Nature reviews. Chemistry最新文献

Coupling experiment and theory to push the state-of-the-art in X-ray spectroscopy 结合实验与理论推动x射线光谱学的发展

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2025-05-30 DOI: 10.1038/s41570-025-00718-2

Zachary Mathe, Dimitrios Maganas, Frank Neese, Serena DeBeer

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引用次数: 0

Decoupling sequence and structure 解耦序列与结构

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2025-05-29 DOI: 10.1038/s41570-025-00726-2

Chuanliu Wu

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Molecular synthesis with gaseous fragment ions on surfaces 表面有气体碎片离子的分子合成

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2025-05-29 DOI: 10.1038/s41570-025-00719-1

Jonas Warneke, Hugo Y. Samayoa-Oviedo, Markus Rohdenburg, Xilai Li, Harald Knorke, Julia Laskin

引用次数: 0

The story of a structural sage 一个建筑圣人的故事

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2025-05-29 DOI: 10.1038/s41570-025-00731-5

Brian Kobilka, Stephanie Greed

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Fear the worst, smell the best. 怕最坏，闻最好。

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2025-05-19 DOI: 10.1038/s41570-025-00727-1

Stephanie Greed

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Rings make more room 戒指能腾出更多空间

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2025-05-15 DOI: 10.1038/s41570-025-00723-5

Anna K. Patterson

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Element sets for schools 学校元素集

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2025-05-14 DOI: 10.1038/s41570-025-00724-4

Stuart R. Batten

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The role and structure of molecular glues in plant signalling networks 分子胶在植物信号网络中的作用和结构

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2025-05-12 DOI: 10.1038/s41570-025-00717-3

Fidel Lozano-Elena, Sebastian Wendeborn

{"title":"The role and structure of molecular glues in plant signalling networks","authors":"Fidel Lozano-Elena, Sebastian Wendeborn","doi":"10.1038/s41570-025-00717-3","DOIUrl":"https://doi.org/10.1038/s41570-025-00717-3","url":null,"abstract":"Protein–protein interactions are one of the pillars of all life processes. Many signalling molecules work by promoting and stabilizing these interactions. These molecular ‘glues’ bind simultaneously to two proteins inducing their interaction, which would be otherwise less favourable or non-favourable. Importantly, they can be harnessed for a clinical purpose, but, despite advances in medicine, the wealth of natural molecular glues in plants have only rarely been commercially utilized. These molecular glues may be plant-endogenous or plant-exogenous small molecules or peptides, and they may be involved in many different processes, such as growth promotion or stress response, opening new opportunities for crop protection, along with other applications. In this Review, we analyse the underlying structural motives and molecular interactions in detail, classifying the modes of actions based on their nature (small ligands versus peptides) and receptor classes. We discuss both natural metabolites and mimetics of such compounds, highlighting similarities and differences between signalling pathways and comparing them with relevant mechanisms in mammals.<figure></figure>","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"1 1","pages":""},"PeriodicalIF":36.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Terahertz calorimetry spotlights the role of water in biological processes. 太赫兹量热法强调了水在生物过程中的作用。

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2025-05-09 DOI: 10.1038/s41570-025-00712-8

Simone Pezzotti, Wanlin Chen, Fabio Novelli, Xiaoqing Yu, Claudius Hoberg, Martina Havenith

{"title":"Terahertz calorimetry spotlights the role of water in biological processes.","authors":"Simone Pezzotti, Wanlin Chen, Fabio Novelli, Xiaoqing Yu, Claudius Hoberg, Martina Havenith","doi":"10.1038/s41570-025-00712-8","DOIUrl":"https://doi.org/10.1038/s41570-025-00712-8","url":null,"abstract":"Terahertz (THz) calorimetry is a framework that allows for the deduction and quantification of changes in solvation entropy and enthalpy associated with biological processes in real-time. Fundamental biological processes are inherently non-equilibrium, and a small imbalance in free energy can trigger protein condensation or folding. Although biophysical techniques typically focus mainly on structural characterization, water is often ignored. Being a generic solvent, the intermolecular protein-water interactions act as a strong competitor for intramolecular protein-protein interactions, leading to a delicate balance between functional structure formation and complete solvation. Characteristics for biological processes are large, but competing enthalpic and entropic solvation contributions to the total Gibbs free energy lead to subtle energy differences of only a few kJ mol-1 that are capable of dictating biological functions. THz calorimetry spotlights these intermolecular coupled protein-water interactions. With experimental advances in THz technology, a new frequency window has opened, which is ideally suited to probe these low-frequency intermolecular interactions. The future impact of these studies is based on the belief that the observed changes in solvation entropy and enthalpy are not secondary effects but dictate biological function.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":" ","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Power dressing 穿着

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2025-04-30 DOI: 10.1038/s41570-025-00720-8

Alexander Rosu-Finsen

引用次数: 0