Modern Rheumatology最新文献_第9页

The first nationwide epidemiological survey of chronic recurrent multifocal osteomyelitis in Japan. 日本首次慢性复发性多灶性骨髓炎的全国流行病学调查。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-05-30 DOI: 10.1093/mr/roaf045

Yukako Maeda, Eitaro Hiejima, Kazushi Izawa, Kenichi Nishimura, Yasuo Yazawa, Naomi Iwata, Masahito Michikura, Hideki Ishikawa, Shuichi Ito, Yoshikazu Nakamura, Ryuta Nishikomori, Takahiro Yasumi

{"title":"The first nationwide epidemiological survey of chronic recurrent multifocal osteomyelitis in Japan.","authors":"Yukako Maeda, Eitaro Hiejima, Kazushi Izawa, Kenichi Nishimura, Yasuo Yazawa, Naomi Iwata, Masahito Michikura, Hideki Ishikawa, Shuichi Ito, Yoshikazu Nakamura, Ryuta Nishikomori, Takahiro Yasumi","doi":"10.1093/mr/roaf045","DOIUrl":"https://doi.org/10.1093/mr/roaf045","url":null,"abstract":"Objectives: Chronic nonbacterial osteomyelitis (CNO)/chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory disorder characterised by aseptic inflammation of bone tissue. The number of patients and the clinical picture of CNO/CRMO in Japan is unknown; therefore, we conducted the first nationwide epidemiological survey.Methods: In the primary survey, the number of patients diagnosed with CNO/CRMO between 2015 and 2019 in paediatrics, rheumatology, orthopaedic surgery and dermatology departments of various institutions was investigated. In the second survey, the clinical pictures of these patients were assessed.Results: The primary survey reported 289 patients, and the estimated number of patients nationwide was 434 (95% confidence interval, 367-501). The second survey analysed 205 patients. The median number of radiological bone lesions was three and the bone affected most frequently was the tibia. Tumour necrosis factor inhibitors showed higher efficacy and lower relapse rates than NSAIDs or bisphosphonates. Cases that responded to tocilizumab and canakinumab were also reported. Earlier diagnosis was associated with higher rates of symptom- or drug-free status at the last follow-up visit.Conclusions: This is the first nationwide study in Japan, and one of the largest multi-centre studies worldwide, to provide comprehensive epidemiological data about CNO/CRMO.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Mid-term outcomes of distal tibial oblique osteotomy for rheumatoid arthritis-associated ankle arthropathy: A comparison with osteoarthritis outcomes. 修正：胫骨远端斜截骨术治疗类风湿性关节炎相关踝关节病变的中期结果：与骨关节炎结果的比较。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-05-13 DOI: 10.1093/mr/roaf038

引用次数: 0

VE-cadherin may suppress inflammation depending on the phase of inflammation of rheumatoid arthritis. 根据类风湿性关节炎的炎症阶段，VE-cadherin 可抑制炎症。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-04-08 DOI: 10.1093/mr/roae107

Shinichiro Nishimi, Sayaka Fukuse, Yusuke Miwa, Kuninobu Wakabayashi, Takeo Isozaki

{"title":"VE-cadherin may suppress inflammation depending on the phase of inflammation of rheumatoid arthritis.","authors":"Shinichiro Nishimi, Sayaka Fukuse, Yusuke Miwa, Kuninobu Wakabayashi, Takeo Isozaki","doi":"10.1093/mr/roae107","DOIUrl":"10.1093/mr/roae107","url":null,"abstract":"Objectives: A disintegrin and metalloproteinase (ADAM)-15 and vascular endothelial (VE)-cadherin are involved in angiogenesis. We investigated the relationship between ADAM-15 and VE-cadherin expressions in rheumatoid arthritis (RA).Methods: VE-cadherin concentrations in the serum of patients with RA were measured using the enzyme linked immunosorbent assay. We stimulated fibroblast-like synoviocytes (RA-FLS) with VE-cadherin and measured the vascular endothelial growth factor (VEGF) and inflammatory cytokine levels using ELISA. We also examined the correlation between serum VE-cadherin levels and DAS-28ESR, and used the Matrigel assay to examine VE-cadherin involvement in angiogenesis.Results: Serum VE-cadherin levels were significantly higher in patients with RA than in healthy controls. A negative correlation was observed between VE-cadherin and DAS-28ESR. VEGF, chemokine ligand 16, intercellular adhesion molecule-1, and interleukin-8 levels in the supernatant of RA-FLS or human umbilical vein endothelial cells stimulated with VE-cadherin were significantly lower than those in the controls. The number of intercellular bridges formed by endothelial cells using Matrigel significantly decreased in RA synovial fluids from which VE-cadherin had been removed compared to synovial fluids treated with control immunoglobulin G.Conclusion: VE-cadherin may have an inhibitory effect on inflammation depending on the phase of RA inflammation.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"449-457"},"PeriodicalIF":1.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical study on the utility of allergy tests to detect IgE-mediated anaphylaxis after diclofenac etalhyaluronate administration. 关于过敏试验在检测服用双氯芬酸乙醛脲酸酯后 IgE 介导的过敏性休克中的实用性的临床研究。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-04-08 DOI: 10.1093/mr/roae091

Yoshimichi Okayama, Koremasa Hayama, Shuhei Takada, Dai Muramatsu, Yuji Nobuoka, Akiko Yagami

{"title":"Clinical study on the utility of allergy tests to detect IgE-mediated anaphylaxis after diclofenac etalhyaluronate administration.","authors":"Yoshimichi Okayama, Koremasa Hayama, Shuhei Takada, Dai Muramatsu, Yuji Nobuoka, Akiko Yagami","doi":"10.1093/mr/roae091","DOIUrl":"10.1093/mr/roae091","url":null,"abstract":"Objectives: This study was conducted to investigate factors involved in anaphylaxis related to diclofenac etalhyaluronate (DEH) [product name: Joyclu® (JCL)] (containing DEH and macrogol 400), which is used to treat patients with osteoarthritis.Methods: Patients with osteoarthritis were divided into two groups that had (experienced patients) or had not experienced anaphylactic symptoms after JCL administration (nonexperienced patients). Five tests performed to assess factors related to anaphylaxis consisted of a skin prick test as the primary endpoint and the other tests including basophil activation test, allergen-specific IgE tests using enzyme-linked immunosorbent assay or immunochromatographic kits, and genetic study were secondary endpoints.Results: The skin prick test showed 4 (wheal)/7 (erythema) of 15 experienced patients and 0/3 of 19 nonexperienced patients were positive for any of the test reagents containing DEH. The basophil activation test showed two experienced patients were positive for test reagents containing DEH. DEH- and diclofenac-allergen-specific IgE were detected in 3 and 1 of 12 experienced patients, respectively. No clear results were shown in the other tests.Conclusions: DEH may be the main factor involved in the development of anaphylaxis. The skin prick test was more sensitive than the basophil activation and allergen-specific IgE tests for identifying factors associated with anaphylaxis.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"565-578"},"PeriodicalIF":1.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between osteoarthritis-related serum biochemical markers over 10-13 years and knee symptoms in middle-aged adults. 10-13年骨关节炎相关血清生化指标与中年人膝关节症状的关系

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-04-08 DOI: 10.1093/mr/roae113

Ambrish Singh, Alison Venn, Leigh Blizzard, Brooklyn J Fraser, Graeme Jones, John Burgess, Venkat Parameswaran, Lyn March, Flavia Cicuttini, Changhai Ding, Benny Antony

{"title":"Association between osteoarthritis-related serum biochemical markers over 10-13 years and knee symptoms in middle-aged adults.","authors":"Ambrish Singh, Alison Venn, Leigh Blizzard, Brooklyn J Fraser, Graeme Jones, John Burgess, Venkat Parameswaran, Lyn March, Flavia Cicuttini, Changhai Ding, Benny Antony","doi":"10.1093/mr/roae113","DOIUrl":"10.1093/mr/roae113","url":null,"abstract":"Objectives: To examine associations between osteoarthritis (OA)-related biochemical markers and knee symptoms in middle-aged adults over 10-13 year follow-up.Methods: Blood samples were collected during the Childhood Determinants of Adult Health (CDAH)-1 study (2004-06) and follow-up at CDAH-3. Serum samples from baseline (n=156) and follow-up (n=167) were analyzed for cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3, and hyaluronan (HA) using enzyme-linked immunosorbent assays. Knee symptoms were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale at follow-up. Zero-inflated Poisson regression models adjusted for age, sex, and body mass index were used for analysis.Results: Significant associations were observed between COMP, MMP-3, and HA with knee pain and WOMAC-total score at follow-up. Baseline MMP-3 [ratio of means (RoM): 1.013; 95% CI: 1.006, 1.020], cumulative COMP (baseline + follow-up) [RoM: 1.022; 95% CI: 1.011, 1.033], and increased HA levels over time [RoM: 1.014; 95% CI: 1.007, 1.020] were positively associated with knee pain after 10-13 years.Conclusion: Cumulative COMP, baseline MMP-3, and changes in HA were associated with knee pain over a a 10-13 year follow-up. These markers may help predict future knee symptoms in middle-aged adults.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"585-593"},"PeriodicalIF":1.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knee joint dysfunction in the patients immediately before arthroplasty was well reflected by locomotive syndrome, not physical frailty. 关节置换术前患者的膝关节功能障碍主要表现为运动综合征，而非体质虚弱。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-04-08 DOI: 10.1093/mr/roae093

Kentaro Inui, Shingo Maeda, Shuji Yamada, Koji Mandai, Yoshito Minami, Kentaro Ueno, Hirotsugu Ohashi, Tesshu Ikawa

{"title":"Knee joint dysfunction in the patients immediately before arthroplasty was well reflected by locomotive syndrome, not physical frailty.","authors":"Kentaro Inui, Shingo Maeda, Shuji Yamada, Koji Mandai, Yoshito Minami, Kentaro Ueno, Hirotsugu Ohashi, Tesshu Ikawa","doi":"10.1093/mr/roae093","DOIUrl":"10.1093/mr/roae093","url":null,"abstract":"Objectives: We assessed physical function by three different methods in patients with knee osteoarthritis just before total knee arthroplasty (TKA) and investigated the relationship with pre-operative factors.Methods: All patients scheduled to undergo TKA were assessed for basic attributes, clinical assessment, radiography, whole-body mode dual-energy X-ray absorptiometry, knee muscle strength, and frailty, sarcopenia, locomotive syndrome (LS) were evaluated.Results: Among 204 patients (213 knees), 172 women the overall distribution in frailty was no: 14.6%, pre-frailty: 58.5%, frailty: 26.8%; in sarcopenia no: 93.3%, yes: 3.4%, severe: 3.4%; and in LS Stage 0: 0%, Stage 1: 3.3%, Stage 2: 11.4%, Stage 3: 85.3% . Eighty-seven per cent of the patients with frailty and 92% with LS Stage 3 did not suffer from sarcopenia. Statistically significant relationships were observed between sarcopenia and frailty, while there was no relationship between LS and frailty or LS and sarcopenia. Multivariate analysis of related factors with severity levels for frailty and LS revealed statistically significant correlations for frailty with gait speed, and LS with Knee Society Score and muscle strength.Conclusion: In patients with knee osteoarthritis frailty and LS were not related to sarcopenia. Knee joint dysfunction without sarcopenia was well reflected by LS, but not by frailty.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"579-584"},"PeriodicalIF":1.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the diagnostic and therapeutic value of submandibular gland elastography in patients with immunoglobulin G4-related sialadenitis. 评估颌下腺弹性成像对免疫球蛋白 G4 相关性唾液腺炎患者的诊断和治疗价值。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-04-08 DOI: 10.1093/mr/roae098

Saki Shibuki, Tsukasa Saida, Hiroto Tsuboi, Takashi Kamimaki, Maki Ota, Yohei Sugaya, Naoya Ichinose, Miki Yoshida, Isao Matsumoto, Takahito Nakajima

{"title":"Assessing the diagnostic and therapeutic value of submandibular gland elastography in patients with immunoglobulin G4-related sialadenitis.","authors":"Saki Shibuki, Tsukasa Saida, Hiroto Tsuboi, Takashi Kamimaki, Maki Ota, Yohei Sugaya, Naoya Ichinose, Miki Yoshida, Isao Matsumoto, Takahito Nakajima","doi":"10.1093/mr/roae098","DOIUrl":"10.1093/mr/roae098","url":null,"abstract":"Objectives: To investigate the utility of shear wave elastography (SWE) values in differentiating IgG4-related submandibular sialadenitis (IgG4-RSS) from healthy individuals and in monitoring the response to glucocorticoid treatment.Methods: Patients with IgG4-RSS who underwent ultrasound between 2017 and 2023 were included. Gland size, border, internal echo pattern, vascularity, and SWE were measured. These parameters were compared with those of the healthy controls, and before and after treatment.Results: Thirty-one glands from 16 patients were analysed. All glands had a nodular shape; the nodular hypoechoic was the most prevalent pattern, followed by the diffuse hypoechoic; the reticular was the least common. Most glands had rich vascularity, whereas two glands had minimal vascularity. The depth (mean 18 mm) and SWE (mean 3.57 m/s) were significantly higher in IgG-RSS (P = .003 and <.001, respectively) than in the healthy controls. Nine glands from five patients were enrolled to evaluate the treatment response. After treatment, the margins became smoother and all glands showed a reduction in size, hypoechoic area, and vascularity. The mean SWE decreased from 3.56 m/s to 2.50 m/s with a significant difference between pre- and post-treatment (P < .001).Conclusions: The SWE is useful for diagnosing IgG4-RSS and assessing the effectiveness of treatment.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"548-556"},"PeriodicalIF":1.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2024 Update of the Japan College of Rheumatology Clinical Practice Guidelines for the Management of Rheumatoid Arthritis: Secondary publication. 2024年日本风湿病学会类风湿关节炎管理临床实践指南更新-二次出版。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-04-08 DOI: 10.1093/mr/roaf006

Masayoshi Harigai, Yuko Kaneko, Eiichi Tanaka, Shintaro Hirata, Hideto Kameda, Kayoko Kaneko, Mitsumasa Kishimoto, Masataka Kohno, Masayo Kojima, Toshihisa Kojima, Akio Morinobu, Ayako Nakajima, Takahiko Sugihara, Mie Fusama, Nobuyuki Yajima, Ryo Yanai, Yutaka Kawahito

{"title":"2024 Update of the Japan College of Rheumatology Clinical Practice Guidelines for the Management of Rheumatoid Arthritis: Secondary publication.","authors":"Masayoshi Harigai, Yuko Kaneko, Eiichi Tanaka, Shintaro Hirata, Hideto Kameda, Kayoko Kaneko, Mitsumasa Kishimoto, Masataka Kohno, Masayo Kojima, Toshihisa Kojima, Akio Morinobu, Ayako Nakajima, Takahiko Sugihara, Mie Fusama, Nobuyuki Yajima, Ryo Yanai, Yutaka Kawahito","doi":"10.1093/mr/roaf006","DOIUrl":"10.1093/mr/roaf006","url":null,"abstract":"Objectives: The aim of this study is to update the Japan College of Rheumatology Clinical Practice Guidelines for the Management of Rheumatoid Arthritis (CPG for RA).Methods: The recommendations were developed based on the evidence published until the end of June 2022 using the Grading of Recommendations Assessment, Development, and Evaluation. The steering committee, CPG panel, systematic review (SR) group, and SR support team were organised.Results: The treatment goal and drug treatment algorithm required no modifications; however, the footnotes of the drug treatment algorithm were modified. SR of 21 new or updated recommendations for subcutaneous methotrexate (n = 1), biological disease-modifying antirheumatic drugs (n = 1), rituximab (n = 5), Janus kinase inhibitors (n = 6), biosimilars (n = 2), older patients (n = 4), and pregnancy and lactation (n = 2) was conducted. The recommendations for comorbidities and surgery and rehabilitation remained unchanged from the 2020 CPG for RA.Conclusions: The 2024 CPG for RA, which provide recommendations that reflect the current healthcare environment for rheumatoid arthritis in Japan, can be used effectively as a tool for shared decision-making between rheumatologists and patients in the treatment of RA.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"387-401"},"PeriodicalIF":1.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alkaline phosphatase is useful for predicting giant cell arteritis complications in patients with polymyalgia rheumatica. 碱性磷酸酶有助于预测多发性风湿性关节炎患者的巨细胞关节炎并发症。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-04-08 DOI: 10.1093/mr/roae101

Ryo Yamashita, Yusuke Izumi, Jun Hiramoto

{"title":"Alkaline phosphatase is useful for predicting giant cell arteritis complications in patients with polymyalgia rheumatica.","authors":"Ryo Yamashita, Yusuke Izumi, Jun Hiramoto","doi":"10.1093/mr/roae101","DOIUrl":"10.1093/mr/roae101","url":null,"abstract":"Objectives: This study determined whether alkaline phosphatase (ALP) can be used to distinguish giant cell arteritis (GCA) complications in patients with polymyalgia rheumatica (PMR).Methods: This retrospective study included patients diagnosed with PMR between January 2014 and October 2023 at our hospital. The predictive accuracy of biomarkers for diagnosing GCA was evaluated. Logistic regression was performed to identify factors predicting GCA complications.Results: In total, 128 participants were included in this study and divided into two groups: isolated PMR (n = 111) and PMR with GCA (n = 17). The median ALP level of PMR with GCA group was significantly higher than that of the isolated PMR group (242.0 [interquartile range, 221.0-595.0] vs. 187.0 [interquartile range 97.5-254.5] U/L, P < .001). Setting a cut-off value of 214 U/L for ALP yielded a sensitivity and specificity of 0.88 and 0.55, respectively, for diagnosing GCA. Multivariate analysis revealed that ALP was a significant independent variable in the complications of GCA (odds ratio, 25.2; P = .032).Conclusions: ALP can help distinguish GCA complications in patients with PMR.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"529-534"},"PeriodicalIF":1.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Late-onset rheumatoid arthritis: Justifying the need for international practice guidelines and classification criteria. 迟发性类风湿关节炎：证明需要国际实践指南和分类标准。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-04-08 DOI: 10.1093/mr/roae117

Chokan Baimukhamedov, Marina Baimukhamedova

引用次数: 0