{"title":"弥漫性特发性骨骼肥厚症患者肌肉质量和数量的评估。","authors":"Kosei Ono, Takayoshi Shimizu, Masaki Sakamoto, Masaya Kubota, Masahiro Yakami, Takashi Sono, Ryusuke Nakamoto, Koichi Murata, Shuichi Matsuda, Bungo Otsuki","doi":"10.1093/mr/roaf084","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Diffuse idiopathic skeletal hyperostosis (DISH) may reduce spinal mobility and affect muscle quantity and quality, increasing sarcopenia risk. However, longitudinal data are limited. We investigated muscle quantity, quality, and their changes in DISH using computed tomography (CT) and bioelectrical impedance analysis (BIA).</p><p><strong>Methods: </strong>We analysed health screening data including participants who underwent CT and BIA twice over five years. We identified 143 DISH patients (58.0 ± 8.4 years, 19 females) and 143 age- and sex-matched controls (58.4 ± 8.8 years, 19 females). At L3, psoas and posterior paraspinal muscle (PSM) areas were measured on CT and normalized to height squared as muscle index (MI, cm2/m2). Muscle density was assessed in Hounsfield units (HU). Skeletal muscle mass index (SMI, kg/m2) was obtained from BIA.</p><p><strong>Results: </strong>At baseline, DISH had higher MI (psoas: 347.5 ± 86.0 versus 294.8 ± 81.7, p < 0.001; PSM: 809.3 ± 146.2 versus 758.8 ± 130.7, p = 0.002) but lower HU (psoas: 36.0 ± 9.1 versus 40.9 ± 5.2, p < 0.001; PSM: 39.0 ± 8.8 versus 42.0 ± 7.4, p = 0.002). SMI was similar (7.9 ± 0.9 versus 7.7 ± 0.9, p = 0.212). Over five years, DISH MI declined (psoas: 334.3 ± 94.9, p = 0.006; PSM: 782.6 ± 166.4, p = 0.007), while controls showed no change (psoas: 294.7 ± 94.1, p = 0.695; PSM: 757.2 ± 170.3, p = 0.776).</p><p><strong>Conclusion: </strong>DISH patients have greater muscle mass but lower quality and trend toward decline, suggesting sarcopenia risk.</p>","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Assessment of Muscle Quality and Quantity in Individuals with Diffuse Idiopathic Skeletal Hyperostosis.\",\"authors\":\"Kosei Ono, Takayoshi Shimizu, Masaki Sakamoto, Masaya Kubota, Masahiro Yakami, Takashi Sono, Ryusuke Nakamoto, Koichi Murata, Shuichi Matsuda, Bungo Otsuki\",\"doi\":\"10.1093/mr/roaf084\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Diffuse idiopathic skeletal hyperostosis (DISH) may reduce spinal mobility and affect muscle quantity and quality, increasing sarcopenia risk. However, longitudinal data are limited. We investigated muscle quantity, quality, and their changes in DISH using computed tomography (CT) and bioelectrical impedance analysis (BIA).</p><p><strong>Methods: </strong>We analysed health screening data including participants who underwent CT and BIA twice over five years. We identified 143 DISH patients (58.0 ± 8.4 years, 19 females) and 143 age- and sex-matched controls (58.4 ± 8.8 years, 19 females). At L3, psoas and posterior paraspinal muscle (PSM) areas were measured on CT and normalized to height squared as muscle index (MI, cm2/m2). Muscle density was assessed in Hounsfield units (HU). Skeletal muscle mass index (SMI, kg/m2) was obtained from BIA.</p><p><strong>Results: </strong>At baseline, DISH had higher MI (psoas: 347.5 ± 86.0 versus 294.8 ± 81.7, p < 0.001; PSM: 809.3 ± 146.2 versus 758.8 ± 130.7, p = 0.002) but lower HU (psoas: 36.0 ± 9.1 versus 40.9 ± 5.2, p < 0.001; PSM: 39.0 ± 8.8 versus 42.0 ± 7.4, p = 0.002). SMI was similar (7.9 ± 0.9 versus 7.7 ± 0.9, p = 0.212). Over five years, DISH MI declined (psoas: 334.3 ± 94.9, p = 0.006; PSM: 782.6 ± 166.4, p = 0.007), while controls showed no change (psoas: 294.7 ± 94.1, p = 0.695; PSM: 757.2 ± 170.3, p = 0.776).</p><p><strong>Conclusion: </strong>DISH patients have greater muscle mass but lower quality and trend toward decline, suggesting sarcopenia risk.</p>\",\"PeriodicalId\":18705,\"journal\":{\"name\":\"Modern Rheumatology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-10-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Modern Rheumatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/mr/roaf084\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Modern Rheumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/mr/roaf084","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的：弥漫性特发性骨骼肥厚症（DISH）可降低脊柱活动度，影响肌肉数量和质量，增加肌肉减少的风险。然而，纵向数据有限。我们使用计算机断层扫描（CT）和生物电阻抗分析（BIA）研究了DISH的肌肉数量、质量及其变化。方法：我们分析了健康筛查数据，包括五年内两次接受CT和BIA检查的参与者。我们确定了143例DISH患者（58.0±8.4岁，19名女性）和143例年龄和性别匹配的对照组（58.4±8.8岁，19名女性）。在L3，腰大肌和后棘旁肌（PSM）区域在CT上测量，并归一化为高度平方作为肌肉指数（MI, cm2/m2）。以Hounsfield单位（HU）评估肌肉密度。骨骼肌质量指数（SMI, kg/m2）由BIA测定。结果：基线时，DISH患者心肌梗死发生率较高（腰大肌347.5±86.0 vs 294.8±81.7）。结论：DISH患者肌量较大，但质量较差，且有下降趋势，提示肌少症风险。
Assessment of Muscle Quality and Quantity in Individuals with Diffuse Idiopathic Skeletal Hyperostosis.
Objectives: Diffuse idiopathic skeletal hyperostosis (DISH) may reduce spinal mobility and affect muscle quantity and quality, increasing sarcopenia risk. However, longitudinal data are limited. We investigated muscle quantity, quality, and their changes in DISH using computed tomography (CT) and bioelectrical impedance analysis (BIA).
Methods: We analysed health screening data including participants who underwent CT and BIA twice over five years. We identified 143 DISH patients (58.0 ± 8.4 years, 19 females) and 143 age- and sex-matched controls (58.4 ± 8.8 years, 19 females). At L3, psoas and posterior paraspinal muscle (PSM) areas were measured on CT and normalized to height squared as muscle index (MI, cm2/m2). Muscle density was assessed in Hounsfield units (HU). Skeletal muscle mass index (SMI, kg/m2) was obtained from BIA.
Results: At baseline, DISH had higher MI (psoas: 347.5 ± 86.0 versus 294.8 ± 81.7, p < 0.001; PSM: 809.3 ± 146.2 versus 758.8 ± 130.7, p = 0.002) but lower HU (psoas: 36.0 ± 9.1 versus 40.9 ± 5.2, p < 0.001; PSM: 39.0 ± 8.8 versus 42.0 ± 7.4, p = 0.002). SMI was similar (7.9 ± 0.9 versus 7.7 ± 0.9, p = 0.212). Over five years, DISH MI declined (psoas: 334.3 ± 94.9, p = 0.006; PSM: 782.6 ± 166.4, p = 0.007), while controls showed no change (psoas: 294.7 ± 94.1, p = 0.695; PSM: 757.2 ± 170.3, p = 0.776).
Conclusion: DISH patients have greater muscle mass but lower quality and trend toward decline, suggesting sarcopenia risk.
期刊介绍：
Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery.
Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered.
Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions
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