Gillian M. Cadden, Claudia Caltagirone, Jennifer Leigh, Emily R. Draper
{"title":"Growing pains","authors":"Gillian M. Cadden, Claudia Caltagirone, Jennifer Leigh, Emily R. Draper","doi":"10.1038/s41570-026-00814-x","DOIUrl":"10.1038/s41570-026-00814-x","url":null,"abstract":"To write this article, the authors, members of the International Women in Supramolecular Chemistry (WISC) network surveyed colleagues who care for older children about the challenges of integrating that role with their academic careers.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 4","pages":"233-234"},"PeriodicalIF":51.7,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthetic methodologies for the chemical recycling of fluorocarbons","authors":"Shannon E. S. Farley, Mark R. Crimmin","doi":"10.1038/s41570-026-00813-y","DOIUrl":"10.1038/s41570-026-00813-y","url":null,"abstract":"Fluorochemicals are ubiquitous in modern life. Despite their importance, current approaches to manufacture fluorochemicals are linear and fluorine-containing products tend to be single-use, causing environmental and ecosystem damage on disposal. In this Review, we describe synthetic methods that harvest fluoride (F–) from fluorocarbons and deliver it to other molecules through either transfer fluorination or fluoride shuttling. We also summarize related approaches, transfer hydrofluorination and HF shuttling in which hydrogen fluoride (HF) is generated in situ from one fluorocarbon and used to prepare another, along with recent breakthroughs in fluoroalkene cross-metathesis. Our focus is on reactions that can be applied to industrially relevant fluorochemicals, namely refrigerants and fluoropolymers. We provide insight into the mechanisms that break and remake carbon–fluorine bonds as part of linear reaction sequences or catalytic manifolds. Limitations of the current methodologies are highlighted, and opportunities for future developments are discussed. The fluorochemical industry is extensive, but fundamentally unsustainable. In this Review, we highlight synthetic methods for recycling fluorocarbons, with a focus on methods that can be applied for industrially relevant fluorochemicals including refrigerants and fluoropolymers.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 4","pages":"277-287"},"PeriodicalIF":51.7,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mapping a career in electron microscopy","authors":"Paul A. Midgley, Stephanie Greed","doi":"10.1038/s41570-026-00816-9","DOIUrl":"10.1038/s41570-026-00816-9","url":null,"abstract":"Ahead of his 60th birthday, Paul A. Midgley, Professor of Materials Science at the University of Cambridge, discussed his life in science.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 4","pages":"235-236"},"PeriodicalIF":51.7,"publicationDate":"2026-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147492955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peter A. Reinhardt, Samuella B. Sigmann, Leah R. McEwen, Ellen M. Cox, Grace Baysinger, Anna L. Dunn, Kang Chen, Adelina Voutchkova-Kostal
{"title":"Enhancing chemical safety information for the future","authors":"Peter A. Reinhardt, Samuella B. Sigmann, Leah R. McEwen, Ellen M. Cox, Grace Baysinger, Anna L. Dunn, Kang Chen, Adelina Voutchkova-Kostal","doi":"10.1038/s41570-026-00808-9","DOIUrl":"10.1038/s41570-026-00808-9","url":null,"abstract":"The safe manufacture, transport and use of chemicals — in short, the entire chemistry enterprise — depends on high-quality chemical safety information. That information must be accurate, audience-appropriate, comprehensive and based on data derived from research. The globally harmonized system of classification and labelling has standardized how chemical hazards are determined by manufacturers and then communicated to users through the use of labels and safety data sheets, but it has not been globally adopted. To lower risk to acceptable levels, users of chemicals rely on authoritative information to complete risk assessments. Safety data sheets are important tools, but they are merely a starting point for the risk assessment process — they can be insufficiently detailed, poorly curated and difficult to search. There is also an unrealistic expectation that users have the appropriate competencies to apply the information to risk-based safety principles such as RAMP (recognize hazards, assess risks, minimize risks and prepare for emergencies). The primary emphasis of this article is to raise awareness of persistent challenges with accessing and applying chemical safety information and to present a call to action for key stakeholders and expert groups to address these issues. High-quality chemical safety information is essential, but information is often fragmented, inconsistent and incomplete. As a result, users face unrealistic expectations in applying risk-based principles. This article highlights persistent challenges and urges stakeholders to improve access, accuracy and application of chemical safety data.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 4","pages":"288-304"},"PeriodicalIF":51.7,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quantum sieving from thermal desorption","authors":"Sibo Chetry","doi":"10.1038/s41570-026-00815-w","DOIUrl":"10.1038/s41570-026-00815-w","url":null,"abstract":"Sibo Chetry explains how an ultrahigh-vacuum chamber with a cryostat and temperature-controlled sample stage can be used for quantum sieving by thermal desorption of an isotopic mixture.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 4","pages":"237-237"},"PeriodicalIF":51.7,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peihong Tong, Ruolan Wang, Yang Zhou, Yuanyuan Liu, Xiaoqiang Chen, Tony D. James, Mingle Li, Xiaojun Peng
{"title":"Enhancing the targeting ability of metal–organic frameworks in cancer therapy and diagnosis","authors":"Peihong Tong, Ruolan Wang, Yang Zhou, Yuanyuan Liu, Xiaoqiang Chen, Tony D. James, Mingle Li, Xiaojun Peng","doi":"10.1038/s41570-026-00807-w","DOIUrl":"10.1038/s41570-026-00807-w","url":null,"abstract":"In cancer diagnosis and treatment, ‘accurate diagnosis’ and ‘targeted therapy’ are the primary focus and key goals of many research groups. Metal–organic frameworks (MOFs) have attracted considerable attention in cancer diagnosis and treatment owing to their structural diversity and multifunctionality. Starting in 2010, MOFs with targeting capabilities have been gradually developed and applied in the field of biomedicine. This Review provides readers with a simple guide to help design bioenabled MOFs for specific bioapplications. First, construction strategies of MOFs with targeting functions are classified, including non-covalent interaction, covalent interaction and coordinative interaction strategies. Then, the applications of MOFs modified by antibodies, peptides, aptamers, carbohydrates, cell membranes and other targeting strategies are discussed. Finally, the future challenges and prospects for constructing MOFs with targeting functionalities are outlined to provide guidelines for the next generation of MOFs capable of achieving accurate cancer diagnosis and treatment and to accelerate the development of MOFs in clinical applications. This Review introduces methods for enhancing the targeting ability of metal–organic frameworks (MOFs), reviews their applications when modified with different types of targeting molecules and provides guidance for the next-generation MOFs to achieve accurate cancer diagnosis and treatment.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 4","pages":"258-276"},"PeriodicalIF":51.7,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond ligase logic for proteolysis","authors":"Yudong Song, Xinyi Jiang","doi":"10.1038/s41570-026-00810-1","DOIUrl":"10.1038/s41570-026-00810-1","url":null,"abstract":"Direct recruitment of target proteins is a ubiquitination-independent approach for protein degradation and provides an alternative approach to proteolysis-targeting chimeras (PROTACs) for targeted protein degradation.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 4","pages":"240-241"},"PeriodicalIF":51.7,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Matter in ångström-scale two-dimensional confinement","authors":"Mingzhan Wang \u0000 (, ), Jian Jiang \u0000 (, ), Changxiong Huang \u0000 (, ), Wenjun Zhang \u0000 (, ), Xiao Cheng Zeng \u0000 (, )","doi":"10.1038/s41570-026-00805-y","DOIUrl":"10.1038/s41570-026-00805-y","url":null,"abstract":"Matter exhibits strikingly different structures and behaviours in strongly confined spaces compared with its bulk form. These differences become particularly pronounced when the confinement is reduced to the ångström scale, comparable with the characteristic size of atoms, ions and molecules. Advances in layered two-dimensional (2D) materials — including both van der Waals and non-van-der-Waals materials — have enabled the precise fabrication of ångström-scale 2D confinement systems, opening a new frontier for investigating matter properties and mass transport at this extreme scale. In this Review, we summarize the methods used for precisely fabricating such confined systems, the novel structural transformations of matter that arise and their associated physicochemical properties, and the unique molecular and ionic transport phenomena observed and their underlying mechanisms. We also critically assess the knowledge gaps, technological implications and untapped potential of this burgeoning field. Under confinement, matter shows different structures and behaviours, which are particularly pronounced at the ångström scale. This Review focuses on the new structures and properties of matter under such ångström-scale 2D confinement.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 4","pages":"243-257"},"PeriodicalIF":51.7,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Catalytic droplets","authors":"Tomohiro Nobeyama","doi":"10.1038/s41570-026-00812-z","DOIUrl":"10.1038/s41570-026-00812-z","url":null,"abstract":"A recent study showed peptides could self-assemble into catalytic droplets that could promote an aqueous aldol addition. This approach provides a proof of concept example of a droplet working as a reaction field to accelerate chemical reactions.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 4","pages":"242-242"},"PeriodicalIF":51.7,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tumour microenvironment in the surgical spotlight","authors":"Dang Nguyen, Peter R. Meinig","doi":"10.1038/s41570-026-00809-8","DOIUrl":"10.1038/s41570-026-00809-8","url":null,"abstract":"Surgical tumour removal is often hindered by unclear margins. A recent study has developed a ‘spray on’ fluorescent probe system that rapidly stains and highlights tumour edges, enabling high contrast, real time margin detection that can be used directly in the surgical field.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 4","pages":"238-239"},"PeriodicalIF":51.7,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147383316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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