Modern Rheumatology最新文献_第8页

Correction to: Anti-arthritic effects of polyunsaturated fatty acid-rich supplementation combined with selective soluble epoxide hydrolase inhibitors in a collagen-induced arthritis mouse model. 更正：在胶原诱导的关节炎小鼠模型中，富含多不饱和脂肪酸的补充剂联合选择性可溶性环氧化物水解酶抑制剂的抗关节炎作用。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-06-20 DOI: 10.1093/mr/roaf055

引用次数: 0

Correction to: Anti-arthritic effects of polyunsaturated fatty acid-rich supplementation combined with selective soluble epoxide hydrolase inhibitors in a collagen-induced arthritis mouse model. 更正：在胶原诱导的关节炎小鼠模型中，富含多不饱和脂肪酸的补充剂联合选择性可溶性环氧化物水解酶抑制剂的抗关节炎作用。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-06-11 DOI: 10.1093/mr/roaf039

引用次数: 0

Romosozumab increases bone mineral density in Japanese older adults with osteoporosis. Romosozumab增加日本老年骨质疏松症患者的骨矿物质密度。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-06-09 DOI: 10.1093/mr/roaf054

Shohei Anno, Tadashi Okano, Yuko Sugioka, Shigeyuki Wakitani, Takahiro Iida

{"title":"Romosozumab increases bone mineral density in Japanese older adults with osteoporosis.","authors":"Shohei Anno, Tadashi Okano, Yuko Sugioka, Shigeyuki Wakitani, Takahiro Iida","doi":"10.1093/mr/roaf054","DOIUrl":"https://doi.org/10.1093/mr/roaf054","url":null,"abstract":"Objectives: This study aimed to evaluate the efficacy of romosozumab in older Japanese patients with osteoporosis.Methods: Bone mineral density (BMD) was measured at 0, 4, 6, and 12 months after romosozumab treatment.Results: Of 125 patients with osteoporosis (mean age: 77.6 ± 7.5 years), 115 completed BMD measurements at the lumbar spine, total hip, and femoral neck. The BMD at the lumbar spine (11.5%, p < 0.01), total hip (3.0%, p < 0.01), and femoral neck (3.7%, p < 0.01) increased 12 months after treatment. There were no differences in the improvement ratio of BMD after 12 months of treatment at the lumbar spine, total hip, and femoral neck among 76 patients aged ≥75 years and 39 aged < 75 years (11.0 versus 12.5%: p = 0.48, 3.0 versus 3.0%: p = 0.83, 3.6 versus 4.1%: p = 0.92), 48 with prior treatment of osteoporosis and 67 without prior treatment of osteoporosis (10.8 versus 12.1%: p = 0.56, 2.1 versus 3.7%: p = 0.25, 2.8 versus 4.5%: p = 0.61), and 55 patients with a history of fragility fracture and 60 without a history of fragility fracture (11.8 versus 11.3%: p = 0.88, 2.4 versus 3.5%: p = 0.51, 2.0 versus 5.3%: p = 0.11).Conclusions: Romosozumab improved BMD at the lumbar spine, total hip, and femoral neck in older adults with osteoporosis.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nation-wide cohort study of Japanese patients with ANCA-associated vasculitis using rituximab: effectiveness and safety after two years. 日本anca相关性血管炎患者使用利妥昔单抗的全国性队列研究：两年后的有效性和安全性

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-06-09 DOI: 10.1093/mr/roaf052

Kenji Nagasaka, Koichi Amano, Hiroko Nagafuchi, Ken-Ei Sada, Yoshinori Komagata, Masahiro Yamamura, Masaru Kato, Tomomi Endo, Izaya Nakaya, Tsutomu Takeuchi, Yohko Murakawa, Takahiko Sugihara, Masaya Saito, Taichi Hayashi, Shunsuke Furuta, Kazunori Karasawa, Shogo Banno, Shuichiro Endo, Masako Majima, Hiroaki Dobashi, Shinya Kaname, Naoto Tamura, Yoshiriro Arimura, Masayoshi Harigai

{"title":"Nation-wide cohort study of Japanese patients with ANCA-associated vasculitis using rituximab: effectiveness and safety after two years.","authors":"Kenji Nagasaka, Koichi Amano, Hiroko Nagafuchi, Ken-Ei Sada, Yoshinori Komagata, Masahiro Yamamura, Masaru Kato, Tomomi Endo, Izaya Nakaya, Tsutomu Takeuchi, Yohko Murakawa, Takahiko Sugihara, Masaya Saito, Taichi Hayashi, Shunsuke Furuta, Kazunori Karasawa, Shogo Banno, Shuichiro Endo, Masako Majima, Hiroaki Dobashi, Shinya Kaname, Naoto Tamura, Yoshiriro Arimura, Masayoshi Harigai","doi":"10.1093/mr/roaf052","DOIUrl":"https://doi.org/10.1093/mr/roaf052","url":null,"abstract":"Objectives: To evaluate the efficacy and safety of rituximab (RTX) for microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) in Japan.Methods: Patients with MPA and GPA treated with RTX at each institution were enrolled and followed-up prospectively. Two years of data were analysed.Results: Seventy-five patients were received RTX for remission induction therapy and 57 were observed beyond 6 months. Thirty-five did and 22 did not receive any additional RTX treatment. RTX dosing patterns were diverse. During the 2-year observation period, 56 (74.7%) patients achieved remission; however, 11 (19.6%) patients relapsed. Five patients experienced major relapses, three experienced minor relapses, and three experienced unclassified relapses. Of the 75 patients treated with RTX as remission induction therapy, 63 severe adverse events (SAEs) were observed in 33 patients during the 2-year observation period. Thirty-nine SAEs occurred by 6 months and 24 SAEs were observed after 6 months. Of the 12 patients with SAEs after 6 months, four received RTX after 6 months, resulting in six events. The most common SAE was infection during the first six months and after six months.Conclusions: The effectiveness and safety of RTX for MPA and GPA in Japan were demonstrated over a 2-year observation period.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of glucocorticoid dose reduction in microscopic polyangiitis: a multicentre REVEAL cohort study. 减少糖皮质激素剂量治疗显微多血管炎的安全性：一项多中心REVEAL队列研究。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-06-09 DOI: 10.1093/mr/roaf053

Hirofumi Miyake, Takuya Kotani, Shogo Matsuda, Ayana Okazaki, Yuichi Masuda, Mikihito Shoji, Atsushi Manabe, Keiichiro Kadoba, Ryosuke Hiwa, Wataru Yamamoto, Naoko Ito, Yohei Fujiki, Muneyuki Hatta, Mayu Shiomi, Ryu Watanabe, Motomu Hashimoto

{"title":"Safety of glucocorticoid dose reduction in microscopic polyangiitis: a multicentre REVEAL cohort study.","authors":"Hirofumi Miyake, Takuya Kotani, Shogo Matsuda, Ayana Okazaki, Yuichi Masuda, Mikihito Shoji, Atsushi Manabe, Keiichiro Kadoba, Ryosuke Hiwa, Wataru Yamamoto, Naoko Ito, Yohei Fujiki, Muneyuki Hatta, Mayu Shiomi, Ryu Watanabe, Motomu Hashimoto","doi":"10.1093/mr/roaf053","DOIUrl":"https://doi.org/10.1093/mr/roaf053","url":null,"abstract":"Objectives: This retrospective, multicentre study evaluated the safety of reducing glucocorticoids in patients with microscopic polyangiitis (MPA).Methods: 223 newly diagnosed MPA patients, with treatment initiated between 2005 and 2023 in the REVEAL cohort, were divided by 6-month glucocorticoid dose (≤10 vs >10 mg/day prednisolone-equivalent). Baseline characteristics were balanced using overlap weighting based on age, sex, disease severity, disease activity, lung/kidney involvement, initial treatment, and year of treatment initiation. 10-year outcomes were assessed using Cox models, and predictors of glucocorticoid dose at 6 months were evaluated using logistic regression.Results: Reducing glucocorticoids to ≤10 mg/day at 6 months did not show increased risks of all-cause mortality, infection-related mortality, infections requiring hospitalisation, all relapses, and major relapses. Treatment initiation ≥2020 was linked to glucocorticoid dose ≤10 mg/day at 6 months (odds ratio 5.54, 95% confidence interval 2.78-11.43). Sensitivity analysis (12 mg/day threshold) showed similar results.Conclusions: Reducing glucocorticoids to ≤10 mg/day at 6 months was not linked to increased mortality, infection, or relapse, suggesting it may be a feasible intermediate target. However, more aggressive glucocorticoid reduction per guidelines might be needed for further infection risk reduction. Individualised tapering with close monitoring remains crucial.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of anti-citrullinated protein antibodies with changes in bone density in patients with rheumatoid arthritis treated with romosozumab for one year: a cohort study. 抗瓜氨酸化蛋白抗体与类风湿关节炎患者接受romosozumab治疗一年骨密度变化的关联：一项队列研究

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-06-03 DOI: 10.1093/mr/roaf051

Yuya Terajima, Yoshia Miyawaki, Koji Takasugi, Ryozo Harada, Wataru Yamamoto, Kazuhiko Ezawa, Natsuki Kubota, Kazuya Matsumoto, Kenta Shidahara, Kei Hirose, Takato Nakadoi, Shoichi Nawachi, Yosuke Asano, Yu Katayama, Eri Katsuyama, Takayuki Katsuyama, Mariko Takano-Narazaki, Yoshinori Matsumoto, Jun Wada

引用次数: 0

Assessment of the Dorsal Tangent of the Metacarpal Neck as an Intraoperative Reference for Metacarpophalangeal Joint Arthroplasty. 掌颈背切线作为掌指关节成形术参考的评估。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-06-02 DOI: 10.1093/mr/roaf050

Hyunho Lee, Kana Kataoka, Yoshiaki Tomizuka, Yosuke Sano, Masahiko Yanagisawa, Junichiro Kan, Yutaka Sano, Hitoshi Kiuchi, Manabu Shimizu, Soya Nagao, Takao Ishii, Kazuyoshi Nakanishi

{"title":"Assessment of the Dorsal Tangent of the Metacarpal Neck as an Intraoperative Reference for Metacarpophalangeal Joint Arthroplasty.","authors":"Hyunho Lee, Kana Kataoka, Yoshiaki Tomizuka, Yosuke Sano, Masahiko Yanagisawa, Junichiro Kan, Yutaka Sano, Hitoshi Kiuchi, Manabu Shimizu, Soya Nagao, Takao Ishii, Kazuyoshi Nakanishi","doi":"10.1093/mr/roaf050","DOIUrl":"https://doi.org/10.1093/mr/roaf050","url":null,"abstract":"Objectives: In metacarpophalangeal (MCP) joint arthroplasty, some implants require an oblique osteotomy of the metacarpal neck. If the osteotomy is not aligned with the rotational axis, the osteotomy surface itself can tilt ulnarly, leading to unintended ulnar deviation of the finger. This study aimed to evaluate whether the dorsal tangent angle (DTA) of the metacarpal neck can serve as a reliable intraoperative reference for rotational alignment during MCP joint arthroplasty.Methods: This cross-sectional study analysed CT data from 44 hands of 44 Japanese patients (15 hands from 15 RA patients and 29 hands from 29 non-RA patients). Three-dimensional CT models of the 2nd to 5th metacarpals were generated, and the DTA was measured as the angle between the dorsal tangent of the metacarpal neck and the rotational axis of the metacarpal head. Differences in DTA among the metacarpals and gender differences were analysed.Results: The median DTA increased progressively from the 2nd to the 5th metacarpals (77.5°, 82.0°, 87.8°, and 94.6°, respectively). A significant gender difference was observed in the 3rd metacarpal, with a greater DTA in women than in men (84.4° versus 78.7°). No significant differences in DTA were found between the RA and non-RA groups, both in the overall population and when the analysis was limited to women.Conclusions: The dorsal tangent of the metacarpal neck can serve as a reliable intraoperative reference for rotational alignment in MCP joint arthroplasty. Supination is recommended for the 2nd and 3rd metacarpals, though a slightly reduced degree of supination is preferable for the 3rd metacarpal, particularly in women.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased Prevalence of Gastrointestinal involvement in Behçet's Syndrome Patients with Gynaecological Disorders. behaperet综合征合并妇科疾病患者胃肠道受累的患病率增加。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-06-02 DOI: 10.1093/mr/roaf048

Isso Saito, Yusho Ishii, Hiroko Sato, Tsuyoshi Shirai, Hiroshi Fujii

{"title":"Increased Prevalence of Gastrointestinal involvement in Behçet's Syndrome Patients with Gynaecological Disorders.","authors":"Isso Saito, Yusho Ishii, Hiroko Sato, Tsuyoshi Shirai, Hiroshi Fujii","doi":"10.1093/mr/roaf048","DOIUrl":"https://doi.org/10.1093/mr/roaf048","url":null,"abstract":"Objectives: This study aimed to investigate the clinical significance of coexisting gynaecological disorders (GD) in patients with Behçet's syndrome (BS).Methods: This study included patients with BS who visited Department of Rheumatology in the Tohoku University Hospital from 2022 to 2023. Among these patients, the manifestation and the treatment of BS were investigated.Results: This group included 37 female patients with BS and GD (BS-FG), 36 female patients with BS without any GD (BS-FWG) and 67 male patients with BS (BS-M). The prevalence of gastrointestinal involvement was significantly higher in BS-FG (48.6%) than in BS-FWG (22.2%, p = 0.041) and BS-M (17.9%, p = 0.0043). The prevalence of ocular involvement was lower in BS-FG (35.1%) than in BS-FWG (50%, p = 0.24) and BS-M (64.2%, p = 0.022). The frequency of anti-TNFα antibody usage was lower among patients in the BS-FWG group than those in the BS-M and BS-FG groups (p = 0.0055 and p = 0.20). The maximum prednisolone dosage and the rates of surgery for BS tended to be higher in BS-FG and BS-M than in BS-FWG.Conclusions: Our study revealed that gastrointestinal involvement is more common in BS-FG, and BS-FG frequently requires intensive treatment similar to BS-M.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between sleep-disordered breathing and moderate to severe depression in systemic lupus erythematosus: the TRUMP2-SLE study. 系统性红斑狼疮患者睡眠呼吸障碍与中度至重度抑郁之间的关系：TRUMP2-SLE研究

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-05-30 DOI: 10.1093/mr/roaf047

Yuichi Ishikawa, Nao Oguro, Takanori Ichikawa, Dai Kishida, Natsuki Sakurai, Chiharu Hidekawa, Kenta Shidahara, Keigo Hayashi, Yoshia Miyawaki, Yasuhiro Shimojima, Ryusuke Yoshimi, Ken-Ei Sada, Nobuyuki Yajima, Noriaki Kurita

{"title":"Association between sleep-disordered breathing and moderate to severe depression in systemic lupus erythematosus: the TRUMP2-SLE study.","authors":"Yuichi Ishikawa, Nao Oguro, Takanori Ichikawa, Dai Kishida, Natsuki Sakurai, Chiharu Hidekawa, Kenta Shidahara, Keigo Hayashi, Yoshia Miyawaki, Yasuhiro Shimojima, Ryusuke Yoshimi, Ken-Ei Sada, Nobuyuki Yajima, Noriaki Kurita","doi":"10.1093/mr/roaf047","DOIUrl":"https://doi.org/10.1093/mr/roaf047","url":null,"abstract":"Objectives: Depression is a common mood disorder in systemic lupus erythematosus (SLE) patients, affecting quality of life and medication adherence. Sleep-disordered breathing (SDB) is a known contributor to depression in the general population, but its prevalence and impact on depression in SLE remain unclear. This study aimed to investigate the prevalence of SDB and its association with depression.Methods: A cross-sectional study was conducted among 414 Japanese adults with SLE from five university hospitals. The main exposure was high-risk SDB, assessed with the Berlin Questionnaire. The main outcome was moderate to severe depression evaluated using the Patient Health Questionnaire-9. Poisson regression models with robust error variance estimated adjusted prevalence ratios (aPRs).Results: The mean age and BMI were 47.5 years and 22.1 kg/m2. The prevalence of high-risk SDB and moderate to severe depression were 15.2% (95% confidence interval: 11.9%-19.0%) and 19.1% (95% CI: 15.4%-23.2%). High-risk SDB was associated with moderate to severe depression (aPR 2.63, 95% CI 1.62-4.27), with a dose-dependent relationship according to the number of positive risk categories.Conclusions: SDB is common in SLE and is associated with depression. SLE patients with SDB symptoms should undergo concurrent depression screening.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-05-30 DOI: 10.1093/mr/roaf044

Shinya Hirahara, Yasuhiro Katsumata, Ken-Ei Sada, Hiroko Nagafuchi, Eiichi Tanaka, Masayoshi Harigai

{"title":"Health-related quality of life and work productivity in Japanese patients with primarily stable ANCA-associated vasculitis: a multicenter cross-sectional study.","authors":"Shinya Hirahara, Yasuhiro Katsumata, Ken-Ei Sada, Hiroko Nagafuchi, Eiichi Tanaka, Masayoshi Harigai","doi":"10.1093/mr/roaf044","DOIUrl":"https://doi.org/10.1093/mr/roaf044","url":null,"abstract":"Objectives: We aimed to investigate the health-related quality of life (HRQoL) and work productivity of Japanese patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).Methods: We conducted a cross-sectional study of Japanese patients with AAV at three university hospitals using the HRQoL and Work Productivity and Activity Impairment questionnaires.Results: Ninety-two patients with AAV participated. The values of all eight subscale scores and physical component summary (PCS) and role component summary (RCS) scores of the Medical Outcomes Study Short Form-36 (SF-36) and the 5-level EuroQoL 5-Dimensions Questionnaire (EQ-5D-5L) index values of the AAV patients were significantly lower than the Japanese population norms. The Birmingham Vasculitis Activity Score and Vasculitis Damage Index were weakly and negatively correlated with the SF-36 PCS scores. Among the 25 patients with AAV who worked for pay, the absenteeism and presenteeism due to AAV were 17% and 32%, respectively, and were mild-to-moderately and negatively correlated with the SF-36 PCS and RCS scores and the EQ-5D-5L index values.Conclusion: The HRQoL of Japanese patients with AAV was poorer than that of the general population and was partly associated with disease activity and damage accrual. In employed patients, impaired work productivity was observed and negatively associated with HRQoL.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0