Molecules and Cells最新文献_第9页

Cover and caption 封面和标题

IF 3.8 3区生物学

Molecules and Cells Pub Date : 2024-02-01 DOI: 10.1016/S1016-8478(24)00058-X

引用次数: 0

Sensory nerve and neuropeptide diversity in adipose tissues 脂肪组织中的感觉神经和神经肽多样性

IF 3.8 3区生物学

Molecules and Cells Pub Date : 2024-02-01 DOI: 10.1016/j.mocell.2024.100030

Gargi Mishra, Kristy L. Townsend

{"title":"Sensory nerve and neuropeptide diversity in adipose tissues","authors":"Gargi Mishra, Kristy L. Townsend","doi":"10.1016/j.mocell.2024.100030","DOIUrl":"10.1016/j.mocell.2024.100030","url":null,"abstract":"<div><p>Both brown and white adipose tissues (BAT/WAT) are innervated by the peripheral nervous system, including efferent sympathetic nerves that communicate from the brain/central nervous system out to the tissue, and afferent sensory nerves that communicate from the tissue back to the brain and locally release neuropeptides to the tissue upon stimulation. This bidirectional neural communication is important for energy balance and metabolic control, as well as maintaining adipose tissue health through processes like browning (development of metabolically healthy brown adipocytes in WAT), thermogenesis, lipolysis, and adipogenesis. Decades of sensory nerve denervation studies have demonstrated the particular importance of adipose sensory nerves for brown adipose tissue and WAT functions, but far less is known about the tissue’s sensory innervation compared to the better-studied sympathetic nerves and their neurotransmitter norepinephrine. In this review, we cover what is known and not yet known about sensory nerve activities in adipose, focusing on their effector neuropeptide actions in the tissue.</p></div>","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1016847824000359/pdfft?md5=148038ab6dbe2084b83138a0dd382c93&pid=1-s2.0-S1016847824000359-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139746985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The emerging era of multidisciplinary metabolism research 新兴的多学科代谢研究时代。

IF 3.8 3区生物学

Molecules and Cells Pub Date : 2024-02-01 DOI: 10.1016/j.mocell.2024.100032

Jongsoon Lee

引用次数: 0

Editorial Board Members/Copyright 编委会成员/版权

IF 3.8 3区生物学

Molecules and Cells Pub Date : 2024-02-01 DOI: 10.1016/S1016-8478(24)00060-8

引用次数: 0

Altered lipid metabolism as a predisposing factor for liver metastasis in MASLD 脂质代谢改变是MASLD肝转移的诱发因素。

IF 3.8 3区生物学

Molecules and Cells Pub Date : 2024-02-01 DOI: 10.1016/j.mocell.2024.100010

So Jung Kim , Jeongeun Hyun

{"title":"Altered lipid metabolism as a predisposing factor for liver metastasis in MASLD","authors":"So Jung Kim , Jeongeun Hyun","doi":"10.1016/j.mocell.2024.100010","DOIUrl":"10.1016/j.mocell.2024.100010","url":null,"abstract":"<div><p>Recently, the incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing due to the high prevalence of metabolic conditions, such as obesity and type 2 diabetes mellitus. Steatotic liver is a hotspot for cancer metastasis in MASLD. Altered lipid metabolism, a hallmark of MASLD, remodels the tissue microenvironment, making it conducive to the growth of metastatic liver cancer. Tumors exacerbate the dysregulation of hepatic metabolism by releasing extracellular vesicles and particles into the liver. Altered lipid metabolism influences the proliferation, differentiation, and functions of immune cells, contributing to the formation of an immunosuppressive and metastasis-prone liver microenvironment in MASLD. This review discusses the mechanisms by which the steatotic liver promotes liver metastasis progression, focusing on its role in fostering an immunosuppressive microenvironment in MASLD. Furthermore, this review highlights lipid metabolism manipulation strategies for the therapeutic management of metastatic liver cancer.</p></div>","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1016847824000037/pdfft?md5=0f96546f4bc43b3ce064cb2fe952565d&pid=1-s2.0-S1016847824000037-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OASIS portable: User-friendly offline suite for secure survival analysis 便携式 OASIS：用于安全生存分析的用户友好型离线套件。

IF 3.8 3区生物学

Molecules and Cells Pub Date : 2024-02-01 DOI: 10.1016/j.mocell.2024.100011

Seong Kyu Han , Hyunwoo C. Kwon , Jae-Seong Yang , Sanguk Kim , Seung-Jae V. Lee

引用次数: 0

Marchf6: A guardian against cytosol-spilled POMC-induced ferroptosis Marchf6：防止细胞质溢出 POMC 诱导的铁突变的卫士。

IF 3.8 3区生物学

Molecules and Cells Pub Date : 2024-02-01 DOI: 10.1016/j.mocell.2024.100008

Sang-Hyeon Mun, Cheol-Sang Hwang

引用次数: 0

Unraveling the mystery of oligogenic inheritance under way? 正在揭开寡基因遗传之谜？

IF 3.8 3区生物学

Molecules and Cells Pub Date : 2024-01-01 DOI: 10.1016/j.mocell.2023.10.002

Yerim Lee, Jaesang Kim

引用次数: 0

Function and regulation of nitric oxide signaling in Drosophila 果蝇体内一氧化氮信号的功能与调控

IF 3.8 3区生物学

Molecules and Cells Pub Date : 2024-01-01 DOI: 10.1016/j.mocell.2023.12.004

Sangyun Jeong

{"title":"Function and regulation of nitric oxide signaling in Drosophila","authors":"Sangyun Jeong","doi":"10.1016/j.mocell.2023.12.004","DOIUrl":"10.1016/j.mocell.2023.12.004","url":null,"abstract":"<div><p>Nitric oxide (NO) serves as an evolutionarily conserved signaling molecule that plays an important role in a wide variety of cellular processes. Extensive studies in <em>Drosophila melanogaster</em> have revealed that NO signaling is required for development, physiology, and stress responses in many different types of cells. In neuronal cells, multiple NO signaling pathways appear to operate in different combinations to regulate learning and memory formation, synaptic transmission, selective synaptic connections, axon degeneration, and axon regrowth. During organ development, elevated NO signaling suppresses cell cycle progression, whereas downregulated NO leads to an increase in larval body size via modulation of hormone signaling. The most striking feature of the <em>Drosophila</em> NO synthase is that various stressors, such as neuropeptides, aberrant proteins, hypoxia, bacterial infection, and mechanical injury, can activate <em>Drosophila</em> NO synthase, initially regulating cellular physiology to enable cells to survive. However, under severe stress or pathophysiological conditions, high levels of NO promote regulated cell death and the development of neurodegenerative diseases. In this review, I highlight and discuss the current understanding of molecular mechanisms by which NO signaling regulates distinct cellular functions and behaviors.</p></div>","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1016847823252565/pdfft?md5=fe343c570fcd664f3f2eb25079fa6b37&pid=1-s2.0-S1016847823252565-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138989752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ER stress and unfolded protein response (UPR) signaling modulate GLP-1 receptor signaling in the pancreatic islets ER应激和折叠蛋白反应（UPR）信号调节胰岛中的GLP-1受体信号传导

IF 3.8 3区生物学

Molecules and Cells Pub Date : 2024-01-01 DOI: 10.1016/j.mocell.2023.12.002

Yurong Gao , Hanguk Ryu , Hyejin Lee , Young-Joon Kim , Ji-Hye Lee , Jaemin Lee

{"title":"ER stress and unfolded protein response (UPR) signaling modulate GLP-1 receptor signaling in the pancreatic islets","authors":"Yurong Gao , Hanguk Ryu , Hyejin Lee , Young-Joon Kim , Ji-Hye Lee , Jaemin Lee","doi":"10.1016/j.mocell.2023.12.002","DOIUrl":"10.1016/j.mocell.2023.12.002","url":null,"abstract":"<div><p>Insulin is essential for maintaining normoglycemia and is predominantly secreted in response to glucose stimulation by β-cells. Incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide, also stimulate insulin secretion. However, as obesity and type 2 diabetes worsen, glucose-dependent insulinotropic polypeptide loses its insulinotropic efficacy, whereas GLP-1 receptor (GLP-1R) agonists continue to be effective owing to its signaling switch from Gs to Gq. Herein, we demonstrated that endoplasmic reticulum (ER) stress induced a transition from Gs to Gq in GLP-1R signaling in mouse islets. Intriguingly, chemical chaperones known to alleviate ER stress, such as 4-PBA and TUDCA, enforced GLP-1R’s Gq utilization rather than reversing GLP-1R’s signaling switch induced by ER stress or obese and diabetic conditions. In addition, the activation of X-box binding protein 1 (XBP1) or activating transcription factor 6 (ATF6), 2 key ER stress-associated signaling (unfolded protein response) factors, promoted Gs utilization in GLP-1R signaling, whereas Gq employment by ER stress was unaffected by XBP1 or ATF6 activation. Our study revealed that ER stress and its associated signaling events alter GLP-1R’s signaling, which can be used in type 2 diabetes treatment.</p></div>","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1016847823252541/pdfft?md5=ee2b156b8a71f002eb64d694ae623355&pid=1-s2.0-S1016847823252541-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138993844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0