National Science Review最新文献_第9页

Non-linear ion transport in nanopores for the design of ultracapacitive ionic memristors. 纳米孔非线性离子输运用于超电容性离子记忆电阻器的设计。

IF 16.3 1区综合性期刊

National Science Review Pub Date : 2024-12-14 eCollection Date: 2025-01-01 DOI: 10.1093/nsr/nwae437

Panlong Li, Stefan Kaskel

引用次数: 0

Unveiling metal-support interactions through interpretable machine learning. 通过可解释的机器学习揭示金属支持相互作用。

IF 16.3 1区综合性期刊

National Science Review Pub Date : 2024-12-14 eCollection Date: 2025-01-01 DOI: 10.1093/nsr/nwae455

Junzhong Xie, Ding Ma

引用次数: 0

Reply to comment by Compagnoni et al. on "First finding of continental deep subduction in the Sesia Zone of Western Alps and implications for subduction dynamics". 回复Compagnoni等人关于“西阿尔卑斯山脉Sesia带首次发现大陆深俯冲及其俯冲动力学意义”的评论。

IF 16.3 1区综合性期刊

National Science Review Pub Date : 2024-12-12 eCollection Date: 2024-12-01 DOI: 10.1093/nsr/nwae457

Yi-Xiang Chen, Kun Zhou, Qiang He, Yong-Fei Zheng, Hans-Peter Schertl, Kun Chen

引用次数: 0

Comment on "First finding of continental deep subduction in the Sesia Zone of Western Alps and implications for subduction dynamics". 评“西阿尔卑斯山脉塞西亚带首次发现大陆深俯冲及其俯冲动力学意义”。

IF 16.3 1区综合性期刊

National Science Review Pub Date : 2024-12-12 eCollection Date: 2024-12-01 DOI: 10.1093/nsr/nwae454

Roberto Compagnoni, Mattia Gilio, Stefano Ghignone, Emanuele Scaramuzzo, Alessia Borghini, Marco Bruno

引用次数: 0

Sustainable management of riverine N₂O emission baselines. 河流N2O排放基线的可持续管理。

IF 16.3 1区综合性期刊

National Science Review Pub Date : 2024-12-11 eCollection Date: 2025-02-01 DOI: 10.1093/nsr/nwae458

Shuo Wang, Wei Zhi, Shengjie Li, Tao Lyu, Guodong Ji

{"title":"Sustainable management of riverine N2O emission baselines.","authors":"Shuo Wang, Wei Zhi, Shengjie Li, Tao Lyu, Guodong Ji","doi":"10.1093/nsr/nwae458","DOIUrl":"10.1093/nsr/nwae458","url":null,"abstract":"The riverine N2O fluxes are assumed to linearly increase with nitrate loading. However, this linear relationship with a uniform EF5r is poorly constrained, which impedes the N2O estimation and mitigation. Our meta-analysis discovered a universal N2O emission baseline (EF5r = k/[NO3 -], k = 0.02) for natural rivers. Anthropogenic impacts caused an overall increase in baselines and the emergence of hotspots, which constitute two typical patterns of anthropogenic sources. The k values of agricultural and urban rivers increased to 0.09 and 0.05, respectively, with 11% and 14% of points becoming N2O hotspots. Priority control of organic and NH4 + pollution could eliminate hotspots and reduce emissions by 51.6% and 63.7%, respectively. Further restoration of baseline emissions on nitrate removal is a long-term challenge considering population growth and declining unit benefits (ΔN-N2O/N-NO3 -). The discovery of EF lines emphasized the importance of targeting hotspots and managing baseline emissions sustainably to balance social and environmental benefits.","PeriodicalId":18842,"journal":{"name":"National Science Review","volume":"12 2","pages":"nwae458"},"PeriodicalIF":16.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The circadian clock orchestrates spermatogonial differentiation and fertilization by regulating retinoic acid signaling in vertebrates. 在脊椎动物中，生物钟通过调节视黄酸信号来协调精原细胞的分化和受精。

IF 16.3 1区综合性期刊

National Science Review Pub Date : 2024-12-11 eCollection Date: 2025-03-01 DOI: 10.1093/nsr/nwae456

Taole Liu, Wei He, Zhaomin Zhong, Chenchen Lu, Lianxin Wu, Ziming Wang, William Kojo Smith, Quan Shi, Qiaoming Long, Han Wang

{"title":"The circadian clock orchestrates spermatogonial differentiation and fertilization by regulating retinoic acid signaling in vertebrates.","authors":"Taole Liu, Wei He, Zhaomin Zhong, Chenchen Lu, Lianxin Wu, Ziming Wang, William Kojo Smith, Quan Shi, Qiaoming Long, Han Wang","doi":"10.1093/nsr/nwae456","DOIUrl":"10.1093/nsr/nwae456","url":null,"abstract":"The circadian clock generates and maintains ∼24-hour oscillations in almost all organs. The testis, however, remains mysterious, without a clear understanding of its circadian functions. Our time-series transcriptome analysis reveals more than 1000 rhythmically expressed genes in the zebrafish and mouse testes, respectively. Canonical circadian clock genes are rhythmically expressed in Sertoli cells and regulate retinoic acid (RA) production, which is also evidenced by their co-expression with RA synthesis genes in single Sertoli cells. Genetic and pharmacological manipulations and temporal desynchronization revealed that the circadian clock-regulated RA signaling synchronizes spermatogonial differentiation via zbtb16a and promotes fertilization via izumo1 in zebrafish. Our findings indicate that the testicular circadian clock contributes to reproduction in a cell-specific manner through RA signaling, highlighting circadian roles in male fertility.","PeriodicalId":18842,"journal":{"name":"National Science Review","volume":"12 3","pages":"nwae456"},"PeriodicalIF":16.3,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A deep learning framework for in silico screening of anticancer drugs at the single-cell level. 用于单细胞水平抗癌药物的计算机筛选的深度学习框架。

IF 16.3 1区综合性期刊

National Science Review Pub Date : 2024-12-10 eCollection Date: 2025-02-01 DOI: 10.1093/nsr/nwae451

Peijing Zhang, Xueyi Wang, Xufeng Cen, Qi Zhang, Yuting Fu, Yuqing Mei, Xinru Wang, Renying Wang, Jingjing Wang, Hongwei Ouyang, Tingbo Liang, Hongguang Xia, Xiaoping Han, Guoji Guo

{"title":"A deep learning framework for in silico screening of anticancer drugs at the single-cell level.","authors":"Peijing Zhang, Xueyi Wang, Xufeng Cen, Qi Zhang, Yuting Fu, Yuqing Mei, Xinru Wang, Renying Wang, Jingjing Wang, Hongwei Ouyang, Tingbo Liang, Hongguang Xia, Xiaoping Han, Guoji Guo","doi":"10.1093/nsr/nwae451","DOIUrl":"10.1093/nsr/nwae451","url":null,"abstract":"Tumor heterogeneity plays a pivotal role in tumor progression and resistance to clinical treatment. Single-cell RNA sequencing (scRNA-seq) enables us to explore heterogeneity within a cell population and identify rare cell types, thereby improving our design of targeted therapeutic strategies. Here, we use a pan-cancer and pan-tissue single-cell transcriptional landscape to reveal heterogeneous expression patterns within malignant cells, precancerous cells, as well as cancer-associated stromal and endothelial cells. We introduce a deep learning framework named Shennong for in silico screening of anticancer drugs for targeting each of the landscape cell clusters. Utilizing Shennong, we could predict individual cell responses to pharmacologic compounds, evaluate drug candidates' tissue damaging effects, and investigate their corresponding action mechanisms. Prioritized compounds in Shennong's prediction results include FDA-approved drugs currently undergoing clinical trials for new indications, as well as drug candidates reporting anti-tumor activity. Furthermore, the tissue damaging effect prediction aligns with documented injuries and terminated discovery events. This robust and explainable framework has the potential to accelerate the drug discovery process and enhance the accuracy and efficiency of drug screening.","PeriodicalId":18842,"journal":{"name":"National Science Review","volume":"12 2","pages":"nwae451"},"PeriodicalIF":16.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-phosgene route: catalytic carbonylation of amines to form unsymmetrical ureas. 非光气途径：催化胺羰基化形成不对称脲。

IF 16.3 1区综合性期刊

National Science Review Pub Date : 2024-12-09 eCollection Date: 2025-01-01 DOI: 10.1093/nsr/nwae450

Shunji Xie, Ye Wang

引用次数: 0

Real-time mapping of gapless 24-hour surface PM₁₀ in China. 中国24小时无间隙地面PM10实时制图。

IF 16.3 1区综合性期刊

National Science Review Pub Date : 2024-12-09 eCollection Date: 2025-02-01 DOI: 10.1093/nsr/nwae446

Xutao Zhang, Ke Gui, Hengheng Zhao, Nanxuan Shang, Zhaoliang Zeng, Wenrui Yao, Lei Li, Yu Zheng, Hujia Zhao, Yurun Liu, Yucong Miao, Yue Peng, Ye Fei, Fugang Li, Baoxin Li, Hong Wang, Zhili Wang, Yaqiang Wang, Huizheng Che, Xiaoye Zhang

{"title":"Real-time mapping of gapless 24-hour surface PM10 in China.","authors":"Xutao Zhang, Ke Gui, Hengheng Zhao, Nanxuan Shang, Zhaoliang Zeng, Wenrui Yao, Lei Li, Yu Zheng, Hujia Zhao, Yurun Liu, Yucong Miao, Yue Peng, Ye Fei, Fugang Li, Baoxin Li, Hong Wang, Zhili Wang, Yaqiang Wang, Huizheng Che, Xiaoye Zhang","doi":"10.1093/nsr/nwae446","DOIUrl":"10.1093/nsr/nwae446","url":null,"abstract":"Large-scale mapping of surface coarse particulate matter (PM10) concentration remains a key focus for air quality monitoring. Satellite aerosol optical depth (AOD)-based data fusion approaches decouple the non-linear AOD-PM10 relationship, enabling high-resolution PM10 data acquisition, but are limited by spatial incompleteness and the absence of nighttime data. Here, a gridded visibility-based real-time surface PM10 retrieval (RT-SPMR) framework for China is introduced, addressing the gap in seamless hourly PM10 data within the 24-hour cycle. This framework utilizes multisource data inputs and dynamically updated machine-learning models to produce 6.25-km gridded 24-hour PM10 data. Cross-validation showed that the RT-SPMR model's daily retrieval accuracy surpassed prior studies. Additionally, through rolling iterative validation experiments, the model exhibited strong generalization capability and stability, demonstrating its suitability for operational deployment. Taking a record-breaking dust storm as an example, the model proved effective in tracking the fine-scale evolution of the dust intrusion process, especially in under-observed areas. Consequently, the operational RT-SPMR framework provides comprehensive real-time capability for monitoring PM10 pollution in China, and has the potential to improve the accuracy of dust storm forecasting models by enhancing the PM10 initial field.","PeriodicalId":18842,"journal":{"name":"National Science Review","volume":"12 2","pages":"nwae446"},"PeriodicalIF":16.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lattice plainification and band engineering lead to high thermoelectric cooling and power generation in n-type Bi₂Te₃ with mass production. 晶格化和能带工程实现了n型Bi2Te3的高热电冷却和高产能。

IF 16.3 1区综合性期刊

National Science Review Pub Date : 2024-12-06 eCollection Date: 2025-02-01 DOI: 10.1093/nsr/nwae448

Dongrui Liu, Shulin Bai, Yi Wen, Jiayi Peng, Shibo Liu, Haonan Shi, Yichen Li, Tao Hong, Huiqiang Liang, Yongxin Qin, Lizhong Su, Xin Qian, Dongyang Wang, Xiang Gao, Zhihai Ding, Qian Cao, Qing Tan, Bingchao Qin, Li-Dong Zhao

{"title":"Lattice plainification and band engineering lead to high thermoelectric cooling and power generation in n-type Bi2Te3 with mass production.","authors":"Dongrui Liu, Shulin Bai, Yi Wen, Jiayi Peng, Shibo Liu, Haonan Shi, Yichen Li, Tao Hong, Huiqiang Liang, Yongxin Qin, Lizhong Su, Xin Qian, Dongyang Wang, Xiang Gao, Zhihai Ding, Qian Cao, Qing Tan, Bingchao Qin, Li-Dong Zhao","doi":"10.1093/nsr/nwae448","DOIUrl":"10.1093/nsr/nwae448","url":null,"abstract":"Thermoelectrics can mutually convert between thermal and electrical energy, ensuring its utilization in both power generation and solid-state cooling. Bi2Te3 exhibits promising room-temperature performance, making it the sole commercially available thermoelectrics to date. Guided by the lattice plainification strategy, we introduce trace amounts of Cu into n-type Bi2(Te, Se)3 (BTS) to occupy Bi vacancies, thereby simultaneously weakening defect scattering and modulating the electronic bands. Meanwhile, the interstitial Cu can bond with the BTS matrix to form extra electron transport pathways. The multiple occupations of Cu substantially boost carrier mobility and electrical performance. Consequently, the BTS + 0.2%Cu achieves a room-temperature ZT of ∼1.3 with an average ZT ave of ∼1.2 at 300-523 K. Moreover, the kilogram-scale ingot designed for mass production also exhibits high uniformity. Finally, we fabricate a full-scale device that achieves an excellent conversion efficiency of ∼6.4% and a high cooling ΔT max of ∼70.1 K, both of which outperform commercial devices.","PeriodicalId":18842,"journal":{"name":"National Science Review","volume":"12 2","pages":"nwae448"},"PeriodicalIF":16.3,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0