Modern Rheumatology最新文献_第7页

Relation between hydroxychloroquine dose and continuation rate in patients with systemic lupus erythematosus. 系统性红斑狼疮患者服用羟氯喹的剂量与持续率之间的关系

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-12-25 DOI: 10.1093/mr/roae062

Shuhei Takeyama, Michihito Kono, Kuniyuki Aso, Kazuro Kamada, Maria Tada, Masato Tarumi, Yui Kosumi, Masaru Yoshimura, Keita Ninagawa, Ryo Hisada, Yuichiro Fujieda, Masaru Kato, Olga Amengual, Tatsuya Atsumi

{"title":"Relation between hydroxychloroquine dose and continuation rate in patients with systemic lupus erythematosus.","authors":"Shuhei Takeyama, Michihito Kono, Kuniyuki Aso, Kazuro Kamada, Maria Tada, Masato Tarumi, Yui Kosumi, Masaru Yoshimura, Keita Ninagawa, Ryo Hisada, Yuichiro Fujieda, Masaru Kato, Olga Amengual, Tatsuya Atsumi","doi":"10.1093/mr/roae062","DOIUrl":"10.1093/mr/roae062","url":null,"abstract":"Objectives: Hydroxychloroquine (HCQ) is recommended at a target dose of 5 mg/kg per actual body weight to reduce the risk of retinopathy in systemic lupus erythematosus (SLE). However, the efficacy of HCQ has been established at doses of 6.5 mg/kg per ideal body weight. This study aimed to clarify the effects of the HCQ dose on the continuation rate in Japanese patients, who generally have a lower body mass index than Western patients.Methods: This retrospective single-centre observational study enrolled patients with SLE on HCQ therapy. Patients were divided into two groups with a dose per actual body weight [the low-dose (<5 mg/kg) group and the high-dose (≥5 mg/kg) group], and continuation rates were compared. The efficacy of 1-year HCQ therapy was assessed in patients without additional immunosuppressive agents and biologics.Results: Of the 231 patients enrolled, 48 (20.8%) discontinued HCQ. The HCQ dose per actual body weight was identified as an independent risk factor for discontinuation. The low-dose group showed a significantly higher 1-year HCQ continuation rate than the high-dose group (83.2% vs. 72.8%, respectively). Both groups showed reductions in glucocorticoid requirement and serological activity after 1-year HCQ therapy.Conclusions: HCQ <5 mg/kg per actual body weight may facilitate greater continuation.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"110-117"},"PeriodicalIF":1.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severity scores, damage indices, and the concept of the colchicine-resistant patient in familial Mediterranean fever. 家族性地中海热的严重程度评分、损害指数和秋水仙碱耐药患者的概念。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-12-25 DOI: 10.1093/mr/roae067

Ozan Er, Helin Akay, Mehmet Emre Ozgozen, Didem Gulhan, Serdal Ugurlu

引用次数: 0

Challenges nurses face in providing care for patients with juvenile idiopathic arthritis. 护士在为青少年特发性关节炎患者提供护理时面临的挑战。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-12-25 DOI: 10.1093/mr/roae041

Mie Fusama, Hideko Nakahara, Takako Miyamae, Masaaki Mori, Yukitomo Urata, Kimito Kawahata, Yutaka Kawahito, Masayo Kojima, Takahiko Sugihara, Motomu Hashimoto, Atsuko Murashima, Nobuyuki Yajima, Toshihiro Matsui

{"title":"Challenges nurses face in providing care for patients with juvenile idiopathic arthritis.","authors":"Mie Fusama, Hideko Nakahara, Takako Miyamae, Masaaki Mori, Yukitomo Urata, Kimito Kawahata, Yutaka Kawahito, Masayo Kojima, Takahiko Sugihara, Motomu Hashimoto, Atsuko Murashima, Nobuyuki Yajima, Toshihiro Matsui","doi":"10.1093/mr/roae041","DOIUrl":"10.1093/mr/roae041","url":null,"abstract":"Objectives: This study aimed at identifying challenges nurses face in caring for patients with juvenile idiopathic arthritis (JIA) in Japan.Methods: Nurses certified by the Japan Rheumatism Foundation were asked to describe their challenges in caring for JIA patients. Data were analysed using qualitative content analysis.Results: Responses were collected from 89 participants. Fifty-eight issues were identified from 40 participants with experience in caring for JIA patients. Sixteen categories emerged, which were grouped into five challenges: communication, understanding, expertise, system, and collaboration. Care for JIA patients included different challenges from adult patients with rheumatoid arthritis, such as complicated patient-parent relationships, inadequate patient independence, and insufficient patient information. Moreover, 76 issues from 49 participants with no experience were identified. Seven categories emerged, which were grouped into two challenges: expertise and opportunity. Issues included in expertise between both groups were similar. Even with no experience in caring for JIA patients, nurses recognized the importance of acquiring knowledge.Conclusions: This is the first study in Japan regarding the difficulties nurses face in caring for JIA patients. Multidisciplinary team care and a comprehensive understanding of the patient journey, including relationships with guardians, acquaintances, and healthcare providers, are crucial to improve treatment outcome and overall patient quality of life.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"185-193"},"PeriodicalIF":1.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140898765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of sarilumab in a Japanese population with rheumatoid arthritis by age group: Data from an interim analysis of a postmarketing surveillance study. 按年龄组划分的日本类风湿关节炎患者使用沙利单抗的安全性：上市后监测研究的中期分析数据。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-12-25 DOI: 10.1093/mr/roae051

Hideto Kameda, Sadatomo Tasaka, Toshiya Takahashi, Katsuhisa Suzuki, Naoki Soeda, Hubert van Hoogstraten, Remco Diab, Yoshiya Tanaka

{"title":"Safety of sarilumab in a Japanese population with rheumatoid arthritis by age group: Data from an interim analysis of a postmarketing surveillance study.","authors":"Hideto Kameda, Sadatomo Tasaka, Toshiya Takahashi, Katsuhisa Suzuki, Naoki Soeda, Hubert van Hoogstraten, Remco Diab, Yoshiya Tanaka","doi":"10.1093/mr/roae051","DOIUrl":"10.1093/mr/roae051","url":null,"abstract":"Objectives: Using data from a postmarketing surveillance, this interim subgroup analysis investigated the safety of sarilumab in younger (<65 years) and older patients (≥65 and ≥75 years) with rheumatoid arthritis.Methods: During this interim analysis, patients who were treated with sarilumab in Japan were enrolled between June 2018 and 2021. Data collected by 12 January 2022 were analysed, with adverse drug events monitored over 52 weeks.Results: Of 972 patients with available data, the proportion of patients aged <65 years, ≥65 years, and ≥75 years was 40.8%, 59.2%, and 27.8%, respectively. Most patients (95.5%) received the standard 200 mg dose of sarilumab as the initial dose. Adverse drug reactions were reported in 24.6% of patients, with serious events accounting for 6.4% of cases. No malignancy and low incidences of adverse drug reactions of special interest were reported across all age groups (<65 years, 7.8%; ≥65 years, 8.2%; ≥75 years, 8.5%). When stratified by absolute neutrophil count above and below the lower limit of normal, there were no numerical differences in incidences of serious and non-serious infections between age groups.Conclusions: Regardless of age, sarilumab therapy was well tolerated by patients with rheumatoid arthritis, with no new safety signals reported in this study.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"42-49"},"PeriodicalIF":1.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunological biomarkers in patients with radiographic axial spondyloarthritis, an exploratory longitudinal Swedish study. 一项探索性瑞典纵向研究：放射性轴性脊椎关节炎患者的免疫生物标志物。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-12-25 DOI: 10.1093/mr/roae039

Urban Hellman, Kristina Lejon, Lan Do, Mats Geijer, Xenofon Baraliakos, Torsten Witte, Helena Forsblad-d'Elia

{"title":"Immunological biomarkers in patients with radiographic axial spondyloarthritis, an exploratory longitudinal Swedish study.","authors":"Urban Hellman, Kristina Lejon, Lan Do, Mats Geijer, Xenofon Baraliakos, Torsten Witte, Helena Forsblad-d'Elia","doi":"10.1093/mr/roae039","DOIUrl":"10.1093/mr/roae039","url":null,"abstract":"Objectives: There is a need for more specific biomarkers to diagnose and predict disease course in patients with axial spondyloarthritis (axSpA). This study aimed to study immunological plasma biomarkers at different time-points in radiographic (r)-axSpA patients overall and stratified by sex and compare these biomarker patterns in r-axSpA patients concerning disease phenotypes and disease activity.Methods: Plasma samples were analysed from r-axSpA patients at and prior (Pre-Backbone) inclusion in the Backbone study. Interferon gamma, interleukin-10, -17A, -17F, -22, -23, -6, MCP-1, TNF-α, VEGF-A, MIF, IgA anti-CD74, zonulin, ESR, hsCRP, white blood cell count, and blood lipids were measured.Results: Biomarker pattern discriminated significantly between r-axSpA patients in Backbone and Pre-Backbone compared with controls. When stratifying by sex, it was possible to discriminate between male and female r-axSpA patients in Backbone vs controls and between male r-axSpA patients in pre-Backbone and controls. In Backbone, markers with high discriminative capacity were MIF, IgA anti-CD74, and MCP-1. In Pre-Backbone, IL-6, TNF-α, MIF, triglycerides, cholesterol, IL-10, and zonulin displayed high discriminative capacity.Conclusion: Based on their temporal pattern and mutual relationship, we suggest studying MIF, IgA anti-CD74, and MCP-1 in depth, at more time points, to further elucidate disease-driving mechanisms in this complex disease.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"134-143"},"PeriodicalIF":1.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between falls and the use of hypnotics, antidepressants, antipsychotics, and anxiolytics in patients with rheumatoid arthritis: A cross-sectional study. 类风湿性关节炎患者跌倒与使用催眠药、抗抑郁药、抗精神病药和抗焦虑药之间的关系：一项横断面研究。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-12-25 DOI: 10.1093/mr/road118

Kosuke Sakurai, Ryo Yanai, Takeo Isozaki, Nobuyuki Yajima

{"title":"Relationship between falls and the use of hypnotics, antidepressants, antipsychotics, and anxiolytics in patients with rheumatoid arthritis: A cross-sectional study.","authors":"Kosuke Sakurai, Ryo Yanai, Takeo Isozaki, Nobuyuki Yajima","doi":"10.1093/mr/road118","DOIUrl":"10.1093/mr/road118","url":null,"abstract":"Objectives: This cross-sectional study aimed to determine the relationship between falls and the use of psychotropic medications in patients with rheumatoid arthritis (RA).Methods: The psychotropic medication group included patients with RA prescribed psychotropic medications [hypnotics/sedatives, antidepressants, antipsychotics, and anxiolytic (benzodiazepines) drugs]. Poisson regression with robust variance was performed to investigate the relationship between falls and the use of psychotropic medications, with adjustment for age, sex, RA disease activity, stroke, dementia, diabetes mellitus, and osteoarthritis.Results: Of the 307 patients enrolled, 49 (16.0%) used psychotropic medications and 70 (22.8%) experienced at least one fall per year. Nineteen of the 49 patients (38.8%) taking psychotropic medications and 51 of 258 (19.8%) not taking psychotropic medications experienced at least one fall per year. Falls were significantly more frequent in the group with psychotropic medications than in the group without psychotropic medications (adjusted incidence rate ratio, 1.63; 95% confidence interval, 1.08-2.48; P = .02). No relationship was found between the number of falls and the use of psychotropic medications (adjusted incidence rate ratio, 1.16; 95% confidence interval, 0.39-3.44; P = .78).Conclusions: There may be a relationship between psychotropic medication use and falls in patients with RA.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"64-71"},"PeriodicalIF":1.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors contributing to the improvement in Japanese Health Assessment Questionnaire after 3 years of treatment with abatacept in biologic-naïve rheumatoid arthritis patients: Interim results of a long-term, observational, multicentre study in Japan (ORIGAMI). 类风湿关节炎患者在接受阿帕他赛治疗 3 年后 J-HAQ 改善的因素：日本一项长期多中心观察性研究（ORIGAMI）的中期结果。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-12-25 DOI: 10.1093/mr/roae043

Kenta Misaki, Eiichi Tanaka, Eisuke Inoue, Naoto Tamura, Fuminori Hirano, Yoshinori Taniguchi, Hiroshi Sato, Taio Naniwa, Hideto Oshikawa, Tamami Yoshitama, Yuya Takakubo, Yoko Suzuki, Shinkichi Himeno, Katsuki Tsuritani, Shigeru Matsumoto, Hisashi Yamanaka, Masayoshi Harigai

{"title":"Factors contributing to the improvement in Japanese Health Assessment Questionnaire after 3 years of treatment with abatacept in biologic-naïve rheumatoid arthritis patients: Interim results of a long-term, observational, multicentre study in Japan (ORIGAMI).","authors":"Kenta Misaki, Eiichi Tanaka, Eisuke Inoue, Naoto Tamura, Fuminori Hirano, Yoshinori Taniguchi, Hiroshi Sato, Taio Naniwa, Hideto Oshikawa, Tamami Yoshitama, Yuya Takakubo, Yoko Suzuki, Shinkichi Himeno, Katsuki Tsuritani, Shigeru Matsumoto, Hisashi Yamanaka, Masayoshi Harigai","doi":"10.1093/mr/roae043","DOIUrl":"10.1093/mr/roae043","url":null,"abstract":"Objectives: We investigated the long-term effectiveness, safety, and factors affecting Japanese Health Assessment Questionnaire (J-HAQ) improvement during abatacept treatment in Japanese rheumatoid arthritis (RA) patients.Methods: The Orencia® Registry in Geographically Assembled Multicenter Investigation (ORIGAMI) study is an ongoing observational study of biologic-naïve RA patients with moderate disease activity treated with subcutaneous abatacept (125 mg, once weekly). Patients treated with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) were extracted from the Institute of Rheumatology, Rheumatoid Arthritis (IORRA) registry as a historical, weighted control group. The primary end point for this interim analysis was the proportion of patients with J-HAQ remission (score ≤0.5) at 3 years.Results: Among 279 abatacept-treated and 220 csDMARD-treated patients, J-HAQ remission was achieved at 3 years in 40.5% [95% confidence interval (CI) 34.7-46.2%] and 28.9% (95% CI 9.9-47.8%), respectively. Age, RA duration <1 year, baseline J-HAQ score, and Simplified Disease Activity Index remission at 6 months were associated with 3-year J-HAQ remission in the abatacept group. Overall, 24/298 patients (8.1%; safety analysis set) experienced serious adverse drug reactions with an incidence of 5.3 per 100 person-years.Conclusions: This study confirmed the 3-year effectiveness and safety and revealed potential factors associated with J-HAQ remission in biologic-naïve RA patients treated with abatacept in real-world clinical practice.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"17-26"},"PeriodicalIF":1.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140898732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the arthritis divide: Exploring treatment response and impact in late-onset vs. young-onset rheumatoid arthritis. 揭开关节炎鸿沟的面纱：探索晚发型与年轻发型类风湿关节炎的治疗反应和影响。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-12-25 DOI: 10.1093/mr/roae069

Nariaki Hao, Hajime Ishikawa, Asami Abe, Masanori Sudo, Sayuri Takamura, Hiroshi Otani, Satoshi Ito, Kiyoshi Nakazono, Akira Murasawa

{"title":"Unveiling the arthritis divide: Exploring treatment response and impact in late-onset vs. young-onset rheumatoid arthritis.","authors":"Nariaki Hao, Hajime Ishikawa, Asami Abe, Masanori Sudo, Sayuri Takamura, Hiroshi Otani, Satoshi Ito, Kiyoshi Nakazono, Akira Murasawa","doi":"10.1093/mr/roae069","DOIUrl":"10.1093/mr/roae069","url":null,"abstract":"Objectives: The impact of osteoarthritis (OA) on the initial treatment response of rheumatoid arthritis (RA) by treat-to-target practice was compared between the patients with an onset age of ≥65 years old [late-onset RA (LORA)] and those with an onset age of <65 years old [young-onset RA (YORA)].Methods: A retrospective study was conducted on the patients with RA, who were referred to Department of Rheumatology, Niigata Rheumatic Center without treatment between January 2021 and July 2022. Patients with grade ≥3 OA according to the Kellgren-Lawrence (K-L) classification in either the knee or hand were classified in the OA (+) group and others were in the OA (-) group. The clinical data were compared at diagnosis and 1 year after the initial treatment between the groups for 74 LORA and 59 YORA patients, respectively.Results: One year after starting treatment in the LORA patients, the OA (+) group had poorer disease activity control and greater disability in several activities of daily living than the OA (-) group. In the YORA patients, there were no differences in activities of daily living disability between the groups.Conclusions: In the initial treatment of the LORA patients, the prevalence of OA was high, and the impact of OA on LORA was larger than on YORA.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"50-56"},"PeriodicalIF":1.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucocorticoid tapering pace in microscopic polyangiitis and granulomatosis with polyangiitis in Japanese real-world practice: A propensity score-matched retrospective cohort study from the J-CANVAS registry. 在日本现实世界的实践中，显微镜下多血管炎和肉芽肿病伴多血管炎的糖皮质激素逐渐减少的速度：来自J-CANVAS注册的倾向评分匹配的回顾性队列研究。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-12-24 DOI: 10.1093/mr/roae112

Ryo Nishioka, Satoshi Omura, Daiki Nakagomi, Yoshiyuki Abe, Masatoshi Kadoya, Naoho Takizawa, Atsushi Nomura, Yuji Kukida, Naoya Kondo, Yasuhiko Yamano, Takuya Yanagida, Koji Endo, Shintaro Hirata, Kiyoshi Matsui, Tohru Takeuchi, Kunihiro Ichinose, Masaru Kato, Ryo Yanai, Yusuke Matsuo, Yasuhiro Shimojima, Ryota Okazaki, Tomoaki Takata, Takafumi Ito, Mayuko Moriyama, Ayuko Takatani, Yoshia Miyawaki, Toshiko Ito-Ihara, Takashi Kawaguchi, Nobuyuki Yajima, Takashi Kida, Yutaka Kawahito, Ichiro Mizushima

{"title":"Glucocorticoid tapering pace in microscopic polyangiitis and granulomatosis with polyangiitis in Japanese real-world practice: A propensity score-matched retrospective cohort study from the J-CANVAS registry.","authors":"Ryo Nishioka, Satoshi Omura, Daiki Nakagomi, Yoshiyuki Abe, Masatoshi Kadoya, Naoho Takizawa, Atsushi Nomura, Yuji Kukida, Naoya Kondo, Yasuhiko Yamano, Takuya Yanagida, Koji Endo, Shintaro Hirata, Kiyoshi Matsui, Tohru Takeuchi, Kunihiro Ichinose, Masaru Kato, Ryo Yanai, Yusuke Matsuo, Yasuhiro Shimojima, Ryota Okazaki, Tomoaki Takata, Takafumi Ito, Mayuko Moriyama, Ayuko Takatani, Yoshia Miyawaki, Toshiko Ito-Ihara, Takashi Kawaguchi, Nobuyuki Yajima, Takashi Kida, Yutaka Kawahito, Ichiro Mizushima","doi":"10.1093/mr/roae112","DOIUrl":"https://doi.org/10.1093/mr/roae112","url":null,"abstract":"Objective: To assess the prevalence and outcomes among regimens of glucocorticoid tapering for microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) in real-world practice.Methods: We retrospectively examined the Japan Collaborative Registry of ANCA-associated Vasculitis (J-CANVAS) registry, and evaluated the prevalence of glucocorticoid tapering regimens in the PEXIVAS trial. In patients with newly diagnosed MPA and GPA, we compared outcomes among standard and reduced pace regimens. Relapse-free survival rates were compared after propensity score matching.Results: Of 364 eligible patients, 113 (31.0%) received standard tapering and 251 slower tapering. After matching, 87 pairs no significant difference was observed in relapse-free survival (p=0.506). Regarding the reduced regimen, there were so few patients (14/364, 3.8%) that statistical analysis was not performed.Conclusions: The glucocorticoid tapering for MPA and GPA in Japanese real-world practice was found to be generally slower than the standard regimen revealing a huge evidence-practice gap. Additionally, slower tapering did not improve relapse-free survival and might cause unnecessary glucocorticoid exposure.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between osteoarthritis-related serum biochemical markers over 10-13 years and knee symptoms in middle-aged adults. 10-13年骨关节炎相关血清生化指标与中年人膝关节症状的关系

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2024-12-19 DOI: 10.1093/mr/roae113

Ambrish Singh, Alison Venn, Leigh Blizzard, Brooklyn J Fraser, Graeme Jones, John Burgess, Venkat Parameswaran, Lyn March, Flavia Cicuttini, Changhai Ding, Benny Antony

{"title":"Association between osteoarthritis-related serum biochemical markers over 10-13 years and knee symptoms in middle-aged adults.","authors":"Ambrish Singh, Alison Venn, Leigh Blizzard, Brooklyn J Fraser, Graeme Jones, John Burgess, Venkat Parameswaran, Lyn March, Flavia Cicuttini, Changhai Ding, Benny Antony","doi":"10.1093/mr/roae113","DOIUrl":"https://doi.org/10.1093/mr/roae113","url":null,"abstract":"Objectives: To describe the associations between OA-related biochemical markers and knee symptoms in middle-aged adults followed up over 10-13 years.Methods: Blood samples were collected during the Childhood Determinants of Adult Health (CDAH)-1 study (year: 2004-06) and 10-13 year follow-up at CDAH-3. Serum samples from baseline (n=156) and follow-up (n=167) were analyzed for three OA-related biomarkers [cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3, and hyaluronan (HA)] using non-isotopic enzyme-linked immunosorbent assay (ELISA). Knee symptoms were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale at follow-up. Univariable and multivariable (adjusted for age, sex, and body mass index (BMI)) zero-inflated Poisson (ZIP) regression models were used for analysis.Results: In cross-sectional multivariable models, significant positive associations between COMP [ratio of means (RoM): 1.156; 95%CI: 0.989, 1.324], MMP-3 [RoM: 1.013; 95%CI: 1.001, 1.025], and HA [RoM: 1.008; 95%CI: 1.002, 1.015] with knee pain and WOMAC-total score were observed in middle-aged adults. Baseline serum MMP-3 [RoM: 1.013; 95%CI: 1.006, 1.020], sum of serum COMP [RoM: 1.022; 95%CI: 1.011, 1.033], and an increase in the serum HA [RoM: 1.014; 95%CI:1.007, 1.020] were significantly positively associated with knee pain assessed after 10-13 years.Conclusion: The cumulative COMP levels in young adulthood (baseline) and mid-adulthood (follow-up), MMP-3 levels in young adulthood (baseline), and change in HA levels over the follow-up period were positively associated with knee pain assessed after 10-13 years. These biochemical markers measured in middle-aged adults may be explored further as a predictor of future knee symptoms.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0