Modern Rheumatology最新文献

{"title":"Correction to: Long-term safety and efficacy of belimumab in Japanese patients with SLE: A 7-year open-label continuation study.","authors":"","doi":"10.1093/mr/roae014","DOIUrl":"10.1093/mr/roae014","url":null,"abstract":"","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"929-933"},"PeriodicalIF":1.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140068511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relapses and treatment status in elderly and non-elderly patients with eosinophilic granulomatosis with polyangiitis: A retrospective observational study using Japanese nationwide claims data.","authors":"Masami Taniguchi, Haruki Koike, Hayato Oka, Keita Ono, Kazuya Sumi, Yuki Kato, Yoshifumi Arita, Masakazu Fujiwara, Naoyuki Makita, Koichi Amano","doi":"10.1093/mr/roaf026","DOIUrl":"10.1093/mr/roaf026","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to better understand the relapse rate for eosinophilic granulomatosis with polyangiitis, a rare, debilitating form of vasculitis, in Japanese elderly and non-elderly patients, along with their treatment statuses.</p><p><strong>Methods: </strong>This retrospective, observational study used claims data from April 2019 to March 2022 representing approximately 8 million insured individuals in Japan. Patients aged ≥18 years were identified and stratified into elderly (≥65 years) and non-elderly (<65 years) groups. The proportion of patients experiencing relapses and their treatment statuses were assessed during a 1-year follow-up period.</p><p><strong>Results: </strong>Among the 651 eligible patients with eosinophilic granulomatosis with polyangiitis enrolled, 38.86% experienced a relapse during the follow-up period. This proportion was similar between the elderly (36.34%) and non-elderly (42.59%) groups. Moreover, fewer elderly than non-elderly patients were prescribed biologics (22.16% vs. 37.26%) and immunosuppressants (20.36% vs. 29.28%), despite having higher percentages of corticosteroid-related comorbidities.</p><p><strong>Conclusions: </strong>The disease burden of eosinophilic granulomatosis with polyangiitis in Japan remains substantial, with over one-third of patients experiencing a relapse, regardless of age. Age-specific management strategies optimizing biologics and immunosuppressant use while minimizing adverse events are needed to improve the outcomes of these patients in Japan.</p>","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"884-893"},"PeriodicalIF":1.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of pulmonary artery wall thickness by transthoracic echocardiography in Behçet's disease.","authors":"Gizem Kırmızıer, Elif Altunel Kılınç, Gizem Varkal, Zeynep Tüzün, İpek Türk, Rabia Eker Akıllı, Süleyman Özbek","doi":"10.1093/mr/roaf040","DOIUrl":"10.1093/mr/roaf040","url":null,"abstract":"<p><strong>Objectives: </strong>Vascular inflammation is a key feature of Behçet's disease (BD), with studies showing increased vein wall thickness. The pulmonary artery, sharing structural features with veins, is of particular importance in BD. This study aimed to assess pulmonary artery wall thickness (PAWT) using transthoracic echocardiography and examine its association with disease manifestations, including major organ involvement (MOI) and mucocutaneous-limited disease (MLD), in comparison to healthy controls (HCs).</p><p><strong>Methods: </strong>This cross-sectional study included 67 patients with BD (43 with MOI, 24 with MLD) and 46 HCs. PAWT was measured from the middle of the pulmonary valve and pulmonary artery bifurcation in the parasternal short axis by an experienced cardiologist blinded to clinical data.</p><p><strong>Results: </strong>PAWT was significantly higher in patients with BD (3.5 ± 0.9 mm) than in HCs (2.7 ± 0.5 mm) (P < .001). Patients with MOI had significantly greater thickness than those with MLD and HCs (3.9 ± 0.7, 2.7 ± 0.6, 2.7 ± 0.5 mm, respectively; P < .001). The increase in thickness was most pronounced in patients with vascular involvement (P = .03).</p><p><strong>Conclusions: </strong>PAWT is greater in BD with MOI. Routine measurement may help detect vascular complications.</p>","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"916-922"},"PeriodicalIF":1.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Support for Patients with Rheumatoid Arthritis Provided by Care and Welfare Professionals in Japan: A Cross-sectional study.","authors":"Toshihiro Matsui, Mie Fusama, Kimito Kawahata, Ryoko Sakai, Takahiko Sugihara, Miho Tsujimura, Isao Matsushita, Nobuyuki Yajima, Takeo Isozaki, Noriyoshi Shimahara, Shotaro Suzuki, Rei Ono, Shinya Taguchi, Shigeto Tohma, Ryo Yanai, Hideshi Yamazaki, Toshie Kadonaga, Hiroaki Nakabayashi, Chiaki Ando, Masayo Kojima, Yutaka Kawahito","doi":"10.1093/mr/roaf080","DOIUrl":"https://doi.org/10.1093/mr/roaf080","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the knowledge, experience, and challenges faced by care and welfare professionals in supporting patients with rheumatoid arthritis (RA) in Japan, and to identify issues related to coordination between medical and welfare services.</p><p><strong>Methods: </strong>A nationwide questionnaire survey was conducted using stratified regional sampling. The target population included 1 000 members each from the Japan Care Manager Association (JCMA) and the Japanese Association of Certified Social Workers (JASW). The survey assessed respondents' knowledge of RA, support experience, actual practices, views on interdisciplinary collaboration, and perceptions of patients' understanding of available systems.</p><p><strong>Results: </strong>Valid responses were obtained from 390 JCMA members and 330 JASW members. While basic knowledge of RA symptoms and disease course was common, awareness of RA-specific medications was limited, especially among JASW respondents. Many participants had little experience supporting RA patients. Reported challenges included insufficient information from physicians, a lack of structured information sharing, and underestimation of care needs in long-term care certification. Patients and families also showed limited understanding of healthcare and welfare systems.</p><p><strong>Conclusions: </strong>The findings highlight the need for improved education, better interdisciplinary coordination, and enhanced information sharing. Comprehensive efforts are essential to ensure continuous, high-quality care for RA patients in community settings.</p>","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbiota-Immune Axis in the Regulation of Rheumatoid Arthritis: From Mechanism to Precision Probiotic Strategies.","authors":"Yudi Hao","doi":"10.1093/mr/roaf081","DOIUrl":"https://doi.org/10.1093/mr/roaf081","url":null,"abstract":"<p><p>Rheumatoid Arthritis (RA) is a progressive autoimmune disorder with substantial global health and economic impacts. Despite advancements in conventional therapies, biologics, and targeted drugs, challenges such as adverse effects, cost, and interindividual heterogeneity underscore the need for safer, precision-based treatments. Notably, emerging evidence highlights the pivotal role of the gut microbiota-immune axis in RA pathogenesis. Affected individuals typically exhibit gut dysbiosis, marked by increased pro-inflammatory taxa and reduced anti-inflammatory species, which disrupts immune homeostasis through Th17/Treg imbalance, molecular mimicry, and compromised gut barrier integrity. These processes drive systemic inflammation, exacerbating both articular destruction and extra-articular manifestations. Probiotics demonstrate therapeutic potential by modulating this axis via microbiota restoration, barrier reinforcement, and immune regulation. Strain-specific effects have been documented in both preclinical and clinical studies, although efficacy varies depending on host genetics, baseline microbiota composition, and intervention protocols-a variability underscoring the need for personalized probiotic selection. This review consolidates current knowledge on gut microbiota-immune crosstalk in RA and explores probiotics as precision therapeutics. Integrating multi-omics (metagenomics, metabolomics) with targeted probiotic strategies could enable the development of personalized interventions. While translational obstacles persist, including mechanistic complexity and limited clinical validation, the gut microbiota-immune axis offers a novel paradigm for RA management. Future priorities include large-scale trials, biomarker discovery, and combinatorial approaches to advancing microbiome-guided precision medicine in autoimmune diseases.</p>","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Nailfold Videocapillaroscopy in Children with Psoriatic Arthritis: Are There Any Hidden Vascular Signatures?","authors":"Bengisu Menentoğlu, Fatma Gül Demirkan, Selen Duygu Arık, Gülşah Kavrul Kayaalp, Özlem Akgün, Figen Çakmak, Mustafa Çakan, Nuray Aktay Ayaz","doi":"10.1093/mr/roaf079","DOIUrl":"https://doi.org/10.1093/mr/roaf079","url":null,"abstract":"<p><strong>Objectives: </strong>Juvenile psoriatic arthritis (JPsA), a subtype of juvenile idiopathic arthritis, is a chronic inflammatory disease characterized by joint and skin involvement. Microvascular alterations, including endothelial dysfunction and inflammation, are thought to contribute to its pathophysiology. Nailfold videocapillaroscopy (NVC) is a non-invasive technique for assessing microvascular changes. This study aimed to evaluate NVC findings in children with JPsA compared to healthy controls, investigating its potential diagnostic and monitoring utility.</p><p><strong>Methods: </strong>This cross-sectional study included 25 children with JPsA and 33 age- and sex-matched healthy controls. NVC was performed on eight fingers per participant, focusing on capillary density, morphology, and the presence of microhemorrhages. Disease activity was assessed using the Juvenile Arthritis Disease Activity Score-27. Statistical analyses compared capillaroscopic findings between groups and explored correlations with clinical parameters.</p><p><strong>Results: </strong>In JPsA patients, tortuous capillaries (84% versus 24%, p < 0.001), crossed capillaries (100% versus 63.6%, p = 0.001), and microhemorrhages (28% versus 0%, p = 0.002) were significantly more frequent compared to controls. No specific capillaroscopy pattern was detected in the JPsA cohort. Capillary density and apical loop widths did not differ significantly between groups (p = 0.92 and p = 0.93, respectively). Disease duration negatively correlated with capillary density (r = -0.484, p = 0.014), suggesting progressive microvascular changes over time.</p><p><strong>Conclusion: </strong>Nailfold videocapillaroscopy revealed distinct microvascular abnormalities in children with JPsA, including increased tortuosity and microhemorrhages, highlighting its potential as a diagnostic and monitoring tool. Longitudinal studies with larger cohorts are warranted to validate these findings and clarify the prognostic significance of NVC in JPsA.</p>","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-U1-RNP antibody positivity is associated with elevated interferon stimulated gene expression scores in SLE irrespective of disease activity: a transcriptome analysis in Japanese patients.","authors":"Takemichi Matsui, Yumi Tsuchida, Takahiro Itamiya, Mineto Ota, Toshihiko Komai, Haruka Tsuchiya, Hirofumi Shoda, Tomohisa Okamura, Keishi Fujio","doi":"10.1093/mr/roaf066","DOIUrl":"https://doi.org/10.1093/mr/roaf066","url":null,"abstract":"<p><strong>Objectives: </strong>With the introduction of anifrolumab to clinical practice, there is a growing interest in identifying factors associated with interferon (IFN) activity in patients with systemic lupus erythematosus (SLE). An association between IFN stimulated-gene (ISG) expression and anti-U1-RNP antibody positivity has been reported. However, data from Asians are scarce. In this study we investigated clinical parameters associated with ISG expression in patients with SLE in Japan.</p><p><strong>Methods: </strong>We utilized transcriptome data from 130 Japanese patients diagnosed with SLE from the ImmuNexUT database. We defined the ISG score as the average normalized expression levels of IFI27, IFI44, IFI44L, and RSAD2. The associations between clinical parameters and the ISG score were assessed.</p><p><strong>Results: </strong>Clinical characteristics were compared between the low and high ISG score groups. Clinical SLEDAI, anti-U1-RNP antibodies, and anti-SS-A antibodies were associated with the high ISG group in multiple logistic regression analysis. Classification and regression tree analysis indicated that anti-U1-RNP antibody positivity was the best serological factor predicting the ISG score. Even among patients with clinically inactive disease, the ISG score was higher in those positive than in those negative for anti-U1-RNP antibodies.</p><p><strong>Conclusion: </strong>Autoantibody profiles, especially anti-U1-RNP antibodies, are useful for predicting ISG scores in Asians.</p>","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac magnetic resonance imaging analysis of cardiac involvement in eosinophilic granulomatosis with polyangiitis.","authors":"Hirotake Inomata, Noboru Kitamura, Hitoshi Uchikawa, Kiichi Sugito, Shinya Asatani, Masahiro Nishihara, Kumiko Akiya, Miho Oshima, Hideki Nakamura","doi":"10.1093/mr/roaf072","DOIUrl":"https://doi.org/10.1093/mr/roaf072","url":null,"abstract":"<p><strong>Objectives: </strong>Eosinophilic granulomatosis with polyangiitis causes complications in various organs. Cardiac involvement affects the prognosis but is difficult to detect during subclinical stages. We compared the results of cardiac magnetic resonance imaging with those of other imaging studies and biomarkers for patients with eosinophilic granulomatosis with polyangiitis and suspected cardiac involvement.</p><p><strong>Methods: </strong>This retrospective observational study included 29 patients diagnosed with and treated for eosinophilic granulomatosis with polyangiitis at our hospital between 2015 and 2022. Of these patients, 16 with suspected cardiac involvement and cardiac magnetic resonance images were selected. Symptoms, autoantibodies, biomarkers, echocardiography, and other test results were compared with imaging findings.</p><p><strong>Results: </strong>Of the 16 patients who underwent cardiac magnetic resonance imaging, eight had findings of cardiac involvement. A univariate analysis indicated significant differences in troponin I, creatine kinase-MB, and N-terminal pro-brain natriuretic peptide between patients with and without findings of cardiac involvement. A multivariate analysis identified creatine kinase-MB as an independent predictive factor for cardiac involvement.</p><p><strong>Conclusions: </strong>Cardiac magnetic resonance imaging used to diagnose subclinical cardiac lesions possibly improved the prognosis of patients with eosinophilic granulomatosis with polyangiitis.</p>","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting CCNE2 to Alleviate Rheumatoid Arthritis through Inducing Senescence and Apoptosis.","authors":"Rui Xu, Youhan Mei, Hanrui Liu, Hong Yi, Hongjian Deng, Ziliang Yu, Wei Liu","doi":"10.1093/mr/roaf077","DOIUrl":"https://doi.org/10.1093/mr/roaf077","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the role of cellular senescence in the progression of rheumatoid arthritis (RA) and demonstrated the potential of targeting Cyclin E2 (CCNE2) in synoviocytes fibroblast to alleviate RA, aiming to establish a robust risk prediction mode for RA and provide theoretical support for clinically targeted therapy.</p><p><strong>Methods: </strong>We analysed the differential gene expression of RA patients and healthy individuals and performed a Gene set enrichment analysis (GSEA). The genes related to cell senescence were downloaded to obtain the intersect genes with the differential genes. LASSO regression analysis was employed to establish a risk prediction model, and the ROC curve was utilized to prove the accuracy of the model. CCNE2 expression was examined by Western blot. In rheumatoid arthritis synovial fibroblasts (RASFs), CCNE2 was knocked down using shRNA to assess its cellular function. Cell viability and apoptosis were evaluated using CCK8 assay and flow cytometry, respectively. SA-β-Gal staining and immunofluorescence for H3K9me2/3 were performed to detect cellular senescence. The expression of senescence-related markers (p16, p21, p53) and SASP factors (e.g. IL-8, MMP-3) was assessed by Western blot and ELISA. For in vivo validation, a collagen-induced arthritis (CIA) mouse model was established, and AAV-mediated intra-articular injection of shCCNE2 was performed. Arthritis index scoring and histological examination (H&E staining) were conducted to evaluate joint inflammation, and CCNE2 expression in synovial tissues was assessed.</p><p><strong>Results: </strong>Risk score = (-0.295 × ANAPC2) + (0.009 × ASF1A) + (1.260 × CCNE2)-(0.186 × CEBPB) + (0.172 × E2F2) + (0.519 × FOS)-(1.036 × FZR1)-(0.296 × MAPK7)-(0.439 × RING1)-(0.37 × TNRC6C) (AUC > 0.6). There was extensive infiltration of inflammatory cells in the synovial tissue of the RA group, accompanied by synovial hyperplasia and the expression level of CCNE2 was significantly increased (P < 0.01). The results of immune infiltration showed, naive B cells, CD8 T cells and M1 macrophages exhibited a strong positive association with the risk score. After knocking out CCNE2 in RASFs, cell viability significantly decreased, while the rate of apoptosis significantly increased (P < 0.01). The activity of SA-β-Gal and H3K9me3 enhanced, and the protein expression levels of p16, p21, and p53 were also significantly increased (P < 0.01). In vivo targeted knockout of CCNE2 significantly ameliorated both arthritis index and inflammatory joint infiltration in RA mice.</p><p><strong>Conclusion: </strong>A risk prediction model for RA was developed. Targeting CCNE2 emerges as a novel RA therapeutic strategy: its suppression induces RASF senescence, consequently mitigating disease progression and joint inflammation.</p>","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using serum cTnT/CK combined with anti-Ro52 antibodies to screen for myocardial involvement and assess prognosis in idiopathic inflammatory myopathy.","authors":"Yinghong Tang, Dongyu Li, Wangyan Liu, Yue Zhang, Jiayi Dai, Wei Qian, Linwei Shan, Lin Li, Qi Hu, Changjing Feng, Yinsu Zhu, Xiaoxuan Sun, Li Ma, Qiang Wang, Lei Zhou","doi":"10.1093/mr/roaf076","DOIUrl":"https://doi.org/10.1093/mr/roaf076","url":null,"abstract":"<p><strong>Objective: </strong>Myocardial involvement in idiopathic inflammatory myopathy (IIM) indicates poor prognosis. This study aimed to identify risk factors for myocardial involvement and assess their prognostic value.</p><p><strong>Methods: </strong>We analysed 92 IIM patients with abnormal cardiac troponin T (cTnT). Myocardial involvement was diagnosed by late gadolinium enhancement on cardiovascular magnetic resonance. All-cause mortality was recorded during follow-up.</p><p><strong>Results: </strong>Among 92 patients, myocardial involvement was observed in 68.5%, who showed increased cTnT/CK ratios and anti-Ro52 antibody positivity rates. Anti-Ro52 positive patients exhibited higher rates of LGE and increased E/e'. Both cTnT/CK (OR = 1.030, p = 0.024) and anti-Ro52 (OR = 5.629, p = 0.003) independently predicted myocardial involvement. A cTnT/CK cut-off > 19.3% predicted myocardial involvement (AUC = 0.660), rising to 0.780 when combined with anti-Ro52. Subgroup analysis showed cTnT/CK was discriminative only in anti-Ro52 negative individuals. During a 36-month follow-up, 18 deaths occurred. Adjusted Cox regression identified cTnI positivity (HR = 7.395, p = 0.001) and cTnT/CK (HR = 1.012, p = 0.037) as independent mortality predictors. Time-dependent ROC at 3 years showed AUCs of 0.68 (cTnI) and 0.64 (cTnT/CK). Kaplan-Meier analysis confirmed worse survival with positive cTnI or high cTnT/CK.</p><p><strong>Conclusion: </strong>The cTnT/CK ratio identifies myocardial involvement and predicts mortality in IIM patients with abnormal cardiac troponin T. Combining it with anti-Ro52 antibodies improves detection of myocardial involvement.</p>","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}