NanoImpact最新文献

{"title":"An integrated approach to assess exposure and early health effects in human populations exposed to micro- and nanoplastics","authors":"Julia Catalán ,&nbsp;Anani K. Afanou ,&nbsp;Jéssica Arribas Arranz ,&nbsp;Arantxa Ballesteros Riaza ,&nbsp;Ivana Banić ,&nbsp;Hubert Dirven ,&nbsp;Irina Estrela-Lopis ,&nbsp;Alba Hernández ,&nbsp;Tomi Kanerva ,&nbsp;Christian Laforsch ,&nbsp;Esther Lenssen ,&nbsp;Martin G.J. Löder ,&nbsp;Susana Pastor ,&nbsp;Hanna Pulli ,&nbsp;Anja F.R.M. Ramsperger ,&nbsp;Igor Snapkow ,&nbsp;Mirjana Turkalj ,&nbsp;Verónica Vela ,&nbsp;Tom Venus ,&nbsp;Runyu Zou ,&nbsp;Enrico Bergamaschi","doi":"10.1016/j.impact.2025.100600","DOIUrl":"10.1016/j.impact.2025.100600","url":null,"abstract":"<div><div>Although cumulative evidence from in vitro and in vivo studies indicates that micro- and nanoplastics (MNPs) can induce toxic effects, and MNPs have been detected in several human fluids and tissues, the consequences of MNP exposure to human health still remain unknown. Human biomonitoring (HBM) studies allow assessing human exposure to MPs and associated adverse health effects, contributing to the risk assessment of these environmental pollutants. To date, reliable human exposure estimates are hindered by the lack of standardized processing and analytical methods to detect MNPs in human tissues, and limited evidence on the MNP-related adverse health effects exists. Occupational environments, where plastics are processed, may represent prioritized settings for such evaluations, as workers typically face higher exposure levels than the general population. Population sub-groups with potentially higher susceptibility, such as children and pregnant women, should also be considered. To develop effective preventive strategies, it is essential to identify and validate sensitive and specific biomarkers of exposure and early biological changes, which could result in adverse health effects. Standardized protocols integrating environmental exposure assessment with HBM, and sensitive methods for evaluating internal dose resulting from cumulative exposure to MNP particles and associated chemicals are needed. Based on the experience gathered by a multidisciplinary panel of experts belonging to the European Research Cluster to Understand the Health Impacts of MNPs (CUSP), this consensus paper describes the key elements that should be part of an integrated HBM approach for MNP exposure, emphasizing existing challenges and proposing solutions for future studies.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"40 ","pages":"Article 100600"},"PeriodicalIF":5.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145620297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From exposure to risk prevention: an integrated, data driven approach to testing and assessing occupational hazards of inhaled nanomaterials","authors":"Luisana Di Cristo ,&nbsp;Brabu Balusamy ,&nbsp;Alessio Romaldini ,&nbsp;Francesca Tombolini ,&nbsp;Riccardo Ferrante ,&nbsp;Delia Cavallo ,&nbsp;Cinzia Lucia Ursini ,&nbsp;Luca Leoncino ,&nbsp;Antonio Esau Del Rio Castillo ,&nbsp;Francesco Bonaccorso ,&nbsp;Sergio Iavicoli ,&nbsp;Fabio Boccuni ,&nbsp;Stefania Sabella","doi":"10.1016/j.impact.2025.100598","DOIUrl":"10.1016/j.impact.2025.100598","url":null,"abstract":"<div><div>Occupational risk assessment of manufactured nanomaterials (MNMs) requires targeted hazard and exposure quantification, which, however, are currently limited by uncertainties about measurements and metrics. Integrated approaches to testing and assessment (IATAs) emerge as efficient tools to streamline the risk assessment of MNMs. This study formulates an Occupational Hazard IATA (OH IATA) to identify and quantify the hazard of involuntarily inhaled MNMs in workplaces. Following general IATA guidance, key toxicity events (KTEs) relevant to inhaled MNMs, such as deposition, accumulation, local or systemic inflammation, and genotoxicity, were identified and incorporated into decision nodes (DNs) within the OH IATA framework. The OH IATA is structured as a decision tree enabling tiered testing strategies, from in vitro to in vivo, to generate evidence addressing the DNs. Hazard profiles are categorized into bands labeled from A (no risk) to E (serious hazard), following ISO control banding principles and including new criteria focusing on key physicochemical descriptors like deposition and dissolution in synthetic biological fluids. The OH IATA was evaluated using industrial case studies such as few-layer graphene (FLG) and graphene oxide (GO), applying a hybrid data-gathering approach that combines next-generation and literature-based data. The results demonstrated that OH IATA successfully assigned hazard bands to the tested MNMs and supported the identification of appropriate control measures. Innovative methods, such as in vitro dissolution quantification in simulant fluids, contributed to the high predictivity of the hazard assessment.</div><div>The OH IATA, integrated with multiparametric exposure testing within the broader “Prevention-through-Design, NanoKey” framework, provides a targeted, data-driven strategy for the assessment and prevention of risks associated with inhaled MNMs in occupational settings. This approach enhances workplace safety, supports regulatory compliance, and promotes long-term sustainability in nanomaterial-based industries.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"40 ","pages":"Article 100598"},"PeriodicalIF":5.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145605045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"15N-isotope tracing reveals enhanced nitrogen uptake, assimilation and physiological response from Nano urea in maize","authors":"Madhan Kumar ,&nbsp;Gomathi Velu ,&nbsp;Marimuthu Subramanian ,&nbsp;Kannan Pandian ,&nbsp;Lakshmanan Arunachalam ,&nbsp;Gowtham Golla ,&nbsp;Shandeep Ganeshan ,&nbsp;Raghu Rajasekaran ,&nbsp;Saranya Nallusamy ,&nbsp;Mohamed Roshan Abu Firnass Mustaffa","doi":"10.1016/j.impact.2025.100592","DOIUrl":"10.1016/j.impact.2025.100592","url":null,"abstract":"<div><div>Nano fertilizers are gaining attention for enhancing agricultural production by increasing the nutrient use efficiency and reducing environmental pollution. While the previous reports suggesting these are all based on various indirect parameters like physiological and biochemical indicators which may not fully capture the actual nutrient uptake, assimilation and translocation. To address the research gap, an experiment was conducted using stable isotopes of nitrogen(¹⁵N) in maize to trace the uptake, assimilation and translocation of foliar applied nano urea (IFFCO Nano Urea Plus) compared with foliar applied conventional urea. Plant samples (leaf, shoot and root) were collected at different time intervals: Initial, 1st,2nd,6th hours, 1st, 2nd, 7th &amp; 14th days after application of various treatments. The tracing of ¹⁵N was done, using Laser Ablation–Combustion–Gas Chromatography–High Resolution Isotope Ratio Mass Spectrometry (LA-CGC-HR-IRMS), for uptake and translocation, while leaf urease activity was assessed for nitrogen assimilation pattern. Physiological parameters like Chlorophyll content (Soil Plant Analysis Development, SPAD value) and chlorophyll fluorescence (effective quantum yield Y(II) and maximum quantum efficiency Fv/fm) also studied alongside. The results showed that plants treated with nano urea had higher total percent nitrogen derived from foliar fertilization (%Ndff) (0.43 %) than conventional urea (0.36 %) at 14th day. Nano urea had faster absorption of 92.5 % in just 2 days while the conventional urea has 75.9 % at same time. The urease activity peaked at 3.123 μmol NH₄⁺/min/g FW for nano urea, compared to 2.141 for conventional urea and 0.177 for the control. The SPAD and chlorophyll fluorescence values also improved with nano urea on 7th day. This study provides first direct quantifiable, isotopic evidence that foliar-applied nano urea is more efficiently absorbed, assimilated and translocated than equimolar conventional urea, offering a mechanistic understanding of enhanced performance in maize.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"40 ","pages":"Article 100592"},"PeriodicalIF":5.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uptake and ecotoxicity of microplastics of different particle sizes in crop species","authors":"Ying Wang ,&nbsp;Fei Li ,&nbsp;Wei Chen ,&nbsp;Zhaozheng Chen ,&nbsp;Yunlong Huo ,&nbsp;Jingrong Song","doi":"10.1016/j.impact.2025.100585","DOIUrl":"10.1016/j.impact.2025.100585","url":null,"abstract":"<div><div>Microplastics (MPs) pollution threatens aquatic and terrestrial ecosystems. Herein, we assessed the uptake of MPs in seedling roots of three crop species exposed to small (0.2 μm) and large (1.0 μm) polystyrene (PS) beads by a microcosm study. Additionally, the physiological ecology of three species was also investigated after 7 d of exposure to different PS bead sizes. The results showed that fresh weight and growth inhibition was unaffected by particle sizes, while root length, shoot mass and root mass inhibition was significantly higher in <em>C. sativus</em> than that in <em>P. vulgaris</em> and <em>S. bicolor</em> (mean 28.6, 5.5 and 2.8 in <em>C. sativus, P. vulgaris</em> and <em>S. bicolor</em>, respectively). Uptake and accumulation were higher for small PS beads in <em>P. vulgaris</em> and <em>C. sativus</em> compared to that in <em>S. bicolor</em>, while more large PS beads were accumulated in <em>C. sativus</em>. Fluorescence intensity values of PS beads accumulation in different tissues confirmed these results. Malondialdehyde levels in seedling leaves of <em>P. vulgaris</em> and <em>C. sativus</em> were elevated in PS treatment groups but unchanged in <em>S. bicolor</em>. The highest and lowest proline content were observed for 0.2 μm and control groups, respectively. The Catalase activity was decreased in <em>S. bicolor</em> and <em>C. sativus</em> for large beads, with the average values of 17.5 and 20.3 Ug⁻¹ FW, respectively. In conclusion, different PS bead sizes significantly affected the accumulation and distribution in all species, as well as the antioxidant response. A better understanding the difference in MPs uptake and ecotoxicity between different species will help ensure food safety and effective agricultural environmental management.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"39 ","pages":"Article 100585"},"PeriodicalIF":5.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the ink: cellular and molecular effects of iron-based pigments on macrophages","authors":"Marianne Vitipon ,&nbsp;Esther Akingbagbohun ,&nbsp;Fabienne Devime ,&nbsp;Hélène Diemer ,&nbsp;Aurélie Hirschler ,&nbsp;Daphna Fenel ,&nbsp;Stéphane Ravanel ,&nbsp;Christine Carapito ,&nbsp;Thierry Rabilloud","doi":"10.1016/j.impact.2025.100578","DOIUrl":"10.1016/j.impact.2025.100578","url":null,"abstract":"<div><div>As ochre, iron oxide is among the most ancient pigments used by mankind for different purposes, including tattooing as demonstrated on tattoed mummies. Iron oxides are still used in tattooing nowadays and especially in dermopigmentation, an area of medical tattoing aiming at restoring the color of skin. This ancient use of iron oxide does not mean that it has no effect on cells, and especially on macrophages, the cells that maintain pigments particles on site in tattoos. We thus investigated in vitro the delayed/sustained effects of iron oxide pigments on macrophages, i.e. the effects occurring a few days after the exposure to pigments, on pigments-loaded macrophages but in a pigment-free medium, mimicking the status of tattooed skin after all the pigment particles have been captured. By combining proteomic and targeted approaches, we determined that red iron oxide (but not black iron oxide) induces perturbations in mitochondria, altering the mitochondrial transmembrane potential. Red iron oxide also induces oxidative stress and the secretion of pro-inflammatory cytokines such as interleukin 6 and tumor necrosis factor. Thus, red iron oxide induces adverse effects on macrophages that may persist over time, owing to its low intracellular dissolution.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"39 ","pages":"Article 100578"},"PeriodicalIF":5.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The fruits of data shepherding: A collection of open FAIR datasets for titanium dioxide coated photocatalytic surfaces","authors":"Irini Furxhi ,&nbsp;Massimo Perucca ,&nbsp;Giovanni Baldi ,&nbsp;Valentina Dami ,&nbsp;Andrea Cioni ,&nbsp;Antti Joonas Koivisto ,&nbsp;Rossella Bengalli ,&nbsp;Paride Mantecca ,&nbsp;Giulia Motta ,&nbsp;Marie Carriere ,&nbsp;Ozge Kose ,&nbsp;Alessia Nicosia ,&nbsp;Fabrizio Ravegnani ,&nbsp;David Burrueco-Subirà ,&nbsp;Ana Candalija ,&nbsp;Joan Cabellos ,&nbsp;Socorro Vázquez-Campos ,&nbsp;Elma Lahive ,&nbsp;Emily Eagles ,&nbsp;Jesus-Maria Lopez de Ipiña ,&nbsp;Anna Costa","doi":"10.1016/j.impact.2025.100583","DOIUrl":"10.1016/j.impact.2025.100583","url":null,"abstract":"<div><div>This paper presents a large-scale collaborative effort within a multi-partner consortium, to systematically structure, curate, and openly share data in alignment with the FAIR principles. The data result from a case study of titanium dioxide (TiO₂) nanomaterials (NMs) for photocatalytic depolluting surfaces, produced via various spray coating techniques under the Safe and Sustainable by Design (SSbD) approach. The data are publicly available through a dedicated Zenodo community (<span><span>https://zenodo.org/communities/asina/records</span><svg><path></path></svg></span>), comprising of individual records that separately host the data and the corresponding metadata. Each dataset is systematically named to reflect its context beginning with “ASINA dataset,” followed by i) the relevant life cycle stage (LCS) from synthesis to end-of-life, ii) the SSbD dimension (i.e., functionality, safety, and environmental aspects), and iii) the assessed features (e.g., physicochemical properties, hazard evaluation, functionality assessment) facilitating searchability. The data files include “descriptors” excel tab, which is a harmonized version derived from primary data for visualization, data integration and future modeling applications. Metadata are provided in separate records and include detailed information such as contributor name and affiliations, experimental protocols, instrumentation, dictionary definitions, ontologies, and licensing terms. The data and metadata files are mutually paired in Zenodo using related identifiers, where each data file includes the DOI of its corresponding metadata file, and vice versa. In total, 43 interlinked records are provided capturing the case study, offering structured and machine-actionable resources that support modeling, data integration and harmonization efforts within the nanosafety and nanoinformatics communities. This effort was coordinated through dedicated data shepherding, which enabled trust-building, metadata alignment, and consistent FAIR implementation across partners.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"39 ","pages":"Article 100583"},"PeriodicalIF":5.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Titanium dioxide nanoparticles drive the enhanced pro-inflammation response, worsening oxidative injure and gut microbiota dysbiosis in experimental colitis mice","authors":"Xiaoyan Feng ,&nbsp;Tao You ,&nbsp;Jiajun Guo ,&nbsp;Hengyi Xu","doi":"10.1016/j.impact.2025.100574","DOIUrl":"10.1016/j.impact.2025.100574","url":null,"abstract":"<div><div>With the wide use of titanium dioxide nanoparticles (TiO₂ NPs) in food products, inflammatory bowel disease (IBD) was inevitably to ingest it. In this work, we daily administered TiO₂ NPs to mice, followed by dextran sulfate sodium (DSS)-drinking for 7 days to obtain the colitis model. Excitedly, shorten colon length, earlier and increased weigh body loss, higher disease activity index score, as well as disorganized pathological structure were observed in colitis mice with TiO₂ NPs exposure. Moreover, the significant changes in overproduction of inflammatory cytokines and oxidative injure were detected in colon. 16S rDNA sequencing results showed that TiO₂ NPs broke the balance of gut microbiota, including decreased α-diversity index, reduced the total operational taxonomic units (OTUs) number and altered the community distribution and compositions. To find the key bacterial regulator, we further analyzed the abundance change of differential species, found that the relative abundance of short-chain fatty acid (SCFAs)-producing bacteria (<em>Muribaculaceae</em>, <em>Ruminococcus</em>, <em>Clostridia</em>, etc.) noticeably reduced, while the relative abundance of pathogenic bacteria (<em>Gastranaerophilaceae</em>, <em>Helicobacter</em>, <em>Escherichia-Shigella</em>, etc.) dramatically augmented. The mutual cooperation of reduced SCFAs and elevated inflammatory factors induced the form of inflammation-oxidative cascade cycle. Our work highlighted the risk assessment of dietary nanoparticles on the IBD population and identified the key microbial regulators, looking forward to provide the target therapeutic strategies for IBD affected by environmental factors.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"39 ","pages":"Article 100574"},"PeriodicalIF":4.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of real food matrices on the behavior and toxicity of polystyrene nanoplastics during digestion simulation","authors":"Kamil Urgun ,&nbsp;Nazım Sergen Mısırlı ,&nbsp;Berfin Ece Şen ,&nbsp;Ümran Uygun ,&nbsp;Sasitorn Aueviriyavit ,&nbsp;Wittaya Pimtong ,&nbsp;Fahriye Ceyda Dudak","doi":"10.1016/j.impact.2025.100577","DOIUrl":"10.1016/j.impact.2025.100577","url":null,"abstract":"<div><div>Nanoplastics are emerging contaminants that can enter the human body through food consumption, raising concerns about their potential health impacts. Among these, polystyrene nanoplastics (PS-NPs) are frequently used in toxicological studies due to their widespread use in food-contact materials and their well-defined physicochemical properties. In this study, we investigated the behavior and cytotoxicity of PS-NPs in the presence of a nutritionally relevant, real food matrix (milk) under simulated three-phase gastrointestinal digestion. PS-NPs of three different sizes (30 nm, 100 nm, and 450 nm) were characterized before and after digestion using SEM, TEM, DLS, and XPS to monitor changes in aggregation and corona structure. Our findings demonstrated that milk proteins and digestive enzymes adsorbed onto the PS-NP surfaces, forming a complex protein corona. The aggregation behavior and composition of the protein corona were markedly influenced by particle size during the digestion process. Corona structures were detected on all particle sizes following digestion; however, extensive web-like agglomerates were uniquely observed in the 30 nm particles. While the presence of milk during digestion did not significantly alter the cytotoxicity of the 30 nm and 450 nm particles, it resulted in a marked reduction in cell viability for the 100 nm particles. These results suggest that the food matrix significantly modulates nanoplastic behavior and toxicity in the gastrointestinal environment.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"39 ","pages":"Article 100577"},"PeriodicalIF":5.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attenuation of CuO ENP toxicity in aquatic media through progressive transformations","authors":"Mikołaj Feculak ,&nbsp;Susana Loureiro ,&nbsp;Patrícia V. Silva ,&nbsp;Fábio Yu Chen ,&nbsp;Patryk Oleszczuk ,&nbsp;Magdalena Kończak ,&nbsp;Izabela Jośko","doi":"10.1016/j.impact.2025.100587","DOIUrl":"10.1016/j.impact.2025.100587","url":null,"abstract":"<div><div>CuO engineered nanoparticles (ENPs) are widely used across various industries, resulting in their environmental release and subsequent transformation. This study examined the impact of chemical (sulphidation), biological (bovine serum albumin (BSA) corona), and double transformations (sulphidation + BSA coating) of CuO ENPs on the immobilisation of <em>Daphnia magna</em> (0.63–10 mg Cu/L) and the inhibition of root growth of <em>Lepidium sativum</em> (10–160 mg Cu/L). Transformations of CuO ENPs altered their chemical composition, morphology, and surface chemistry; the extent of changes depended on the transformation type. Dual transformations of CuO ENPs generated properties distinct from pristine and singly transformed ENPs. The transformations affected CuO ENP behaviour in aqueous media, including aggregation, dissolution rate, and ζ potential, ultimately influencing toxicity. Sulphidation increased CuO ENP dissolution fivefold, resulting in complete <em>D. magna</em> immobilisation. In contrast, BSA coating mitigated toxicity across all ENPs, enhancing daphnia mobility by 30–95 %. High CuO ENP concentrations inhibited L. <em>sativum</em> root growth, while all transformed ENPs exhibited reduced phytotoxicity. The reduced metal ion release from CuO ENPs only partly explained the lower toxicity of transformed CuO ENPs. Interactions between ENPs and biota were additionally modulated by ζ potential, aggregation kinetics, and organic surface coatings that restrict direct contact, and inorganic compounds. These results underscore the critical role of ENP transformations in modulating their toxicity to organisms.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"39 ","pages":"Article 100587"},"PeriodicalIF":5.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145054366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boosting advanced material's innovation – Are we regulatory prepared?","authors":"Kathrin Schwirn ,&nbsp;Angelina Gadermann ,&nbsp;Eric A.J. Bleeker ,&nbsp;Doris Völker ,&nbsp;Elisabeth Heunisch ,&nbsp;Anna Pohl ,&nbsp;Adriënne Sips ,&nbsp;Agnes G. Oomen","doi":"10.1016/j.impact.2025.100576","DOIUrl":"10.1016/j.impact.2025.100576","url":null,"abstract":"<div><div>In its policy communications, the European Commission placed advanced materials (AdMa) at the forefront of its strategic agenda, highlighting them as crucial elements to strive for a more sustainable, competitive, and resilient Europe. AdMa are referred to as a broad and heterogeneous group of materials that have been deliberately designed to achieve new, improved or specific functionalities. They are considered to support global challenges such as the energy transition, sustainable mobility concepts or health protection by offering technical solutions. AdMa comprise for instance nanomaterials with an upper size limit of 100 nm that are more complex in structure or composition. However, there are other AdMa that are not or only conditionally considered as nanomaterial. Based on current technical opportunities and innovation funding, it is expected that some of them will be marketed in considerable quantities. At the same time, these developments bring legal challenges related to chemical safety. In this publication we present regulatory challenges and questions that are linked with AdMa in the nanosize range and beyond. This includes considerations on a legal definition of AdMa, and whether AdMa should be regarded as substances, mixtures or articles, methodological challenges and regulatory relevant research to make regulatory risk assessment fit for purpose. Finally, we present a way forward by proposing actions for different stakeholders to encourage Regulatory Preparedness among policy makers and authorities and increase legal clarity for innovators. Timely addressing the regulatory needs in a fit for purpose chemicals legislation and regulatory risk assessment framework will facilitate and enable reaching the European Commission's goals and strategies towards a more sustainable, competitive, and resilient Europe.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"39 ","pages":"Article 100576"},"PeriodicalIF":4.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}