Modern Rheumatology最新文献_第2页

Does the alcohol flushing response modify the relationship between alcohol consumption and the risk of developing osteonecrosis of the femoral head? A multicenter case-control study in Japan. 酒精潮红反应是否改变了饮酒与股骨头坏死风险之间的关系？日本一项多中心病例对照研究。

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-04-13 DOI: 10.1093/mr/roaf107

Tetsuro Tani, Wataru Ando, Wakaba Fukushima, Hidetoshi Hamada, Masaki Takao, Takuaki Yamamoto, Takashi Sakai, Nobuhiko Sugano

{"title":"Does the alcohol flushing response modify the relationship between alcohol consumption and the risk of developing osteonecrosis of the femoral head? A multicenter case-control study in Japan.","authors":"Tetsuro Tani, Wataru Ando, Wakaba Fukushima, Hidetoshi Hamada, Masaki Takao, Takuaki Yamamoto, Takashi Sakai, Nobuhiko Sugano","doi":"10.1093/mr/roaf107","DOIUrl":"10.1093/mr/roaf107","url":null,"abstract":"Objectives: Alcohol consumption is a recognized risk factor for osteonecrosis of the femoral head (ONFH), as well as hypertension, and malignant tumors. Aldehyde dehydrogenase 2 (ALDH2) activity influences alcohol-associated risks by modulating acetaldehyde metabolism; however, its role in ONFH remains unclear. This study aimed to investigate whether the alcohol flushing response, a proxy for ALDH2, modifies the relationship between alcohol consumption and ONFH.Methods: A hospital-based case-control study was conducted on newly diagnosed patients with ONFH and controls recruited. Information on alcohol flushing responses was collected using a self-administered questionnaire and categorized into current/former flushers (inactive ALDH2) and never flushers (active ALDH2). Odds ratios (OR) and their 95% confidence intervals (CI) of various levels of alcohol consumption (habitual drinking, heavy drinking, and drinking of ≥320 g/week) were assessed for ONFH using a logistic regression model. Stratified analysis and multiplicative interaction were used to investigate the effect modification by the alcohol flushing response on the association between alcohol consumption and ONFH.Results: A total of 118 cases with ONFH and 213 controls were included (mean age, 45 years; 197 men and 134 women). The adjusted ORs of alcohol consumption for the development of ONFH were 1.5 (95% CI: 0.4-6.0) and 3.7 (0.3-41.3) for habitual drinking, 1.6 (0.4-5.6) and 2.0 (0.1-24.2) for heavy drinking, and 3.8 (0.8-17.6) and 4.5 (0.4-49.2) for drinking of ≥320 g/week among current/former and never flushers, respectively. No significant multiplicative interactions were observed.Conclusions: Alcohol flushing response may not modify the relationship between alcohol consumption and the risk of ONFH.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"476-482"},"PeriodicalIF":1.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The significance of participation in peer support groups for people with rheumatoid arthritis: a qualitative study. 类风湿关节炎患者参加同伴支持小组的意义：一项定性研究。

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-04-13 DOI: 10.1093/mr/roaf101

Izumi Kobayashi, Hideko Nakahara, Mie Fusama

{"title":"The significance of participation in peer support groups for people with rheumatoid arthritis: a qualitative study.","authors":"Izumi Kobayashi, Hideko Nakahara, Mie Fusama","doi":"10.1093/mr/roaf101","DOIUrl":"10.1093/mr/roaf101","url":null,"abstract":"Objectives: This study examines how rheumatoid arthritis (RA) peer support groups affect patients' lives and identifies the roles of these groups.Methods: Twelve RA patients from a peer support group participated in a focus group interview discussing reasons for joining, emotional changes, and disease management. Data were analysed using qualitative methods.Results: The analysis identified 65 codes, organized into 22 subcategories and synthesized into five pre- and five post-membership experience categories. The five pre-membership categories were: prolonged time for diagnosis, persistent anxiety even after starting treatment, expectation of interacting with peers with the same disease, encounter with the peer support group, and decision to join due to worsening condition. The five post-membership categories were meeting peers with whom they could empathize, need to understand their own illnesses, diverse information from other members' experiences, active participation in treatment and a place to belong and share with understanding peers. The group was considered to be a supportive community where patients can obtain necessary information, peer support, and increased treatment motivation.Conclusions: This study indicates that peer support group could be valuable social resources, helping patients manage illness and improve quality of life.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"381-386"},"PeriodicalIF":1.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of musculoskeletal ultrasound in diagnosing and managing chronic inflammatory arthritis in overweight and obese patients: a narrative review. 肌肉骨骼超声在超重和肥胖患者慢性炎症性关节炎的诊断和治疗中的作用：一个叙述性的回顾。

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-04-13 DOI: 10.1093/mr/roaf116

Giovanni Ciancio, Beatrice Maranini, Gilda Sandri, Gabriele Amati, Alessandra Bortoluzzi, Ettore Silvagni, Marcello Govoni, Dilia Giuggioli

{"title":"Role of musculoskeletal ultrasound in diagnosing and managing chronic inflammatory arthritis in overweight and obese patients: a narrative review.","authors":"Giovanni Ciancio, Beatrice Maranini, Gilda Sandri, Gabriele Amati, Alessandra Bortoluzzi, Ettore Silvagni, Marcello Govoni, Dilia Giuggioli","doi":"10.1093/mr/roaf116","DOIUrl":"10.1093/mr/roaf116","url":null,"abstract":"Obesity and metabolic syndrome play a significant role in the complexity of chronic inflammatory arthritis. By promoting systemic inflammation and altering immune responses, these conditions can amplify joint-related symptoms, such as pain, synovitis, and enthesitis. This inflammatory and mechanical burden complicates clinical evaluation, as traditional disease activity scores may be skewed by excess weight, leading to inaccurate assessments. Imaging techniques like musculoskeletal ultrasound (MSUS) offer a promising tool to detect subclinical inflammation and improve diagnostic accuracy. This review examines the role of MSUS in the management of obese patients with inflammatory arthritis. We explore how MSUS can be leveraged to detect subclinical inflammation, improve diagnostic accuracy, and guide more effective management strategies. We also discuss the limitations of MSUS in this patient population, including the impact of excessive adipose tissue on image quality and the need for standardized protocols.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"326-334"},"PeriodicalIF":1.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145668931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness and safety of tocilizumab, an anti-interleukin-6 receptor antibody, in 342 Japanese patients with multicentric Castleman disease: a 3-year, prospective, observational study. 抗白细胞介素-6受体抗体tocilizumab在342名日本多中心Castleman病患者中的有效性和安全性：一项为期3年的前瞻性观察性研究

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-04-13 DOI: 10.1093/mr/roaf100

Norihiro Nishimoto, Miho Murakami, Takeshi Johkoh, Seiji Hayashi, Shiro Ohshima, Masao Mizuki, Takahiro Kakehi, Yuichi Kawata, Shinichi Matsuda, Misato Hashizume, Shin-Ichi Nakatsuka

{"title":"Effectiveness and safety of tocilizumab, an anti-interleukin-6 receptor antibody, in 342 Japanese patients with multicentric Castleman disease: a 3-year, prospective, observational study.","authors":"Norihiro Nishimoto, Miho Murakami, Takeshi Johkoh, Seiji Hayashi, Shiro Ohshima, Masao Mizuki, Takahiro Kakehi, Yuichi Kawata, Shinichi Matsuda, Misato Hashizume, Shin-Ichi Nakatsuka","doi":"10.1093/mr/roaf100","DOIUrl":"10.1093/mr/roaf100","url":null,"abstract":"Objectives: Multicentric Castleman disease (MCD) is a rare lymphoproliferative disorder characterized by multifocal lymphadenopathy and systemic inflammatory symptoms. This single-arm, prospective, observational, postmarketing surveillance (UMIN000023071) assessed the real-world effectiveness and safety of tocilizumab in Japanese patients with MCD.Methods: Patients with MCD received tocilizumab intravenous infusion 8 mg/kg every 2 weeks for up to 3 years. Effectiveness outcomes included enlarged lymph node regression; improvement in laboratory findings, associated symptoms, and organ involvement; and change in corticosteroid doses. Safety was assessed through adverse events (AEs).Results: A total of 342 patients were included. Tocilizumab was continued for >152 weeks in 70.1% of patients. After treatment, 58.9% of patients showed lymph node regression. Laboratory test values were improved, and most evaluable patients reported improvements in associated symptoms, including night sweats, anorexia, fever, and fatigue. Organ involvement, including pulmonary disease, rash, and hepatosplenomegaly, was 'improved' or 'stable' in more than half of evaluable patients. Tocilizumab treatment resulted in corticosteroid dose reduction. The most commonly reported AEs were infections and infestations; respiratory, thoracic, and mediastinal disorders; and gastrointestinal disorders.Conclusions: The effectiveness and safety of tocilizumab in Japanese patients with MCD was confirmed for up to 3 years, without new safety concerns.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"456-468"},"PeriodicalIF":1.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145337281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of lower limb exercise therapy on the patients with rheumatoid arthritis: an analysis based on severity of joint damage. 基于关节损伤程度的下肢运动治疗对类风湿关节炎患者的疗效分析。

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-04-13 DOI: 10.1093/mr/roaf102

Rie Kurose, Yuji Wakai

{"title":"Effect of lower limb exercise therapy on the patients with rheumatoid arthritis: an analysis based on severity of joint damage.","authors":"Rie Kurose, Yuji Wakai","doi":"10.1093/mr/roaf102","DOIUrl":"10.1093/mr/roaf102","url":null,"abstract":"Objective: Exercise therapy is widely recommended for patients with rheumatoid arthritis (RA), but the ideal parameters and appropriate patient selection remain controversial. This study aimed to assess the effectiveness and safety of lower limb exercise therapy in RA-affected knees, stratified by radiographic severity of joint destruction.Methods: We retrospectively analysed RA patients who participated in a 3-month lower limb exercise therapy. Participants were divided into two groups according to the Larsen grading classification (LG): mild destruction (LG II-III) and advanced destruction (LG IV-V). Functional outcomes and disease activity parameters were compared between two groups of LG II-III and IV-V.Results: Patients in the LG II-III group showed improvements in lower limb functions, including enhanced strength of the gluteus muscles, with no worsening of RA disease activity. Conversely, some patients in the LG IV-V group experienced declines in the 10-m walk time, timed up and go test, patient visual analogue scale, and stair climbing ability. Some patients in the LG IV-V group had intensified anti-rheumatic drug therapy.Conclusions: Lower limb exercise therapy appears safe and effective for RA knees with mild destruction but may risk functional decline in patients with advanced damage. Radiographic evaluation is essential for tailoring therapy to individual joint status.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"375-380"},"PeriodicalIF":1.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and retention rate of rituximab in Japanese rheumatoid arthritis patients with a history of other iatrogenic immunodeficiency-associated lymphoproliferative disorders. 利妥昔单抗在有其他医源性免疫缺陷相关淋巴细胞增生性疾病史的日本类风湿性关节炎患者中的疗效和保留率

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-04-13 DOI: 10.1093/mr/roaf114

Yoshiki Nagai, Issei Takahashi, Naoto Yokogawa, Kota Shimada

{"title":"Efficacy and retention rate of rituximab in Japanese rheumatoid arthritis patients with a history of other iatrogenic immunodeficiency-associated lymphoproliferative disorders.","authors":"Yoshiki Nagai, Issei Takahashi, Naoto Yokogawa, Kota Shimada","doi":"10.1093/mr/roaf114","DOIUrl":"10.1093/mr/roaf114","url":null,"abstract":"Objectives: The present study aimed to evaluate the efficacy, safety, and retention rate of rituximab (RTX) in Japanese rheumatoid arthritis (RA) patients with a history of other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OIIA-LPD).Methods: Between January 1, 2014, and July 31, 2024, 3 392 RA patients were registered in our institutional database, and 74 of these had OIIA-LPD. Amongst patients who achieved remission after the onset of OIIA-LPD, those who subsequently received RTX were retrospectively identified. Clinical data, including the Disease Activity Score for 28 joints-C reactive protein (DAS28-CRP) value, Clinical Disease Activity Index (CDAI) score, adverse events, and RTX retention rate, were analyzed.Results: Fourteen patients received RTX for RA after OIIA-LPD remission. The mean DAS28-CRP value at baseline and at month 6, 12, 24, and 36 was 3.91 ± 1.40, 3.03 ± 3.20, 2.45 ± 1.09, 2.22 ± 0.62, and 1.93 ± 0.78, respectively. The respective CDAI score was 15.2 ± 7.74, 4.91 ± 3.80, 6.19 ± 4.46, 5.08 ± 3.03, and 4.18 ± 3.28. Four infections were observed. The RTX retention rate at month 12, 24, and 36 was 85.1%, 76.6%, and 76.6%, respectively.Conclusions: Even in real-world clinical practice, RTX demonstrated long-term efficacy in reducing disease activity in Japanese RA patients with a history of OIIA-LPD. RTX appears to be a viable treatment option for this patient population.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"353-358"},"PeriodicalIF":1.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145573916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retention of baricitinib-treated patients with rheumatoid arthritis in Japan: Interim results from a prospective observational cohort study. baricitinib治疗的类风湿性关节炎患者在日本的保留率：一项前瞻性观察队列研究的中期结果

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-04-13 DOI: 10.1093/mr/roaf113

Yuko Kaneko, Chaochen Wang, Naoto Tsujimoto, Masaru Tanaka, Kei Ikeda

{"title":"Retention of baricitinib-treated patients with rheumatoid arthritis in Japan: Interim results from a prospective observational cohort study.","authors":"Yuko Kaneko, Chaochen Wang, Naoto Tsujimoto, Masaru Tanaka, Kei Ikeda","doi":"10.1093/mr/roaf113","DOIUrl":"10.1093/mr/roaf113","url":null,"abstract":"Objectives: To assess the retention rate, changes in disease activity and patient-reported outcomes (PROs), and predictors of treatment discontinuation among baricitinib-treated patients with rheumatoid arthritis (RA) in routine clinical practice in Japan.Methods: This ongoing, multi-centre, prospective, observational study (starting February 2021) included ≥20-year-old baricitinib-treated patients with RA. Baricitinib's retention rate and effectiveness were evaluated until 12 months. The association between patient characteristics and retention was evaluated using Random Forest analysis.Results: This interim analysis included 353 patients (mean [standard deviation; SD] age 63.4 [13.6] years; 70.0% female). The 12-month retention rate was 70.2% (95% confidence interval [CI] 65.1, 74.6). The 12-month remission rates were 35.3%, 41.1%, and 79.6% per Clinical Disease Activity Index, Simplified Disease Activity Index, and Disease Activity Score with 28 joints-C-reactive protein. The mean (SD) changes in PROs from baseline scores were: physician global assessment of disease activity (-33.8 [27.8]), patient global assessment of disease activity (-18.3 [29.4]), Health Assessment Questionnaire-Disability Index (-0.33 [0.53]), and pain (-19.4 [27.0]). Ten variables influenced the model's prediction of treatment discontinuation.Conclusions: Evidence from this interim analysis suggested the favourable effectiveness and drug survival of baricitinib in real-world Japanese patients with RA.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"335-344"},"PeriodicalIF":1.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145573850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological and clinical insights into Behçet's disease in Japan: a 2019 nationwide analysis. 日本behaperet病的流行病学和临床见解：2019年全国分析

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-04-13 DOI: 10.1093/mr/roaf103

Yuki Mizuki, Nobuyuki Horita, Mitsuhiro Takeno, Akira Meguro, Yohei Kirino, Tatsukata Kawagoe, Takuto Sakono, Mami Ishihara, Shigeaki Ohno, Nobuhisa Mizuki

{"title":"Epidemiological and clinical insights into Behçet's disease in Japan: a 2019 nationwide analysis.","authors":"Yuki Mizuki, Nobuyuki Horita, Mitsuhiro Takeno, Akira Meguro, Yohei Kirino, Tatsukata Kawagoe, Takuto Sakono, Mami Ishihara, Shigeaki Ohno, Nobuhisa Mizuki","doi":"10.1093/mr/roaf103","DOIUrl":"10.1093/mr/roaf103","url":null,"abstract":"Objectives: To clarify contemporary epidemiological and clinical trends of Behçet's disease in Japan by analysing the 2019 National Database of Designated Intractable Diseases (MHLW), describing patient demographics, organ involvement, impact on daily life, and treatment patterns.Methods: This study analysed the 2019 data from the National Database of Designated Intractable Diseases of Japan, provided by the Japanese Ministry of Health, Labour and Welfare. We focused on age distribution, symptom frequency, daily life impact, and treatment trends.Results: In the 2019 database, 10 406 patients with BD were registered. The median age was 55 years, with a higher proportion of women affected (53.2%). Serious manifestations such as ocular, vascular, and central nervous system involvement were more frequent in males, whereas females showed more mucocutaneous and articular symptoms, representing mild forms of the disease. Pharmacological treatment was common (93.8%), with corticosteroids (44.3%), colchicine (50.9%), infliximab (17.0%), and adalimumab (9.6%) being frequently used. BD significantly affected daily life, with nearly one-third experiencing impaired mobility or depression.Conclusions: This nationwide analysis highlighted sex-based differences in clinical features and found that BD continues to substantially affect quality of life. The widespread use of biologics suggests a shift in therapeutic strategies.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"422-429"},"PeriodicalIF":1.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145345939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Grip strength asymmetry as a better indicator of residual hand symptoms than absolute grip strength after achieving treat-to-target in rheumatoid arthritis. 类风湿关节炎患者达到治疗目标后，握力不对称比绝对握力更能反映残手症状。

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-04-13 DOI: 10.1093/mr/roaf110

Yoshifumi Ohashi, Mochihito Suzuki, Yasumori Sobue, Kenya Terabe, Shuji Asai, Shiro Imagama, Nobunori Takahashi

{"title":"Grip strength asymmetry as a better indicator of residual hand symptoms than absolute grip strength after achieving treat-to-target in rheumatoid arthritis.","authors":"Yoshifumi Ohashi, Mochihito Suzuki, Yasumori Sobue, Kenya Terabe, Shuji Asai, Shiro Imagama, Nobunori Takahashi","doi":"10.1093/mr/roaf110","DOIUrl":"10.1093/mr/roaf110","url":null,"abstract":"Objective: This study aimed to identify factors associated with residual hand symptoms in well-controlled rheumatoid arthritis (RA) patients.Methods: Data from 464 RA patients with DAS28-ESR < 3.2 and bilateral grip strength measurements were analysed. Grip strength asymmetry was defined as a grip difference rate ≥ 20%, calculated as follows: (Stronger hand grip strength-Weaker hand grip strength)/Stronger hand grip strength × 100. Patients were grouped by the presence (n = 107) or absence (n = 357) of hand symptoms. Multivariable logistic regression was used to identify associated factors. The relationship between grip strength asymmetry and hand symptoms was also examined.Results: Patients with hand symptoms were younger (64.3 versus 69.1 years), had higher DAS28-ESR scores (2.42 versus 2.04), and a greater grip difference rate (19.9% versus 14.5%) compared to those without. Multivariable analysis showed that age (OR 0.97), Steinbrocker stage (OR 1.36), and grip difference rate (OR 1.02) were independently associated with hand symptoms. The prevalence of hand symptoms and swelling was higher in the grip strength asymmetry group than in the non-asymmetry group (hand symptoms: 30.8% versus 19.8%; swelling: 11.2% versus 5.3%).Conclusions: Grip strength asymmetry may serve as a simple and accessible marker for residual joint symptoms in RA patients achieving T2T.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"367-374"},"PeriodicalIF":1.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics and prognosis of non-spontaneously regressing immunodeficiency-associated lymphoproliferative disorders in patients with rheumatoid arthritis after methotrexate discontinuation. 甲氨蝶呤停药后类风湿关节炎患者非自发消退性免疫缺陷相关淋巴细胞增生性疾病的特点和预后

IF 1.9 4区医学

Modern Rheumatology Pub Date : 2026-04-13 DOI: 10.1093/mr/roaf115

Miyu Wakatsuki, Hiroyuki Yamashita, Masatoshi Hotta, Hiroshi Kaneko

{"title":"Characteristics and prognosis of non-spontaneously regressing immunodeficiency-associated lymphoproliferative disorders in patients with rheumatoid arthritis after methotrexate discontinuation.","authors":"Miyu Wakatsuki, Hiroyuki Yamashita, Masatoshi Hotta, Hiroshi Kaneko","doi":"10.1093/mr/roaf115","DOIUrl":"10.1093/mr/roaf115","url":null,"abstract":"Objective: To investigate the risk factors and prognosis of non-spontaneously regressing immunodeficiency-associated lymphoproliferative disorders (LPDs) after methotrexate (MTX) discontinuation in patients with rheumatoid arthritis (RA).Methods: We retrospectively reviewed medical records of 38 patients with MTX-associated LPD and compared the characteristics of those with and without spontaneous regression (SR) of LPDs (SR versus non-SR groups: N = 22 versus 16) and of survivors and non-survivors in the non-SR group (N = 5 deaths).Results: The SR and non-SR groups were comparable regarding age, sex, RA duration and activity, MTX use duration and dose, LPD stage and histological characteristics (lymphoma types and Epstein-Barr encoding region in situ hybridisation positivity). However, the non-SR group had significantly higher lactate dehydrogenase (LDH) levels at LPD diagnosis and lower lymphocyte recovery 1 month after MTX withdrawal. Multivariate analysis revealed poor lymphocyte recovery 1 month after MTX withdrawal as a risk factor for non-SR (odds ratio: 7.12; P = .02). Log-rank test showed that elevated LDH levels (>250 U/L) were significantly associated with death (P = .02).Conclusions: Lack of lymphocyte recovery 1 month after MTX discontinuation was a risk factor for non-spontaneously regressive LPD. High LDH level was associated with death in these cases.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"359-366"},"PeriodicalIF":1.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145715154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0