Modern Rheumatology最新文献_第8页

Ultrasound-detected knee synovitis in patients with rheumatoid arthritis after total knee arthroplasty. 全膝关节置换术后类风湿关节炎患者超声检测到的膝关节滑膜炎

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae074

Yuji Miyoshi, Eisuke Takamasu, Ryosuke Takada, Yuichi Nagase

{"title":"Ultrasound-detected knee synovitis in patients with rheumatoid arthritis after total knee arthroplasty.","authors":"Yuji Miyoshi, Eisuke Takamasu, Ryosuke Takada, Yuichi Nagase","doi":"10.1093/mr/roae074","DOIUrl":"10.1093/mr/roae074","url":null,"abstract":"Objectives: To evaluate the prevalence of ultrasound (US)-detected knee synovitis in patients with rheumatoid arthritis (RA) with a history of total knee arthroplasty (TKA) and to explore its association with RA disease activity and clinical outcomes.Methods: The present, retrospective, cross-sectional study retrieved the data from electronic medical records of patients with RA who were followed up for TKA and had musculoskeletal ultrasound assessment at the study centre from 1 January 2021 through 31 December 2021.Results: Forty-two patients with 67 post-TKA knee joints were enrolled in the present study. US-detected synovitis of the post-TKA knee was present in 15 knees (22.4%) and 12 patients (28.6%). There was no difference in disease activity scores or the pain domain of Knee Injury and Osteoarthritis Outcome Score between the patients with (n = 12) and without (n = 30) US-detected knee synovitis. The proportion of patients with the intensification of antirheumatic drugs after MSUS assessment was significantly higher in patients with US-detected synovitis compared to those without US-detected synovitis (41.7 versus 6.7%, P = .01).Conclusions: US-detected synovitis of the knee was present at 22.4% of post-TKA knee joints. Patients with US-detected synovitis of post-TKA knees were likely to receive an intensification of antirheumatic drugs.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"280-286"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nationwide epidemiological survey of juvenile idiopathic arthritis during transition to young adulthood in Japan using the National Database of Designated Incurable Diseases of Japan. 利用日本国家指定不治之症数据库，对日本幼年特发性关节炎向青年期过渡的全国流行病学调查。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae076

Yuzaburo Inoue, Ryoko Sakai, Eisuke Inoue, Kanako Mitsunaga, Masaki Shimizu, Takahiko Sugihara, Masakazu Matsushita, Ken Yamaji, Masaaki Mori, Naoki Shimojo, Takako Miyamae

{"title":"Nationwide epidemiological survey of juvenile idiopathic arthritis during transition to young adulthood in Japan using the National Database of Designated Incurable Diseases of Japan.","authors":"Yuzaburo Inoue, Ryoko Sakai, Eisuke Inoue, Kanako Mitsunaga, Masaki Shimizu, Takahiko Sugihara, Masakazu Matsushita, Ken Yamaji, Masaaki Mori, Naoki Shimojo, Takako Miyamae","doi":"10.1093/mr/roae076","DOIUrl":"10.1093/mr/roae076","url":null,"abstract":"Objectives: We aimed to assess the unmet medical needs of young adult patients with juvenile idiopathic arthritis (JIA) by evaluating real-world treatment data.Methods: We analysed data on JIA in the age group of 20-29 years from the National Database of Designated Incurable Diseases of Japan, which records severe cases or those requiring high-cost medical care registered between April 2018 and March 2020.Results: Overall, 322 patients with JIA transitioning to adulthood were included. A high frequency of methotrexate use was observed among all JIA subtypes. The frequency of methotrexate use at registration was significantly higher in patients with rheumatoid factor-positive polyarthritis and those with oligoarthritis or polyarthritis than in those with systemic arthritis. The historical use percentage of any biological disease-modifying antirheumatic drug was ≥85% for all JIA subtypes. The proportion of patients with ≥2 biological disease-modifying antirheumatic drug prescriptions was significantly higher in patients with rheumatoid factor-positive polyarthritis than in those with systemic arthritis.Conclusions: High-cost drugs were necessary for many patients with JIA transitioning to young adulthood and registered in the database. Further studies on the medical interventions and support for these patients are needed.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"359-365"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phosphatidylserine-dependent antiprothrombin antibodies as a key predictor for systemic lupus erythematosus in patients with primary antiphospholipid syndrome: A retrospective longitudinal cohort study. 磷脂酰丝氨酸依赖性抗凝血酶抗体是原发性抗磷脂综合征患者患系统性红斑狼疮的主要预测因素：一项回顾性纵向队列研究。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae073

Jiang Wei, Yuichiro Fujieda, Yusuke Fujita, Yusuke Ogata, Ryo Hisada, Michihito Kono, Olga Amengual, Masaru Kato, Tatsuya Atsumi

{"title":"Phosphatidylserine-dependent antiprothrombin antibodies as a key predictor for systemic lupus erythematosus in patients with primary antiphospholipid syndrome: A retrospective longitudinal cohort study.","authors":"Jiang Wei, Yuichiro Fujieda, Yusuke Fujita, Yusuke Ogata, Ryo Hisada, Michihito Kono, Olga Amengual, Masaru Kato, Tatsuya Atsumi","doi":"10.1093/mr/roae073","DOIUrl":"10.1093/mr/roae073","url":null,"abstract":"Objectives: Primary antiphospholipid syndrome (PAPS) is an autoimmune disorder characterized by thrombosis and pregnancy morbidity. Although PAPS is distinct from systemic lupus erythematosus (SLE), the two conditions share clinical features and susceptibility genes. Progression from PAPS to SLE is well recognized. However, risk factors for this transition are poorly understood. We aimed to identify predictors of progression to SLE in patients with PAPS.Methods: A longitudinal single-centre study was conducted at Hokkaido University Hospital from 1990 to 2021. Baseline characteristics, including clinical features, laboratory data, and antiphospholipid antibody profiles, were compared between patients who progressed to SLE (SLE group) and those who did not (non-SLE group).Results: Among 64 patients diagnosed with PAPS at baseline, nine (13.8%) progressed to SLE over a mean follow-up duration of 9 years (incidence rate, 1.61 per 100 person-years). At the time of the diagnosis of PAPS, the SLE group had a higher prevalence of phosphatidylserine-dependent antiprothrombin antibody (aPS/PT) and anti-dsDNA antibodies compared to the non-SLE group. Other clinical findings, autoantibody profiles, and serum complement levels were similar between the two groups. Multivariate Cox analysis showed that aPS/PT IgG was significantly associated with SLE development (hazard ratio: 10.3, 95% confidence interval: 1.13-92.6, P = .04).Conclusions: aPS/PT IgG may be a predictive factor for new-onset SLE in patients with PAPS, suggesting its utility in guiding risk stratification and monitoring strategies for these patients.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"300-306"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy and childbirth in Takayasu arteritis in Japan: A nationwide retrospective study. 日本高安动脉炎患者的妊娠和分娩：全国范围内的回顾性研究。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae068

Takako Miyamae, Yusuke Manabe, Takahiko Sugihara, Natsuka Umezawa, Hajime Yoshifuji, Naoto Tamura, Yoshiyuki Abe, Shunsuke Furuta, Hiroko Nagafuchi, Jun Ishizaki, Naoko Nakano, Tatsuya Atsumi, Kohei Karino, Koichi Amano, Takahiko Kurasawa, Shuichi Ito, Ryusuke Yoshimi, Noriyoshi Ogawa, Shogo Banno, Taio Naniwa, Satoshi Ito, Akinori Hara, Shinya Hirahara, Haruhito A Uchida, Yasuhiro Onishi, Yohko Murakawa, Yoshinori Komagata, Yoshikazu Nakaoka, Masayoshi Harigai

{"title":"Pregnancy and childbirth in Takayasu arteritis in Japan: A nationwide retrospective study.","authors":"Takako Miyamae, Yusuke Manabe, Takahiko Sugihara, Natsuka Umezawa, Hajime Yoshifuji, Naoto Tamura, Yoshiyuki Abe, Shunsuke Furuta, Hiroko Nagafuchi, Jun Ishizaki, Naoko Nakano, Tatsuya Atsumi, Kohei Karino, Koichi Amano, Takahiko Kurasawa, Shuichi Ito, Ryusuke Yoshimi, Noriyoshi Ogawa, Shogo Banno, Taio Naniwa, Satoshi Ito, Akinori Hara, Shinya Hirahara, Haruhito A Uchida, Yasuhiro Onishi, Yohko Murakawa, Yoshinori Komagata, Yoshikazu Nakaoka, Masayoshi Harigai","doi":"10.1093/mr/roae068","DOIUrl":"10.1093/mr/roae068","url":null,"abstract":"Objectives: This study aimed to understand the status quo of medical treatments and pregnancy outcomes in patients with Takayasu arteritis (TAK) and children's birth outcomes.Methods: This study retrospectively enrolled patients with TAK who conceived after the disease onset and were managed at medical facilities participating in the Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis.Results: This study enrolled 51 cases and 68 pregnancies during 2019-21. Of these, 48 cases and 65 pregnancies resulted in delivery and live-born babies. The median age of diagnosis and delivery was 22 and 31 years, respectively. Preconception therapy included prednisolone (PSL) in 51 (78.5%, median 7.5 mg/day), immunosuppressants in 18 (27.7%), and biologics in 12 (18.5%) pregnancies. Six cases underwent surgical treatment before pregnancy. Medications during pregnancy included PSL in 48 (73.8%, median: 9 mg/day), immunosuppressants in 13 (20.0%), and biologics in 9 (13.8%) pregnancies. TAK relapsed in four (6.2%) and eight (12.3%) pregnancies during pregnancy and after delivery, respectively. Additionally, 13/62 (20.9%) preterm infants and 17/59 (28.8%) low-birth-weight infants were observed, and none had serious postnatal abnormalities.Conclusions: Most pregnancies in TAK were manageable with PSL at ≤10 mg/day. Relapse during pregnancy and postpartum occurred in <20% of pregnancies.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"339-344"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New perspective on the clinical and laboratory characteristics of rheumatoid pleural effusion: A 29-case series. 类风湿胸腔积液临床和实验室特征的新视角：29例系列病例。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae082

Saki Sada Minoda, Ryuichi Minoda Sada, Hiroyuki Akebo, Yukio Tsugihashi, Kazuhiro Hatta

{"title":"New perspective on the clinical and laboratory characteristics of rheumatoid pleural effusion: A 29-case series.","authors":"Saki Sada Minoda, Ryuichi Minoda Sada, Hiroyuki Akebo, Yukio Tsugihashi, Kazuhiro Hatta","doi":"10.1093/mr/roae082","DOIUrl":"10.1093/mr/roae082","url":null,"abstract":"Objective: Rheumatoid pleural effusion (RPE) usually occurs in middle-aged men. Pleural fluid analyses have revealed high lactate dehydrogenase (LDH) levels and low pH and glucose levels in RPE. We aimed to investigate the clinical and laboratory features of patients with RPE since the beginning of the 21st century.Methods: Medical records of patients with RPE were reviewed between May 2006 and October 2021. The patients were divided into <60 year (younger) and ≥60 year (older) groups.Results: The younger group comprised 6 patients (median age 53.5 years, female 33%) and older group comprised 23 patients (median age 76 years, female 52.2%). Compared to the younger group, the older group had fewer cases of fever (83.3 versus 18.2%, P = .007) and chest pain (66.7 versus 8.7%, P = .008). In pleural fluid analysis, the older group presented higher pH (P = .004) and lower LDH levels (P = .044). Seven patients died during the follow-up period.Conclusion: Most patients with RPE were over 60 years of age, and approximately half of them were female. The pleural fluid analysis showed milder inflammation in older patients than in middle-aged patients. The mortality rate of patients with RPE was distinctly higher than that previously reported.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"249-255"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A biopsychosocial questionnaire for patients with primary Sjögren's syndrome: The BETY-Biopsychosocial Questionnaire. 针对初级斯约格伦综合征患者的生物心理社会调查问卷：BETY-生物心理社会问卷。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae085

Gamze Nur Ahıskalı, Orkun Tüfekçi, Nur Banu Karaca, Mustafa Ekici, Nazlı Elif Nacar, Sinan Buran, Mine Kantar, Şule Apraş Bilgen, Sedat Kiraz, Edibe Ünal

{"title":"A biopsychosocial questionnaire for patients with primary Sjögren's syndrome: The BETY-Biopsychosocial Questionnaire.","authors":"Gamze Nur Ahıskalı, Orkun Tüfekçi, Nur Banu Karaca, Mustafa Ekici, Nazlı Elif Nacar, Sinan Buran, Mine Kantar, Şule Apraş Bilgen, Sedat Kiraz, Edibe Ünal","doi":"10.1093/mr/roae085","DOIUrl":"10.1093/mr/roae085","url":null,"abstract":"Objective: The BETY-Biopsychosocial Questionnaire (BETY-BQ) is a scale developed to assess the biopsychosocial domains of patients with rheumatic diseases under a single roof. The study aimed to determine the validity and reliability of the BETY-BQ in patients with primary Sjögren's syndrome (pSS).Methods: At enrollment and 1 week, 91 patients with pSS completed the BETY-BQ. Construct validity was measured by correlating the BETY-BQ total score responses with the Health Assessment Questionnaire, Hospital Anxiety and Depression Scale, 36-Item Short-Form Health Survey, EULAR Sjögren's Syndrome Patient-Reported Index, EULAR Sjögren's Syndrome Disease Activity Index, Primary Sjögren's Syndrome Quality of Life questionnaire, and Euro-QoL 5D.Results: The BETY-BQ correlated high to moderate with Health Assessment Questionnaire, bodily pain subscale of 36-Item Short-Form Health Survey, Euro-Qol 5D, Primary Sjögren's Syndrome Quality of Life questionnaire, Hospital Anxiety and Depression Scale, and EULAR Sjögren's Syndrome Patient-Reported Index (0.776 to 0.557, P < .05). Spearman's correlation coefficients between BETY-BQ total scores at baseline and average 1 week were very high (rho = 0.98, P < .001) and indicated substantial agreement between test-retest scores (intraclass correlation coefficient = 0.99, P < .001). Internal consistency reliability at baseline was 0.91 for the BETY-BQ.Conclusions: BETY-BQ is valid and reliable for assessing biopsychosocial status in patients with pSS and can be used to measure outcomes in pSS.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"326-331"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rheumatoid arthritis increases complication risks in elderly hip fracture patients: A Japanese nationwide medical claims database study. 类风湿性关节炎增加老年髋部骨折患者的并发症风险..：日本全国医疗索赔数据库研究。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae088

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Ryuichi Kanabuchi, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

{"title":"Rheumatoid arthritis increases complication risks in elderly hip fracture patients: A Japanese nationwide medical claims database study.","authors":"Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Ryuichi Kanabuchi, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori","doi":"10.1093/mr/roae088","DOIUrl":"10.1093/mr/roae088","url":null,"abstract":"Objectives: This study aimed to evaluate the outcomes and complications associated with hip fractures in patients with rheumatoid arthritis (RA) relative to those without RA.Methods: Using the Japanese National Administrative Diagnosis Procedure Combination database, we examined cases of hip fractures from April 2016 to March 2023. After one to three propensity score matching for age, sex, and complications, we examined the association between RA, complications, and mortality during hospitalization in elderly patients with hip fractures.Results: The findings revealed that elderly Japanese RA patients with hip fractures had significantly higher complications of pneumonia than elderly hip fracture patients without RA, with a ratio of 1.232 [95% confidence interval (CI): 1.065-1.426, P = .0056], and pulmonary embolism, with a ratio of 1.155 (95% CI: 1.036-1.287, P = .009) in multivariate logistic regression analyses. Although not significantly elevated, it also found a trend towards higher mortality during hospitalization, with a ratio of 1.179 (95% CI: 0.973-1.429, P = .096).Conclusions: This study revealed a significant association between RA and increased complications, including pneumonia and pulmonary embolism in hip fractures in the elderly. Implementing preventive strategies is essential to minimizing complications in the treatment of hip fractures in patients with RA.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"287-293"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RNA N6-methyladenosine modification in arthritis: New insights into pathogenesis. 关节炎中的 RNA N6-甲基腺苷修饰：对发病机制的新认识

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae080

Haowei Chen, Anran Xuan, Xiaorui Shi, Tianxiang Fan, Song Xue, Jianzhao Ruan, Xiaoshuai Wang, Su'an Tang, Weizhong Qi, Haitao Sun, Canzhao Liu, Shuai He, Changhai Ding, Zhaohua Zhu

引用次数: 0

Evaluation of lacrimal gland vascularization using superb microvascular imaging: A potential diagnostic tool in Sjögren's syndrome. 利用超级微血管成像评估泪腺血管：斯约格伦综合征的潜在诊断工具。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae081

Ciğdem Samur Salbas, Sadettin Uslu, Ender Salbas

{"title":"Evaluation of lacrimal gland vascularization using superb microvascular imaging: A potential diagnostic tool in Sjögren's syndrome.","authors":"Ciğdem Samur Salbas, Sadettin Uslu, Ender Salbas","doi":"10.1093/mr/roae081","DOIUrl":"10.1093/mr/roae081","url":null,"abstract":"Objectives: The aim of this study is to evaluate the superb microvascular imaging (SMI) findings of the lacrimal glands for the sonographic diagnosis of primary Sjögren's syndrome (pSS).Methods: Twenty-one patients with pSS and 20 healthy groups were evaluated. Dry eye symptoms and their effects on vision-related functions were evaluated with McMonnies and Ocular Surface Disease Index (OSDI) questionnaires. Lacrimal glands were evaluated by power Doppler ultrasonography (PDUS), colour Doppler ultrasonography (CDUS), and SMI.Results: Dry eye symptoms, as determined by McMonnies and OSDI, were significantly more severe in patients with pSS than in the control group (P = .001 and P = .021, respectively). Lacrimal gland vascular activity rates and hypoechoic areas were significantly higher in pSS patients compared to the control group (P < .05). The detection rates of the degree of vascularity in the lacrimal glands of patients with pSS were higher with SMI compared to CDUS and PDUS. In addition, SMI positively correlated with CDUS, PDUS, OSDI, and McMonnies.Conclusions: Evaluation of the lacrimal gland by the SMI was found to be excellent in predicting the likelihood of individuals having pSS compared to CDUS and PDUS. This technique may serve as a reliable and noninvasive adjunctive tool for assessing the degree of lacrimal vascularity in pSS.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"320-325"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of social frailty in patients with rheumatoid arthritis: Data from a multicentre observational study (T-FLAG study). 类风湿性关节炎患者社会脆弱性的普遍性：一项多中心观察研究（T-FLAG 研究）的数据。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae078

Mochihito Suzuki, Shuji Asai, Yoshifumi Ohashi, Yasumori Sobue, Hisato Ishikawa, Kenya Terabe, Ryo Sato, Hironobu Kosugiyama, Junya Hasegawa, Yusuke Ohno, Takaya Sugiura, Shiro Imagama

{"title":"Prevalence of social frailty in patients with rheumatoid arthritis: Data from a multicentre observational study (T-FLAG study).","authors":"Mochihito Suzuki, Shuji Asai, Yoshifumi Ohashi, Yasumori Sobue, Hisato Ishikawa, Kenya Terabe, Ryo Sato, Hironobu Kosugiyama, Junya Hasegawa, Yusuke Ohno, Takaya Sugiura, Shiro Imagama","doi":"10.1093/mr/roae078","DOIUrl":"10.1093/mr/roae078","url":null,"abstract":"Objectives: The aim of this study was to investigate the prevalence of social frailty and associated factors.Methods: A total of 655 consecutive patients who were able to complete the Kihon Checklist (KCL) and the Questionnaire on Social Frailty between June and August 2022 were enrolled. Social frailty was assessed using the Makizako Social Frailty Index. Patient characteristics were analysed by analysis of variance. Factors associated with social frailty were analysed using multivariate logistic analysis. Spearman's rank correlation coefficients were used to examine correlations between each KCL domain and social frailty.Results: The mean age was 68 years, and the disease duration was 12 years; 73% of patients were female. Social frailty was present in 30.8% of patients, with 36.5% classified as social prefrailty. Multivariate analysis revealed age and Health Assessment Questionnaire-Disability Index to be independent factors associated with social frailty. The proportion of social frailty increased with increasing age and worsening Health Assessment Questionnaire-Disability Index scores. The KCL domain 'Isolation' was the most strongly associated with social frailty (r = .601, P < .001), with higher scores associated with a higher proportion of social frailty.Conclusions: Social frailty in patients with rheumatoid arthritis is associated with age and physical impairment (Health Assessment Questionnaire-Disability Index). Moreover, the KCL domain 'Isolation' was strongly associated with social frailty.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"234-239"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0