Nature Catalysis最新文献_第5页

Nickel nanoparticles encapsulated inside mesoporous MoO2 for industrially stable anion-exchange membrane water electrolysis 介孔MoO2包封镍纳米颗粒用于工业稳定阴离子交换膜电解

IF 48.3 1区化学

Nature Catalysis Pub Date : 2026-07-30 DOI: 10.1038/s41929-026-01585-w

Zhiheng Li, Gaoxin Lin, Linqin Wang, Wen Wu, Yunxuan Ding, Licheng Sun

{"title":"Nickel nanoparticles encapsulated inside mesoporous MoO2 for industrially stable anion-exchange membrane water electrolysis","authors":"Zhiheng Li, Gaoxin Lin, Linqin Wang, Wen Wu, Yunxuan Ding, Licheng Sun","doi":"10.1038/s41929-026-01585-w","DOIUrl":"10.1038/s41929-026-01585-w","url":null,"abstract":"The hydrogen evolution reaction (HER) plays a vital role in the production of green hydrogen, but it still faces practical issues, including low cost-efficiency, reduced catalytic activity and limited lifetime under industry-required ampere-scale current densities. Here we report a heterogeneous nucleation strategy to produce a scaled-up, inexpensive, energy-efficient and highly stable NiMo-based electrode (that is, h-Ni/MoO2) for HER electrolysis. The abundant inner surface formed by H2O release during annealing favours an encapsulated structure of the h-Ni/MoO2 catalyst, that is, Ni nanoparticles in porous MoO2 matrix, which ensures high HER activity (low overpotential of 70.9 ± 4.5 mV) and high HER stability (over 25,000 h) in 1 M KOH at −1,000 mA cm−2. When using h-Ni/MoO2 as the cathode catalyst, practical anion-exchange membrane water electrolysis delivers high activity (for example, 5.6 A cm−2 at 1.8 V and 10.2 A cm−2 at 2.0 V) and high durability (for example, over 2,000 h at 1,000 mA cm−2). NiMo-based catalysts exhibit excellent activity for the hydrogen evolution reaction in alkaline electrolytes, but achieving high stability remains a challenge. Now a synthetic strategy is presented to prepare highly active and stable Ni/MoO2 cathode catalysts for anion-exchange membrane water electrolysis.","PeriodicalId":18845,"journal":{"name":"Nature Catalysis","volume":"9 8","pages":"869-881"},"PeriodicalIF":48.3,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148612702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The interphase behind lithium-mediated ammonia 锂介导的氨的间期

IF 48.3 1区化学

Nature Catalysis Pub Date : 2026-07-23 DOI: 10.1038/s41929-026-01570-3

David Kumar Yesudoss, Abdoulaye Djire

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Defining screening of peptide-functionalizing biocatalysts 定义肽功能化生物催化剂的筛选

IF 48.3 1区化学

Nature Catalysis Pub Date : 2026-07-23 DOI: 10.1038/s41929-026-01577-w

Florian Hubrich

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Industrial waste reformed 工业废物改造

IF 48.3 1区化学

Nature Catalysis Pub Date : 2026-07-23 DOI: 10.1038/s41929-026-01586-9

Chenyu Wang

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When aggregation induces photocatalysis 当聚集诱导光催化时

IF 48.3 1区化学

Nature Catalysis Pub Date : 2026-07-23 DOI: 10.1038/s41929-026-01592-x

Saunak Das

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A tailored CoA ligase–N-acyltransferase cascade for on-DNA amide bond formation gives access to broad substrate scope 量身定制的辅酶A连接酶- n-酰基转移酶级联，用于dna上酰胺键的形成，可获得广泛的底物范围

IF 48.3 1区化学

Nature Catalysis Pub Date : 2026-07-17 DOI: 10.1038/s41929-026-01576-x

Daniela Schaub, Alice Lessing, Fabian Meyer, Peter Stockinger, Miquel Estévez-Gay, Michael Eichenberger, Gerlis von Haugwitz, Andreas Gloger, Jörg Scheuermann, Rebecca Buller

{"title":"A tailored CoA ligase–N-acyltransferase cascade for on-DNA amide bond formation gives access to broad substrate scope","authors":"Daniela Schaub, Alice Lessing, Fabian Meyer, Peter Stockinger, Miquel Estévez-Gay, Michael Eichenberger, Gerlis von Haugwitz, Andreas Gloger, Jörg Scheuermann, Rebecca Buller","doi":"10.1038/s41929-026-01576-x","DOIUrl":"10.1038/s41929-026-01576-x","url":null,"abstract":"DNA-encoded chemical library (DEL) technology is a powerful tool in early-stage drug discovery. Although widely applied in industry and academia, challenges persist in generating DELs with high quality and chemical diversity. Low yields in building-block incorporation, limited selectivity and, most importantly, DNA damage from harsh reaction conditions compromise library quality, reduce signal-to-noise in affinity selections and ultimately hinder drug discovery. Here we show that tailored enzymes can be harnessed for the effective construction of molecular diversity on DNA under mild conditions. Targeting amide bond formation, we designed a cascade of complementary coenzyme A ligases and rationally tailored N-acyltransferases to access a broad amide scope on-DNA (>120 examples), identifying structural elements that optimize the biocatalysts’ DNA compatibility in the process. Integrating the enzymatic cascade with chemical synthesis led to the construction of a diverse DEL without damage to the DNA barcode, highlighting the biocatalysts’ applicability for early scaffold construction and late-stage functionalization. DNA-encoded library (DEL) synthesis can be constrained by DNA damage and limited reaction scope under conventional chemistry. Here a complementary CoA ligase–N-acyltransferase cascade is engineered to enable high yield, DNA-compatible amide formation, expanding substrate scope and DEL quality.","PeriodicalId":18845,"journal":{"name":"Nature Catalysis","volume":"9 8","pages":"834-847"},"PeriodicalIF":48.3,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41929-026-01576-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148459866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Atomic-layer titration reveals optimal SrO termination for oxygen incorporation in perovskite oxides 原子层滴定法揭示了钙钛矿氧化物中氧掺入的最佳SrO终止

IF 48.3 1区化学

Nature Catalysis Pub Date : 2026-07-15 DOI: 10.1038/s41929-026-01582-z

引用次数: 0

Unlocking ketene–Heck coupling via activation energy modulation in Pd catalysis Pd催化中激活能调制解锁烯酮- heck偶联

IF 48.3 1区化学

Nature Catalysis Pub Date : 2026-07-13 DOI: 10.1038/s41929-026-01579-8

Binlin Zhao, Changping Fang, Pei Gu, Xiaowu Fang, Mengning Wang, Qiuzhu Wang, Mengtao Ma, Minyan Wang, Zhuangzhi Shi

{"title":"Unlocking ketene–Heck coupling via activation energy modulation in Pd catalysis","authors":"Binlin Zhao, Changping Fang, Pei Gu, Xiaowu Fang, Mengning Wang, Qiuzhu Wang, Mengtao Ma, Minyan Wang, Zhuangzhi Shi","doi":"10.1038/s41929-026-01579-8","DOIUrl":"10.1038/s41929-026-01579-8","url":null,"abstract":"The Mizoroki–Heck reaction represents a powerful method for carbon–carbon bond formation between aryl (pseudo)halides and olefins, yet its scope remains largely limited to olefinic partners and products. Here we address this limitation by introducing ketenes—highly reactive but underexplored intermediates—as coupling partners in a Heck-type transformation. Under palladium-catalysed, redox-neutral conditions, saturated acid chlorides generate ketenes in situ, which then couple directly with iodoarenes via an insertion step followed by β-hydride elimination, delivering enones as the products. The method also accommodates vinyl triflates, enabling efficient synthesis of divinyl ketones. Precise control of halide species, temperature and stoichiometry suppresses acid chloride decomposition and promotes in situ ketene generation for subsequent coupling. Combined experimental and computational studies reveal detailed mechanistic insights into stereoselectivity, rate-determining steps and side-reaction inhibition via activation energy modulation. This strategy seamlessly merges Heck coupling with ketene reactivity, unlocking access to diverse, complex molecular architectures. The Heck reaction is one of the most widely utilized in organic chemistry. Now the authors present a Heck-type transformation for the direct conversion of saturated acid chlorides into α,β-unsaturated ketones with iodoarenes via ketenes.","PeriodicalId":18845,"journal":{"name":"Nature Catalysis","volume":"9 9","pages":"943-952"},"PeriodicalIF":48.3,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148432535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Bifunctional molecular additives enable efficient oxygen reduction reaction on platinum electrodes in the presence of strongly binding anions 作者更正：双功能分子添加剂在强结合阴离子存在的情况下使铂电极上的氧还原反应有效

IF 48.3 1区化学

Nature Catalysis Pub Date : 2026-07-13 DOI: 10.1038/s41929-026-01591-y

Kaiyue Zhao, Linke Fu, Zelong Qiao, Yuke Li, Chaoran Huang, Bingyuan Chen, Zihan Jin, Xiaoqing Cao, Junrong Zheng, Shaojun Guo, Dapeng Cao, Xiaoxia Chang, Bingjun Xu

引用次数: 0

Direct copper-catalysed deaminative cyanation of aliphatic primary amines 直接铜催化脂肪族伯胺脱氨氰化反应

IF 48.3 1区化学

Nature Catalysis Pub Date : 2026-07-10 DOI: 10.1038/s41929-026-01578-9

Jiang-Hao Xue, Shuang Lin, Jiawu Huang, Taeseok Kang, Bumsu Park, Mark D. Levin, Myojeong Kim, Honggen Wang

{"title":"Direct copper-catalysed deaminative cyanation of aliphatic primary amines","authors":"Jiang-Hao Xue, Shuang Lin, Jiawu Huang, Taeseok Kang, Bumsu Park, Mark D. Levin, Myojeong Kim, Honggen Wang","doi":"10.1038/s41929-026-01578-9","DOIUrl":"10.1038/s41929-026-01578-9","url":null,"abstract":"The cyano group is a versatile motif in medicinal chemistry, serving as both a target and a precursor to other functional groups. However, direct deaminative cyanation of aliphatic amines remains a challenge due to the inertness of C–N bonds and the instability of amines under oxidative conditions. Here we report a catalytic, direct deaminative cyanation of aliphatic primary amines without preactivation. This method employs an anomeric amide for radical generation from amines and TMSCN as the cyano source, with a copper catalyst and N-fluorosulfonamide reagent cooperatively facilitating both radical coupling and propagation. This work integrates anomeric amide activation with transition-metal-catalysed bond formation. The strategy enables not only efficient cyanation but also asymmetric deaminative cyanation, stereocentre inversion and downstream transformations such as homologation and CO insertion, providing versatile tools for amine diversification. Direct deaminative cyanation of aliphatic amines is hampered by inert C–N bonds and oxidative instability. Now a copper-catalysed, preactivation-free approach enabled by anomeric amide activation is reported that also includes an asymmetric variant.","PeriodicalId":18845,"journal":{"name":"Nature Catalysis","volume":"9 9","pages":"934-942"},"PeriodicalIF":48.3,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41929-026-01578-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148432539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0