{"title":"Assembling a new generation of radiopharmaceuticals with supramolecular theranostics","authors":"Guillermo Moreno-Alcántar, Marike Drexler, Angela Casini","doi":"10.1038/s41570-024-00657-4","DOIUrl":"https://doi.org/10.1038/s41570-024-00657-4","url":null,"abstract":"<p>Supramolecular chemistry has been used to tackle some of the major challenges in modern science, including cancer therapy and diagnosis. Supramolecular platforms provide synthetic flexibility, rapid generation through self-assembly, facile labelling, unique topologies, tunable reversibility of the enabling noncovalent interactions, and opportunities for host–guest chemistry and mechanical bonding. In this Review, we summarize recent advances in the design and radiopharmaceutical application of discrete self-assembled coordination complexes and mechanically interlocked molecules — namely, metallacages and rotaxanes, respectively — as well as in situ-forming supramolecular aggregates, specifically pinpointing their potential as next-generation radiotheranostic agents. The outlook of such supramolecular constructs for potential applications in the clinic is discussed.</p><figure></figure>","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"2 1","pages":""},"PeriodicalIF":36.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142519216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Holding your nerve in academia whilst managing multiple sclerosis","authors":"Aisha N. Bismillah, Stephen D. P. Fielden","doi":"10.1038/s41570-024-00661-8","DOIUrl":"10.1038/s41570-024-00661-8","url":null,"abstract":"Multiple sclerosis (MS) is a degenerative disease of the central nervous system. Two early-career researchers in supramolecular chemistry share their experiences of navigating academia whilst managing MS.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 11","pages":"793-794"},"PeriodicalIF":38.1,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Understanding the chemistry of mesostructured porous nanoreactors","authors":"Yuzhu Ma, Haitao Li, Jian Liu, Dongyuan Zhao","doi":"10.1038/s41570-024-00658-3","DOIUrl":"https://doi.org/10.1038/s41570-024-00658-3","url":null,"abstract":"<p>Porous nanoreactors mimic the structures and functions of cells, providing an adaptable material with multiple functions and effects. These reactors can be nanoscale containers and shuttles or catalytic centres, drawing in reactants for cascading reactions with multishelled designs. The detailed construction of multi-level reactors at the nanometre scale remains a great challenge, but to regulate the reaction pathways within a reactor, designs of great intricacy are required. In this Review, we define the basic structural characteristics of porous nanoreactors, while also discussing the design principles and synthetic chemistry of these structures with respect to their emerging applications in energy storage and heterogeneous catalysis. Finally, we describe the difficulties of the structural optimization of these reactors and propose possible ways to improve porous nanoreactor design for future applications.</p><figure></figure>","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"63 1","pages":""},"PeriodicalIF":36.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An algorithmic looking glass for transitions","authors":"Alexander Rosu-Finsen","doi":"10.1038/s41570-024-00667-2","DOIUrl":"10.1038/s41570-024-00667-2","url":null,"abstract":"Glass transition temperatures are determined through, for instance, calorimetry, but maybe machine learning models can predict them. Here, researchers test this idea with published data as input for the model, to find a close correlation between predicted and experimental values. ","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 11","pages":"797-797"},"PeriodicalIF":38.1,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reflections on a Nobel Prize-winning legacy","authors":"Jean-Pierre Sauvage, Stephanie Greed","doi":"10.1038/s41570-024-00651-w","DOIUrl":"10.1038/s41570-024-00651-w","url":null,"abstract":"Ahead of his 80th birthday, Jean-Pierre Sauvage discussed his career in science from a lab in his cellar to the Nobel Prize in Chemistry.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 11","pages":"795-796"},"PeriodicalIF":38.1,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reprogramming the genetic code with flexizymes","authors":"Takayuki Katoh, Hiroaki Suga","doi":"10.1038/s41570-024-00656-5","DOIUrl":"https://doi.org/10.1038/s41570-024-00656-5","url":null,"abstract":"<p>In the canonical genetic code, the 61 sense codons are assigned to the 20 proteinogenic amino acids. Advancements in genetic code manipulation techniques have enabled the ribosomal incorporation of nonproteinogenic amino acids (npAAs). The critical molecule for translating messenger RNA (mRNA) into peptide sequences is aminoacyl-transfer RNA (tRNA), which recognizes the mRNA codon through its anticodon. Because aminoacyl-tRNA synthetases (ARSs) are highly specific for their respective amino acid–tRNA pairs, it is not feasible to use natural ARSs to prepare npAA-tRNAs. However, flexizymes are adaptable aminoacylation ribozymes that can be used to prepare diverse aminoacyl-tRNAs at will using amino acids activated with suitable leaving groups. Regarding recognition elements, flexizymes require only an aromatic ring in either the leaving group or side chain of the activated amino acid, and the conserved 3′-end CCA of the tRNA. Therefore, flexizymes allow virtually any amino acid to be charged onto any tRNA. The flexizyme system can handle not only <span>l</span>-α-amino acids with side chain modifications but also various backbone-modified npAAs. This Review describes the development of flexizyme variants and discusses their structure and mechanism and their applications in genetic code reprogramming for the synthesis of unique peptides and proteins.</p><figure></figure>","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"65 1","pages":""},"PeriodicalIF":36.3,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2D magnets filled with lithium","authors":"Liang Mei, Ruijie Yang","doi":"10.1038/s41570-024-00660-9","DOIUrl":"10.1038/s41570-024-00660-9","url":null,"abstract":"Room-temperature magnetism is challenging for 2D materials as they tend to lose their magnetic order at increasing temperatures. Now, researchers have achieved room temperature magnetism in lithium-intercalated chromium iodide.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 11","pages":"798-798"},"PeriodicalIF":38.1,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142398247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Asymmetric phase-transfer catalysis","authors":"Hyo-Jun Lee, Keiji Maruoka","doi":"10.1038/s41570-024-00642-x","DOIUrl":"10.1038/s41570-024-00642-x","url":null,"abstract":"Over the past three decades, chiral phase-transfer catalysts (PTCs) have emerged as highly successful organocatalysts in a diverse range of asymmetric reactions. A substantial number of chiral PTCs have now already been discovered and utilized in dependable routes to enantioenriched products. These extend beyond the classical cationic PTCs with the emergence of anionic phase-transfer catalysis and hydrogen-bonding phase-transfer catalysis providing new asymmetric synthetic approaches. Nevertheless, the application level of chiral PTCs in both academic and industrial processes is below our expectation. This Review highlights the notable advances in chiral PTCs, including challenges, limitations and efforts to overcome them. Following this, the potential for sustainable chiral PTCs is described with a focus on using photocatalysed, flow and electrochemical synthesis. Chiral phase-transfer catalysts are practical and powerful organocatalysts for asymmetric synthesis. This Review illustrates notable recent advances of chiral phase-transfer catalysts, including challenges, limitations and potential solutions, as well as future opportunities to improve sustainability.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 11","pages":"851-869"},"PeriodicalIF":38.1,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chad T. Palumbo, Erik T. Ouellette, Jie Zhu, Yuriy Román-Leshkov, Shannon S. Stahl, Gregg T. Beckham
{"title":"Accessing monomers from lignin through carbon–carbon bond cleavage","authors":"Chad T. Palumbo, Erik T. Ouellette, Jie Zhu, Yuriy Román-Leshkov, Shannon S. Stahl, Gregg T. Beckham","doi":"10.1038/s41570-024-00652-9","DOIUrl":"10.1038/s41570-024-00652-9","url":null,"abstract":"Lignin, the heterogeneous aromatic macromolecule found in the cell walls of vascular plants, is an abundant feedstock for the production of biochemicals and biofuels. Many valorization schemes rely on lignin depolymerization, with decades of research focused on accessing monomers through C–O bond cleavage, given the abundance of β–O–4 bonds in lignin and the large number of available C–O bond cleavage strategies. Monomer yields are, however, invariably lower than desired, owing to the presence of recalcitrant C–C bonds whose selective cleavage remains a major challenge in catalysis. In this Review, we highlight lignin C–C cleavage reactions, including those of linkages arising from biosynthesis (β–1, β–5, β–β and 5–5) and industrial processing (5–CH2–5 and α–5). We examine multiple approaches to C–C cleavage, including homogeneous and heterogeneous catalysis, photocatalysis and biocatalysis, to identify promising strategies for further research and provide guidelines for definitive measurements of lignin C–C bond cleavage. To date, monomer yields from lignin are limited to those attainable through C–O bond cleavage. Cleaving C–C bonds often leads to deleterious product degradation and low monomer yields. Herein we review lignin C–C cleavage reports and advocate for a standardized reporting of yields.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 11","pages":"799-816"},"PeriodicalIF":38.1,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Secrets from a spin-out success story","authors":"Stephanie Greed","doi":"10.1038/s41570-024-00634-x","DOIUrl":"10.1038/s41570-024-00634-x","url":null,"abstract":"Ahead of his 85th birthday, Graham Richards discussed his life in science and its intersection with industry. From a mix-up that led to him reading chemistry at the University of Oxford rather than physics, Richards later became the head of the chemistry department and co-founded Oxford Molecular Plc.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 10","pages":"719-720"},"PeriodicalIF":38.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142329966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}