Non-equilibrium self-assembly for living matter-like properties

IF 38.1 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Abhishek Singh, Payel Parvin, Bapan Saha, Dibyendu Das
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引用次数: 0

Abstract

The soft and wet machines of life emerged as the spatially enclosed ensemble of biomolecules with replicating capabilities integrated with metabolic reaction cycles that operate at far-from-equilibrium. A thorough step-by-step synthetic integration of these elements, namely metabolic and replicative properties all confined and operating far-from-equilibrium, can set the stage from which we can ask questions related to the construction of chemical-based evolving systems with living matter-like properties — a monumental endeavour of systems chemistry. The overarching concept of this Review maps the discoveries on this possible integration of reaction networks, self-reproduction and compartmentalization under non-equilibrium conditions. We deconvolute the events of reaction networks and transient compartmentalization and extend the discussion towards self-reproducing systems that can be sustained under non-equilibrium conditions. Although enormous challenges lie ahead in terms of molecular diversity, information transfer, adaptation and selection that are required for open-ended evolution, emerging strategies to generate minimal metabolic cycles can extend our growing understanding of the chemical emergence of the biosphere of Earth. The origins of complex life forms from simple chemicals remain one of the most enigmatic mysteries. This Review explores how non-equilibrium chemical-based systems can exhibit living matter-like properties with an outlook that connects the possibility of diversification, adaptation and evolution.

Abstract Image

Abstract Image

非平衡自组装实现类生命物质特性
生命的软机器和湿机器是由具有复制能力的生物分子组成的空间封闭集合体,它们与在远离平衡状态下运行的新陈代谢反应循环相结合。将这些元素,即新陈代谢和复制特性全部封闭在远离平衡的环境中运行,进行彻底的逐步合成整合,可以为我们提出与构建具有类似生命物质特性的化学进化系统相关的问题--系统化学的一项艰巨任务--奠定基础。本综述的总体构想映射了非平衡条件下反应网络、自我繁殖和区隔的可能整合发现。我们对反应网络和瞬时区隔化事件进行了解构,并将讨论扩展到可在非平衡态条件下维持的自我繁殖系统。虽然未来在开放式进化所需的分子多样性、信息传递、适应性和选择等方面存在巨大挑战,但生成最小代谢循环的新兴战略可以扩展我们对地球生物圈化学萌发的不断深入的理解。
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来源期刊
Nature reviews. Chemistry
Nature reviews. Chemistry Chemical Engineering-General Chemical Engineering
CiteScore
52.80
自引率
0.80%
发文量
88
期刊介绍: Nature Reviews Chemistry is an online-only journal that publishes Reviews, Perspectives, and Comments on various disciplines within chemistry. The Reviews aim to offer balanced and objective analyses of selected topics, providing clear descriptions of relevant scientific literature. The content is designed to be accessible to recent graduates in any chemistry-related discipline while also offering insights for principal investigators and industry-based research scientists. Additionally, Reviews should provide the authors' perspectives on future directions and opinions regarding the major challenges faced by researchers in the field.
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