Nature reviews. Chemistry最新文献

Organic chemistry for kids 儿童有机化学

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2024-09-09 DOI: 10.1038/s41570-024-00647-6

Arismel Tena Meza, Laura G. Wonilowicz, Neil K. Garg

引用次数: 0

Molecular complexity as a driving force for the advancement of organic synthesis 分子复杂性是推动有机合成发展的动力

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2024-09-09 DOI: 10.1038/s41570-024-00645-8

Brandon A. Wright, Richmond Sarpong

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Conformational control over proton-coupled electron transfer in metalloenzymes. 金属酶中质子耦合电子转移的构象控制。

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-09-02 DOI: 10.1038/s41570-024-00646-7

Saman Fatima, Lisa Olshansky

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Non-equilibrium self-assembly for living matter-like properties 非平衡自组装实现类生命物质特性

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2024-08-23 DOI: 10.1038/s41570-024-00640-z

Abhishek Singh, Payel Parvin, Bapan Saha, Dibyendu Das

{"title":"Non-equilibrium self-assembly for living matter-like properties","authors":"Abhishek Singh, Payel Parvin, Bapan Saha, Dibyendu Das","doi":"10.1038/s41570-024-00640-z","DOIUrl":"https://doi.org/10.1038/s41570-024-00640-z","url":null,"abstract":"<p>The soft and wet machines of life emerged as the spatially enclosed ensemble of biomolecules with replicating capabilities integrated with metabolic reaction cycles that operate at far-from-equilibrium. A thorough step-by-step synthetic integration of these elements, namely metabolic and replicative properties all confined and operating far-from-equilibrium, can set the stage from which we can ask questions related to the construction of chemical-based evolving systems with living matter-like properties — a monumental endeavour of systems chemistry. The overarching concept of this Review maps the discoveries on this possible integration of reaction networks, self-reproduction and compartmentalization under non-equilibrium conditions. We deconvolute the events of reaction networks and transient compartmentalization and extend the discussion towards self-reproducing systems that can be sustained under non-equilibrium conditions. Although enormous challenges lie ahead in terms of molecular diversity, information transfer, adaptation and selection that are required for open-ended evolution, emerging strategies to generate minimal metabolic cycles can extend our growing understanding of the chemical emergence of the biosphere of Earth.</p><figure></figure>","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":null,"pages":null},"PeriodicalIF":36.3,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142045632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding covalency in molecular f-block compounds from the synergy of spectroscopy and quantum chemistry 从光谱学和量子化学的协同作用中了解分子 f 块化合物中的共价性

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-08-22 DOI: 10.1038/s41570-024-00641-y

Nikolas Kaltsoyannis, Andrew Kerridge

引用次数: 0

Watching RNA in action with a green lantern 观看 RNA 带着绿灯行动。

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-08-19 DOI: 10.1038/s41570-024-00643-w

Subhajit Dutta

引用次数: 0

The role of biomolecular condensates in protein aggregation 生物分子凝聚体在蛋白质聚集中的作用。

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-08-12 DOI: 10.1038/s41570-024-00635-w

Brent S. Visser, Wojciech P. Lipiński, Evan Spruijt

{"title":"The role of biomolecular condensates in protein aggregation","authors":"Brent S. Visser, Wojciech P. Lipiński, Evan Spruijt","doi":"10.1038/s41570-024-00635-w","DOIUrl":"10.1038/s41570-024-00635-w","url":null,"abstract":"There is an increasing amount of evidence that biomolecular condensates are linked to neurodegenerative diseases associated with protein aggregation, such as Alzheimer’s disease and amyotrophic lateral sclerosis, although the mechanisms underlying this link remain elusive. In this Review, we summarize the possible connections between condensates and protein aggregation. We consider both liquid-to-solid transitions of phase-separated proteins and the partitioning of proteins into host condensates. We distinguish five key factors by which the physical and chemical environment of a condensate can influence protein aggregation, and we discuss their relevance in studies of protein aggregation in the presence of biomolecular condensates: increasing the local concentration of proteins, providing a distinct chemical microenvironment, introducing an interface wherein proteins can localize, changing the energy landscape of aggregation pathways, and the presence of chaperones in condensates. Analysing the role of biomolecular condensates in protein aggregation may be essential for a full understanding of amyloid formation and offers a new perspective that can help in developing new therapeutic strategies for the prevention and treatment of neurodegenerative diseases. Biomolecular condensates help organize cell components under normal conditions but can also be involved in pathological protein aggregation when condensate proteins carry mutations or under stress conditions. This Review discusses the possible mechanisms behind such aggregation processes that potentially lead to neurodegenerative diseases.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":null,"pages":null},"PeriodicalIF":38.1,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stemming the scientific brain drain in Nepal 遏制尼泊尔科学人才外流。

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-08-08 DOI: 10.1038/s41570-024-00638-7

Sushila Maharjan, Stephanie Greed

引用次数: 0

Illuminating the deaf experience at STEM conferences 在科学、技术、工程和数学会议上点亮聋人的体验。

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-08-08 DOI: 10.1038/s41570-024-00639-6

Anna M. Kasper, Victoria A. Popov, Sara K. Blick-Nitko, Kameron B. Kinast, Kat Womack, Nikki D. Cherry

引用次数: 0

Visible and near-infrared light-induced photoclick reactions 可见光和近红外线诱发的光点击反应。

IF 38.1 1区化学

Nature reviews. Chemistry Pub Date : 2024-08-07 DOI: 10.1038/s41570-024-00633-y

Youxin Fu, Nadja A. Simeth, Wiktor Szymanski, Ben L. Feringa

{"title":"Visible and near-infrared light-induced photoclick reactions","authors":"Youxin Fu, Nadja A. Simeth, Wiktor Szymanski, Ben L. Feringa","doi":"10.1038/s41570-024-00633-y","DOIUrl":"10.1038/s41570-024-00633-y","url":null,"abstract":"Photoclick reactions combine the advantages offered by light-driven processes, that is, non-invasive and high spatiotemporal control, with classical click chemistry and have found applications ranging from surface functionalization, polymer conjugation, photocrosslinking, protein labelling and bioimaging. Despite these advances, most photoclick reactions typically require near-ultraviolet (UV) and mid-UV light to proceed. UV light can trigger undesirable responses, including cellular apoptosis, and therefore, visible and near-infrared light-induced photoclick reaction systems are highly desirable. Shifting to a longer wavelength can also reduce degradation of the photoclick reagents and products. Several strategies have been used to induce a bathochromic shift in the wavelength of irradiation-initiating photoclick reactions. For instance, the extension of the conjugated π-system, triplet–triplet energy transfer, multi-photon excitation, upconversion technology, photocatalytic and photoinitiation approaches, and designs involving photocages have all been used to achieve this goal. Current design strategies, recent advances and the outlook for long wavelength-driven photoclick reactions are presented. Photoclick reactions have found applications ranging from surface functionalization and polymer crosslinking to protein labelling and bioimaging, but they typically require near-UV and mid-UV light to proceed. This Review presents and discusses strategies and recent advances for long wavelength-driven photoclick reactions.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":null,"pages":null},"PeriodicalIF":38.1,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0