Modern Rheumatology最新文献_第10页

Safety of glucocorticoid dose reduction in microscopic polyangiitis: a multicentre REVEAL cohort study. 减少糖皮质激素剂量治疗显微多血管炎的安全性：一项多中心REVEAL队列研究。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-06-09 DOI: 10.1093/mr/roaf053

Hirofumi Miyake, Takuya Kotani, Shogo Matsuda, Ayana Okazaki, Yuichi Masuda, Mikihito Shoji, Atsushi Manabe, Keiichiro Kadoba, Ryosuke Hiwa, Wataru Yamamoto, Naoko Ito, Yohei Fujiki, Muneyuki Hatta, Mayu Shiomi, Ryu Watanabe, Motomu Hashimoto

{"title":"Safety of glucocorticoid dose reduction in microscopic polyangiitis: a multicentre REVEAL cohort study.","authors":"Hirofumi Miyake, Takuya Kotani, Shogo Matsuda, Ayana Okazaki, Yuichi Masuda, Mikihito Shoji, Atsushi Manabe, Keiichiro Kadoba, Ryosuke Hiwa, Wataru Yamamoto, Naoko Ito, Yohei Fujiki, Muneyuki Hatta, Mayu Shiomi, Ryu Watanabe, Motomu Hashimoto","doi":"10.1093/mr/roaf053","DOIUrl":"https://doi.org/10.1093/mr/roaf053","url":null,"abstract":"Objectives: This retrospective, multicentre study evaluated the safety of reducing glucocorticoids in patients with microscopic polyangiitis (MPA).Methods: 223 newly diagnosed MPA patients, with treatment initiated between 2005 and 2023 in the REVEAL cohort, were divided by 6-month glucocorticoid dose (≤10 vs >10 mg/day prednisolone-equivalent). Baseline characteristics were balanced using overlap weighting based on age, sex, disease severity, disease activity, lung/kidney involvement, initial treatment, and year of treatment initiation. 10-year outcomes were assessed using Cox models, and predictors of glucocorticoid dose at 6 months were evaluated using logistic regression.Results: Reducing glucocorticoids to ≤10 mg/day at 6 months did not show increased risks of all-cause mortality, infection-related mortality, infections requiring hospitalisation, all relapses, and major relapses. Treatment initiation ≥2020 was linked to glucocorticoid dose ≤10 mg/day at 6 months (odds ratio 5.54, 95% confidence interval 2.78-11.43). Sensitivity analysis (12 mg/day threshold) showed similar results.Conclusions: Reducing glucocorticoids to ≤10 mg/day at 6 months was not linked to increased mortality, infection, or relapse, suggesting it may be a feasible intermediate target. However, more aggressive glucocorticoid reduction per guidelines might be needed for further infection risk reduction. Individualised tapering with close monitoring remains crucial.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of anti-citrullinated protein antibodies with changes in bone density in patients with rheumatoid arthritis treated with romosozumab for one year: a cohort study. 抗瓜氨酸化蛋白抗体与类风湿关节炎患者接受romosozumab治疗一年骨密度变化的关联：一项队列研究

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-06-03 DOI: 10.1093/mr/roaf051

Yuya Terajima, Yoshia Miyawaki, Koji Takasugi, Ryozo Harada, Wataru Yamamoto, Kazuhiko Ezawa, Natsuki Kubota, Kazuya Matsumoto, Kenta Shidahara, Kei Hirose, Takato Nakadoi, Shoichi Nawachi, Yosuke Asano, Yu Katayama, Eri Katsuyama, Takayuki Katsuyama, Mariko Takano-Narazaki, Yoshinori Matsumoto, Jun Wada

引用次数: 0

Assessment of the Dorsal Tangent of the Metacarpal Neck as an Intraoperative Reference for Metacarpophalangeal Joint Arthroplasty. 掌颈背切线作为掌指关节成形术参考的评估。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-06-02 DOI: 10.1093/mr/roaf050

Hyunho Lee, Kana Kataoka, Yoshiaki Tomizuka, Yosuke Sano, Masahiko Yanagisawa, Junichiro Kan, Yutaka Sano, Hitoshi Kiuchi, Manabu Shimizu, Soya Nagao, Takao Ishii, Kazuyoshi Nakanishi

{"title":"Assessment of the Dorsal Tangent of the Metacarpal Neck as an Intraoperative Reference for Metacarpophalangeal Joint Arthroplasty.","authors":"Hyunho Lee, Kana Kataoka, Yoshiaki Tomizuka, Yosuke Sano, Masahiko Yanagisawa, Junichiro Kan, Yutaka Sano, Hitoshi Kiuchi, Manabu Shimizu, Soya Nagao, Takao Ishii, Kazuyoshi Nakanishi","doi":"10.1093/mr/roaf050","DOIUrl":"https://doi.org/10.1093/mr/roaf050","url":null,"abstract":"Objectives: In metacarpophalangeal (MCP) joint arthroplasty, some implants require an oblique osteotomy of the metacarpal neck. If the osteotomy is not aligned with the rotational axis, the osteotomy surface itself can tilt ulnarly, leading to unintended ulnar deviation of the finger. This study aimed to evaluate whether the dorsal tangent angle (DTA) of the metacarpal neck can serve as a reliable intraoperative reference for rotational alignment during MCP joint arthroplasty.Methods: This cross-sectional study analysed CT data from 44 hands of 44 Japanese patients (15 hands from 15 RA patients and 29 hands from 29 non-RA patients). Three-dimensional CT models of the 2nd to 5th metacarpals were generated, and the DTA was measured as the angle between the dorsal tangent of the metacarpal neck and the rotational axis of the metacarpal head. Differences in DTA among the metacarpals and gender differences were analysed.Results: The median DTA increased progressively from the 2nd to the 5th metacarpals (77.5°, 82.0°, 87.8°, and 94.6°, respectively). A significant gender difference was observed in the 3rd metacarpal, with a greater DTA in women than in men (84.4° versus 78.7°). No significant differences in DTA were found between the RA and non-RA groups, both in the overall population and when the analysis was limited to women.Conclusions: The dorsal tangent of the metacarpal neck can serve as a reliable intraoperative reference for rotational alignment in MCP joint arthroplasty. Supination is recommended for the 2nd and 3rd metacarpals, though a slightly reduced degree of supination is preferable for the 3rd metacarpal, particularly in women.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased Prevalence of Gastrointestinal involvement in Behçet's Syndrome Patients with Gynaecological Disorders. behaperet综合征合并妇科疾病患者胃肠道受累的患病率增加。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-06-02 DOI: 10.1093/mr/roaf048

Isso Saito, Yusho Ishii, Hiroko Sato, Tsuyoshi Shirai, Hiroshi Fujii

{"title":"Increased Prevalence of Gastrointestinal involvement in Behçet's Syndrome Patients with Gynaecological Disorders.","authors":"Isso Saito, Yusho Ishii, Hiroko Sato, Tsuyoshi Shirai, Hiroshi Fujii","doi":"10.1093/mr/roaf048","DOIUrl":"https://doi.org/10.1093/mr/roaf048","url":null,"abstract":"Objectives: This study aimed to investigate the clinical significance of coexisting gynaecological disorders (GD) in patients with Behçet's syndrome (BS).Methods: This study included patients with BS who visited Department of Rheumatology in the Tohoku University Hospital from 2022 to 2023. Among these patients, the manifestation and the treatment of BS were investigated.Results: This group included 37 female patients with BS and GD (BS-FG), 36 female patients with BS without any GD (BS-FWG) and 67 male patients with BS (BS-M). The prevalence of gastrointestinal involvement was significantly higher in BS-FG (48.6%) than in BS-FWG (22.2%, p = 0.041) and BS-M (17.9%, p = 0.0043). The prevalence of ocular involvement was lower in BS-FG (35.1%) than in BS-FWG (50%, p = 0.24) and BS-M (64.2%, p = 0.022). The frequency of anti-TNFα antibody usage was lower among patients in the BS-FWG group than those in the BS-M and BS-FG groups (p = 0.0055 and p = 0.20). The maximum prednisolone dosage and the rates of surgery for BS tended to be higher in BS-FG and BS-M than in BS-FWG.Conclusions: Our study revealed that gastrointestinal involvement is more common in BS-FG, and BS-FG frequently requires intensive treatment similar to BS-M.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between sleep-disordered breathing and moderate to severe depression in systemic lupus erythematosus: the TRUMP2-SLE study. 系统性红斑狼疮患者睡眠呼吸障碍与中度至重度抑郁之间的关系：TRUMP2-SLE研究

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-05-30 DOI: 10.1093/mr/roaf047

Yuichi Ishikawa, Nao Oguro, Takanori Ichikawa, Dai Kishida, Natsuki Sakurai, Chiharu Hidekawa, Kenta Shidahara, Keigo Hayashi, Yoshia Miyawaki, Yasuhiro Shimojima, Ryusuke Yoshimi, Ken-Ei Sada, Nobuyuki Yajima, Noriaki Kurita

{"title":"Association between sleep-disordered breathing and moderate to severe depression in systemic lupus erythematosus: the TRUMP2-SLE study.","authors":"Yuichi Ishikawa, Nao Oguro, Takanori Ichikawa, Dai Kishida, Natsuki Sakurai, Chiharu Hidekawa, Kenta Shidahara, Keigo Hayashi, Yoshia Miyawaki, Yasuhiro Shimojima, Ryusuke Yoshimi, Ken-Ei Sada, Nobuyuki Yajima, Noriaki Kurita","doi":"10.1093/mr/roaf047","DOIUrl":"https://doi.org/10.1093/mr/roaf047","url":null,"abstract":"Objectives: Depression is a common mood disorder in systemic lupus erythematosus (SLE) patients, affecting quality of life and medication adherence. Sleep-disordered breathing (SDB) is a known contributor to depression in the general population, but its prevalence and impact on depression in SLE remain unclear. This study aimed to investigate the prevalence of SDB and its association with depression.Methods: A cross-sectional study was conducted among 414 Japanese adults with SLE from five university hospitals. The main exposure was high-risk SDB, assessed with the Berlin Questionnaire. The main outcome was moderate to severe depression evaluated using the Patient Health Questionnaire-9. Poisson regression models with robust error variance estimated adjusted prevalence ratios (aPRs).Results: The mean age and BMI were 47.5 years and 22.1 kg/m2. The prevalence of high-risk SDB and moderate to severe depression were 15.2% (95% confidence interval: 11.9%-19.0%) and 19.1% (95% CI: 15.4%-23.2%). High-risk SDB was associated with moderate to severe depression (aPR 2.63, 95% CI 1.62-4.27), with a dose-dependent relationship according to the number of positive risk categories.Conclusions: SDB is common in SLE and is associated with depression. SLE patients with SDB symptoms should undergo concurrent depression screening.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-05-30 DOI: 10.1093/mr/roaf044

Shinya Hirahara, Yasuhiro Katsumata, Ken-Ei Sada, Hiroko Nagafuchi, Eiichi Tanaka, Masayoshi Harigai

{"title":"Health-related quality of life and work productivity in Japanese patients with primarily stable ANCA-associated vasculitis: a multicenter cross-sectional study.","authors":"Shinya Hirahara, Yasuhiro Katsumata, Ken-Ei Sada, Hiroko Nagafuchi, Eiichi Tanaka, Masayoshi Harigai","doi":"10.1093/mr/roaf044","DOIUrl":"https://doi.org/10.1093/mr/roaf044","url":null,"abstract":"Objectives: We aimed to investigate the health-related quality of life (HRQoL) and work productivity of Japanese patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).Methods: We conducted a cross-sectional study of Japanese patients with AAV at three university hospitals using the HRQoL and Work Productivity and Activity Impairment questionnaires.Results: Ninety-two patients with AAV participated. The values of all eight subscale scores and physical component summary (PCS) and role component summary (RCS) scores of the Medical Outcomes Study Short Form-36 (SF-36) and the 5-level EuroQoL 5-Dimensions Questionnaire (EQ-5D-5L) index values of the AAV patients were significantly lower than the Japanese population norms. The Birmingham Vasculitis Activity Score and Vasculitis Damage Index were weakly and negatively correlated with the SF-36 PCS scores. Among the 25 patients with AAV who worked for pay, the absenteeism and presenteeism due to AAV were 17% and 32%, respectively, and were mild-to-moderately and negatively correlated with the SF-36 PCS and RCS scores and the EQ-5D-5L index values.Conclusion: The HRQoL of Japanese patients with AAV was poorer than that of the general population and was partly associated with disease activity and damage accrual. In employed patients, impaired work productivity was observed and negatively associated with HRQoL.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The first nationwide epidemiological survey of chronic recurrent multifocal osteomyelitis in Japan. 日本首次慢性复发性多灶性骨髓炎的全国流行病学调查。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-05-30 DOI: 10.1093/mr/roaf045

Yukako Maeda, Eitaro Hiejima, Kazushi Izawa, Kenichi Nishimura, Yasuo Yazawa, Naomi Iwata, Masahito Michikura, Hideki Ishikawa, Shuichi Ito, Yoshikazu Nakamura, Ryuta Nishikomori, Takahiro Yasumi

{"title":"The first nationwide epidemiological survey of chronic recurrent multifocal osteomyelitis in Japan.","authors":"Yukako Maeda, Eitaro Hiejima, Kazushi Izawa, Kenichi Nishimura, Yasuo Yazawa, Naomi Iwata, Masahito Michikura, Hideki Ishikawa, Shuichi Ito, Yoshikazu Nakamura, Ryuta Nishikomori, Takahiro Yasumi","doi":"10.1093/mr/roaf045","DOIUrl":"https://doi.org/10.1093/mr/roaf045","url":null,"abstract":"Objectives: Chronic nonbacterial osteomyelitis (CNO)/chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory disorder characterised by aseptic inflammation of bone tissue. The number of patients and the clinical picture of CNO/CRMO in Japan is unknown; therefore, we conducted the first nationwide epidemiological survey.Methods: In the primary survey, the number of patients diagnosed with CNO/CRMO between 2015 and 2019 in paediatrics, rheumatology, orthopaedic surgery and dermatology departments of various institutions was investigated. In the second survey, the clinical pictures of these patients were assessed.Results: The primary survey reported 289 patients, and the estimated number of patients nationwide was 434 (95% confidence interval, 367-501). The second survey analysed 205 patients. The median number of radiological bone lesions was three and the bone affected most frequently was the tibia. Tumour necrosis factor inhibitors showed higher efficacy and lower relapse rates than NSAIDs or bisphosphonates. Cases that responded to tocilizumab and canakinumab were also reported. Earlier diagnosis was associated with higher rates of symptom- or drug-free status at the last follow-up visit.Conclusions: This is the first nationwide study in Japan, and one of the largest multi-centre studies worldwide, to provide comprehensive epidemiological data about CNO/CRMO.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Mid-term outcomes of distal tibial oblique osteotomy for rheumatoid arthritis-associated ankle arthropathy: A comparison with osteoarthritis outcomes. 修正：胫骨远端斜截骨术治疗类风湿性关节炎相关踝关节病变的中期结果：与骨关节炎结果的比较。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-05-13 DOI: 10.1093/mr/roaf038

引用次数: 0

VE-cadherin may suppress inflammation depending on the phase of inflammation of rheumatoid arthritis. 根据类风湿性关节炎的炎症阶段，VE-cadherin 可抑制炎症。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-04-08 DOI: 10.1093/mr/roae107

Shinichiro Nishimi, Sayaka Fukuse, Yusuke Miwa, Kuninobu Wakabayashi, Takeo Isozaki

{"title":"VE-cadherin may suppress inflammation depending on the phase of inflammation of rheumatoid arthritis.","authors":"Shinichiro Nishimi, Sayaka Fukuse, Yusuke Miwa, Kuninobu Wakabayashi, Takeo Isozaki","doi":"10.1093/mr/roae107","DOIUrl":"10.1093/mr/roae107","url":null,"abstract":"Objectives: A disintegrin and metalloproteinase (ADAM)-15 and vascular endothelial (VE)-cadherin are involved in angiogenesis. We investigated the relationship between ADAM-15 and VE-cadherin expressions in rheumatoid arthritis (RA).Methods: VE-cadherin concentrations in the serum of patients with RA were measured using the enzyme linked immunosorbent assay. We stimulated fibroblast-like synoviocytes (RA-FLS) with VE-cadherin and measured the vascular endothelial growth factor (VEGF) and inflammatory cytokine levels using ELISA. We also examined the correlation between serum VE-cadherin levels and DAS-28ESR, and used the Matrigel assay to examine VE-cadherin involvement in angiogenesis.Results: Serum VE-cadherin levels were significantly higher in patients with RA than in healthy controls. A negative correlation was observed between VE-cadherin and DAS-28ESR. VEGF, chemokine ligand 16, intercellular adhesion molecule-1, and interleukin-8 levels in the supernatant of RA-FLS or human umbilical vein endothelial cells stimulated with VE-cadherin were significantly lower than those in the controls. The number of intercellular bridges formed by endothelial cells using Matrigel significantly decreased in RA synovial fluids from which VE-cadherin had been removed compared to synovial fluids treated with control immunoglobulin G.Conclusion: VE-cadherin may have an inhibitory effect on inflammation depending on the phase of RA inflammation.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"449-457"},"PeriodicalIF":1.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical study on the utility of allergy tests to detect IgE-mediated anaphylaxis after diclofenac etalhyaluronate administration. 关于过敏试验在检测服用双氯芬酸乙醛脲酸酯后 IgE 介导的过敏性休克中的实用性的临床研究。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-04-08 DOI: 10.1093/mr/roae091

Yoshimichi Okayama, Koremasa Hayama, Shuhei Takada, Dai Muramatsu, Yuji Nobuoka, Akiko Yagami

{"title":"Clinical study on the utility of allergy tests to detect IgE-mediated anaphylaxis after diclofenac etalhyaluronate administration.","authors":"Yoshimichi Okayama, Koremasa Hayama, Shuhei Takada, Dai Muramatsu, Yuji Nobuoka, Akiko Yagami","doi":"10.1093/mr/roae091","DOIUrl":"10.1093/mr/roae091","url":null,"abstract":"Objectives: This study was conducted to investigate factors involved in anaphylaxis related to diclofenac etalhyaluronate (DEH) [product name: Joyclu® (JCL)] (containing DEH and macrogol 400), which is used to treat patients with osteoarthritis.Methods: Patients with osteoarthritis were divided into two groups that had (experienced patients) or had not experienced anaphylactic symptoms after JCL administration (nonexperienced patients). Five tests performed to assess factors related to anaphylaxis consisted of a skin prick test as the primary endpoint and the other tests including basophil activation test, allergen-specific IgE tests using enzyme-linked immunosorbent assay or immunochromatographic kits, and genetic study were secondary endpoints.Results: The skin prick test showed 4 (wheal)/7 (erythema) of 15 experienced patients and 0/3 of 19 nonexperienced patients were positive for any of the test reagents containing DEH. The basophil activation test showed two experienced patients were positive for test reagents containing DEH. DEH- and diclofenac-allergen-specific IgE were detected in 3 and 1 of 12 experienced patients, respectively. No clear results were shown in the other tests.Conclusions: DEH may be the main factor involved in the development of anaphylaxis. The skin prick test was more sensitive than the basophil activation and allergen-specific IgE tests for identifying factors associated with anaphylaxis.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"565-578"},"PeriodicalIF":1.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0