分子复杂性是推动有机合成发展的动力

IF 38.1 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Brandon A. Wright, Richmond Sarpong
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引用次数: 0

摘要

生成分子复杂性是合成化学领域的首要目标。在逆合成分析中,分子复杂性的概念对于识别生产性断裂和开发高效的全合成至关重要。然而,这一定义领域的概念经常被直观地引用,而没有精确的定义或对其微妙之处的理解。量化分子复杂性的方法将有助于以更严谨、可靠和可重复的方式描述合成状态。作为评估这些方法对该领域现状的重要性的第一步,我们在此介绍我们对分子复杂性量化的发展及其对化学合成的影响的看法。将这些方法从计算机辅助合成规划和药物化学推广应用到传统的 "复杂分子 "合成实践中,有可能发现新的机遇和更有效的合成方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Molecular complexity as a driving force for the advancement of organic synthesis

Molecular complexity as a driving force for the advancement of organic synthesis

Molecular complexity as a driving force for the advancement of organic synthesis
The generation of molecular complexity is a primary goal in the field of synthetic chemistry. In the context of retrosynthetic analysis, the concept of molecular complexity is central to identifying productive disconnections and the development of efficient total syntheses. However, this field-defining concept is frequently invoked on an intuitive basis without precise definition or appreciation of its subtleties. Methods for quantifying molecular complexity could prove useful for characterizing the state of synthesis in a more rigorous, reliable and reproducible fashion. As a first step to evaluating the importance of these methods to the state of the field, here we present our perspective on the development of molecular complexity quantification and its implications for chemical synthesis. The extension and application of these methods beyond computer-aided synthesis planning and medicinal chemistry to the traditional practice of ‘complex molecule’ synthesis could have the potential to unearth new opportunities and more efficient approaches for synthesis. Quantifying molecular complexity has the potential to enhance retrosynthetic analysis and, thus, aid the development of efficient total syntheses. This Perspective discusses methods for rigorous, reproducible complexity measurement, highlighting their potential to revolutionize traditional complex molecule synthesis and uncover new synthetic opportunities.
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来源期刊
Nature reviews. Chemistry
Nature reviews. Chemistry Chemical Engineering-General Chemical Engineering
CiteScore
52.80
自引率
0.80%
发文量
88
期刊介绍: Nature Reviews Chemistry is an online-only journal that publishes Reviews, Perspectives, and Comments on various disciplines within chemistry. The Reviews aim to offer balanced and objective analyses of selected topics, providing clear descriptions of relevant scientific literature. The content is designed to be accessible to recent graduates in any chemistry-related discipline while also offering insights for principal investigators and industry-based research scientists. Additionally, Reviews should provide the authors' perspectives on future directions and opinions regarding the major challenges faced by researchers in the field.
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