Modern Rheumatology最新文献

Exploratory comparison of diffusion-weighted whole-body imaging with background body signal suppression and 18F-FDG PET/CT for assessing disease activity in large-vessel vasculitis. 带有背景信号抑制的弥散加权全身成像与18F-FDG PET/CT评估大血管炎疾病活动性的探索性比较

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-05-08 DOI: 10.1093/mr/roag037

Yuji Nozaki, Atsuhiro Yamamoto, Daisuke Tomita, Tomoko Hyodo, Hayato Kaida, Kazunari Ishii, Koji Kinoshita

{"title":"Exploratory comparison of diffusion-weighted whole-body imaging with background body signal suppression and 18F-FDG PET/CT for assessing disease activity in large-vessel vasculitis.","authors":"Yuji Nozaki, Atsuhiro Yamamoto, Daisuke Tomita, Tomoko Hyodo, Hayato Kaida, Kazunari Ishii, Koji Kinoshita","doi":"10.1093/mr/roag037","DOIUrl":"https://doi.org/10.1093/mr/roag037","url":null,"abstract":"Objectives: To compare diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) with ^18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for assessing disease activity in large-vessel vasculitis (LVV), and to evaluate whether segment-level analysis provides complementary information beyond global grading.Methods: We enrolled 25 patients with LVV (Takayasu arteritis [TAK], n = 11; giant cell arteritis [GCA], n = 14). Two blinded readers graded 11 arterial territories (18 segments) on a four-point visual scale for DWIBS and FDG-PET/CT. Global imaging grades were calculated as segment-averaged means. Correlations with serum C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were assessed.Results: Global mean DWIBS grades correlated significantly with FDG-PET/CT grades (r = 0.72) and with CRP levels (r = 0.53). Territory-level mapping revealed diffuse central aortic involvement in GCA, whereas TAK showed more focal and segment-limited patterns. DWIBS demonstrated lower sensitivity in motion-prone regions but appeared to better reflect clinical activity and more frequently detected subclavian artery involvement in TAK compared with FDG-PET/CT. Residual vascular signals were also observed in some patients classified as being in clinical remission.Conclusions: DWIBS shows good agreement with FDG-PET/CT and provides a radiation- and contrast-free approach for assessing LVV. Global mean grades alone showed limited discriminatory power and may underestimate disease activity in focal or segment-limited involvement. Integrating segment-level imaging findings with clinical and laboratory markers may improve assessment of disease activity. Multicenter validation and longitudinal studies are warranted.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Pan-Immune-Inflammation Value and Mortality in Osteoarthritis: Evidence for Elevated Risk at Higher Levels. 泛免疫炎症值与骨关节炎死亡率之间的关系：高水平风险升高的证据。

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-05-08 DOI: 10.1093/mr/roag038

Donghai Wang, Fang Li, Yantong Liu, Shixuan Wang

{"title":"Association Between Pan-Immune-Inflammation Value and Mortality in Osteoarthritis: Evidence for Elevated Risk at Higher Levels.","authors":"Donghai Wang, Fang Li, Yantong Liu, Shixuan Wang","doi":"10.1093/mr/roag038","DOIUrl":"https://doi.org/10.1093/mr/roag038","url":null,"abstract":"Objective: Systemic inflammation plays a key role in the progression of osteoarthritis (OA). The aim of this study was to explore the association of an emerging systemic inflammation marker, the pan-immune-inflammation value (PIV), with all-cause and cardiovascular disease (CVD) mortality in patients with OA.Methods: OA participants from the National Health and Nutrition Examination Survey 1999-2018 were included. PIV was calculated according to the following formula: PIV = (platelet count × neutrophil count × monocyte count)/lymphocyte count. OA was assessed through self-report, and mortality was obtained by matching to the National Death Index.Results: A total of 3903 participants with OA were included. During the follow-up period, 1032 individuals died, 359 of whom died of CVD. After adjusting for all confounders, lnPIV was positively associated with all-cause and CVD mortality in the OA population (HR 1.273 and 1.364, respectively; p=0.002 and p=0.004). Participants with PIV at Q4 had a significantly increased risk of mortality compared to Q1 (HR 1.439 and 1.506, respectively). These associations all demonstrated nonlinear relationships and were significant only after the inflection point, suggesting a threshold effect rather than a bidirectional pattern. Alcohol consumption influenced the association between PIV and CVD mortality. However, receiver operating characteristic analyses demonstrated the limited predictive value of PIV for long-term mortality.Conclusions: Higher PIV was associated with increased risk of all-cause and CVD mortality in US adults with OA. High-quality studies are needed to explore the value of PIV in clinical mortality prediction models.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Narrative Review of the Diagnostic Role of Muscle Biopsy in Small- to Medium-Vessel Vasculitis: Consideration of Imaging-Guided Procedures. 对肌肉活检在中小血管炎诊断中的作用的综述：对成像引导程序的考虑。

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-05-07 DOI: 10.1093/mr/roag036

Shin-Ichiro Ohmura

{"title":"A Narrative Review of the Diagnostic Role of Muscle Biopsy in Small- to Medium-Vessel Vasculitis: Consideration of Imaging-Guided Procedures.","authors":"Shin-Ichiro Ohmura","doi":"10.1093/mr/roag036","DOIUrl":"https://doi.org/10.1093/mr/roag036","url":null,"abstract":"Muscle biopsy (MB) remains an important diagnostic option in small- to medium-vessel vasculitis, particularly when other tissue biopsies are non-diagnostic. This narrative review aimed to clarify the diagnostic role of MB, summarize key histopathological features, and evaluate the clinical utility of imaging-guided procedures. A structured literature search of Medline/PubMed (2000-2025) identified 10 relevant studies for synthesis. Available evidence indicates that skeletal muscle is a valuable tissue for detecting vasculitic lesions, even in the absence of myalgia or creatine kinase elevation. Reported diagnostic yields vary across studies, reflecting differences in patient selection, biopsy techniques, and imaging use. Higher yields have been reported in imaging-guided procedures, particularly MRI-guided biopsy. However, evidence is largely derived from small retrospective and heterogeneous cohorts. Adequate sampling, including epimysial and perimysial tissue with appropriate staining, is essential to improve diagnostic reliability. In clinical practice, MB should be considered when suspicion of vasculitis persists despite non-diagnostic initial investigations. MRI may assist in identifying target biopsy sites and reducing sampling error. Overall, MB demonstrates diagnostic value in clinical practice, although results vary considerably and evidence remains heterogeneous.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Brain Metabolism and Cognitive Impairment in Childhood-Onset Systemic Lupus Using Fluorodeoxyglucose Positron Emission Tomography. 利用氟脱氧葡萄糖正电子发射断层扫描研究儿童期全身性狼疮的脑代谢和认知障碍。

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-04-14 DOI: 10.1093/mr/roag017

Flávia Patrícia Sena Teixeira Santos, Gilda Aparecida Ferreira, Alexei Manso Machado, Jonas Jadim de Paula, Kalline Cristina Prata De Souza, Lucas Teles Carvalho Godoy Sampaio, Marcelo Mamede, Carlos Malamut, Humberto Correa

{"title":"Exploring Brain Metabolism and Cognitive Impairment in Childhood-Onset Systemic Lupus Using Fluorodeoxyglucose Positron Emission Tomography.","authors":"Flávia Patrícia Sena Teixeira Santos, Gilda Aparecida Ferreira, Alexei Manso Machado, Jonas Jadim de Paula, Kalline Cristina Prata De Souza, Lucas Teles Carvalho Godoy Sampaio, Marcelo Mamede, Carlos Malamut, Humberto Correa","doi":"10.1093/mr/roag017","DOIUrl":"https://doi.org/10.1093/mr/roag017","url":null,"abstract":"Objectives: As biochemical and functional abnormalities often precede structural changes in disease, fluorine-18 fluorodeoxyglucose positron emission tomography may allow early detection of cerebral involvement in neuropsychiatric lupus. This study evaluated the correlation between cerebral glucose metabolism, assessed by fluorodeoxyglucose positron emission tomography, and cognitive impairment in young adults with childhood-onset systemic lupus.Methods: Twenty-one patients with childhood-onset systemic lupus underwent clinical and neuropsychological assessment, followed by fluorodeoxyglucose positron emission tomography brain imaging. Scans were compared with those of 22 healthy female controls. Images were non-rigidly registered to a standardized template, allowing voxel-wise analysis using adjusted t-tests. Associations between metabolism and cognitive performance were analysed using Pearson and Spearman correlation coefficients and Student's t-tests.Results: Hypometabolism was observed in the cerebellum, parietal, occipital, limbic, and frontal lobes, while hypermetabolism in the sub lobar region, temporal lobe, and areas of the limbic and frontal lobes. Memory deficits correlated with hypermetabolism in the left hemisphere, Brodmann area 13; attention impairments with hypermetabolism in area 20 and hypometabolism in areas 7 and 18; and executive dysfunction with hypometabolism, particularly in the left hemisphere.Conclusion: Fluorodeoxyglucose positron emission tomography may assist in identifying early functional brain abnormalities related to cognitive dysfunction in childhood-onset systemic lupus.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of anakinra for acute calcium pyrophosphate deposition disease flare: a systematic review and meta-analysis. 阿那白那治疗急性焦磷酸钙沉积病的疗效和安全性：系统综述和荟萃分析。

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-04-13 DOI: 10.1093/mr/roaf105

Pannathorn Nakaphan, Somkiat Phutinart, Patavee Pajareya, Priabprat Jansem, Sireenada Sattawatthamrong, Nattanicha Chaisrimaneepan, Pim Jetanalin, Noppachai Siranart

{"title":"Efficacy and safety of anakinra for acute calcium pyrophosphate deposition disease flare: a systematic review and meta-analysis.","authors":"Pannathorn Nakaphan, Somkiat Phutinart, Patavee Pajareya, Priabprat Jansem, Sireenada Sattawatthamrong, Nattanicha Chaisrimaneepan, Pim Jetanalin, Noppachai Siranart","doi":"10.1093/mr/roaf105","DOIUrl":"10.1093/mr/roaf105","url":null,"abstract":"Objective: Calcium pyrophosphate deposition disease (CPPD) is a common inflammatory arthritis among older adults. Comorbidities often limit conventional treatment of acute CPPD flare. Anakinra, an interleukin-1 inhibitor, is a promising alternative. We aimed to evaluate the efficacy and safety of anakinra in acute CPPD flares.Methods: We systematically searched studies from MEDLINE, EMBASE, and the Cochrane Database up until August 2024. The primary outcome was a positive treatment response between Day 3 and Day 5 after anakinra initiation. Secondary outcomes included changes in pain ratings assessed by the visual analogue scales (VAS), C-reactive protein (CRP) levels, tender joint counts (TJCs), swollen joint counts (SJCs), and steroid usage.Results: Six studies were included in our meta-analysis: five observational studies and one randomized controlled trial. A total of 84 patients were included in our analysis. Subjective physician assessments of clinical response were reported in all studies with a combined positive treatment response rate of 76% (95% CI: 61-86, I2 = 0%). Our pooled analysis also showed a significant reduction of VAS scores by 48.12 mm (95% CI: 53.21-43.03, I2 = 0%) and CRP levels by 62.09 mg/L (95% CI: 97.74-26.44, I2 = 77%) from baseline. Reductions of TJC and SJC were also demonstrated: 4.86 (95% CI: 5.48-4.23, I2 = 0%) and 3.65 (95% CI: -12.53 to 5.22, I2 = 54%), respectively. Adverse reactions included injection site reaction, rash, bacterial pneumonitis, and neutropenia.Conclusions: Anakinra is a promising alternative treatment for patients with acute CPPD flare as it showed desirable clinical responses and a favourable safety profile.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"469-475"},"PeriodicalIF":1.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145482547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends and health inequalities in the global, regional, and national prevalence of rheumatoid arthritis from 1990 to 2021: insights from the Global Burden of Disease Study 2021. 1990年至2021年全球、地区和国家类风湿性关节炎患病率的趋势和健康不平等：来自2021年全球疾病负担研究的见解

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-04-13 DOI: 10.1093/mr/roaf111

Wenhui Li, Hualan Lin, Chunxia Huang, Jingjing Guo, Yingjie Leng, Yonglong Yan

{"title":"Trends and health inequalities in the global, regional, and national prevalence of rheumatoid arthritis from 1990 to 2021: insights from the Global Burden of Disease Study 2021.","authors":"Wenhui Li, Hualan Lin, Chunxia Huang, Jingjing Guo, Yingjie Leng, Yonglong Yan","doi":"10.1093/mr/roaf111","DOIUrl":"10.1093/mr/roaf111","url":null,"abstract":"Background: Rheumatoid arthritis (RA) is a significant autoimmune disorder leading to chronic joint inflammation and considerable morbidity. It poses a major public health concern due to its increasing prevalence and the associated economic burden on healthcare systems worldwide. Understanding the global, regional, and national trends in RA prevalence is crucial for developing effective interventions.Methods: This study utilized data from the Global Burden of Disease (GBD) 2021 database to analyse RA prevalence from 1990 to 2021, employing all-age prevalence rates and age-standardized prevalence rates to assess trends. Decomposition and health inequality analyses were conducted using statistical methods, including the slope index of inequality and concentration index.Results: The global RA cases surged from ~7.96 million in 1990 to 17.92 million by 2021. The age-standardized prevalence rate reached 208.9 per 100,000 individuals, with high socio-demographic index (SDI) regions reporting an all-age prevalence rate of 440.9 per 100,000, contrasted with low SDI regions at 65.02. Decomposition analysis revealed that population growth (52.38%) and age structure shifts (30.87%) were significant contributors to the rising prevalence.Conclusion: The findings underscore the growing global burden of RA, particularly in higher SDI regions, highlighting critical health inequalities. Addressing these disparities is essential for effective interventions, emphasizing the need for targeted healthcare strategies to improve outcomes for affected populations. Future research should continue to explore the multifactorial nature of RA and the socio-economic determinants influencing its prevalence.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"387-395"},"PeriodicalIF":1.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145513589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in rheumatoid arthritis medication in pregnancy: a retrospective observational study using a Japanese claims database. 妊娠期类风湿关节炎药物的变化：一项使用日本索赔数据库的回顾性观察研究。

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-04-13 DOI: 10.1093/mr/roaf106

Yuichi Shiotsuki, Miho Iida, Shiori Tsuchiya, Minako Matsumoto, Daisuke Sugiyama

{"title":"Changes in rheumatoid arthritis medication in pregnancy: a retrospective observational study using a Japanese claims database.","authors":"Yuichi Shiotsuki, Miho Iida, Shiori Tsuchiya, Minako Matsumoto, Daisuke Sugiyama","doi":"10.1093/mr/roaf106","DOIUrl":"10.1093/mr/roaf106","url":null,"abstract":"Objectives: To examine changes in rheumatoid arthritis (RA) medication prescriptions during the peri-delivery period, and to explore recent RA prescription trends using a Japanese claims database.Methods: This retrospective observational cohort study used an insurance claims database provided by JMDC Inc. We identified pregnant women with RA who delivered between April 2018 and October 2023. The outcome was the initiation or resumption of intensive treatment after delivery, defined as new or restarting of biologic disease modifying anti-rheumatic drugs (DMARDs), targeted synthetic DMARDs, oral corticosteroids (OCS), or methotrexate.Results: We identified 229 mothers with RA and 246 deliveries. Intensive treatment was initiated in 55 (22.4%) deliveries. Continuation of the same prescription from before delivery was observed in 106 (43.1%) deliveries. The most frequent new prescription postpartum was methotrexate in 18 (7.3%) deliveries. OCS were the most commonly prescribed medications throughout the observation period. Tumour necrosis factor alpha inhibitors were prescribed at similar rates as OCS before pregnancy and in the first trimester, but declined during the second and third trimesters, and returned postpartum.Conclusions: The number of deliveries that required intensive treatment postpartum was lower than in previous studies. Our results suggest that the latest guidelines for pregnant women with RA help control disease activity.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"345-352"},"PeriodicalIF":1.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presence of myositis-specific autoantibodies may predict favourable outcomes to rituximab in patients with idiopathic inflammatory myositis: Retrospective observational study. 存在肌炎特异性自身抗体可预测特发性炎性肌炎患者利妥昔单抗的有利结果：回顾性观察研究

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-04-13 DOI: 10.1093/mr/roaf097

Emin Oğuz, Nevzat Koca, Murat Bektaş

{"title":"Presence of myositis-specific autoantibodies may predict favourable outcomes to rituximab in patients with idiopathic inflammatory myositis: Retrospective observational study.","authors":"Emin Oğuz, Nevzat Koca, Murat Bektaş","doi":"10.1093/mr/roaf097","DOIUrl":"10.1093/mr/roaf097","url":null,"abstract":"Objective: This study aimed to evaluate the autoantibody profile, including myositis-associated autoantibodies (MAAs) and myositis-specific autoantibodies (MSAs), and their influence on outcomes of rituximab (RTX) treatment in patients with IIM.Methods: This retrospective observational study included data from patients with idiopathic inflammatory myositis (IIM) who met at least one of the following criteria: Bohan and Peter, ACR/EULAR 2017, and European Neuromuscular Center (ENMC) criteria.Results: Fifty-three patients, 72% of whom were female, were included. Among them, 32.1% had a clinical diagnosis of dermatomyositis, 35.8% antisynthetase syndrome (ASS), 15.3% overlap syndrome, 11.3% polymyositis, and 5.7% had immune-mediated necrotizing myopathy. RTX was used in 49% of the patients, and nearly half of them (46%) had ASS. Remission was achieved in 77%, a partial response was observed in 11.5%, and unresponsiveness/active disease was observed in 11.5% of patients receiving RTX. Relapse was lower, and mortality tended to be lower in patients receiving RTX. In multivariate analysis, MSA positivity was associated with remission in those receiving RTX.Conclusions: In our study, RTX was safe and effective in patients with IIM who had an inadequate response or severe disease at admission. Furthermore, the presence of MSAs may predict a favourable response to RTX treatment in patients with IIM.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"407-414"},"PeriodicalIF":1.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency of labrum tears in painful hips with and without acetabular dysplasia in Japanese patients. 日本患者伴或不伴髋臼发育不良的髋关节疼痛中唇唇撕裂的频率。

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-04-13 DOI: 10.1093/mr/roaf117

Naoki Sugita, Keisuke Watarai, Mamoru Niitsu, Nobuhiko Okada, Yuki Shiko, Fumihiko Kimura, Yohei Kawasaki, Yuho Kadono

{"title":"Frequency of labrum tears in painful hips with and without acetabular dysplasia in Japanese patients.","authors":"Naoki Sugita, Keisuke Watarai, Mamoru Niitsu, Nobuhiko Okada, Yuki Shiko, Fumihiko Kimura, Yohei Kawasaki, Yuho Kadono","doi":"10.1093/mr/roaf117","DOIUrl":"10.1093/mr/roaf117","url":null,"abstract":"Objectives: This study aimed to investigate the frequency of labral tears (LT) using 3.0-Tesla magnetic resonance imaging among different age groups of Japanese patients with or without acetabular dysplasia.Methods: This was a retrospective study including 481 Japanese patients with hip pain. These patients were divided into two groups according to the degree of acetabular coverage: dysplasia (n = 256) and nondysplasia (n = 225) groups, respectively.Results: LT was observed in 341 (71%) patients with pre- or early-stage osteoarthritis and hip pain on magnetic resonance imaging. A multivariable logistic regression analysis revealed that the risk of labrum tears increased with age (odds ratio [OR] = 1.04; 95% confidence interval [CI] = 1.03-1.06; P < .001) and acetabular dysplasia (OR = 1.80; 95% CI = 1.15-2.82; P = .0096). Patients in their twenties in the dysplasia group showed a significantly higher rate of LT than those in the nondysplasia group (74% vs. 38%, P = .029).Conclusions: A high rate of LT was observed in Japanese patients with pre- or early-stage osteoarthritis and hip pain regardless of the degree of acetabular coverage. Patients in their twenties with dysplasia showed a significantly higher rate of LT than those without dysplasia.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"483-489"},"PeriodicalIF":1.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and effectiveness of canakinumab in Japanese patients with cryopyrin-associated periodic syndrome: final results from a post-marketing surveillance in Japan. canakinumab在日本冷冻素相关周期性综合征患者中的安全性和有效性：日本上市后监测的最终结果

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-04-13 DOI: 10.1093/mr/roaf104

Chihiro Kato, Takayoshi Sasajima, Ryuta Nishikomori

{"title":"Safety and effectiveness of canakinumab in Japanese patients with cryopyrin-associated periodic syndrome: final results from a post-marketing surveillance in Japan.","authors":"Chihiro Kato, Takayoshi Sasajima, Ryuta Nishikomori","doi":"10.1093/mr/roaf104","DOIUrl":"10.1093/mr/roaf104","url":null,"abstract":"Objectives: To assess the real-world safety and effectiveness of canakinumab, a monoclonal anti-interleukin-1β antibody, in patients with cryopyrin-associated periodic syndrome (CAPS) in a real-world setting in Japan.Methods: All patients with CAPS who received canakinumab treatment after drug approval in Japan were registered in a post-marketing all-patient surveillance with 2-year observation period and a follow-up period of up to 5 years.Results: Of 93 patients in the safety analysis set, the proportion of patients with any adverse drug reactions (ADRs) and any serious ADRs was 33.33% and 4.30%, respectively. The most common ADRs were infections and infestations (21.51%). Of 70 new and 18 continuing patients (roll-over from a previous clinical trial) in the effectiveness analysis set, the proportion of responders among new and continuing patients, who achieved both clinical and serological remissions, was 78.57% and 83.33%, respectively, at Week 24. Most responders remained without relapse after the remission until Week 104 (98.11% of new and 100% of continuing patients). Clinical symptoms related to auditory, joint, visual, renal, and central nervous system maintained or improved in the majority of patients.Conclusions: Canakinumab was well-tolerated and effective during long-term treatment for patients with CAPS in the real-world setting.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"447-455"},"PeriodicalIF":1.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145564770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0