Female reproductive disease, endometriosis: From inflammation to infertility

IF 3.7 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules and Cells Pub Date : 2025-01-01 DOI:10.1016/j.mocell.2024.100164

Wonhyoung Park , Whasun Lim , Miji Kim , Hyewon Jang , Soo Jin Park , Gwonhwa Song , Sunwoo Park

引用次数: 0

Abstract

Despite the fact that endometriosis is a common gynecological disease that occurs in 10% of women of reproductive age, the pathogenesis and treatment strategy are not clear to date. Endometriosis patients are commonly characterized by adhesions in the pelvis or ovaries, which leads to prolonged inflammation in the abdominal cavity. To handle the chronic inflammation, changes of immune cells, including T cells, NK cells, and macrophage, are accompanied. Therefore, diverse cytokines and adhesions of the abdominal cavity lead to poor quality of ovarian follicles, inappropriate response to the hormone, and infertility. This review will guide researchers to summarize the molecular changes and identify new treatment strategies for endometriosis-mediated inflammation and pregnancy failure.

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女性生殖疾病，子宫内膜异位症：从炎症到不孕。

尽管子宫内膜异位症是一种常见的妇科疾病，发生率为10%的育龄妇女，但其发病机制和治疗策略至今尚不清楚。子宫内膜异位症患者通常以骨盆或卵巢粘连为特征，导致腹腔长期炎症。在慢性炎症的处理过程中，免疫细胞包括t细胞、NK细胞和巨噬细胞都发生了变化。因此，多种细胞因子和腹腔粘连导致卵巢卵泡质量差，对激素反应不恰当，导致不孕。本文综述将指导研究人员总结子宫内膜异位症介导的炎症和妊娠失败的分子变化，并确定新的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecules and Cells 生物-生化与分子生物学

CiteScore

6.60

自引率

10.50%

发文量

审稿时长

2.3 months

期刊介绍： Molecules and Cells is an international on-line open-access journal devoted to the advancement and dissemination of fundamental knowledge in molecular and cellular biology. It was launched in 1990 and ISO abbreviation is "Mol. Cells". Reports on a broad range of topics of general interest to molecular and cell biologists are published. It is published on the last day of each month by the Korean Society for Molecular and Cellular Biology.