Nature reviews. Chemistry最新文献_第10页

Stories from the scientist who changed how we visualize proteins 来自科学家的故事，他改变了我们看待蛋白质的方式。

IF 51.7 1区化学

Nature reviews. Chemistry Pub Date : 2026-01-27 DOI: 10.1038/s41570-026-00800-3

Jane Richardson, Stephanie Greed

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Making chemistry compute with non-steady-state chemical dynamics 用非稳态化学动力学进行化学计算

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Nature reviews. Chemistry Pub Date : 2026-01-26 DOI: 10.1038/s41570-026-00796-w

Xuan Ji, Yueqi Chen, Xi Yu, Christian A. Nijhuis

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First-principles approaches and concepts to simulate electrochemical interfaces 模拟电化学界面的第一性原理方法和概念

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Nature reviews. Chemistry Pub Date : 2026-01-23 DOI: 10.1038/s41570-025-00792-6

Mira Todorova, Stefan Wippermann, Jörg Neugebauer

{"title":"First-principles approaches and concepts to simulate electrochemical interfaces","authors":"Mira Todorova, Stefan Wippermann, Jörg Neugebauer","doi":"10.1038/s41570-025-00792-6","DOIUrl":"10.1038/s41570-025-00792-6","url":null,"abstract":"Ab initio techniques have revolutionized the way theory helps practitioners to explore mechanisms governing reactions or properties, and develop new strategies for materials discovery and design. Nevertheless, their application to electrochemical systems remains limited, due to challenges electronic structure calculations face in achieving realistic descriptions of electrified solid–liquid interfaces, including potential and pH control or free energies of barrier configurations. The extension of the scope of simulations to achieve potential control, inherent to electrochemical experiments, is just emerging. In this Review, we discuss approaches to describing electrified interfaces between solid electrodes and liquid electrolytes in realistic environments. By exchanging energy, electronic charge and ions with their environment, electrochemical interfaces are thermodynamically open systems. Additionally, large electrostatic potential and field fluctuations occur on timescales and length scales relevant to chemical reactions. We discuss the key challenges for incorporating these features into ab initio simulations to facilitate broader community use and provide a new level of realism when exploring fundamental electrochemistry from first principles. State-of-the-art approaches for modelling electrified solid–electrolyte interfaces are critically discussed, highlighting key challenges in incorporating thermodynamic open-boundary conditions, large electrostatic potentials and their dynamic fluctuations into realistic ab initio simulations.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 2","pages":"133-146"},"PeriodicalIF":51.7,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146033869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The geopolitical future for chemistry 化学的地缘政治未来

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Nature reviews. Chemistry Pub Date : 2026-01-23 DOI: 10.1038/s41570-026-00797-9

João Avó, Carina I. C. Crucho

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Ion migration in perovskite solar cells 钙钛矿太阳能电池中的离子迁移。

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Nature reviews. Chemistry Pub Date : 2026-01-21 DOI: 10.1038/s41570-025-00790-8

Jarla Thiesbrummel, Jovana V. Milić, Carsten Deibel, Erik C. Garnett, Shuxia Tao, Thomas Kirchartz, Antonio Guerrero, Petra Cameron, Wolfgang Tress, M. Saiful Islam, Bruno Ehrler

{"title":"Ion migration in perovskite solar cells","authors":"Jarla Thiesbrummel, Jovana V. Milić, Carsten Deibel, Erik C. Garnett, Shuxia Tao, Thomas Kirchartz, Antonio Guerrero, Petra Cameron, Wolfgang Tress, M. Saiful Islam, Bruno Ehrler","doi":"10.1038/s41570-025-00790-8","DOIUrl":"10.1038/s41570-025-00790-8","url":null,"abstract":"Metal halide perovskite solar cells have considerable potential for next-generation solar power production. However, if not controlled, the migration of mobile ions can hamper the stability of perovskite solar cells. Intensive research efforts have devised methods of suppressing ion migration and degradation in perovskite materials, resulting in solar cells that are stable over thousands of hours during accelerated ageing testing. Here, we review the chemical origins of ion migration, its effect on material and device performance and stability, and strategies to mitigate its impact. Ion migration originates in the soft lattice of the halide perovskite framework and its low defect-formation energy, but there are many different strategies to reduce its effects, from compositional engineering of materials and device architecture changes to additives and strain engineering. The field has made great progress in understanding the origin and properties of mobile ions in halide perovskites and has improved operational stability beyond expectations. Nonetheless, there are still ample opportunities to further improve the long-term durability of perovskite solar cells, either by reducing ion migration or its effect on solar cell efficiency. Ion migration plays a crucial role in perovskite solar cells. This Review covers its mechanisms, impact on device performance and degradation, measurement techniques, and emerging strategies towards controlling ion migration.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 3","pages":"179-195"},"PeriodicalIF":51.7,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146015392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Programming DNA machines to move 编程DNA机器来移动。

IF 51.7 1区化学

Nature reviews. Chemistry Pub Date : 2026-01-19 DOI: 10.1038/s41570-025-00791-7

Selma Piranej, Luona Zhang, Alisina Bazrafshan, Wenxiao Deng, Khalid Salaita

{"title":"Programming DNA machines to move","authors":"Selma Piranej, Luona Zhang, Alisina Bazrafshan, Wenxiao Deng, Khalid Salaita","doi":"10.1038/s41570-025-00791-7","DOIUrl":"10.1038/s41570-025-00791-7","url":null,"abstract":"DNA nanotechnology has rapidly evolved, leading to the development of dynamic nanoscale and microscale devices that mimic natural molecular machinery. This Review explores the latest advancements in DNA-based machines, motors and switches, emphasizing the need for clear definitions to distinguish between these often-interchanged terms. By analysing key performance metrics such as speed, force generation, efficiency and autonomy, we provide a framework for evaluating these devices against their biological counterparts, including motor proteins such as myosin and kinesin. We highlight innovative design strategies such as strand displacement, DNA origami and hybrid systems, which enhance the functionality of DNA-based constructs and bridge the gap between synthetic and natural systems. These advancements have promising applications in areas such as targeted drug delivery, biosensing and nanofabrication, although challenges in achieving the high performance and efficiency seen in biological systems remain. Through a synthesis of current research, this Review outlines the opportunities and challenges in the development of DNA-based nanoscale and microscale devices. The development of DNA-based machines is transforming fields such as drug delivery and biosensing. Here, design strategies are discussed and key performance metrics — speed, force generation, efficiency and autonomy — are examined to provide insights into the future of DNA nanotechnology.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 3","pages":"158-178"},"PeriodicalIF":51.7,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Tin, Sn!

IF 51.7 1区化学

Nature reviews. Chemistry Pub Date : 2026-01-08 DOI: 10.1038/s41570-025-00794-4

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Biomolecular coronas govern the environmental fate of metal–organic frameworks 生物分子冕控制着金属-有机框架的环境命运。

IF 51.7 1区化学

Nature reviews. Chemistry Pub Date : 2026-01-02 DOI: 10.1038/s41570-025-00789-1

Pankti Dhumal, Swaroop Chakraborty, Iseult Lynch

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Strengthening school–university collaborations 加强校际合作。

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Nature reviews. Chemistry Pub Date : 2026-01-02 DOI: 10.1038/s41570-025-00788-2

Patrick I. T. Thomson, Alastair W. Wark, Alan R. Kennedy, Fraser J. Scott

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The role of ionizing radiation-initiated reactions in targeted activation of chemotherapeutics 电离辐射引发的反应在化疗药物靶向激活中的作用。

IF 51.7 1区化学

Nature reviews. Chemistry Pub Date : 2025-12-15 DOI: 10.1038/s41570-025-00779-3

Juncheng Liu, Antonia G. Denkova, Rienk Eelkema

{"title":"The role of ionizing radiation-initiated reactions in targeted activation of chemotherapeutics","authors":"Juncheng Liu, Antonia G. Denkova, Rienk Eelkema","doi":"10.1038/s41570-025-00779-3","DOIUrl":"10.1038/s41570-025-00779-3","url":null,"abstract":"Ionizing radiation-induced drug release is a combined chemoradiation therapy, which aims to reduce the systemic toxicity of chemotherapeutics. Radiation is used for both radiotherapy and to trigger the release of a chemotherapeutic. To understand radiation-induced drug activation and to design new radiation-sensitive chemotherapeutics, it is important to become familiar with the underlying reaction mechanisms. Here, we provide an overview of the crucial process of water radiolysis induced by ionizing radiation and the mechanisms of reactive species generation. We also discuss the reactivity of these species with cellular components and chemical functional groups, to give insight into selective drug activation in complex cellular environments. Finally, we discuss recent progress on radiation-induced drug release focusing on the reaction of water radiolysis products with drug caging groups and the yield of released drugs. We aim to bridge the gap between basic chemical processes in water radiolysis and their relevance for drug release and provide suggestions on the design of radiation-sensitive prodrugs or nanocarriers. This Review explores how ionizing radiation triggers drug release via water radiolysis, detailing reactive species, drug activation mechanisms and strategies for designing radiation-sensitive prodrugs and nanocarriers to enhance chemoradiation therapy with reduced systemic toxicity.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"10 1","pages":"72-87"},"PeriodicalIF":51.7,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145763292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0