{"title":"Like will reduce like","authors":"Johannes Kreutzer","doi":"10.1038/s41570-024-00581-7","DOIUrl":"10.1038/s41570-024-00581-7","url":null,"abstract":"The reduction of molecular species containing arene to alkali metal cation interactions with other alkali metals has been found to contradict the expectation provided by simple considerations of relative reduction potentials.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":null,"pages":null},"PeriodicalIF":36.3,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139522691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lithium chooses the channel","authors":"Stephanie Greed","doi":"10.1038/s41570-024-00577-3","DOIUrl":"10.1038/s41570-024-00577-3","url":null,"abstract":"By drawing inspiration from ion transport in biology, researchers have developed highly selective channels for the separation and enrichment of Li+ ions from complex aqueous solutions.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":null,"pages":null},"PeriodicalIF":36.3,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139522694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alessia Munzone, Vincent G. H. Eijsink, Jean-Guy Berrin, Bastien Bissaro
{"title":"Publisher Correction: Expanding the catalytic landscape of metalloenzymes with lytic polysaccharide monooxygenases","authors":"Alessia Munzone, Vincent G. H. Eijsink, Jean-Guy Berrin, Bastien Bissaro","doi":"10.1038/s41570-024-00580-8","DOIUrl":"10.1038/s41570-024-00580-8","url":null,"abstract":"","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":null,"pages":null},"PeriodicalIF":36.3,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41570-024-00580-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139521504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Voltammetric drug testing makes sense at the border","authors":"Robin Van Echelpoel, Karolien De Wael","doi":"10.1038/s41570-023-00571-1","DOIUrl":"10.1038/s41570-023-00571-1","url":null,"abstract":"The European BorderSens project leverages voltammetric sensors, developed with end-users’ input, to rapidly and accurately detect illicit drugs. By embracing practicalities and validation, this technology has the potential to combat the illicit drug problem.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":null,"pages":null},"PeriodicalIF":36.3,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139432644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alessia Munzone, Vincent G. H. Eijsink, Jean-Guy Berrin, Bastien Bissaro
{"title":"Expanding the catalytic landscape of metalloenzymes with lytic polysaccharide monooxygenases","authors":"Alessia Munzone, Vincent G. H. Eijsink, Jean-Guy Berrin, Bastien Bissaro","doi":"10.1038/s41570-023-00565-z","DOIUrl":"10.1038/s41570-023-00565-z","url":null,"abstract":"Lytic polysaccharide monooxygenases (LPMOs) have an essential role in global carbon cycle, industrial biomass processing and microbial pathogenicity by catalysing the oxidative cleavage of recalcitrant polysaccharides. Despite initially being considered monooxygenases, experimental and theoretical studies show that LPMOs are essentially peroxygenases, using a single copper ion and H2O2 for C–H bond oxygenation. Here, we examine LPMO catalysis, emphasizing key studies that have shaped our comprehension of their function, and address side and competing reactions that have partially obscured our understanding. Then, we compare this novel copper–peroxygenase reaction with reactions catalysed by haem iron enzymes, highlighting the different chemistries at play. We conclude by addressing some open questions surrounding LPMO catalysis, including the importance of peroxygenase and monooxygenase reactions in biological contexts, how LPMOs modulate copper site reactivity and potential protective mechanisms against oxidative damage. Lytic polysaccharide monooxygenases are key enzymes in biomass processing and pathogenicity. They are, to our knowledge, the first known copper enzymes capable of utilizing H2O2 to hydroxylate C–H bonds. This Review draws a portrait of the catalytic paths at play and highlights outstanding questions in their reactivity.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":null,"pages":null},"PeriodicalIF":36.3,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139407821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Spectrum of the past","authors":"Michael A. Skinnider","doi":"10.1038/s41570-023-00570-2","DOIUrl":"10.1038/s41570-023-00570-2","url":null,"abstract":"Thirty-four years ago, Curry and Rumelhart described a neural network-based approach to annotate tandem mass spectra. Their ideas foreshadowed several important developments in computational mass spectrometry over the past decade, but many of the challenges they discuss remain relevant today.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":null,"pages":null},"PeriodicalIF":36.3,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139106311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Engineered and total biosynthesis of fungal specialized metabolites","authors":"Russell J. Cox","doi":"10.1038/s41570-023-00564-0","DOIUrl":"10.1038/s41570-023-00564-0","url":null,"abstract":"Filamentous fungi produce a very wide range of complex and often bioactive metabolites, demonstrating their inherent ability as hosts of complex biosynthetic pathways. Recent advances in molecular sciences related to fungi have afforded the development of new tools that allow the rational total biosynthesis of highly complex specialized metabolites in a single process. Increasingly, these pathways can also be engineered to produce new metabolites. Engineering can be at the level of gene deletion, gene addition, formation of mixed pathways, engineering of scaffold synthases and engineering of tailoring enzymes. Combination of these approaches with hosts that can metabolize low-value waste streams opens the prospect of one-step syntheses from garbage. The total biosynthesis and engineering of complex natural products is now routinely achieved in filamentous fungal host organisms. This technology offers substantial advantages over traditional total chemical synthesis for the production of both known and new specialized metabolites.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":null,"pages":null},"PeriodicalIF":36.3,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139081823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Making cells from bacteria","authors":"Stephanie Greed","doi":"10.1038/s41570-023-00573-z","DOIUrl":"10.1038/s41570-023-00573-z","url":null,"abstract":"Cable bacteria are able to conduct electrons to interconvert oxygen and water. Here, researchers have isolated the conducting cable bacteria skeletons to demonstrate their activity in an electrochemical cell.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":null,"pages":null},"PeriodicalIF":36.3,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139081830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Making a new resolution","authors":"Stephen G. Davey","doi":"10.1038/s41570-023-00574-y","DOIUrl":"10.1038/s41570-023-00574-y","url":null,"abstract":"A route to synthetically interesting axially chiral diaryl ethers combines an asymmetric desymmetrization and a kinetic resolution.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":null,"pages":null},"PeriodicalIF":36.3,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139081551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A radiant start to life","authors":"Alexander Rosu-Finsen","doi":"10.1038/s41570-023-00572-0","DOIUrl":"10.1038/s41570-023-00572-0","url":null,"abstract":"If intense ionizing radiation was present at a time of prebiotic life, protocells would have needed protection. Researchers have shown that peptide-containing coacervates can harbour DNA strands, which can then be coated with Mn-containing coacervates protecting the interior from radiation.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":null,"pages":null},"PeriodicalIF":36.3,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139081546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}