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Transition metal complexes as optical probes for super-resolution microscopy. 过渡金属配合物作为超分辨显微镜的光学探针。
IF 36.3 1区 化学
Nature reviews. Chemistry Pub Date : 2025-10-16 DOI: 10.1038/s41570-025-00764-w
Sumit Kumar Pramanik,Sreejesh Sreedharan,Noufal Kandoth,Jorge Bernardino de la Serna,Amitava Das,Jim A Thomas
{"title":"Transition metal complexes as optical probes for super-resolution microscopy.","authors":"Sumit Kumar Pramanik,Sreejesh Sreedharan,Noufal Kandoth,Jorge Bernardino de la Serna,Amitava Das,Jim A Thomas","doi":"10.1038/s41570-025-00764-w","DOIUrl":"https://doi.org/10.1038/s41570-025-00764-w","url":null,"abstract":"The suite of techniques encompassing optical super-resolution microscopy can facilitate detailed visualization of biological structures and biochemical transformations at unprecedented levels of resolution and contrast; however, they depend on imaging probes with specific biophysical and photophysical properties. In this context, metal complexes with tuneable photo-excited states and stability towards photobleaching are promising candidates for advanced imaging techniques. This Review illustrates how, by selecting appropriate optical properties and luminescence responses, metal complexes can be utilized as probes for a range of super-resolution microscopy techniques, including multimodal imaging, to study subcellular architecture and dynamics with nanoscale resolution. Limitations and challenges of the existing molecular probes are also discussed. By highlighting these recent innovations and providing suggestions for future directions, this Review further underscores the importance of optical probes in pushing the boundaries of super-resolution microscopy and advancing our understanding of complex biological systems.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"19 1","pages":""},"PeriodicalIF":36.3,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bringing geopolitics to the periodic table. 将地缘政治纳入元素周期表。
IF 51.7 1区 化学
Nature reviews. Chemistry Pub Date : 2025-10-13 DOI: 10.1038/s41570-025-00766-8
João Avó, Carina I C Crucho
{"title":"Bringing geopolitics to the periodic table.","authors":"João Avó, Carina I C Crucho","doi":"10.1038/s41570-025-00766-8","DOIUrl":"https://doi.org/10.1038/s41570-025-00766-8","url":null,"abstract":"","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":" ","pages":""},"PeriodicalIF":51.7,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of chemical reactivity on the quality and stability of RNA-LNP pharmaceuticals. 化学反应性对RNA-LNP药物质量和稳定性的影响。
IF 51.7 1区 化学
Nature reviews. Chemistry Pub Date : 2025-10-08 DOI: 10.1038/s41570-025-00763-x
Tristan Kovačič, Heinrich Haas, Lior Stotsky-Oterin, Aleš Štrancar, Urban Bren, Dan Peer
{"title":"The impact of chemical reactivity on the quality and stability of RNA-LNP pharmaceuticals.","authors":"Tristan Kovačič, Heinrich Haas, Lior Stotsky-Oterin, Aleš Štrancar, Urban Bren, Dan Peer","doi":"10.1038/s41570-025-00763-x","DOIUrl":"https://doi.org/10.1038/s41570-025-00763-x","url":null,"abstract":"<p><p>Lipid nanoparticles (LNPs) are the most established platform for delivery of mRNA payloads. Their tunability and streamlined manufacturing facilitated an unprecedentedly rapid scale-up during the COVID-19 pandemic. However, being multicomponent, complex systems also poses a challenge of controlling their quality and safety. Analytical checkpoints need to be established to characterize LNPs on multiple levels during development and commercialization. This Perspective centres on the chemical reactivity and purity of mRNA-LNP components, which need to be addressed as raw materials, drug substance, excipients, and the fully formed and stored product. Herein, we describe such appropriate orthogonal analytics to design and analyse LNP formulations. For such novel biopharmaceuticals, better controls that go beyond the current analytical workflow and address the nuanced chemical stability, which helps ensure reproducibility, stability and safety, need to be established.</p>","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":" ","pages":""},"PeriodicalIF":51.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Separating light from lighter. 将光与打火机分开。
IF 51.7 1区 化学
Nature reviews. Chemistry Pub Date : 2025-09-26 DOI: 10.1038/s41570-025-00761-z
Muhammad Fernadi Lukman, Pranjit Das, Hrittik Karmakar
{"title":"Separating light from lighter.","authors":"Muhammad Fernadi Lukman, Pranjit Das, Hrittik Karmakar","doi":"10.1038/s41570-025-00761-z","DOIUrl":"https://doi.org/10.1038/s41570-025-00761-z","url":null,"abstract":"","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":" ","pages":""},"PeriodicalIF":51.7,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scientific collaboration to rid the world of chemical weapons. 科学合作消除世界化学武器。
IF 51.7 1区 化学
Nature reviews. Chemistry Pub Date : 2025-09-26 DOI: 10.1038/s41570-025-00762-y
Daan Noort, Peter J Hotchkiss
{"title":"Scientific collaboration to rid the world of chemical weapons.","authors":"Daan Noort, Peter J Hotchkiss","doi":"10.1038/s41570-025-00762-y","DOIUrl":"https://doi.org/10.1038/s41570-025-00762-y","url":null,"abstract":"","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":" ","pages":""},"PeriodicalIF":51.7,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of supramolecular self-association of organocatalysts on catalytic performance 有机催化剂的超分子自缔合对催化性能的影响。
IF 51.7 1区 化学
Nature reviews. Chemistry Pub Date : 2025-09-17 DOI: 10.1038/s41570-025-00751-1
Shounak Hinge, Sohom Kundu, Jochen Niemeyer
{"title":"The impact of supramolecular self-association of organocatalysts on catalytic performance","authors":"Shounak Hinge,&nbsp;Sohom Kundu,&nbsp;Jochen Niemeyer","doi":"10.1038/s41570-025-00751-1","DOIUrl":"10.1038/s41570-025-00751-1","url":null,"abstract":"Organocatalysis has emerged as a powerful tool in homogeneous catalysis, and especially in enantioselective catalysis. Importantly, the functional groups that are key to the reactivity of organocatalysts also allow for noncovalent interactions between catalyst molecules, both in the absence and in the presence of the reaction substrates. Such noncovalent interactions can lead to catalyst self-association, which can affect the catalytic behaviour of the respective organocatalyst, in terms of both reaction rates and enantioselectivities. In this Review, we present examples of such catalyst self-association in various organocatalysts, including ureas, thioureas, squaramides, peptides, silanediols and phosphoric acids. We analyse the known solid-state and solution-phase structures and discuss the influence of self-association in catalysis. We hope to illustrate the importance of catalyst self-association, which should be taken into account by practitioners of organocatalysis and catalyst designers. Non-covalent interactions between organocatalyst molecules can change catalytic behaviour, leading to changes in reaction rates and selectivities. This Review discusses how to identify such interactions, measure their effect on catalysis and ultimately how to avoid or exploit them in synthesis.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"9 10","pages":"688-706"},"PeriodicalIF":51.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reclaiming rare earths 回收稀土。
IF 51.7 1区 化学
Nature reviews. Chemistry Pub Date : 2025-09-17 DOI: 10.1038/s41570-025-00759-7
Alexander M. Brown
{"title":"Reclaiming rare earths","authors":"Alexander M. Brown","doi":"10.1038/s41570-025-00759-7","DOIUrl":"10.1038/s41570-025-00759-7","url":null,"abstract":"The isolation of critical materials from minerals is challenging due to their comparable chemical properties and tendency to co-exist with one another. Instead of driving lanthanide separation by chemical extraction, a study leverages solubility differences between adjacent lanthanides to isolate Nd from used NdFeB magnets.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"9 10","pages":"654-654"},"PeriodicalIF":51.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A tale of two systems of electron counting 两个电子计数系统的故事
IF 51.7 1区 化学
Nature reviews. Chemistry Pub Date : 2025-09-16 DOI: 10.1038/s41570-025-00760-0
Joseph Q. Nguyen, Haruko Tateyama
{"title":"A tale of two systems of electron counting","authors":"Joseph Q. Nguyen,&nbsp;Haruko Tateyama","doi":"10.1038/s41570-025-00760-0","DOIUrl":"10.1038/s41570-025-00760-0","url":null,"abstract":"Electron counting and oxidation states are fundamental concepts used for understanding a molecule’s electronic structure. A recent study of PuO2 provides insights into how covalency can impact our assessment of the electronic structures of f-element materials.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"9 10","pages":"655-655"},"PeriodicalIF":51.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Don’t let generative AI shape how we see chemistry 不要让生成式人工智能影响我们对化学的看法
IF 51.7 1区 化学
Nature reviews. Chemistry Pub Date : 2025-09-16 DOI: 10.1038/s41570-025-00757-9
Audrey Moores, Vânia G. Zuin Zeidler
{"title":"Don’t let generative AI shape how we see chemistry","authors":"Audrey Moores,&nbsp;Vânia G. Zuin Zeidler","doi":"10.1038/s41570-025-00757-9","DOIUrl":"10.1038/s41570-025-00757-9","url":null,"abstract":"When generative artificial intelligence (AI) draws molecules, it doesn’t just get the science wrong — it risks reshaping how we see chemistry, spreading incorrect representations of our world that mislead learners, distort peer-reviewed reports, and erode trust in scientific work and rigour.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"9 10","pages":"649-650"},"PeriodicalIF":51.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
#labdaptations for inclusive laboratory research 适应包容性实验室研究
IF 51.7 1区 化学
Nature reviews. Chemistry Pub Date : 2025-09-15 DOI: 10.1038/s41570-025-00756-w
Katharine A. Hubert
{"title":"#labdaptations for inclusive laboratory research","authors":"Katharine A. Hubert","doi":"10.1038/s41570-025-00756-w","DOIUrl":"10.1038/s41570-025-00756-w","url":null,"abstract":"Disabled scientists encounter many barriers in laboratory spaces, especially a lack of accessible lab equipment. #labdaptations is an ever-growing database of inclusive equipment created to improve the accessibility of laboratory work.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"9 10","pages":"647-648"},"PeriodicalIF":51.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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