Modern Rheumatology最新文献_第2页

Nationwide epidemiological survey of juvenile idiopathic arthritis during transition to young adulthood in Japan using the National Database of Designated Incurable Diseases of Japan. 利用日本国家指定不治之症数据库，对日本幼年特发性关节炎向青年期过渡的全国流行病学调查。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae076

Yuzaburo Inoue, Ryoko Sakai, Eisuke Inoue, Kanako Mitsunaga, Masaki Shimizu, Takahiko Sugihara, Masakazu Matsushita, Ken Yamaji, Masaaki Mori, Naoki Shimojo, Takako Miyamae

{"title":"Nationwide epidemiological survey of juvenile idiopathic arthritis during transition to young adulthood in Japan using the National Database of Designated Incurable Diseases of Japan.","authors":"Yuzaburo Inoue, Ryoko Sakai, Eisuke Inoue, Kanako Mitsunaga, Masaki Shimizu, Takahiko Sugihara, Masakazu Matsushita, Ken Yamaji, Masaaki Mori, Naoki Shimojo, Takako Miyamae","doi":"10.1093/mr/roae076","DOIUrl":"10.1093/mr/roae076","url":null,"abstract":"Objectives: We aimed to assess the unmet medical needs of young adult patients with juvenile idiopathic arthritis (JIA) by evaluating real-world treatment data.Methods: We analysed data on JIA in the age group of 20-29 years from the National Database of Designated Incurable Diseases of Japan, which records severe cases or those requiring high-cost medical care registered between April 2018 and March 2020.Results: Overall, 322 patients with JIA transitioning to adulthood were included. A high frequency of methotrexate use was observed among all JIA subtypes. The frequency of methotrexate use at registration was significantly higher in patients with rheumatoid factor-positive polyarthritis and those with oligoarthritis or polyarthritis than in those with systemic arthritis. The historical use percentage of any biological disease-modifying antirheumatic drug was ≥85% for all JIA subtypes. The proportion of patients with ≥2 biological disease-modifying antirheumatic drug prescriptions was significantly higher in patients with rheumatoid factor-positive polyarthritis than in those with systemic arthritis.Conclusions: High-cost drugs were necessary for many patients with JIA transitioning to young adulthood and registered in the database. Further studies on the medical interventions and support for these patients are needed.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"359-365"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New perspective on the clinical and laboratory characteristics of rheumatoid pleural effusion: A 29-case series. 类风湿胸腔积液临床和实验室特征的新视角：29例系列病例。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae082

Saki Sada Minoda, Ryuichi Minoda Sada, Hiroyuki Akebo, Yukio Tsugihashi, Kazuhiro Hatta

{"title":"New perspective on the clinical and laboratory characteristics of rheumatoid pleural effusion: A 29-case series.","authors":"Saki Sada Minoda, Ryuichi Minoda Sada, Hiroyuki Akebo, Yukio Tsugihashi, Kazuhiro Hatta","doi":"10.1093/mr/roae082","DOIUrl":"10.1093/mr/roae082","url":null,"abstract":"Objective: Rheumatoid pleural effusion (RPE) usually occurs in middle-aged men. Pleural fluid analyses have revealed high lactate dehydrogenase (LDH) levels and low pH and glucose levels in RPE. We aimed to investigate the clinical and laboratory features of patients with RPE since the beginning of the 21st century.Methods: Medical records of patients with RPE were reviewed between May 2006 and October 2021. The patients were divided into <60 year (younger) and ≥60 year (older) groups.Results: The younger group comprised 6 patients (median age 53.5 years, female 33%) and older group comprised 23 patients (median age 76 years, female 52.2%). Compared to the younger group, the older group had fewer cases of fever (83.3 versus 18.2%, P = .007) and chest pain (66.7 versus 8.7%, P = .008). In pleural fluid analysis, the older group presented higher pH (P = .004) and lower LDH levels (P = .044). Seven patients died during the follow-up period.Conclusion: Most patients with RPE were over 60 years of age, and approximately half of them were female. The pleural fluid analysis showed milder inflammation in older patients than in middle-aged patients. The mortality rate of patients with RPE was distinctly higher than that previously reported.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"249-255"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rheumatoid arthritis increases complication risks in elderly hip fracture patients: A Japanese nationwide medical claims database study. 类风湿性关节炎增加老年髋部骨折患者的并发症风险..：日本全国医疗索赔数据库研究。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae088

Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Ryuichi Kanabuchi, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

{"title":"Rheumatoid arthritis increases complication risks in elderly hip fracture patients: A Japanese nationwide medical claims database study.","authors":"Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Ryuichi Kanabuchi, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori","doi":"10.1093/mr/roae088","DOIUrl":"10.1093/mr/roae088","url":null,"abstract":"Objectives: This study aimed to evaluate the outcomes and complications associated with hip fractures in patients with rheumatoid arthritis (RA) relative to those without RA.Methods: Using the Japanese National Administrative Diagnosis Procedure Combination database, we examined cases of hip fractures from April 2016 to March 2023. After one to three propensity score matching for age, sex, and complications, we examined the association between RA, complications, and mortality during hospitalization in elderly patients with hip fractures.Results: The findings revealed that elderly Japanese RA patients with hip fractures had significantly higher complications of pneumonia than elderly hip fracture patients without RA, with a ratio of 1.232 [95% confidence interval (CI): 1.065-1.426, P = .0056], and pulmonary embolism, with a ratio of 1.155 (95% CI: 1.036-1.287, P = .009) in multivariate logistic regression analyses. Although not significantly elevated, it also found a trend towards higher mortality during hospitalization, with a ratio of 1.179 (95% CI: 0.973-1.429, P = .096).Conclusions: This study revealed a significant association between RA and increased complications, including pneumonia and pulmonary embolism in hip fractures in the elderly. Implementing preventive strategies is essential to minimizing complications in the treatment of hip fractures in patients with RA.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"287-293"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A biopsychosocial questionnaire for patients with primary Sjögren's syndrome: The BETY-Biopsychosocial Questionnaire. 针对初级斯约格伦综合征患者的生物心理社会调查问卷：BETY-生物心理社会问卷。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae085

Gamze Nur Ahıskalı, Orkun Tüfekçi, Nur Banu Karaca, Mustafa Ekici, Nazlı Elif Nacar, Sinan Buran, Mine Kantar, Şule Apraş Bilgen, Sedat Kiraz, Edibe Ünal

{"title":"A biopsychosocial questionnaire for patients with primary Sjögren's syndrome: The BETY-Biopsychosocial Questionnaire.","authors":"Gamze Nur Ahıskalı, Orkun Tüfekçi, Nur Banu Karaca, Mustafa Ekici, Nazlı Elif Nacar, Sinan Buran, Mine Kantar, Şule Apraş Bilgen, Sedat Kiraz, Edibe Ünal","doi":"10.1093/mr/roae085","DOIUrl":"10.1093/mr/roae085","url":null,"abstract":"Objective: The BETY-Biopsychosocial Questionnaire (BETY-BQ) is a scale developed to assess the biopsychosocial domains of patients with rheumatic diseases under a single roof. The study aimed to determine the validity and reliability of the BETY-BQ in patients with primary Sjögren's syndrome (pSS).Methods: At enrollment and 1 week, 91 patients with pSS completed the BETY-BQ. Construct validity was measured by correlating the BETY-BQ total score responses with the Health Assessment Questionnaire, Hospital Anxiety and Depression Scale, 36-Item Short-Form Health Survey, EULAR Sjögren's Syndrome Patient-Reported Index, EULAR Sjögren's Syndrome Disease Activity Index, Primary Sjögren's Syndrome Quality of Life questionnaire, and Euro-QoL 5D.Results: The BETY-BQ correlated high to moderate with Health Assessment Questionnaire, bodily pain subscale of 36-Item Short-Form Health Survey, Euro-Qol 5D, Primary Sjögren's Syndrome Quality of Life questionnaire, Hospital Anxiety and Depression Scale, and EULAR Sjögren's Syndrome Patient-Reported Index (0.776 to 0.557, P < .05). Spearman's correlation coefficients between BETY-BQ total scores at baseline and average 1 week were very high (rho = 0.98, P < .001) and indicated substantial agreement between test-retest scores (intraclass correlation coefficient = 0.99, P < .001). Internal consistency reliability at baseline was 0.91 for the BETY-BQ.Conclusions: BETY-BQ is valid and reliable for assessing biopsychosocial status in patients with pSS and can be used to measure outcomes in pSS.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"326-331"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of lacrimal gland vascularization using superb microvascular imaging: A potential diagnostic tool in Sjögren's syndrome. 利用超级微血管成像评估泪腺血管：斯约格伦综合征的潜在诊断工具。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae081

Ciğdem Samur Salbas, Sadettin Uslu, Ender Salbas

{"title":"Evaluation of lacrimal gland vascularization using superb microvascular imaging: A potential diagnostic tool in Sjögren's syndrome.","authors":"Ciğdem Samur Salbas, Sadettin Uslu, Ender Salbas","doi":"10.1093/mr/roae081","DOIUrl":"10.1093/mr/roae081","url":null,"abstract":"Objectives: The aim of this study is to evaluate the superb microvascular imaging (SMI) findings of the lacrimal glands for the sonographic diagnosis of primary Sjögren's syndrome (pSS).Methods: Twenty-one patients with pSS and 20 healthy groups were evaluated. Dry eye symptoms and their effects on vision-related functions were evaluated with McMonnies and Ocular Surface Disease Index (OSDI) questionnaires. Lacrimal glands were evaluated by power Doppler ultrasonography (PDUS), colour Doppler ultrasonography (CDUS), and SMI.Results: Dry eye symptoms, as determined by McMonnies and OSDI, were significantly more severe in patients with pSS than in the control group (P = .001 and P = .021, respectively). Lacrimal gland vascular activity rates and hypoechoic areas were significantly higher in pSS patients compared to the control group (P < .05). The detection rates of the degree of vascularity in the lacrimal glands of patients with pSS were higher with SMI compared to CDUS and PDUS. In addition, SMI positively correlated with CDUS, PDUS, OSDI, and McMonnies.Conclusions: Evaluation of the lacrimal gland by the SMI was found to be excellent in predicting the likelihood of individuals having pSS compared to CDUS and PDUS. This technique may serve as a reliable and noninvasive adjunctive tool for assessing the degree of lacrimal vascularity in pSS.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"320-325"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RNA N6-methyladenosine modification in arthritis: New insights into pathogenesis. 关节炎中的 RNA N6-甲基腺苷修饰：对发病机制的新认识

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae080

Haowei Chen, Anran Xuan, Xiaorui Shi, Tianxiang Fan, Song Xue, Jianzhao Ruan, Xiaoshuai Wang, Su'an Tang, Weizhong Qi, Haitao Sun, Canzhao Liu, Shuai He, Changhai Ding, Zhaohua Zhu

引用次数: 0

Clinical features and risk factors for Baker's cyst in patients with rheumatoid arthritis. 类风湿关节炎患者贝克氏囊肿的临床特征和风险因素

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae063

Wan Lan Jiang, Ting Xu, Bi Qing Zhang, Lu Zhang, Min Wu, Wen Xie

{"title":"Clinical features and risk factors for Baker's cyst in patients with rheumatoid arthritis.","authors":"Wan Lan Jiang, Ting Xu, Bi Qing Zhang, Lu Zhang, Min Wu, Wen Xie","doi":"10.1093/mr/roae063","DOIUrl":"10.1093/mr/roae063","url":null,"abstract":"Objectives: Baker's cyst (BC) is a complex complication of rheumatoid arthritis (RA), with a poor prognosis. This paper aimed to analyse the clinical features and risk factors for BC in patients with RA to assist clinicians in early warning and appropriate action.Methods: The clinical features of the hospitalized RA patients with knee affected were analysed retrospectively. The R software was used for the statistical analysis, while logistic regression analyses were used to determine independent risk factors.Results: A total of 367 RA patients with knee affected were studied, and BC was diagnosed in 15.3% of them. The BC group exhibited a higher proportion of knee-only affected than the non-BC group (P < .05), while the attributes linked to disease activity exhibited no disparity. Logistic regression analyses selected two independent risk factors for BC: knee-only affected and anaemia. A total of 26.8% of patients with BC developed rupture, exhibiting a higher proportion of knee-only affected (P < .05), compared to those unruptured.Conclusions: The occurrence and rupture of BC in RA patients were significantly related to local inflammation, but not to systemic one. Incorporating local treatment may be a more advantageous option compared to solely relying on systemic therapy.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"273-279"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of social frailty in patients with rheumatoid arthritis: Data from a multicentre observational study (T-FLAG study). 类风湿性关节炎患者社会脆弱性的普遍性：一项多中心观察研究（T-FLAG 研究）的数据。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae078

Mochihito Suzuki, Shuji Asai, Yoshifumi Ohashi, Yasumori Sobue, Hisato Ishikawa, Kenya Terabe, Ryo Sato, Hironobu Kosugiyama, Junya Hasegawa, Yusuke Ohno, Takaya Sugiura, Shiro Imagama

{"title":"Prevalence of social frailty in patients with rheumatoid arthritis: Data from a multicentre observational study (T-FLAG study).","authors":"Mochihito Suzuki, Shuji Asai, Yoshifumi Ohashi, Yasumori Sobue, Hisato Ishikawa, Kenya Terabe, Ryo Sato, Hironobu Kosugiyama, Junya Hasegawa, Yusuke Ohno, Takaya Sugiura, Shiro Imagama","doi":"10.1093/mr/roae078","DOIUrl":"10.1093/mr/roae078","url":null,"abstract":"Objectives: The aim of this study was to investigate the prevalence of social frailty and associated factors.Methods: A total of 655 consecutive patients who were able to complete the Kihon Checklist (KCL) and the Questionnaire on Social Frailty between June and August 2022 were enrolled. Social frailty was assessed using the Makizako Social Frailty Index. Patient characteristics were analysed by analysis of variance. Factors associated with social frailty were analysed using multivariate logistic analysis. Spearman's rank correlation coefficients were used to examine correlations between each KCL domain and social frailty.Results: The mean age was 68 years, and the disease duration was 12 years; 73% of patients were female. Social frailty was present in 30.8% of patients, with 36.5% classified as social prefrailty. Multivariate analysis revealed age and Health Assessment Questionnaire-Disability Index to be independent factors associated with social frailty. The proportion of social frailty increased with increasing age and worsening Health Assessment Questionnaire-Disability Index scores. The KCL domain 'Isolation' was the most strongly associated with social frailty (r = .601, P < .001), with higher scores associated with a higher proportion of social frailty.Conclusions: Social frailty in patients with rheumatoid arthritis is associated with age and physical impairment (Health Assessment Questionnaire-Disability Index). Moreover, the KCL domain 'Isolation' was strongly associated with social frailty.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"234-239"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of baricitinib in Japanese patients with rheumatoid arthritis in clinical use: 3-year data of all-case postmarketing surveillance study. 巴利昔尼对日本类风湿关节炎患者临床应用的安全性：上市后所有病例监测研究的3年数据。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae064

Nami Okamoto, Tatsuya Atsumi, Michiaki Takagi, Nobunori Takahashi, Tsutomu Takeuchi, Naoto Tamura, Atsuo Nakajima, Ayako Nakajima, Takao Fujii, Hiroaki Matsuno, Taeko Ishii, Naoto Tsujimoto, Atsushi Nishikawa, Machiko Minatoya, Yoshiya Tanaka, Masataka Kuwana

{"title":"Safety of baricitinib in Japanese patients with rheumatoid arthritis in clinical use: 3-year data of all-case postmarketing surveillance study.","authors":"Nami Okamoto, Tatsuya Atsumi, Michiaki Takagi, Nobunori Takahashi, Tsutomu Takeuchi, Naoto Tamura, Atsuo Nakajima, Ayako Nakajima, Takao Fujii, Hiroaki Matsuno, Taeko Ishii, Naoto Tsujimoto, Atsushi Nishikawa, Machiko Minatoya, Yoshiya Tanaka, Masataka Kuwana","doi":"10.1093/mr/roae064","DOIUrl":"10.1093/mr/roae064","url":null,"abstract":"Objectives: To assess safety of baricitinib in Japanese patients with rheumatoid arthritis (RA) in real-world clinical practice.Methods: This all-case postmarketing surveillance study included patients initiating baricitinib for RA from September 2017 to April 2019. Treatment duration was recorded. Safety data were collected for up to 3 years from initiation (up to 4 weeks postdiscontinuation in discontinuing patients).Results: Safety analyses included 4720 patients; 2580 (54.7%) were ≥65 years old. Baricitinib persistence rate was 45.4% (3-year Kaplan-Meier analysis); the most common discontinuation reason was insufficient effectiveness (n = 1005, 21.3%). Serious adverse events occurred in 600 patients [incidence rate (IR) 10.42/100 patient-years (PY); 95% confidence interval, 9.76-11.09]. There were 39 deaths [IR 0.43 (0.30-0.57)/100 PY]. Adverse events of special interest IRs per 100 PY were herpes zoster 4.68 (4.22-5.14), serious infection 3.05 (2.68-3.41), malignancy 1.09 (0.87-1.30), major adverse cardiovascular events 0.35 (0.23-0.48), and venous thromboembolism 0.25 (0.15-0.36). IRs did not increase with prolonged exposure.Conclusions: No new safety concerns were identified during this 3-year postmarketing surveillance study of baricitinib in Japanese patients with RA. Patients and clinicians should be cognizant of herpes zoster and other serious infection risks during baricitinib treatment, especially in the first 6 months.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"215-224"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the efficacy of haemoperfusion for dermatomyositis-associated acute exacerbation of interstitial lung disease: A multicentre retrospective study. 评估血液灌流治疗皮肌炎相关间质性肺炎急性加重的疗效：一项多中心回顾性研究。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-02-21 DOI: 10.1093/mr/roae066

Shuqin Sun, Yanfei Yu, Wenjing Feng, Luyan Sun, Shuo Yang

{"title":"Assessing the efficacy of haemoperfusion for dermatomyositis-associated acute exacerbation of interstitial lung disease: A multicentre retrospective study.","authors":"Shuqin Sun, Yanfei Yu, Wenjing Feng, Luyan Sun, Shuo Yang","doi":"10.1093/mr/roae066","DOIUrl":"10.1093/mr/roae066","url":null,"abstract":"Objectives: Haemoperfusion (HP) is used to treat various diseases, including sepsis and acute respiratory distress syndrome. However, few studies have explored the efficiency of HP in dermatomyositis-associated acute exacerbation of interstitial lung disease.Methods: We conducted a retrospective study. Two hundred and sixteen patients with dermatomyositis-associated acute exacerbation of interstitial lung disease were included. Patients were divided into the HP group (treatment group) and the control group. Changes in oxygenation, haemodynamic parameters, lung ultrasound scores, and inflammatory cytokine levels were evaluated before and after HP in the treatment group. The length of intensive care unit (ICU) stays, duration of ventilator therapy, mortality rate, and incidence of complications were compared between the treatment and control groups.Results: Haemodynamic and oxygenation variables in the treatment group significantly improved after treatment. However, the levels of the inflammatory factors significantly decreased after treatment. The length of ICU stay and the duration of ventilator therapy were significantly shorter in the treatment group than in the control group. The mortality rate of the treatment group was significantly lower than that of the control group.Conclusions: This study demonstrated that HP could improve treatment efficacy in patients with dermatomyositis-associated acute exacerbation of interstitial lung disease.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"314-319"},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0