Nature reviews. Chemistry最新文献_第10页

Automation of air-free synthesis 无气合成自动化

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2024-04-11 DOI: 10.1038/s41570-024-00599-x

Babak A. Mahjour, Connor W. Coley

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The quest for safer nuclear fuels 寻求更安全的核燃料

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2024-04-10 DOI: 10.1038/s41570-024-00596-0

S. Olivia Gunther, Bianca Schacherl

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Non-symmetric stapling of native peptides 原生肽的非对称装订

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2024-04-04 DOI: 10.1038/s41570-024-00591-5

Fa-Jie Chen, Wanzhen Lin, Fen-Er Chen

{"title":"Non-symmetric stapling of native peptides","authors":"Fa-Jie Chen, Wanzhen Lin, Fen-Er Chen","doi":"10.1038/s41570-024-00591-5","DOIUrl":"10.1038/s41570-024-00591-5","url":null,"abstract":"Stapling has emerged as a powerful technique in peptide chemistry. It enables precise control over peptide conformation leading to enhanced properties such as improved stability and enhanced binding affinity. Although symmetric stapling methods have been extensively explored, the field of non-symmetric stapling of native peptides has received less attention, largely as a result of the formidable challenges it poses — in particular the complexities involved in achieving the high chemo-selectivity and site-selectivity required to simultaneously modify distinct proteinogenic residues. Over the past 5 years, there have been significant breakthroughs in addressing these challenges. In this Review, we describe the latest strategies for non-symmetric stapling of native peptides, elucidating the protocols, reaction mechanisms and underlying design principles. We also discuss current challenges and opportunities this field offers for future applications, such as ligand discovery and peptide-based therapeutics. Peptide stapling is a powerful technique used to lock peptide conformations and modulate peptide functions. This Review highlights the newest development in non-symmetric stapling of native peptides bearing natural amino acids, elucidating current advances, challenges and future opportunities.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 5","pages":"304-318"},"PeriodicalIF":36.3,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140349580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tailor-made glycans 定制聚糖

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2024-04-04 DOI: 10.1038/s41570-024-00598-y

Sugyeom Kim, George A. O’Doherty

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Boosting band structure 提升带状结构

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2024-03-28 DOI: 10.1038/s41570-024-00600-7

Alexander Rosu-Finsen

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Electrochemical hydrogenation and oxidation of organic species involving water 有机物的电化学氢化和水氧化。

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2024-03-25 DOI: 10.1038/s41570-024-00589-z

Cuibo Liu, Fanpeng Chen, Bo-Hang Zhao, Yongmeng Wu, Bin Zhang

{"title":"Electrochemical hydrogenation and oxidation of organic species involving water","authors":"Cuibo Liu, Fanpeng Chen, Bo-Hang Zhao, Yongmeng Wu, Bin Zhang","doi":"10.1038/s41570-024-00589-z","DOIUrl":"10.1038/s41570-024-00589-z","url":null,"abstract":"Fossil fuel-driven thermochemical hydrogenation and oxidation using high-pressure H2 and O2 are still popular but energy-intensive CO2-emitting processes. At present, developing renewable energy-powered electrochemical technologies, especially those using clean, safe and easy-to-handle reducing agents and oxidants for organic hydrogenation and oxidation reactions, is urgently needed. Water is an ideal carrier of hydrogen and oxygen. Electrochemistry provides a powerful route to drive water splitting under ambient conditions. Thus, electrochemical hydrogenation and oxidation transformations involving water as the hydrogen source and oxidant, respectively, have been developed to be mild and efficient tools to synthesize organic hydrogenated and oxidized products. In this Review, we highlight the advances in water-participating electrochemical hydrogenation and oxidation reactions of representative organic molecules. Typical electrode materials, performance metrics and key characterization techniques are firstly introduced. General electrocatalyst design principles and controlling the microenvironment for promoting hydrogenation and oxygenation reactions involving water are summarized. Furthermore, paired hydrogenation and oxidation reactions are briefly introduced before finally discussing the challenges and future opportunities of this research field. The use of water for electrochemical hydrogenation and oxidation of organic species provides a sustainable route for synthesizing chemicals. The electrode types, general electrocatalyst selection principles and interface microenvironment control are elucidated, conducive to designing efficient electrocatalysts and reaction systems.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 4","pages":"277-293"},"PeriodicalIF":36.3,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140288576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triplet–triplet annihilation photon upconversion-mediated photochemical reactions 三重-三重湮灭光子上转换介导的光化学反应。

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2024-03-21 DOI: 10.1038/s41570-024-00585-3

Ling Huang, Gang Han

{"title":"Triplet–triplet annihilation photon upconversion-mediated photochemical reactions","authors":"Ling Huang, Gang Han","doi":"10.1038/s41570-024-00585-3","DOIUrl":"10.1038/s41570-024-00585-3","url":null,"abstract":"Photon upconversion is a method for harnessing high-energy excited states from low-energy photons. Such photons, particularly in the red and near-infrared wavelength ranges, can penetrate tissue deeply and undergo less competitive absorption in coloured reaction media, enhancing the efficiency of large-scale reactions and in vivo phototherapy. Among various upconversion methodologies, the organic-based triplet–triplet annihilation upconversion (TTA-UC) stands out — demonstrating high upconversion efficiencies, requiring low excitation power densities and featuring tunable absorption and emission wavelengths. These factors contribute to improved photochemical reactions for fields such as photoredox catalysis, photoactivation, 3D printing and immunotherapy. In this Review, we explore concepts and design principles of organic TTA-UC-mediated photochemical reactions, highlighting notable advancements in the field, as well as identify challenges and propose potential solutions. This Review sheds light on the potential of organic TTA-UC to advance beyond the traditional photochemical reactions and paves the way for research in various fields and clinical applications. Organic-based triplet–triplet annihilation upconversion-mediated photochemical reactions utilize low-energy photons to obtain high-energy excited states leading to notable advancements in photoredox catalysis, photoactivation, 3D printing and immunotherapy. Classifications, design principles, challenges and possible solutions are discussed in this Review.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 4","pages":"238-255"},"PeriodicalIF":36.3,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140184876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robust scientific advisory mechanisms future-proof disarmament treaties 强有力的科学咨询机制为未来的裁军条约保驾护航。

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2024-03-21 DOI: 10.1038/s41570-024-00594-2

Sarah Clapham, Peter J. Hotchkiss

引用次数: 0

Tying the knot with lysine 用赖氨酸打结

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2024-03-18 DOI: 10.1038/s41570-024-00592-4

Ana Koperniku, Nicholas A. Meanwell

引用次数: 0

Solvent effects in anion recognition 阴离子识别中的溶剂效应

IF 36.3 1区化学

Nature reviews. Chemistry Pub Date : 2024-03-06 DOI: 10.1038/s41570-024-00584-4

Sophie C. Patrick, Paul D. Beer, Jason J. Davis

{"title":"Solvent effects in anion recognition","authors":"Sophie C. Patrick, Paul D. Beer, Jason J. Davis","doi":"10.1038/s41570-024-00584-4","DOIUrl":"10.1038/s41570-024-00584-4","url":null,"abstract":"Anion recognition is pertinent to a range of environmental, medicinal and industrial applications. Recent progress in the field has relied on advances in synthetic host design to afford a broad range of potent recognition motifs and novel supramolecular structures capable of effective binding both in solution and at derived molecular films. However, performance in aqueous media remains a critical challenge. Understanding the effects of bulk and local solvent on anion recognition by host scaffolds is imperative if effective and selective detection in real-world media is to be viable. This Review seeks to provide a framework within which these effects can be considered both experimentally and theoretically. We highlight proposed models for solvation effects on anion binding and discuss approaches to retain strong anion binding in highly competitive (polar) solvents. The synthetic design principles for exploiting the aforementioned solvent effects are explored. Anion recognition in competitive, aqueous media remains a critical challenge. Bulk and local solvation models for anion recognition events are herein explored, as well as targeted design approaches to retain strong anion binding in highly polar media.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"8 4","pages":"256-276"},"PeriodicalIF":36.3,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140049928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0