Exploring the multifaceted functions of APPL in metabolism and memory using Drosophila melanogaster

IF 3.7 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules and Cells Pub Date : 2025-01-01 DOI:10.1016/j.mocell.2024.100163

Dharmendra Kumar Nath, Youngseok Lee

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Abstract

Amyloid precursor protein (APP) is a single-pass transmembrane protein abundantly expressed in the central nervous system and implicated in familial Alzheimer’s disease, a progressive neurodegenerative disorder that impairs memory. Here, we investigated the role of amyloid precursor protein-like (APPL) using the model organism Drosophila melanogaster. In this study, Appl null mutants exhibited a reduced lifespan under normal conditions and increased triglyceride levels, which were mitigated by metformin treatment. Additionally, taste-associative memory impairment in Appl^d mutants suggested APPL’s role in memory formation, which was restored by curcumin supplementation. The Appl^d mutants also displayed reduced climbing ability, which was improved by supplementation with vitamins C (ascorbic acid) and B₂ (riboflavin). These findings suggest that APPL is involved in metabolic regulation, cognition, climbing activity, and aging in Drosophila melanogaster.

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利用黑腹果蝇探索类淀粉样前体蛋白（APPL）在新陈代谢和记忆中的多方面功能。

淀粉样前体蛋白（APP）是一种在中枢神经系统中大量表达的单通道跨膜蛋白，与家族性阿尔茨海默病（AD）有关，AD是一种进行性神经退行性疾病，会损害记忆。在这里，我们利用模式生物黑腹果蝇研究了类淀粉样前体蛋白（APPL）的作用。在这项研究中，Appl无效突变体在正常条件下表现出寿命缩短和甘油三酯（TAG）水平升高，而二甲双胍治疗可减轻这种现象。此外，Appld突变体的味觉联想记忆障碍表明APPL在记忆形成中的作用，而姜黄素补充剂可恢复这种作用。Appld突变体的攀爬能力也有所下降，而补充维生素C（抗坏血酸）和B2（核黄素）后，攀爬能力有所提高。这些发现表明，APPL参与了黑腹果蝇的代谢调节、认知、攀爬活动和衰老。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecules and Cells 生物-生化与分子生物学

CiteScore

6.60

自引率

10.50%

发文量

审稿时长

2.3 months

期刊介绍： Molecules and Cells is an international on-line open-access journal devoted to the advancement and dissemination of fundamental knowledge in molecular and cellular biology. It was launched in 1990 and ISO abbreviation is "Mol. Cells". Reports on a broad range of topics of general interest to molecular and cell biologists are published. It is published on the last day of each month by the Korean Society for Molecular and Cellular Biology.