Kasey K Chung, Christina A Rivera, Dory E DeWeese, Neil K Garg, Francesca M Ippoliti, Daniel J Nasrallah
{"title":"Time for o-chem to level up.","authors":"Kasey K Chung, Christina A Rivera, Dory E DeWeese, Neil K Garg, Francesca M Ippoliti, Daniel J Nasrallah","doi":"10.1038/s41570-026-00872-1","DOIUrl":"https://doi.org/10.1038/s41570-026-00872-1","url":null,"abstract":"","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":" ","pages":""},"PeriodicalIF":51.7,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Permeable by design.","authors":"Amr M El-Araby","doi":"10.1038/s41570-026-00871-2","DOIUrl":"https://doi.org/10.1038/s41570-026-00871-2","url":null,"abstract":"","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":" ","pages":""},"PeriodicalIF":51.7,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Subcellular photochemistry for precision spatial protein targeting.","authors":"Moyi Liu, Xiaolin Xiong, Ao Zhang, Taotao Zou","doi":"10.1038/s41570-026-00864-1","DOIUrl":"https://doi.org/10.1038/s41570-026-00864-1","url":null,"abstract":"<p><p>Proteins with conserved active sites but distinct subcellular localizations, such as mislocalized variants, splicing isoforms and isozymes, are prevalent in disease. However, conventional drug design lacks the spatial control needed for their selective targeting. Subcellular photochemistry offers a solution. Light-activated catalysts with spatiotemporal control convert inert prodrugs into active drugs at the desired subcellular location, without affecting conserved proteins at native sites. In this Perspective, we discuss challenges of targeting mislocalized proteins, principles of subcellular photochemistry for site-specific intervention, strategies for anchoring photocatalysts and key examples of subcellular photocatalytic prodrug activation for precision targeting. We also examine limitations of this approach and propose future solutions. This strategy is expected to expand the druggable target repertoire and advance precision medicine.</p>","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":" ","pages":""},"PeriodicalIF":51.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Targeting soluble misfolded oligomers in anti-amyloid research.","authors":"Pernille Vosbein, Hanbin Mao, Chenguang Lou","doi":"10.1038/s41570-026-00867-y","DOIUrl":"https://doi.org/10.1038/s41570-026-00867-y","url":null,"abstract":"<p><p>Protein misfolding drives a range of non-curable diseases, such as Alzheimer disease, Parkinson disease, type 2 diabetes and Huntington disease, that devastate tens of millions of patients each year. The pathological proteins are misfolded into soluble oligomers, which eventually evolve into insoluble amyloid plaques. Increasing evidence suggests that soluble oligomers are the primary cytotoxic species leading to amyloidoses. However, the transient, heterogeneous and low-abundance nature of soluble oligomers makes it extremely challenging to study these species using conventional methods. This Review surveys emerging chemical tools developed for in vitro detection, separation and analysis of soluble amyloid oligomers. We exemplify how the present arsenal can be extended to construct individual amyloid oligomers as potential drug targets. Finally, we summarize their technical limits and discuss possibilities of adapting these chemical tools to target specific soluble oligomers in the fight against amyloidoses.</p>","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":" ","pages":""},"PeriodicalIF":51.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molten salt electrochemistry for next-generation batteries.","authors":"Jiashen Meng, Zhitong Xiao, Lujun Zhu, Lishan Geng, Xufeng Hong, Fang Liu, Quanquan Pang, Liqiang Mai","doi":"10.1038/s41570-026-00866-z","DOIUrl":"https://doi.org/10.1038/s41570-026-00866-z","url":null,"abstract":"<p><p>Inorganic molten salts - composed of freely moving ions at high temperature - have emerged as a new family of electrolytes for batteries owing to their low flammability, high thermal stability and low materials cost. Inorganic molten salt electrolytes surpass their aqueous and organic counterparts by enabling electrochemistry with wider ranges of operating temperatures. Such electrolytes offer abundant charge carriers and unique ionic solvation structures that enhance reaction kinetics, offering superior rate and cycling stabilities. In this Review, we explore molten salt electrochemistry, starting from a fundamental electrochemistry perspective, ending with the batteries and their charge storage mechanisms enabled by molten salt electrolytes. In particular, we discuss the impact of solid-state ion-selective membranes, and also share our perspectives on the future development of advanced molten salt batteries in the frame of materials and electrochemistry innovations.</p>","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":" ","pages":""},"PeriodicalIF":51.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eleanor C Browne, Charles O Stanier, Christopher E Brunet, Hanalei R Lewine, Saeideh Mohammadi, Jeewani N Meepage, Josie K Welker, Elizabeth A Stone
{"title":"Atmospheric chemistry of volatile methyl siloxanes.","authors":"Eleanor C Browne, Charles O Stanier, Christopher E Brunet, Hanalei R Lewine, Saeideh Mohammadi, Jeewani N Meepage, Josie K Welker, Elizabeth A Stone","doi":"10.1038/s41570-026-00862-3","DOIUrl":"https://doi.org/10.1038/s41570-026-00862-3","url":null,"abstract":"<p><p>Volatile methyl siloxanes (VMSs) are high-production-volume, synthetic organosilicon compounds widely detected in the environment. Because they are hydrophobic and volatile, they readily partition to the atmosphere, where they can undergo long-range transport owing to their low gas-phase reactivity. As such, VMSs and their oxidation products are potential tracers of anthropogenic influence, which has caused concerns about their bioaccumulation in remote ecosystems. Multigenerational atmospheric oxidation, primarily by hydroxyl and chlorine radicals to form siloxanol, formate ester and hydroperoxide compounds, has a central role in determining the environmental fate of VMSs. Thermodynamic partitioning of VMS and its oxidation products to aerosol particles (via adsorption and absorption) and environmental media further influences their atmospheric fate. Elucidating oxidation mechanisms and product distributions remains challenging owing to slow reaction kinetics, analytical challenges, absence of authentic standards and the complexity of multiphase chemistry. Advances in analytical methods, chamber studies, flow tube experiments, field campaigns and modelling efforts have underscored the need for an updated assessment of VMS atmospheric chemistry and environmental behaviour. In this Review, we synthesize current knowledge focusing on developments in gas-phase chemistry, multiphase partitioning behaviour, atmospheric measurements and modelling approaches for prominent VMS species and their oxidation products.</p>","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":" ","pages":""},"PeriodicalIF":51.7,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The automated red pen","authors":"Marcelo T. de Oliveira, Sophie Whitehouse","doi":"10.1038/s41570-026-00868-x","DOIUrl":"10.1038/s41570-026-00868-x","url":null,"abstract":"Large language models can grade a stack of chemistry assignments before the kettle has boiled. Whether we should let them depends less on speed than on purpose. Before an AI marker influences grades, it should be validated like an analytical method, with defined limits, quality control and a route to appeal.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 9","pages":"600-601"},"PeriodicalIF":51.7,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Missing marks made visible","authors":"Subhajit Dutta","doi":"10.1038/s41570-026-00861-4","DOIUrl":"10.1038/s41570-026-00861-4","url":null,"abstract":"RNA modifications shape function but are hard to localize. A recent study used an enzyme-based fluorescent method to image queuine-deficient tRNAs in cells.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 9","pages":"605-605"},"PeriodicalIF":51.7,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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