to directly harness the energy trapped in prebiotic molecules, such as nitriles, and avoid the formation of fully hydrolysed monomers. In this Review, we discuss how chemical energy can be built into precursors, retained, and released selectively for polymer synthesis. Looking to the future, the outstanding goals include how nucleic acids can be synthesized, avoiding the formation of fully hydrolysed monomers and what caused information to flow from nucleic acids to proteins. Water is essential for life but paradoxically considered detrimental to the origins of life. Here, we discuss whether avoiding hydrolysed monomers and exploiting the chemical energy in prebiotic precursors may hold the missing key to unlocking biopolymer synthesis.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 11","pages":"817-832"},"PeriodicalIF":38.1,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The current utility and future potential of multiborylated alkanes 多溴化烷烃的当前用途和未来潜力

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-09-26 DOI: 10.1038/s41570-024-00650-x

Kane A. C. Bastick, Dean D. Roberts, Allan J. B. Watson

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Reviving antibiotic power 重振抗生素威力

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-09-24 DOI: 10.1038/s41570-024-00655-6

Sammer Marzouk, Dang Nguyen, Cameron Sabet

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The Not Voodoo website after twenty dynamic years Not Voodoo 网站历经二十年的蓬勃发展。

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-09-24 DOI: 10.1038/s41570-024-00644-9

Alison J. Frontier

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A zwitterionic twist 齐聚物转折

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-09-23 DOI: 10.1038/s41570-024-00654-7

Sihan Xiong, Khalid Shah, Chuang Liu

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Student partnerships for sustainable change 促进可持续变革的学生伙伴关系

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-09-20 DOI: 10.1038/s41570-024-00653-8

Glenn A. Hurst

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Organic chemistry for kids 儿童有机化学

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-09-09 DOI: 10.1038/s41570-024-00647-6

Arismel Tena Meza, Laura G. Wonilowicz, Neil K. Garg

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Molecular complexity as a driving force for the advancement of organic synthesis 分子复杂性是推动有机合成发展的动力

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-09-09 DOI: 10.1038/s41570-024-00645-8

Brandon A. Wright, Richmond Sarpong

{"title":"Molecular complexity as a driving force for the advancement of organic synthesis","authors":"Brandon A. Wright, Richmond Sarpong","doi":"10.1038/s41570-024-00645-8","DOIUrl":"10.1038/s41570-024-00645-8","url":null,"abstract":"The generation of molecular complexity is a primary goal in the field of synthetic chemistry. In the context of retrosynthetic analysis, the concept of molecular complexity is central to identifying productive disconnections and the development of efficient total syntheses. However, this field-defining concept is frequently invoked on an intuitive basis without precise definition or appreciation of its subtleties. Methods for quantifying molecular complexity could prove useful for characterizing the state of synthesis in a more rigorous, reliable and reproducible fashion. As a first step to evaluating the importance of these methods to the state of the field, here we present our perspective on the development of molecular complexity quantification and its implications for chemical synthesis. The extension and application of these methods beyond computer-aided synthesis planning and medicinal chemistry to the traditional practice of ‘complex molecule’ synthesis could have the potential to unearth new opportunities and more efficient approaches for synthesis. Quantifying molecular complexity has the potential to enhance retrosynthetic analysis and, thus, aid the development of efficient total syntheses. This Perspective discusses methods for rigorous, reproducible complexity measurement, highlighting their potential to revolutionize traditional complex molecule synthesis and uncover new synthetic opportunities.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 10","pages":"776-792"},"PeriodicalIF":38.1,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142160386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Conformational control over proton-coupled electron transfer in metalloenzymes 金属酶中质子耦合电子转移的构象控制。

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-09-02 DOI: 10.1038/s41570-024-00646-7

Saman Fatima, Lisa Olshansky

{"title":"Conformational control over proton-coupled electron transfer in metalloenzymes","authors":"Saman Fatima, Lisa Olshansky","doi":"10.1038/s41570-024-00646-7","DOIUrl":"10.1038/s41570-024-00646-7","url":null,"abstract":"From the reduction of dinitrogen to the oxidation of water, the chemical transformations catalysed by metalloenzymes underlie global geochemical and biochemical cycles. These reactions represent some of the most kinetically and thermodynamically challenging processes known and require the complex choreography of the fundamental building blocks of nature, electrons and protons, to be carried out with utmost precision and accuracy. The rate-determining step of catalysis in many metalloenzymes consists of a protein structural rearrangement, suggesting that nature has evolved to leverage macroscopic changes in protein molecular structure to control subatomic changes in metallocofactor electronic structure. The proton-coupled electron transfer mechanisms operative in nitrogenase, photosystem II and ribonucleotide reductase exemplify this interplay between molecular and electronic structural control. We present the culmination of decades of study on each of these systems and clarify what is known regarding the interplay between structural changes and functional outcomes in these metalloenzyme linchpins. Rate-limiting conformational changes often gate the formation of catalytically active metalloenzyme states. We review examples of the interplay between macroscopic changes in protein molecular structure and subatomic changes in metallocofactor electronic structure that together enable precision control over nature’s redox machines.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 10","pages":"762-775"},"PeriodicalIF":38.1,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Non-equilibrium self-assembly for living matter-like properties 非平衡自组装实现类生命物质特性

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-08-23 DOI: 10.1038/s41570-024-00640-z

Abhishek Singh, Payel Parvin, Bapan Saha, Dibyendu Das

{"title":"Non-equilibrium self-assembly for living matter-like properties","authors":"Abhishek Singh, Payel Parvin, Bapan Saha, Dibyendu Das","doi":"10.1038/s41570-024-00640-z","DOIUrl":"10.1038/s41570-024-00640-z","url":null,"abstract":"The soft and wet machines of life emerged as the spatially enclosed ensemble of biomolecules with replicating capabilities integrated with metabolic reaction cycles that operate at far-from-equilibrium. A thorough step-by-step synthetic integration of these elements, namely metabolic and replicative properties all confined and operating far-from-equilibrium, can set the stage from which we can ask questions related to the construction of chemical-based evolving systems with living matter-like properties — a monumental endeavour of systems chemistry. The overarching concept of this Review maps the discoveries on this possible integration of reaction networks, self-reproduction and compartmentalization under non-equilibrium conditions. We deconvolute the events of reaction networks and transient compartmentalization and extend the discussion towards self-reproducing systems that can be sustained under non-equilibrium conditions. Although enormous challenges lie ahead in terms of molecular diversity, information transfer, adaptation and selection that are required for open-ended evolution, emerging strategies to generate minimal metabolic cycles can extend our growing understanding of the chemical emergence of the biosphere of Earth. The origins of complex life forms from simple chemicals remain one of the most enigmatic mysteries. This Review explores how non-equilibrium chemical-based systems can exhibit living matter-like properties with an outlook that connects the possibility of diversification, adaptation and evolution.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 10","pages":"723-740"},"PeriodicalIF":38.1,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142045632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0