Modern Rheumatology最新文献_第8页

The knowledge and skills required for the onco-rheumatologist: Study of four-year consultation records of a high-volume cancer centre. 肿瘤风湿病学家所需的知识和技能：对一家高容量癌症中心四年咨询记录的研究。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-12-19 DOI: 10.1093/mr/roae114

Koichi Takeda, Taro Shiga

{"title":"The knowledge and skills required for the onco-rheumatologist: Study of four-year consultation records of a high-volume cancer centre.","authors":"Koichi Takeda, Taro Shiga","doi":"10.1093/mr/roae114","DOIUrl":"https://doi.org/10.1093/mr/roae114","url":null,"abstract":"Objectives: Onco-rheumatology, the intersection of oncology and rheumatology, is an emerging field requiring further definition. This study aimed to identify the knowledge and skills essential for rheumatologists in clinical oncology.Methods: We retrospectively reviewed consultations with the onco-rheumatology department of a high-volume tertiary cancer centre in Japan from January 2020 to December 2023.Results: We analysed 417 consultations. The most common consultation (229, 55%) was related to immune checkpoint inhibitor-induced immune-related adverse events (irAEs). Of the 238 irAEs in 185 patients, 15% were rheumatic and 85% were non-rheumatic (e.g., hepatobiliary toxicities, colitis). Approximately 25% of non-endocrine irAEs were refractory/relapsing, requiring second-line therapy (e.g., mycophenolate mofetil, biologics, immunoglobulin). In addition to irAE consultations, 137 (33%) consultations were about possible rheumatic diseases. The final diagnosis often related to cancer treatment, such as granulocyte colony-stimulating factor-related aortitis (15 patients, 11%), olaparib-related erythema nodosum (10 patients, 7.3%), and surgical menopause-related arthralgia (10 patients, 7.3%). Five patients (3.6%) were diagnosed with autoinflammatory bone disease mimicking bone tumours.Conclusions: Onco-rheumatologists are expected to play a central role in the management of a wide range of irAEs, not limited to rheumatic irAEs. They must also manage rheumatologic manifestations during cancer treatment and rheumatic diseases that mimic tumours.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laboratory markers predicting tofacitinib efficacy in Japanese patients with rheumatoid arthritis: A pooled analysis of Phase 2/3 randomised controlled clinical trials. 预测托法替尼对日本类风湿性关节炎患者疗效的实验室标记物：2/3期随机对照临床试验的汇总分析

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-12-10 DOI: 10.1093/mr/roae109

Yoshiya Tanaka, Hisashi Yamanaka, Shigeyuki Toyoizumi, Tomohiro Hirose, Tsutomu Takeuchi

{"title":"Laboratory markers predicting tofacitinib efficacy in Japanese patients with rheumatoid arthritis: A pooled analysis of Phase 2/3 randomised controlled clinical trials.","authors":"Yoshiya Tanaka, Hisashi Yamanaka, Shigeyuki Toyoizumi, Tomohiro Hirose, Tsutomu Takeuchi","doi":"10.1093/mr/roae109","DOIUrl":"https://doi.org/10.1093/mr/roae109","url":null,"abstract":"Objectives: We characterised early changes in laboratory parameters in Japanese patients with rheumatoid arthritis (RA) and assessed whether these changes at Month (M)1 were predictive of tofacitinib efficacy at M3.Methods: This post hoc analysis included data from Japanese patients with RA receiving tofacitinib or placebo pooled from two Phase (P)2 studies in Japan (NCT00603512; NCT00687193) and one global P3 study (NCT00847613). Outcomes: changes from baseline in laboratory parameters (Week 2 and M1/3); efficacy endpoints (Disease Activity Score in 28 joints, based on C-reactive protein [DAS28-4(CRP)], DAS28-4, based on erythrocyte sedimentation rate [DAS28-4(ESR)], and American College of Rheumatology-N index) at M3. Univariate/multivariable analyses assessed whether changes in laboratory parameters at M1 were predictive of efficacy outcomes at M3.Results: Overall, 467 patients receiving tofacitinib and 104 receiving placebo were included. Tofacitinib treatment was associated with decreases from baseline in CRP, ESR, neutrophils, and platelets, and increases in lymphocytes, haemoglobin, and lipids up to M3. Decreased platelet count and increased low-density lipoprotein cholesterol and haemoglobin at M1 were predictive of changes in efficacy outcomes at M3.Conclusions: Changes in laboratory parameters at M1 could potentially be used to assess whether tofacitinib therapy will be effective at M3; further investigation is needed.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decreased foot-related quality of life is a risk factor for falls in patients with rheumatoid arthritis. 足部相关生活质量下降是类风湿性关节炎患者跌倒的危险因素。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-12-10 DOI: 10.1093/mr/roae108

Akihisa Haraguchi, Kenta Kamo

{"title":"Decreased foot-related quality of life is a risk factor for falls in patients with rheumatoid arthritis.","authors":"Akihisa Haraguchi, Kenta Kamo","doi":"10.1093/mr/roae108","DOIUrl":"https://doi.org/10.1093/mr/roae108","url":null,"abstract":"Objectives: To assess the need to treat forefoot lesions in rheumatoid arthritis (RA) patients who are unaware of their foot problems.Methods: From April to September 2022, 116 RA patients at our clinic were administered the Self-Administered Foot Evaluation Questionnaire (SAFE-Q), a self-assessment questionnaire on foot-related issues, and underwent forefoot radiography. We also assessed the occurrence of falls one year later. Among the 88 patients who were unaware of foot problems, we analysed the frequency and type of forefoot deformities and conducted a multivariate analysis to identify factors predicting falls during the 12-month follow-up.Results: Of the unaware patients, 64 (72.7%) had forefoot deformities and 17 (19.3%) experienced falls within the first year. The fall group had a history of falls and lower SAFE-Q scores but did not significantly differ from others in terms of forefoot deformities. Multivariate analysis identified a history of falls and lower SAFE-Q scores as predictive factors for future falls.Conclusions: Decreased foot-related quality of life is a risk factor for falls, even in patients who are unaware of their foot problems. Physicians should regularly assess foot-related quality of life using tools such as SAFE-Q to help prevent falls in RA patients.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VE-cadherin may suppress inflammation depending on the phase of inflammation of rheumatoid arthritis. 根据类风湿性关节炎的炎症阶段，VE-cadherin 可抑制炎症。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-12-05 DOI: 10.1093/mr/roae107

Shinichiro Nishimi, Sayaka Fukuse, Yusuke Miwa, Kuninobu Wakabayashi, Takeo Isozaki

{"title":"VE-cadherin may suppress inflammation depending on the phase of inflammation of rheumatoid arthritis.","authors":"Shinichiro Nishimi, Sayaka Fukuse, Yusuke Miwa, Kuninobu Wakabayashi, Takeo Isozaki","doi":"10.1093/mr/roae107","DOIUrl":"https://doi.org/10.1093/mr/roae107","url":null,"abstract":"Objectives A disintegrin and metalloproteinase (ADAM)-15 and vascular endothelial (VE)-cadherin are involved in angiogenesis. We investigated the relationship between ADAM-15 and VE-cadherin expressions in rheumatoid arthritis (RA). Methods VE-cadherin concentrations in the serum of patients with RA were measured using the enzyme linked immunosorbent assay (ELISA). We stimulated fibroblast-like synoviocytes (RA-FLS) with VE-cadherin and measured the vascular endothelial growth factor (VEGF) and inflammatory cytokine levels using ELISA. We also examined the correlation between serum VE-cadherin levels and DAS-28ESR and used the Matrigel assay to examine VE-cadherin involvement in angiogenesis. Results Serum VE-cadherin levels were significantly higher in patients with RA than in healthy controls. A negative correlation was observed between VE-cadherin and DAS-28ESR. VEGF, chemokine ligand 16, intercellular adhesion molecule-1, and interleukin-8 levels in the supernatant of RA-FLS or human umbilical vein endothelial cells stimulated with VE-cadherin were significantly lower than those in the controls. The number of intercellular bridges formed by endothelial cells using Matrigel significantly decreased in RA synovial fluids from which VE-cadherin had been removed compared to synovial fluids treated with control immunoglobulin G. Conclusion VE-cadherin may have an inhibitory effect on inflammation depending on the phase of RA inflammation.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the diagnostic and therapeutic value of submandibular gland elastography in patients with immunoglobulin G4-related sialadenitis. 评估颌下腺弹性成像对免疫球蛋白 G4 相关性唾液腺炎患者的诊断和治疗价值。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-11-28 DOI: 10.1093/mr/roae098

Saki Shibuki, Tsukasa Saida, Hiroto Tsuboi, Takashi Kamimaki, Maki Ota, Yohei Sugaya, Naoya Ichinose, Miki Yoshida, Isao Matsumoto, Takahito Nakajima

{"title":"Assessing the diagnostic and therapeutic value of submandibular gland elastography in patients with immunoglobulin G4-related sialadenitis.","authors":"Saki Shibuki, Tsukasa Saida, Hiroto Tsuboi, Takashi Kamimaki, Maki Ota, Yohei Sugaya, Naoya Ichinose, Miki Yoshida, Isao Matsumoto, Takahito Nakajima","doi":"10.1093/mr/roae098","DOIUrl":"https://doi.org/10.1093/mr/roae098","url":null,"abstract":"Objectives: : To investigate the utility of shear wave elastography values (SWE) in differentiating IgG4-related submandibular sialadenitis (IgG4-RSS) from healthy individuals and in monitoring the response to glucocorticoid treatment.Methods: : Patients with IgG4-RSS who underwent ultrasound between 2017 and 2023 were included. Gland size, border, internal echo pattern, vascularity, and SWE were measured. These parameters were compared with those of the healthy controls, and before and after treatment.Results: Thirty-one glands from 16 patients were analysed. All glands had a nodular shape; the nodular hypoechoic was the most prevalent pattern, followed by the diffuse hypoechoic; the reticular was the least common. Most glands had rich vascularity, whereas two glands had minimal vascularity. The depth (mean 18 mm) and SWE (mean 3.57 m/s) were significantly higher in IgG-RSS (P=0.003 and <0.001, respectively) than in the healthy controlsNine glands from five patients were enrolled to evaluate the treatment response. After treatment, the margins became smoother and all glands showed a reduction in size, hypoechoic area, and vascularity. The mean SWE decreased from 3.56 m/s to 2.50 m/s with a significant difference between pre- and post-treatment (P= <0.001).Conclusions: The SWE is useful for diagnosing IgG4-RSS and assessing the effectiveness of treatment.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness and safety of low-energy shock wave therapy for digital ulcers associated with systemic sclerosis: a phase 3 pivotal clinical trial. 低能量冲击波疗法治疗与系统性硬化症相关的数字溃疡的有效性和安全性：3 期关键临床试验。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-11-18 DOI: 10.1093/mr/roae104

Tomonori Ishii, Yasushi Kawaguchi, Osamu Ishikawa, Hiromitsu Takemori, Naruhiko Takasawa, Hitoshi Kobayashi, Yuichi Takahashi, Hidekata Yasuoka, Takao Kodera, Osamu Takai, Izaya Nakaya, Yukio Sato, Tomomasa Izumiyama, Hiroshi Fujii, Yukiko Kamogawa, Yuko Shirota, Tsuyoshi Shirai, Yoko Fujita, Shinichiro Saito, Shih-Wei Chiu, Takuhiro Yamaguchi, Hiroaki Shimokawa, Hideo Harigae

{"title":"Effectiveness and safety of low-energy shock wave therapy for digital ulcers associated with systemic sclerosis: a phase 3 pivotal clinical trial.","authors":"Tomonori Ishii, Yasushi Kawaguchi, Osamu Ishikawa, Hiromitsu Takemori, Naruhiko Takasawa, Hitoshi Kobayashi, Yuichi Takahashi, Hidekata Yasuoka, Takao Kodera, Osamu Takai, Izaya Nakaya, Yukio Sato, Tomomasa Izumiyama, Hiroshi Fujii, Yukiko Kamogawa, Yuko Shirota, Tsuyoshi Shirai, Yoko Fujita, Shinichiro Saito, Shih-Wei Chiu, Takuhiro Yamaguchi, Hiroaki Shimokawa, Hideo Harigae","doi":"10.1093/mr/roae104","DOIUrl":"https://doi.org/10.1093/mr/roae104","url":null,"abstract":"Objectives: Systemic sclerosis is characterised by ischaemic skin ulcers on the fingertips, and low-energy shock wave therapy is suggested as a novel treatment for ischaemic lesions with angiogenic effects. We aimed to investigate the efficacy and safety of shock wave therapy for skin ulcers in patients with systemic sclerosis.Methods: In this phase 3 pivotal study, we analysed 60 systemic sclerosis patients with digital ulcers that did not disappear after >4 weeks of existing treatment: 30 patients were treated with extracorporeal shock wave therapy and 30 with conventional treatment. The ulcer count reduction observed after an 8-week treatment period was compared between the shock wave therapy and conventional treatment groups.Results: After an 8-week treatment period, the mean reduction in the number of ulcers was 0.83 (standard deviation [SD] 2.79) in the conventional treatment group compared to a more pronounced reduction of 4.47 (SD 2.65) in the shock wave therapy group.Conclusions: The study findings indicate the efficacy of extracorporeal shock wave therapy for refractory digital ulcers associated with systemic sclerosis, which has limited therapeutic options. This therapy is non-invasive and safe and can be used without restriction in combination with other therapies, thus serving as a novel therapeutic method.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-11-16 DOI: 10.1093/mr/roae102

Riki Kurokawa, Sachiko Ohde, Satoshi Kawaai, Hiromichi Tamaki

{"title":"Factors related to acceptance of COVID-19 vaccine booster doses among patients with autoimmune and rheumatic diseases in Japan: A single-center cross-sectional survey.","authors":"Riki Kurokawa, Sachiko Ohde, Satoshi Kawaai, Hiromichi Tamaki","doi":"10.1093/mr/roae102","DOIUrl":"https://doi.org/10.1093/mr/roae102","url":null,"abstract":"Objectives: We studied the current state and factors associated with the acceptance or hesitancy of booster doses of the coronavirus disease 2019 (COVID-19) vaccine among patients with autoimmune and rheumatic diseases (ARDs) in Japan.Methods: A single-center cross-sectional survey was conducted among outpatients with ARDs who visited the Immuno-Rheumatology Center at St. Luke's International Hospital from 1 October to 30 November in 2023. We investigated patient characteristics, COVID-19 vaccination-related status, decision-making preferences, health-related status and independent factors associated with the acceptance or hesitancy of booster doses of the COVID-19 vaccine.Results: A total of 241 patients were included in the analyses, and 198 patients (82.2%) received booster doses while 43 (17.8%) did not. Older age (adjusted odds ratio [aOR] = 0.43, 95% CI: 0.19, 0.95, P = 0.037), having rheumatoid arthritis (RA) (aOR = 0.41, 95% CI: 0.19, 0.92, P = 0.030) and having a physician recommend receiving the vaccine (aOR = 0.47, 95% CI: 0.23, 0.95, P = 0.035) were independently associated with receiving booster doses. The main reasons for hesitancy regarding booster doses were concerns about adverse reactions and long-term safety.Conclusion: Our findings could help physicians counsel patients with ARDs regarding their acceptance of COVID-19 vaccine booster doses to promote appropriate decision-making.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alkaline phosphatase is useful for predicting giant cell arthritis complications in patients with polymyalgia rheumatica. 碱性磷酸酶有助于预测多发性风湿性关节炎患者的巨细胞关节炎并发症。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-11-14 DOI: 10.1093/mr/roae101

Ryo Yamashita, Yusuke Izumi, Jun Hiramoto

{"title":"Alkaline phosphatase is useful for predicting giant cell arthritis complications in patients with polymyalgia rheumatica.","authors":"Ryo Yamashita, Yusuke Izumi, Jun Hiramoto","doi":"10.1093/mr/roae101","DOIUrl":"https://doi.org/10.1093/mr/roae101","url":null,"abstract":"Objectives: This study determined whether alkaline phosphatase can be used to distinguish giant cell arthritis complications in patients with polymyalgia rheumatica.Methods: This retrospective study included patients diagnosed with polymyalgia rheumatica between January 2014 and October 2023 at our hospital. The predictive accuracy of biomarkers for diagnosing giant cell arthritis was evaluated. Logistic regression was performed to identify factors predicting giant cell arthritis complications.Results: In total, 128 participants were included in this study and divided into two groups: isolated polymyalgia rheumatica (n = 111) and polymyalgia rheumatica with giant cell arthritis (n = 17). The median alkaline phosphatase level of polymyalgia rheumatica with giant cell arthritis group was significantly higher than that of the isolated polymyalgia rheumatica group (242.0 [interquartile range, 221.0-595.0] vs. 187.0 [interquartile range 97.5-254.5] U/L, P < 0.001). Setting a cut-off value of 214 U/L for alkaline phosphatase yielded a sensitivity and specificity of 0.88 and 0.55, respectively, for diagnosing giant cell arteritis. Multivariate analysis revealed that alkaline phosphatase was a significant independent variable in the complications of giant cell arteritis (odds ratio, 25.2; P = 0.032).Conclusions: Alkaline phosphatase can help distinguish giant cell arthritis complications in patients with polymyalgia rheumatica.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The abundance of regulatory T cell subsets is associated with the clinical outcomes of sarcoidosis. 调节性 T 细胞亚群的丰富程度与肉样瘤病的临床结果有关。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-11-14 DOI: 10.1093/mr/roae106

Katsuhide Kusaka, Yusuke Miyazaki, Shingo Nakayamada, Satoshi Kubo, Ippei Miyagawa, Yurie Satoh-Kanda, Yasuyuki Todoroki, Masanobu Ueno, Yoshiya Tanaka

{"title":"The abundance of regulatory T cell subsets is associated with the clinical outcomes of sarcoidosis.","authors":"Katsuhide Kusaka, Yusuke Miyazaki, Shingo Nakayamada, Satoshi Kubo, Ippei Miyagawa, Yurie Satoh-Kanda, Yasuyuki Todoroki, Masanobu Ueno, Yoshiya Tanaka","doi":"10.1093/mr/roae106","DOIUrl":"https://doi.org/10.1093/mr/roae106","url":null,"abstract":"Objectives: Some patients with sarcoidosis achieve spontaneous remission, whereas others repeatedly experience relapse. We examined differences in the clinical course of active sarcoidosis according to peripheral blood immunophenotypes before treatment.Methods: This retrospective study compared peripheral blood immunophenotypes between patients with active sarcoidosis (n=28) and healthy control subjects (n=10). Patients with sarcoidosis were divided into the spontaneous remission group without treatment (n=9), the non-relapsed group after treatment (n=13), and the relapsed group after treatment (n=6) and were compared for peripheral blood immunophenotypes and background characteristics at baseline.Results: Patients with sarcoidosis showed increases in activated T helper (Th) 1 cells, activated Th17 cells, and regulatory T (Treg) cell subsets. The proportion of effector Treg cells was highest in the spontaneous remission group, and the proportion of non-suppressive Treg cells was highest in the relapsed group. No differences were observed in the proportions of other CD4+ T cell subsets. The cut-off values for predicting spontaneous remission and relapse were calculated for the effector Treg/non-suppressive Treg ratio. As a result, A ratio ≥1.469 predicted spontaneous remission (75%), while ≤0.722 predicted relapse (66.7%).Conclusion: Effector and non-suppressive Treg cell proportions before treatment may predict spontaneous remission and relapse in active sarcoidosis.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can the affected intestinal segment visualized on abdominal ultrasound predict gastrointestinal tract bleeding in immunoglobulin A vasculitis? 腹部超声波显示的受影响肠段能否预测免疫球蛋白 A 血管炎患者的消化道出血？

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-11-14 DOI: 10.1093/mr/roae103

Merve Cansu Polat, Zahide Ekici Tekin, Avni Merter Keçeli, Elif Çelikel, Vildan Güngörer, Cüneyt Karagöl, Melike Mehveş Kaplan, Nimet Öner, Didem Öztürk, Emine Özçelik, Mehveş Işıklar Ekici, Yasemin Uğur Es, Sultan Nilay Yoğun, Banu Çelikel Acar

{"title":"Can the affected intestinal segment visualized on abdominal ultrasound predict gastrointestinal tract bleeding in immunoglobulin A vasculitis?","authors":"Merve Cansu Polat, Zahide Ekici Tekin, Avni Merter Keçeli, Elif Çelikel, Vildan Güngörer, Cüneyt Karagöl, Melike Mehveş Kaplan, Nimet Öner, Didem Öztürk, Emine Özçelik, Mehveş Işıklar Ekici, Yasemin Uğur Es, Sultan Nilay Yoğun, Banu Çelikel Acar","doi":"10.1093/mr/roae103","DOIUrl":"https://doi.org/10.1093/mr/roae103","url":null,"abstract":"Objective: To evaluate immunoglobulin A vasculitis (IgAV) patients with gastrointestinal (GI) tract involvement and to reveal the relationship between the location and extent of the affected intestinal segment detected on the initial abdominal ultrasound (US) and GI tract bleeding.Methods: This medical record review study was conducted on 117 IgAV patients with GI tract involvement between January 2016- June 2023. Patients were divided into two groups as those with (n=28) and without (n=89) GI tract bleeding. Predictors of GI tract bleeding were investigated by comparing demographic, clinical characteristics and laboratory findings.Results: Gender, age at diagnosis, symptoms at admission, rash distribution, GI tract complaints, and the elapsed time until the development of GI tract symptoms were similar in both groups. There was no difference between small intestinal, large intestinal or small+large intestinal involvement (p=0.89). The ileum was the most commonly affected intestinal segment in patients with and without GI tract bleeding (p=0.37). Jejunal wall thickening (p=0.04) and the number of affected intestinal segments (p=0.008) were higher in patients with GI tract bleeding.Conclusion: In IgAV patients, jejunum involvement and affected multiple intestinal segments shown by abdominal US are associated with GI tract bleeding.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0