Molecular Genetics and Genomics最新文献

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Targeting WWP1 ameliorates osteoarthritis by suppressing KLF15 ubiquitination to restore mtDNA and mitochondrial function. 靶向WWP1通过抑制KLF15泛素化来恢复mtDNA和线粒体功能来改善骨关节炎。
IF 2.1 3区 生物学
Molecular Genetics and Genomics Pub Date : 2026-04-24 DOI: 10.1007/s00438-026-02417-z
Zhiling Li, Wanli Lan, Yong Luo, Ping Liu, Xinyi Li, Hongxing Li
{"title":"Targeting WWP1 ameliorates osteoarthritis by suppressing KLF15 ubiquitination to restore mtDNA and mitochondrial function.","authors":"Zhiling Li, Wanli Lan, Yong Luo, Ping Liu, Xinyi Li, Hongxing Li","doi":"10.1007/s00438-026-02417-z","DOIUrl":"https://doi.org/10.1007/s00438-026-02417-z","url":null,"abstract":"","PeriodicalId":18816,"journal":{"name":"Molecular Genetics and Genomics","volume":"301 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In silico characterization of melanoma-derived mouse lncRNA Gm26982 and comparative analyses with human ortholog. 黑素瘤来源小鼠lncRNA Gm26982的计算机表征及其与人类同源基因的比较分析。
IF 2.1 3区 生物学
Molecular Genetics and Genomics Pub Date : 2026-04-24 DOI: 10.1007/s00438-026-02423-1
Shalini Majumder, Ekarsi Lodh, Tiasha De, Tapan Chowdhury
{"title":"In silico characterization of melanoma-derived mouse lncRNA Gm26982 and comparative analyses with human ortholog.","authors":"Shalini Majumder, Ekarsi Lodh, Tiasha De, Tapan Chowdhury","doi":"10.1007/s00438-026-02423-1","DOIUrl":"https://doi.org/10.1007/s00438-026-02423-1","url":null,"abstract":"","PeriodicalId":18816,"journal":{"name":"Molecular Genetics and Genomics","volume":"301 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SND1 regulates the androgen signaling axis by stabilizing EIF3B mRNA to facilitate the deterioration of prostate cancer. SND1通过稳定EIF3B mRNA调控雄激素信号轴,促进前列腺癌恶化。
IF 2.1 3区 生物学
Molecular Genetics and Genomics Pub Date : 2026-04-16 DOI: 10.1007/s00438-026-02416-0
Ying Li, Chengru Yang, Guoli Cui, Shiliang Gui, Linlin Jia, Yu Chen, Honglin Niu, Hua Xin
{"title":"SND1 regulates the androgen signaling axis by stabilizing EIF3B mRNA to facilitate the deterioration of prostate cancer.","authors":"Ying Li, Chengru Yang, Guoli Cui, Shiliang Gui, Linlin Jia, Yu Chen, Honglin Niu, Hua Xin","doi":"10.1007/s00438-026-02416-0","DOIUrl":"https://doi.org/10.1007/s00438-026-02416-0","url":null,"abstract":"","PeriodicalId":18816,"journal":{"name":"Molecular Genetics and Genomics","volume":"301 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knockout of kdm4aa inhibits early embryonic development in zebrafish via downregulating cyp26a1. 敲除kdm4aa通过下调cyp26a1抑制斑马鱼早期胚胎发育。
IF 2.1 3区 生物学
Molecular Genetics and Genomics Pub Date : 2026-04-15 DOI: 10.1007/s00438-026-02419-x
Rui Deng, Xinqing Cai, Hui Jiang, Yuting Luo, Weiran Chai, Bingshe Han, Junfang Zhang
{"title":"Knockout of kdm4aa inhibits early embryonic development in zebrafish via downregulating cyp26a1.","authors":"Rui Deng, Xinqing Cai, Hui Jiang, Yuting Luo, Weiran Chai, Bingshe Han, Junfang Zhang","doi":"10.1007/s00438-026-02419-x","DOIUrl":"https://doi.org/10.1007/s00438-026-02419-x","url":null,"abstract":"","PeriodicalId":18816,"journal":{"name":"Molecular Genetics and Genomics","volume":"301 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
pka1 deletion induces hyperactivation of the transcription factor Mca1 and drives chromosome mis-segregation in Schizosaccharomyces pombe. pka1缺失诱导转录因子Mca1的过度激活并驱动裂糖酵母染色体错误分离。
IF 2.1 3区 生物学
Molecular Genetics and Genomics Pub Date : 2026-04-15 DOI: 10.1007/s00438-026-02379-2
Moe Yamawaki, Shiho Nishioka, Yasuhiro Matsuo
{"title":"pka1 deletion induces hyperactivation of the transcription factor Mca1 and drives chromosome mis-segregation in Schizosaccharomyces pombe.","authors":"Moe Yamawaki, Shiho Nishioka, Yasuhiro Matsuo","doi":"10.1007/s00438-026-02379-2","DOIUrl":"10.1007/s00438-026-02379-2","url":null,"abstract":"","PeriodicalId":18816,"journal":{"name":"Molecular Genetics and Genomics","volume":"301 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecules of mood: the integrated molecular transducers of exercise's antidepressant effects. 情绪分子:运动抗抑郁作用的综合分子传感器。
IF 2.1 3区 生物学
Molecular Genetics and Genomics Pub Date : 2026-04-11 DOI: 10.1007/s00438-026-02404-4
Ding Yuan
{"title":"Molecules of mood: the integrated molecular transducers of exercise's antidepressant effects.","authors":"Ding Yuan","doi":"10.1007/s00438-026-02404-4","DOIUrl":"https://doi.org/10.1007/s00438-026-02404-4","url":null,"abstract":"","PeriodicalId":18816,"journal":{"name":"Molecular Genetics and Genomics","volume":"301 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phosphosite-centric regulatory network of ATAD2 and its involvement in transcriptional networks. ATAD2磷酸化中心调控网络及其在转录网络中的作用。
IF 2.1 3区 生物学
Molecular Genetics and Genomics Pub Date : 2026-04-11 DOI: 10.1007/s00438-026-02415-1
Amal Fahma, Fathimathul Lubaba, Aswin Mohan, Pathiyil Sajini Sekhar, Athira Perunelly Gopalakrishnan, Rajesh Raju
{"title":"Phosphosite-centric regulatory network of ATAD2 and its involvement in transcriptional networks.","authors":"Amal Fahma, Fathimathul Lubaba, Aswin Mohan, Pathiyil Sajini Sekhar, Athira Perunelly Gopalakrishnan, Rajesh Raju","doi":"10.1007/s00438-026-02415-1","DOIUrl":"https://doi.org/10.1007/s00438-026-02415-1","url":null,"abstract":"<p><p>The phosphorylation dependent regulation of transcription factors, transcriptional co-regulators and chromatin remodelling factors influences transcription. Aberrant transcriptional regulations driven by chromatin-associated oncogenic factors are a feature of various cancers; however, their phosphorylation-dependent regulation remains poorly characterised. ATPase family AAA domain-containing protein 2 (ATAD2) is a chromatin-associated factor implicated in oncogenic transcriptions. Here, we present a comprehensive phosphosite-centric analysis of ATAD2 by integrating data from multiple phosphoproteomic studies, encompassing 859 profiling and 285 differential datasets. From the class 1 differentially regulated phosphosites, four predominant phosphosites-S327, S337, S342, and T1152, emerged as consistently regulated and were frequently detected in diverse tumour datasets. The co-differentially phosphorylated proteins, including their interactors and potential upstream kinases (HASPIN, STK10, CDK12, PRP4K, CDK13, PAK4), were involved in cell cycle, chromatin remodelling, transcription, and DNA repair. Several phosphosites in transcription factors were found to be coregulated along with ATAD2 phosphosites. Phosphorylation at S327 and S342 was broadly upregulated and positively associated with transcriptional activators, suggesting a role in promoting transcription. In contrast, phosphorylation at S337 and T1152 correlated with proteins involved in transcriptional repression, indicating its involvement in inhibitory function. Collectively, these findings indicate the involvement of the ATAD2 phosphoregulatory network in transcriptional regulation and provide insights into the regulatory landscape of ATAD2, laying the groundwork for its potential therapeutic targeting in cancers.</p>","PeriodicalId":18816,"journal":{"name":"Molecular Genetics and Genomics","volume":"301 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling the molecular landscape: an overview on gene expression, epigenetic alterations, and therapeutic challenges in head and neck squamous cell carcinoma. 揭示分子景观:对头颈部鳞状细胞癌的基因表达、表观遗传改变和治疗挑战的综述。
IF 2.1 3区 生物学
Molecular Genetics and Genomics Pub Date : 2026-04-06 DOI: 10.1007/s00438-026-02413-3
Maheshvare Natesan, Suma Mohan, Brindha Gr, Devipriya Nagarajan
{"title":"Unraveling the molecular landscape: an overview on gene expression, epigenetic alterations, and therapeutic challenges in head and neck squamous cell carcinoma.","authors":"Maheshvare Natesan, Suma Mohan, Brindha Gr, Devipriya Nagarajan","doi":"10.1007/s00438-026-02413-3","DOIUrl":"https://doi.org/10.1007/s00438-026-02413-3","url":null,"abstract":"","PeriodicalId":18816,"journal":{"name":"Molecular Genetics and Genomics","volume":"301 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploratory identification of lycorine as a potential inhibitor of the ACP2/YME1L1 prognostic axis in esophageal squamous cell carcinoma: a multi-omics and computational hypothesis. 探索鉴定石蒜碱作为食管癌ACP2/YME1L1预后轴的潜在抑制剂:一个多组学和计算假设。
IF 2.1 3区 生物学
Molecular Genetics and Genomics Pub Date : 2026-04-06 DOI: 10.1007/s00438-026-02402-6
Fang Chen, Junpeng Zhang, Ying Xu, Yalin Wang, Jian Cheng
{"title":"Exploratory identification of lycorine as a potential inhibitor of the ACP2/YME1L1 prognostic axis in esophageal squamous cell carcinoma: a multi-omics and computational hypothesis.","authors":"Fang Chen, Junpeng Zhang, Ying Xu, Yalin Wang, Jian Cheng","doi":"10.1007/s00438-026-02402-6","DOIUrl":"https://doi.org/10.1007/s00438-026-02402-6","url":null,"abstract":"","PeriodicalId":18816,"journal":{"name":"Molecular Genetics and Genomics","volume":"301 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
WGS-based in silico analysis of clinically-associated Klebsiella pneumoniae genomes: insights into antimicrobial resistance, virulence determinants, and plasmid dynamics. 基于wgs的临床相关肺炎克雷伯菌基因组的计算机分析:对抗菌素耐药性、毒力决定因素和质粒动力学的见解。
IF 2.1 3区 生物学
Molecular Genetics and Genomics Pub Date : 2026-04-06 DOI: 10.1007/s00438-026-02414-2
Santhiya Vijayakumar, Sudha Ramaiah
{"title":"WGS-based in silico analysis of clinically-associated Klebsiella pneumoniae genomes: insights into antimicrobial resistance, virulence determinants, and plasmid dynamics.","authors":"Santhiya Vijayakumar, Sudha Ramaiah","doi":"10.1007/s00438-026-02414-2","DOIUrl":"https://doi.org/10.1007/s00438-026-02414-2","url":null,"abstract":"","PeriodicalId":18816,"journal":{"name":"Molecular Genetics and Genomics","volume":"301 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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