Modern Rheumatology最新文献_第6页

Mid-term outcomes of distal tibial oblique osteotomy for rheumatoid arthritis-associated ankle arthropathy: A comparison with osteoarthritis outcomes. 胫骨远端斜截骨术治疗类风湿性关节炎相关踝关节病的中期结果：与骨关节炎结果的比较

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-05 DOI: 10.1093/mr/roaf018

Taihei Miura, Takaaki Noguchi, Makoto Hirao, Kosuke Ebina, Yuki Etani, Gensuke Okamura, Atsushi Goshima, Seiji Okada, Jun Hashimoto, Masato Takao

{"title":"Mid-term outcomes of distal tibial oblique osteotomy for rheumatoid arthritis-associated ankle arthropathy: A comparison with osteoarthritis outcomes.","authors":"Taihei Miura, Takaaki Noguchi, Makoto Hirao, Kosuke Ebina, Yuki Etani, Gensuke Okamura, Atsushi Goshima, Seiji Okada, Jun Hashimoto, Masato Takao","doi":"10.1093/mr/roaf018","DOIUrl":"10.1093/mr/roaf018","url":null,"abstract":"Background: Distal tibial oblique osteotomy (DTOO) has traditionally been contraindicated in 'patients with rheumatoid arthritis (RA)'. However, with advances in RA treatment, an increasing number of patients present with arthritis resembling osteoarthritis (OA), suggesting DTOO as a potential option. This study aimed to compare mid-term clinical and radiographic outcomes of DTOO between the patients with OA and RA.Methods: This study included eight ankles of seven patients with OA (Stage IIIa-IIIb, Takakura-Tanaka classification) and five ankles of five patients with RA (equivalent to Stage IIIa). Clinical outcomes [Japanese Society for Surgery of the Foot (JSSF) ankle/hindfoot scale, Self-Administered Foot Evaluation Questionnaire (SAFE-Q)], radiographic parameters, ankle range of motion (ROM), and complications were assessed preoperatively and at the final follow-up.Results: Postoperative JSSF and SAFE-Q scores improved significantly in both groups, without intergroup differences. Radiographic parameters showed no significant differences preoperatively or postoperatively, with consistent trends across groups. The patients with OA demonstrated significant postoperative ROM improvement, whereas the patients with RA maintained preoperative ROM. Complications included plate removal in one OA case due to discomfort and two RA cases due to infection.Conclusions: DTOO provides good outcomes in the patients with RA with controlled disease activity, suggesting it as a viable joint-preserving surgical option for the selected patients with RA.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"658-664"},"PeriodicalIF":1.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of regional variations and occupation on hand osteoarthritis: Insights from the research on osteoarthritis/osteoporosis against disability study. 地区差异和职业对手部骨关节炎的影响：来自骨关节炎/骨质疏松症与残疾研究的见解。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-05 DOI: 10.1093/mr/roaf002

Ichiko Kojima, Kosuke Uehara, Toshiko Iidaka, Rie Kodama, Shigeyuki Muraki, Hiroyuki Oka, Hiroshi Kawaguchi, Toru Akune, Hiroshi Hashizume, Hiroshi Yamada, Munehito Yoshida, Yutaka Morizaki, Kozo Nakamura, Sakae Tanaka, Noriko Yoshimura

{"title":"Effects of regional variations and occupation on hand osteoarthritis: Insights from the research on osteoarthritis/osteoporosis against disability study.","authors":"Ichiko Kojima, Kosuke Uehara, Toshiko Iidaka, Rie Kodama, Shigeyuki Muraki, Hiroyuki Oka, Hiroshi Kawaguchi, Toru Akune, Hiroshi Hashizume, Hiroshi Yamada, Munehito Yoshida, Yutaka Morizaki, Kozo Nakamura, Sakae Tanaka, Noriko Yoshimura","doi":"10.1093/mr/roaf002","DOIUrl":"10.1093/mr/roaf002","url":null,"abstract":"Objectives: This study aimed to investigate the prevalence of radiographic hand osteoarthritis (HOA) in older Japanese individuals in three distinct regions with unique geographic and occupational characteristics and explore the regional variations and factors, including occupational workload, that affect HOA.Methods: We analysed the radiographic images and data of 1642 participants aged ≥60 years (mean, 75.6 years). After grading the radiographs of both hands using the modified Kellgren-Lawrence (KL) classification, HOA was defined as at least one joint with a KL grade ≥2, and severe HOA was defined as at least one joint with a KL grade ≥3.Results: The overall prevalence rates of HOA and severe HOA were 95.9% and 54.2%, respectively. Regional differences were observed: residence in the mountainous region was associated with HOA and severe HOA, whereas residence in the coastal region was associated with only HOA. Occupational workload was associated with severe HOA in a dose-dependent manner, and heavy work was associated with a higher number of osteoarthritis-affected joints.Conclusion: The present study revealed a high prevalence of HOA in older Japanese individuals and highlighted regional variations in HOA prevalence. A higher occupational workload was associated with a higher risk of severe HOA.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"777-785"},"PeriodicalIF":1.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telemedicine as an alternative to in-person care in the field of rheumatic diseases: A systematic scoping review. 在风湿病领域，远程医疗可替代亲诊：系统性范围界定综述。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-05 DOI: 10.1093/mr/roaf012

Ken-Ei Sada, Shigeru Iwata, Yuzaburo Inoue, Eiichi Tanaka, Keiichiro Nishida, Yutaka Kawahito, Asami Abe, Atsushi Kawakami, Takako Miyamae

{"title":"Telemedicine as an alternative to in-person care in the field of rheumatic diseases: A systematic scoping review.","authors":"Ken-Ei Sada, Shigeru Iwata, Yuzaburo Inoue, Eiichi Tanaka, Keiichiro Nishida, Yutaka Kawahito, Asami Abe, Atsushi Kawakami, Takako Miyamae","doi":"10.1093/mr/roaf012","DOIUrl":"10.1093/mr/roaf012","url":null,"abstract":"Objective: The COVID-19 pandemic prompted the widespread adoption of telemedicine as an alternative to in-person care. This systematic scoping review evaluated the effectiveness, cost-efficiency, and challenges of telemedicine for patients with rheumatic diseases.Methods: A comprehensive search of the MEDLINE database was conducted using specific terms related to rheumatoid or juvenile arthritis, and telemedicine. The literature search included studies published up to March, 2024. In this review, we only considered studies assessing telemedicine as an alternative to in-person care.Results: The search, conducted on 15 March 2024, generated 258 references. Eight reports from three randomized controlled trials and three observational studies were included. Randomized controlled trials have shown that the outcomes of telemedicine intervention are comparable to those of in-person care in terms of disease activity, functional status, and quality of life, while enabling fewer outpatient visits and cost-effectiveness. However, the high dropout rates highlight the importance of patient preferences and comprehensive education. Observational studies revealed similar findings but were limited by a high confounding bias.Conclusion: Telemedicine offers economic advantages and maintains clinical outcomes comparable to those of in-person care. Its success depends on structured patient education and alignment with patient preferences. Further research is required, particularly in the context of healthcare in Japan.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"715-721"},"PeriodicalIF":1.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143409176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic literature review and meta-analysis of the epidemiology and clinical burden of eosinophilic granulomatosis with polyangiitis. 嗜酸性肉芽肿合并多血管炎的流行病学和临床负担的系统文献综述和荟萃分析。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-05 DOI: 10.1093/mr/roaf014

Paul Dolin, Sara Lucas, Amy Gamble, Matthew Turner, Jennifer Rowell

{"title":"Systematic literature review and meta-analysis of the epidemiology and clinical burden of eosinophilic granulomatosis with polyangiitis.","authors":"Paul Dolin, Sara Lucas, Amy Gamble, Matthew Turner, Jennifer Rowell","doi":"10.1093/mr/roaf014","DOIUrl":"10.1093/mr/roaf014","url":null,"abstract":"Objective: To conduct a systematic literature review and meta-analysis for the incidence, prevalence, and mortality of eosinophilic granulomatosis with polyangiitis (EGPA) and describe the clinical burden of EGPA.Methods: Searches were conducted in Ovid MEDLINE and Ovid Embase from January 2019 to June 2023 to identify relevant studies. Data were extracted, and the quality was assessed. Frequentist (random effects) meta-analyses were conducted to estimate EGPA incidence, prevalence, and mortality.Results: Data from 69 unique studies were included. The pooled estimates for EGPA incidence, prevalence, and mortality were 2.15 [95% confidence interval (CI): 0.99, 4.68] cases per million person-years, 34.44 (95% CI: 22.92, 51.76) per million people and 10.63 (95% CI: 7.20, 15.71) per 1000 person-years, respectively. Asthma was the most frequently observed clinical manifestation in patients with EGPA [average of 85.5% (range 42.3-100%)]. Other organs commonly affected included the ear, nose and throat, lungs, nervous system, and heart, and constitutional symptoms were frequently reported.Conclusions: This study confirms that EGPA is a rare disease and is associated with a clear mortality burden. EGPA is a clinically diverse disease; patients experience substantial clinical burden, including treatment-related morbidity and mortality, and there is an unmet need to alleviate this burden.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"697-706"},"PeriodicalIF":1.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The serum amyloid A to C-reactive protein ratio is lower in men than in women because of higher C-reactive protein concentrations in men. 男性血清淀粉样蛋白A与c反应蛋白的比值低于女性，因为男性的c反应蛋白浓度较高。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-05 DOI: 10.1093/mr/roaf004

Hiroshi Uda, Michihito Katayama, Keiji Maeda, Osamu Saiki

{"title":"The serum amyloid A to C-reactive protein ratio is lower in men than in women because of higher C-reactive protein concentrations in men.","authors":"Hiroshi Uda, Michihito Katayama, Keiji Maeda, Osamu Saiki","doi":"10.1093/mr/roaf004","DOIUrl":"10.1093/mr/roaf004","url":null,"abstract":"Objectives: We previously found that discrepancy between serum amyloid A (SAA) and C-reactive protein (CRP) levels linked to the difference of SAA/CRP ratio in patients with early rheumatoid arthritis, and the ratio varied among different patients. This study aimed to determine why the SAA/CRP ratio differed among different patients.Methods: The patients (n = 466) with most of inflammatory diseases were enrolled. After examined CRP and SAA concentrations, we compared the SAA/CRP ratio, and SAA and CRP concentrations in men and women.Results: The SAA/CRP ratio varied dramatically among different patients (33.6-0.140). The 10 highest SAA/CRP ratios were all in women, and half of the 10 lowest ratios were found in men. The loge SAA/CRP ratio was significantly higher in women than in men (P < .0001). The loge SAA concentration was not different between women and men (P = .174), but the loge CRP concentration was significantly higher in men (P < .0001).Conclusions: The SAA/CRP ratio varies considerably among different patients. The SAA/CRP ratio in women is higher than in men because loge CRP but not SAA concentrations in men are higher than in women. The finding is against the conventional view and suggests that the reference range of CRP concentrations in women should be assessed lower than in men.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"677-682"},"PeriodicalIF":1.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-arthritic effects of polyunsaturated fatty acid-rich supplementation combined with selective soluble epoxide hydrolase inhibitors in a collagen-induced arthritis mouse model. 富含多不饱和脂肪酸补充剂联合选择性可溶性环氧化物水解酶抑制剂在胶原诱导关节炎小鼠模型中的抗关节炎作用。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-05 DOI: 10.1093/mr/roaf019

Akiko Yoshida, Kosaku Murakami, Hirotake Tsukamoto, Yunhong Hotta, Yoichi Nakayama, Rintaro Saito, Mirei Shirakashi, Hideaki Tsuji, Ryosuke Hiwa, Shuji Akizuki, Ran Nakashima, Hajime Yoshifuji, Akira Onishi, Masao Tanaka, Tsuneyo Mimori, Akio Morinobu

{"title":"Anti-arthritic effects of polyunsaturated fatty acid-rich supplementation combined with selective soluble epoxide hydrolase inhibitors in a collagen-induced arthritis mouse model.","authors":"Akiko Yoshida, Kosaku Murakami, Hirotake Tsukamoto, Yunhong Hotta, Yoichi Nakayama, Rintaro Saito, Mirei Shirakashi, Hideaki Tsuji, Ryosuke Hiwa, Shuji Akizuki, Ran Nakashima, Hajime Yoshifuji, Akira Onishi, Masao Tanaka, Tsuneyo Mimori, Akio Morinobu","doi":"10.1093/mr/roaf019","DOIUrl":"10.1093/mr/roaf019","url":null,"abstract":"Objectives: Polyunsaturated fatty acids (PUFAs) are healthy fats that contain a double carbon bond. They are made up of omega (ω)-3 and ω-6 PUFAs, where ω-3 PUFAs exhibit beneficial effects, such as the suppression of cardiovascular events and the improvement of abnormal lipid metabolism. However, their effects on rheumatoid arthritis (RA) are unclear. Epoxy fatty acids, which are intermediate metabolites of ω-6 and ω-3 PUFAs, are formed through the action of cytochrome P and possess anti-inflammatory properties. However, they are quickly converted into their inactive forms by soluble epoxide hydrolase.Methods: The protective effects of ω-3 and ω-6 PUFAs on arthritic symptoms with or without soluble epoxide hydrolase inhibitors (sEHis) were investigated in a collagen-induced arthritis mouse model.Results: The group treated with a combination of ω-3 PUFAs and sEHi showed a marked inhibition of arthritis compared to the other groups. Analysis of the faecal flora before the onset of arthritis showed an inverse correlation between the arthritis score and the relative abundance of Lactococcus, suggesting that changes in the intestinal flora in the preclinical stage may influence the onset of arthritis.Conclusions: This study highlights the potential of ω-3 PUFAs combined with sEHi as the novel protective effect for RA.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"665-676"},"PeriodicalIF":1.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequent detection of antinuclear antibodies and low-titre rheumatoid factor in female patients with undifferentiated peripheral spondyloarthritis in Japan: A prospective observational study. 日本女性未分化周围性脊柱炎患者频繁检测抗核抗体和低滴度类风湿因子：一项前瞻性观察研究

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-05 DOI: 10.1093/mr/roaf010

Sho Mokuda, Hiroki Kobayashi, Kei Araki, Michinori Ishitoku, Hirofumi Watanabe, Tomohiro Sugimoto, Yusuke Yoshida, Shintaro Hirata

{"title":"Frequent detection of antinuclear antibodies and low-titre rheumatoid factor in female patients with undifferentiated peripheral spondyloarthritis in Japan: A prospective observational study.","authors":"Sho Mokuda, Hiroki Kobayashi, Kei Araki, Michinori Ishitoku, Hirofumi Watanabe, Tomohiro Sugimoto, Yusuke Yoshida, Shintaro Hirata","doi":"10.1093/mr/roaf010","DOIUrl":"10.1093/mr/roaf010","url":null,"abstract":"Objectives: Studies on the clinical features of undifferentiated peripheral spondyloarthritis (upSpA) are limited. This study explores sex-based manifestations of upSpA and compares upSpA with rheumatoid arthritis (RA) under conditions of low human leukocyte antigen B27 positivity in Japan.Methods: In this multicentre prospective observational study, physical and laboratory findings from 29 upSpA cases (19 females, 10 males) were collected to investigate sex differences. Fourteen patients with RA were also enrolled as a control group to evaluate clinical parameters distinguishing upSpA and RA.Results: Tenderness at the humeral epicondyles and the Achilles tendon were more common in female patients with upSpA than in males. Serum C-reactive protein levels were lower in female patients with upSpA than in male patients. Serum rheumatoid factor levels were lower in upSpA cases than in RA, with a cut-off value of 84 IU/ml differentiating RA from upSpA. An antinuclear antibodies (ANA) test at a dilution of ≥1:160 was detected in about half of the female upSpA cases but not in male cases.Conclusions: Among upSpA and RA cases, female patients with upSpA frequently present with multiple enthesitis, low serum C-reactive protein levels, low-titre rheumatoid factor positivity, and a high incidence of antinuclear antibodies positivity.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"753-761"},"PeriodicalIF":1.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative renoprotective effectiveness of allopurinol and febuxostat among hyperuricaemic patients with preserved kidney function. 别嘌呤醇和非布司他在保留肾功能的高尿酸血症患者中的肾保护效果比较。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-05 DOI: 10.1093/mr/roae115

Atsushi Takayama, Toshiki Fukasawa, Masato Takeuchi, Koji Kawakami

{"title":"Comparative renoprotective effectiveness of allopurinol and febuxostat among hyperuricaemic patients with preserved kidney function.","authors":"Atsushi Takayama, Toshiki Fukasawa, Masato Takeuchi, Koji Kawakami","doi":"10.1093/mr/roae115","DOIUrl":"10.1093/mr/roae115","url":null,"abstract":"Objectives: Early initiation of xanthine oxidase inhibitors may benefit patients with preserved kidney function. However, a direct comparison between the impact of allopurinol and that of febuxostat on long-term kidney function among this population is lacking.Methods: We conducted a retrospective cohort study with a new-user, active-comparator design among patients with estimated glomerular filtration rate (eGFR) within the reference range and no proteinuria. The primary outcome was a composite incidence of significant eGFR decline (≥40% decline from baseline) and all-cause death at 5 years. Adjusted hazard ratios were estimated using Cox's proportional hazard models with inverse probability of treatment and censoring weighting.Results: We analysed 1142 patients (287 with allopurinol and 855 with febuxostat). The adjusted hazard ratios (95% confidence intervals) for allopurinol initiators compared to febuxostat initiators for the composite outcome at 5 years were 0.84 (0.74-0.95). The cause-specific adjusted hazard ratios for allopurinol initiators relative to febuxostat initiators were 0.82 (0.70-0.94) for significant eGFR decline >5 years and 1.08 (0.91-1.24) for all-cause death >5 years.Conclusions: Allopurinol initiators preserved kidney function better than febuxostat >5 years. Clinicians should exercise caution not only when prescribing but also when selecting xanthine oxidase inhibitors, even for patients with preserved kidney function.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"767-776"},"PeriodicalIF":1.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world treatment persistence in csDMARD-IR and bDMARD-IR patients with rheumatoid arthritis in Japan: A large claims database study. 日本类风湿性关节炎csDMARD-IR和bDMARD-IR患者的实际治疗持续性：一项大型索赔数据库研究

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-05 DOI: 10.1093/mr/roaf007

Tsutomu Takeuchi, Craig Pfeifer, Yan Zhong, Yi Piao, Toshihiko Kaise, Mahiro Tani

{"title":"Real-world treatment persistence in csDMARD-IR and bDMARD-IR patients with rheumatoid arthritis in Japan: A large claims database study.","authors":"Tsutomu Takeuchi, Craig Pfeifer, Yan Zhong, Yi Piao, Toshihiko Kaise, Mahiro Tani","doi":"10.1093/mr/roaf007","DOIUrl":"10.1093/mr/roaf007","url":null,"abstract":"Objectives: To investigate treatment persistence for biologic disease-modifying antirheumatic drugs (bDMARDs) and Janus kinase inhibitors (JAKis), including filgotinib, in Japanese patients with rheumatoid arthritis (RA) who have an inadequate response (IR) to conventional synthetic DMARDs (csDMARD-IR) and bDMARDs (bDMARD-IR), and to identify characteristics associated with treatment discontinuation.Methods: We analyzed 2020-2023 health claims data from adults with RA who received ≥1 prescription for bDMARDs or JAKis during the study period and ≥1 prescription for csDMARDs over the previous 6 months. Persistence rates were estimated for the csDMARD-IR (patients naïve to bDMARDs/JAKis) and bDMARD-IR (patients switching to bDMARDs/JAKis from an initial bDMARD) cohorts using the Kaplan-Meier method.Results: Overall, 7208 and 1581 patients were identified in the csDMARD-IR and bDMARD-IR cohorts, respectively. In the csDMARD-IR cohort, 1-year persistence rates were 59%-70% for JAKis (67% for filgotinib) and 53%-69% for bDMARDs. In the bDMARD-IR cohort, 1-year persistence rates were 57%-66% for JAKis (66% for filgotinib) and 19%-91% for bDMARDs. No clinical characteristics were consistently associated with the persistence of JAKi or bDMARD treatment.Conclusions: Rates of persistence among patients taking JAKis, including filgotinib, were approximately 60% or higher in csDMARD-IR and bDMARD-IR cohorts.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"626-636"},"PeriodicalIF":1.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pearls and pitfalls in imaging of axial spondyloarthritis for rheumatologists. 风湿病学家在轴性脊柱炎成像中的缺陷与不足。

IF 1.8 4区医学

Modern Rheumatology Pub Date : 2025-07-05 DOI: 10.1093/mr/roaf034

Taiki Nozaki, Yuko Tsujioka, Hideharu Sugimoto, Yoshitake Yamada, Minoru Yamada, Youichi Yokoyama, Hitomi Fujishiro, Akimoto Nimura, Junya Tsuzaki, Manabu Hase, Masato Okada, Yuko Kaneko, Masahiro Jinzaki

{"title":"Pearls and pitfalls in imaging of axial spondyloarthritis for rheumatologists.","authors":"Taiki Nozaki, Yuko Tsujioka, Hideharu Sugimoto, Yoshitake Yamada, Minoru Yamada, Youichi Yokoyama, Hitomi Fujishiro, Akimoto Nimura, Junya Tsuzaki, Manabu Hase, Masato Okada, Yuko Kaneko, Masahiro Jinzaki","doi":"10.1093/mr/roaf034","DOIUrl":"10.1093/mr/roaf034","url":null,"abstract":"This review provides key insights into sacroiliitis imaging, covering anatomy, imaging techniques, and interpretation. It focuses on normal physiological changes in young to middle-aged women, children, and the elderly that can resemble sacroiliitis. We emphasize the importance of distinguishing between active and structural lesions, as highlighted in the recent ASAS-SPARTAN standardized magnetic resonance imaging protocol. Physicians should be aware that bone marrow oedema signals on magnetic resonance imaging, a hallmark of active inflammation in axial spondyloarthritis, can also be observed in young to middle-aged women, especially postpartum, even without spondyloarthritis. Paediatric sacroiliac joints may show changes mimicking inflammation due to ongoing bone growth. Furthermore, degenerative changes in the sacroiliac joint are common with advancing age and can be mistaken for sacroiliitis or interpreted as structural changes. The presence of accessory sacroiliac joints, prone to degeneration, further complicates diagnosis. Accurate interpretation requires considering these normal variations to avoid misdiagnosing spondyloarthritis. Collaboration between clinicians and radiologists is crucial, especially when encountering atypical or clinically inconsistent findings.","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":"612-625"},"PeriodicalIF":1.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0